Does the Result of Thrombolysis with Recombinant Tissue-Type Plasminogen Activator (rt-PA) in Rabbits Depend on the Erythrocyte- and Fibrin-Content of a Thrombus?;Hängt das Ergebnis einer Thrombolyse mit rekombinantem Gewebe-Plasminogenaktivator (rt-PA) beim Kaninchen vom Erythrozyten- und Fibringehalt eines Thrombus ab?

RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren

Volumn 176, Issue 1, 2004, Pages 98-105

  Kirchhof, Klaus ^a,b   Sikinger, M ^a   Welzel, T ^a   Zoubaa, S ^a   Sartor, K ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b KLINIKUM AUGSBURG   (Germany)

Author keywords

Erythrocytes; Experimental thrombolysis; Fibrin; Rabbit; Stroke

Indexed keywords

ALTEPLASE; FIBRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; BLEEDING; BLOOD CLOT; BLOOD CLOT LYSIS; BRAIN PERFUSION; CONTROLLED STUDY; DRUG EFFICACY; EMBOLISM; ERYTHROCYTE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RABBIT; STROKE; THROMBOEMBOLISM; THROMBUS;

ANIMALS; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; DATA INTERPRETATION, STATISTICAL; DISEASE MODELS, ANIMAL; ERYTHROCYTES; FIBRIN; FIBRINOLYTIC AGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; INTRACRANIAL EMBOLISM AND THROMBOSIS; MALE; PLASMINOGEN ACTIVATORS; PROGNOSIS; RABBITS; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0942287005     PISSN: 14389029     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-814671     Document Type: Article

References (30)

