Fitness costs of various mobile genetic elements in enterococcus faecium and enterococcus faecalis

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 12, 2013, Pages 2755-2765

  Starikova, Irina ^a   Al Haroni, Mohammed ^b   Werner, Guido ^c   Roberts, Adam P ^b   Sørum, Vidar ^a   Nielsen, Kaare M ^a,d   Johnsen, Pål J ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ROBERT KOCH INSTITUTE   (Germany)

^d Center for Biosafety   (Norway)

Author keywords

Adaptation; Antimicrobial resistance; Directional selection; Horizontal gene transfer; PAI; Plasmids; Tn6000; Tn916

Indexed keywords

NUCLEASE S1;

ANTIBIOTIC RESISTANCE; ARTICLE; ASSAY; CONJUGATION; COST; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; FITNESS; HOST; HYBRIDIZATION; LABORATORY; NONHUMAN; PATHOGENICITY ISLAND; PLASMID; SOUTHERN BLOTTING; TRANSPOSON;

ADAPTATION; ANTIMICROBIAL RESISTANCE; DIRECTIONAL SELECTION; HORIZONTAL GENE TRANSFER; PAI; PLASMIDS; TN6000; TN916;

CONJUGATION, GENETIC; ENERGY METABOLISM; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; GENE TRANSFER, HORIZONTAL; INTERSPERSED REPETITIVE SEQUENCES;

EID: 84887536164     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt270     Document Type: Article

References (49)

