Pathology and Diagnostic Criteria of Clostridium difficile Enteric Infection in Horses

Veterinary Pathology

Volumn 50, Issue 6, 2013, Pages 1028-1036

  Diab, S S ^a   Rodriguez Bertos, A ^b   Uzal, F A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Clostridium difficile; colitis; enteritis; enterotoxemia; equine; pathology; toxins

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL TOXIN; ENTEROTOXIN; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL; CLOSTRIDIUM INFECTIONS; COLITIS; DIARRHEA; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HORSE; HORSE DISEASES; INTESTINE; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY; NEWBORN; PATHOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; RETROSPECTIVE STUDY; VETERINARY;

ANIMALS; ANIMALS, NEWBORN; BACTERIAL PROTEINS; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COLITIS; DIARRHEA; ENTERITIS; ENTEROTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HORSE DISEASES; HORSES; INTESTINES; MALE; RETROSPECTIVE STUDIES;

EID: 84887533308     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985813489039     Document Type: Article

References (38)

1. Arroyo LG,Weese JS,Staempfli HR.Experimental Clostridium difficile enterocolitis in foals.J Vet Intern Med. 2004;18:734-738.
2. Barbut F,Petit JC.Epidemiology of Clostridium difficile-associated infections.Clin Microbiol Infect. 2001;7:405-410.
3. Baverud V.Clostridium difficile diarrhea: infection control in horses.Vet Clin North Am Equine Pract. 2004;20:615-630.
4. Baverud V,Franklin A,Gunnarsson A, et al.Clostridium difficile associated with acute colitis in mares when their foals are treated with erythromycin and rifampicin for Rhodococcus equi pneumonia.Equine Vet J. 1998;30:482-488.
5. Baverud V,Gunnarsson A,Karlsson M, et al.Antimicrobial susceptibility of equine and environmental isolates of Clostridium difficile.Microb Drug Resist. 2004;10:57-63.
6. Baverud V,Gustafsson A,Franklin A, et al.Clostridium difficile: prevalence in horses and environment, and antimicrobial susceptibility.Equine Vet J. 2003;35:465-471.
7. Baverud V,Gustafsson A,Franklin A, et al.Clostridium difficile associated with acute colitis in mature horses treated with antibiotics.Equine Vet J. 1997;29:279-284.
8. Cordes DO,Perry BD,Rikihisa Y, et al.Enterocolitis caused by Ehrlichia sp. in the horse (Potomac horse fever).Vet Pathol. 1986;23:471-477.
9. Delmee M.Laboratory diagnosis of Clostridium difficile disease.Clin Microbiol Infect. 2001;7:411-416.
10. Diab SS,Kinde H,Moore J, et al.Pathology of Clostridium perfringens type C enterotoxemia in horses.Vet Pathol. 2012;49:255-263.
11. Gustafsson A,Baverud V,Gunnarsson A, et al.Study of faecal shedding of Clostridium difficile in horses treated with penicillin.Equine Vet J. 2004;36:180-182.
12. Gustafsson A,Baverud V,Gunnarsson A, et al.The association of erythromycin ethylsuccinate with acute colitis in horses in Sweden.Equine Vet J. 1997;29:314-318.
13. Jones RL,Adney WS,Alexander AF, et al.Hemorrhagic necrotizing enterocolitis associated with Clostridium difficile infection in four foals.J Am Vet Med Assoc. 1988;193:76-79.
14. Jones RL,Adney WS,Shideler RK.Isolation of Clostridium difficile and detection of cytotoxin in the feces of diarrheic foals in the absence of antimicrobial treatment.J Clin Microbiol. 1987;25:1225-1227.
15. Jubb K,Palmer NPathology of Domestic Animals. 5th ed. Philadelphia, PA: Elsevier Saunders; 2007:193-204.Maxie MG, ed. Philadelphia, PA: Elsevier Saunders; 2007:193-204.