1. Bednar MM, McAuliffe T, Raymond S, Gross CE. Tissue plasminogen activator reduces brain injury in a rabbit model of thromboembolic stroke. Stroke 1990; 21: 1705-1709
2. Benes V, Zabramski JM, Boston M, Puca A, Spetzler RF. Effect of intra-arterial tissue plasminogen activator and urokinase on autologous arterial emboli in the cerebral circulation of rabbits. Stroke 1990; 21: 1594-1599
3. Hamilton MG, Lee JS, Cummings PJ, Zabramski JM. A comparison of intra-arterial and intravenous tissue-type plasminogen activator on autologous arterial emboli in the cerebral circulation of rabbits. Stroke 1994; 25: 651-656
4. Gross CE, Raymond SJ, Howard DB, Bednar MM. Delayed tissue-plasminogen activator therapy in a rabbit model of thromboembolic stroke. Neurosurgery 1995; 36: 1172-1177
5. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581-1587
6. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, Kummer R von, Boysen G, Bluhmki E, Höxter G, Mahagne MH, Hennerici M, for the ECASS Study Group. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 1995; 274: 1017-1025
7. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P, for the Second European-Australasian Acute Stroke Study Investigators. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998; 352: 1245-1251
8. Steiner T, Bluhmki E, Kaste M, Toni D, Trouillas P, von Kummer R, Hacke W, for the ECASS Study Group. The ECASS 3-hour cohort. Secondary analysis of ECASS data by time stratification. Cerebrovasc Dis 1998; 8: 198-203
9. del Zoppo GJ. Clinical trials in acute stroke: why have they not been successful? Neurology 1998; 51 (3 Suppl 3): S59-S61
10. Hacke W, Brott T, Caplan L, Meier D, Fieschi C, Kummer R von, Donnan G, Heiss WD, Wahlgren NG, Spranger M, Boysen G, Marler JR. Thrombolysis in acute ischemic stroke: controlled trials and clinical experience. Neurology 1999; 53 (7 Suppl. 4): S3-S14
11. Vanderschueren S, Van Vlaenderen I, Collen D. Intravenous thrombolysis with recombinant staphylokinase versus tissue-type plasminogen activator in a rabbit embolic stroke model. Stroke 1997; 28: 1783-1788
12. Yenari MA, Lee LK, Beaulieu C, Sun GH, Kunis D, Chang D, Albers GW, Moseley ME, Steinberg GK. Thrombolysis with reteplase, an unglycosylated plasminogen activator variant, in experimental embolic stroke. J Stroke Cerebrovasc Dis 1998; 7: 179-186
13. Castaigne P, Lhermitte F, Gautier JC, Escourolle R, Derouesné C. Internal carotid artery occlusion. A study of 61 instances in 50 patients with post-mortem data. Brain 1970; 93: 231-258
14. Jörgensen L, Torvik A. Ischaemic cerebrovascular diseases in an autopsy series. Part 2. Prevalence, location, pathogenesis, and clinical course of cerebral infarcts. J Neurol Sci 1969; 9: 285-320
15. Torvik A, Jörgensen L. Thrombotic and embolic occlusions of the carotid arteries in an autopsy series. Part 2. Cerebral lesions and clinical course. J Neurol Sci 1966; 3: 410-432
16. Kirchhof K, Welzel T, Zoubaa S, Lichy C, Sikinger M, Lorbacher de Ruiz H, Sartor K. New method of embolus preparation for standardized embolic stroke in rabbits. Stroke 2002; 33: 2329-2333
17. Golanov EV, Reis DJ. Contribution of cerebral edema to the neuronal salvage elicited by stimulation of cerebellar fastigial nucleus after occlusion of the middle cerebral artery in rat. J Cereb Blood Flow Metab 1995; 15: 172-174
18. Urban I, Richard P. A stereotaxic atlas of the New Zealand rabbit's brain. Springfield, Illinois, USA C C Thomas 1972; 1: 76-81
19. Fisel CR, Ackerman JL, Buxton RB, Garrido L, Belliveau JW, Rosen BR, Brady TJ. MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology. Magn Reson Med 1991; 17: 336-347
20. Rosen BR, Belliveau JW, Vevea JM, Brady TJ. Perfusion imaging with NMR contrast agents. Magn Reson Med 1990; 14: 249-265
21. Blinc A, Keber D, Lahajnar G, Stegnar M, Zidansek A, Demsar F. Lysing patterns of retracted blood clots with diffusion or bulk flow transport of plasma with urokinase into clots - a magnetic resonance imaging study in vitro. Thromb Haemost 1992; 68: 667-671
22. Carr ME, Hardin CL. Fibrin has larger pores when formed in the presence of erythrocytes. Am J Physiol 1987; 253: H1069-H1073
23. Jorgensen L. Experimental platelet and coagulation thrombi. Acta Path et Microbiol Scandinav 1964; 62: 189-223
24. Chapman I. Morphogenesis of occluding coronary artery thrombosis. Arch Path 1965; 80: 256-261
25. Rodman NF, Painter JC, McDevitt NB. Platelet disintegration during clotting. J Cell Biol 1963; 16: 225-241
26. Brown BG, Gallery CA, Badger RS, Kennedy JW, Mathey D, Bolson EL, Dodge HT. Incomplete lysis of thrombus in the moderate underlying atherosclerotic lesion during intracoronary infusion of streptokinase for acute myocardial infarction: quantitative angiographic observations. Circulation 1986; 73: 653-661
27. Ueda T, Hatakeyama T, Kumon Y, Sakaki S, Uraoka T. Evaluation of risk of hemorrhagic transformation in local intra-arterial thrombolysis in acute ischemic stroke by initial SPECT. Stroke 1994; 25: 298-303
28. Xi G, Hua Y, Bhasin RR, Ennis SR, Keep RF, Hoff JT. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke 2001; 32: 2932-2938
29. Kirchhof K, Welzel T, Mecke C, Zoubaa S, Sartor K. Differentiation of white, mixed, and red thrombi: value of CT in estimation of the prognosis of thrombolysis - phantom study. Radiology 2003; 228: 126-130
30. Kirchhof K, Mecke C, Lichy C, Sartor K. Die Röntgendichte am Ort thrombembolischer zerebraler Gefäßverschlüsse: Prognostischer Faktor für eine Lysetherapie? Fortschr Röntgenstr 2003; 175: 1130-1137