1. Billstrom H, Lund B, Sullivan A et al. Virulence and antimicrobial resistance in clinical Enterococcus faecium. Int J Antimicrob Agents 2008; 32: 374-7.
2. Johnsen PJ, Townsend JP, Bohn T et al. Factors affecting the reversal of antimicrobial-drug resistance. Lancet Infect Dis 2009; 9: 357-64.
3. Willems RJ, Bonten MJ. Glycopeptide-resistant enterococci: deciphering virulence, resistance and epidemicity. Curr Opin Infect Dis 2007; 20: 384-90.
4. Willems RJ, Top J, van Santen M et al. Global spread of vancomycinresistant Enterococcus faecium from distinct nosocomial genetic complex. Emerg Infect Dis 2005; 11: 821-8.
5. Hegstad K, Mikalsen T, Coque T M et al. Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium. Clin Microbiol Infect 2010; 16: 541-54.
6. Roberts AP, Mullany P. Tn916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance. FEMS Microbiol Rev 2011; 35: 856-71.
7. Novais C, Freitas AR, Silveira E et al. Different genetic supports for the tet(S) genein enterococci. Antimicrob AgentsChemother 2012;56: 6014-8.
8. Laverde Gomez JA, Hendrickx AP,Willems RJ et al. Intra- and interspecies genomic transfer of the Enterococcus faecalis pathogenicity island. PLoS One 2011; 6: e16720.
9. Uttley AH, Collins CH, Naidoo J et al. Vancomycin-resistant enterococci. Lancet 1988; 1: 57-8.
10. Courvalin P. Vancomycin resistance in gram-positive cocci. Clin Infect Dis 2006; 42 Suppl 1: S25-34.
11. Arthur M, Molinas C, Depardieu F et al. Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol 1993; 175: 117-27.
12. Simonsen G S,Myhre M R,Dahl K H et al. Typeabilityof Tn1546-like elements in vancomycin-resistant enterococci using long-range PCRs and specific analysis of polymorphic regions. Microb Drug Resist 2000; 6: 49-57.
13. Willems RJ, Top J, van Schaik W et al. Restricted gene flow among hospital subpopulations of Enterococcus faecium. MBio 2012; 3: e00151-12.
14. Werner G, Coque TM, Franz CMAP et al. Enterococci-tales of a drug resistance gene trafficker. Int J Med Microbiol 2013; doi: 10.1016/ j.ijmm.2013.03.001.
15. Zhu W, Clark NC, McDougal LK et al. Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. Antimicrob Agents Chemother 2008; 52: 452-7.
16. Willems RJ, Hanage WP, Bessen DE et al. Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance. FEMS Microbiol Rev 2011; 35: 872-900.
17. Jasni AS, Mullany P, Hussain H et al. Demonstration of conjugative transposon (Tn5397)-mediated horizontal gene transfer between Clostridium difficile and Enterococcus faecalis. Antimicrob Agents Chemother 2010; 54: 4924-6.
18. Levin BR, Lipsitch M, Perrot V et al. The population genetics of antibiotic resistance. Clin Infect Dis 1997; 24 Suppl 1: S9-16.
19. Andersson DI, Hughes D. Antibiotic resistance and its cost: is it possible to reverse resistance? Nat Rev Microbiol 2010; 8: 260-71.
20. Bouma JE, Lenski RE. Evolution of a bacteria/plasmid association. Nature 1988; 335: 351-2.
21. Schrag SJ, Perrot V. Reducing antibiotic resistance. Nature 1996; 381: 120-1.
22. Andersson DI, Levin BR. The biological cost of antibiotic resistance. Curr Opin Microbiol 1999; 2: 489-93.
23. Martinez JL, Baquero F, Andersson DI. Predicting antibiotic resistance. Nat Rev Microbiol 2007; 5: 958-65.
24. Bjorkholm B, Sjolund M, Falk PG et al. Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori. Proc Natl Acad Sci USA 2001; 98: 14607-12.
25. Bjorkman J, Nagaev I, Berg OG et al. Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science 2000; 287: 1479-82.
26. Gagneux S, Long CD, Small PM et al. The competitive cost of antibiotic resistance inMycobacteriumtuberculosis. Science 2006; 312: 1944-6.
27. Maisnier-Patin S, Berg OG, Liljas L et al. Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium. Mol Microbiol 2002; 46: 355-66.
28. Rozen DE, McGee L, Levin BR et al. Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 2007; 51: 412-6.
29. Dahlberg C, Chao L. Amelioration of the cost of conjugative plasmid carriage in Eschericha coli K12. Genetics 2003; 165: 1641-9.
30. Johnsen PJ, Simonsen GS, Olsvik O et al. Stability, persistence, and evolution of plasmid-encoded VanA glycopeptide resistance in enterococci in the absence of antibiotic selection in vitro and in gnotobioticmice. Microb Drug Resist 2002; 8: 161-70.
31. Foucault ML, Depardieu F, Courvalin P et al. Inducible expression eliminates the fitness cost of vancomycin resistance in enterococci. Proc Natl Acad Sci USA 2010; 107: 16964-9.
32. Roberts AP, Hennequin C, Elmore M et al. Development of an integrative vector for the expression of antisense RNA in Clostridium difficile. J Microbiol Methods 2003; 55: 617-24.
33. Roberts AP, Davis IJ, Seville L et al. Characterization of the ends and target site of a novel tetracycline resistance-encoding conjugative transposon from Enterococcus faecium 664.1H1. J Bacteriol 2006; 188: 4356-61.
34. Brouwer MS, Mullany P, Roberts AP. Characterization of the conjugative transposon Tn6000 from Enterococcus casseliflavus 664.1H1 (formerly Enterococcus faecium 664.1H1). FEMS Microbiol Lett 2010; 309: 71-6.
35. Werner G, Freitas AR, Coque TM et al. Host range of enterococcal vanA plasmids among Gram-positive intestinal bacteria. J Antimicrob Chemother 2011; 66: 273-82.
36. Dahl KH,Mater DD, Flores MJ et al. Transferof plasmidandchromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection. J Antimicrob Chemother 2007; 59: 478-86.
37. Lenski RE, Rose MR, Simpson SC et al. Long-term experimental evolution in Escherichia coli. 1. Adaptation and divergence during 2,000 generations. Am Nat 1991; 138: 1315-41.
38. Ray JL, Harms K, Wikmark OG et al. Sexual isolation in Acinetobacter baylyi is locus-specific and varies 10,000-fold over the genome. Genetics 2009; 182: 1165-81.
39. Levin BR, Perrot V, Walker N. Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria. Genetics 2000; 154: 985-97.
40. Starikova I,HarmsK,Haugen P et al. Atrade-off between the fitness cost of functional integrases and long-term stability of integrons. PLoS Path 2012; 8: e1003043.
41. Manganelli R, Romano L, Ricci S et al. Dosage of Tn916 circular intermediates in Enterococcus faecalis. Plasmid 1995; 34: 48-57.
42. Elena SF, Lenski RE. Test of synergistic interactions among deleterious mutations in bacteria. Nature 1997; 390: 395-8.
43. Petersen A, Aarestrup FM, OlsenJE. The invitro fitness cost of antimicrobial resistance in Escherichia coli varieswith the growth conditions. FEMS Microbiol Lett 2009; 299: 53-9.
44. Dionisio F, Conceicao IC, Marques AC et al. The evolution of a conjugative plasmid and its ability to increase bacterial fitness. Biol Lett 2005; 1: 250-2.
45. Enne VI, Bennett PM, Livermore DM et al. Enhancement of host fitness by the sul2-coding plasmid p9123 in the absence of selective pressure. J Antimicrob Chemother 2004; 53: 958-63.
46. Humphrey B, Thomson NR, Thomas CM et al. Fitness of Escherichia coli strains carrying expressed and partially silent IncN and IncP1 plasmids. BMC Microbiol 2012; 12: 53.
47. Heuer H, Fox RE, Top EM. Frequent conjugative transfer accelerates adaptation of a broad-host-range plasmid to an unfavorable Pseudomonas putida host. FEMS Microbiol Ecol 2007; 59: 738-48.
48. De Gelder L, Ponciano JM, Joyce P et al. Stability of a promiscuous plasmid in different hosts: no guarantee for a long-term relationship. Microbiology 2007; 153: 452-63.
49. Johnsen PJ, Townsend JP, Bohn T et al. Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures. J Antimicrob Chemother 2011; 66: 608-10.