16. Keel MK,Songer JG.The comparative pathology of Clostridium difficile-associated disease.Vet Pathol. 2006;43:225-240.
17. Kelly CM.Colitis X in the horse.N Z Vet J. 1972;20:190-192.
18. Kuehne SA,Cartman ST,Heap JT, et al.The role of toxin A and toxin B in Clostridium difficile infection.Nature. 2010;467:711-713.
19. Kuehne SA,Cartman ST,Minton NP.Both, toxin A and toxin B, are important in Clostridium difficile infection.Gut Microbes. 2011;2:252-255.
20. Madewell BR,Tang YJ,Jang S, et al.Apparent outbreaks of Clostridium difficile-associated diarrhea in horses in a veterinary medical teaching hospital.J Vet Diagn Invest. 1995;7:343-346.
21. Magdesian KG,Hirsch DC,Jang SS, et al.Characterization of Clostridium difficile isolates from an outbreak of enteritis in neonatal foals.In: Wernery U, Wade JF, Mumford JA, Kaaden O-R, eds. Equine infections disease VIII. Newmarket, UK: R & W Publications, Ltd;. 1999;:561-562.
22. Magdesian KG,Hirsh DC,Jang SS, et al.Characterization of Clostridium difficile isolates from foals with diarrhea: 28 cases (1993-1997).J Am Vet Med Assoc. 2002;220:67-73.
23. Perrin J,Cosmetatos I,Gallusser A, et al.Clostridium difficile associated with typhlocolitis in an adult horse.J Vet Diagn Invest. 1993;5:99-101.
24. Pothoulakis C,Castagliuolo I,Kelly CP, et al.Clostridium difficile-associated diarrhea and colitis: pathogenesis and therapy.Int J Antimicrob Agents. 1993;3:17-32.
25. Rooney JR,Bryans JT,Doll ER.Colitis "X" of horses.J Am Vet Med Assoc. 1963;142:510-511.
26. Ruby R,Magdesian KG,Kass PH.Comparison of clinical, microbiologic, and clinicopathologic findings in horses positive and negative for Clostridium difficile infection.J Am Vet Med Assoc. 2009;234:777-784.
27. Sayeed S,Uzal FA,Fisher DJ, et al.Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model.Mol Microbiol. 2008;67:15-30.
28. Songer JG.Clostridial enteric diseases of domestic animals.Clin Microbiol Rev. 1996;9:216-234.
29. Songer JG.The emergence of Clostridium difficile as a pathogen of food animals.Anim Health Res Rev. 2004;5:321-326.
30. Songer JG,Uzal FA.Clostridial enteric infections in pigs.J Vet Diagn Invest. 2005;17:528-536.
31. Taha S,Johansson O,Rivera Jonsson S, et al.Toxin production by and adhesive properties of Clostridium difficile isolated from humans and horses with antibiotic-associated diarrhea.Comp Immunol Microbiol Infect Dis. 2007;30:163-174.
32. Tschudin-Sutter S,Widmer AF,Perl TM.Clostridium difficile: novel insights on an incessantly challenging disease.Curr Opin Infect Dis. 2012;25:405-411.
33. Umemura T,Ohishi H,Ikemoto Y, et al.Histopathology of colitis X in the horse.Nihon Juigaku Zasshi. 1982;44:717-724.
34. Uzal FA,Diab SS,Blanchard P, et al.Clostridium perfringens type C and Clostridium difficile co-infection in foals.Vet Microbiol. 2012;156:395-402.
35. Weese JS,Staempfli HR,Prescott JF.Isolation of environmental Clostridium difficile from a veterinary teaching hospital.J Vet Diagn Invest. 2000;12:449-452.
36. Weese JS,Staempfli HR,Prescott JF.A prospective study of the roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in equine diarrhoea.Equine Vet J. 2001;33:403-409.
37. Weese JS,Staempfli HR,Prescott JF.Survival of Clostridium difficile and its toxins in equine feces: implications for diagnostic test selection and interpretation.J Vet Diagn Invest. 2000;12:332-336.
38. Weese JS,Toxopeus L,Arroyo L.Clostridium difficile associated diarrhoea in horses within the community: predictors, clinical presentation and outcome.Equine Vet J. 2006;38:185-188.