메뉴 건너뛰기




Volumn 19, Issue 41, 2013, Pages 6947-6956

Are metabolic factors still important in the era of direct antiviral agents in patients with chronic hepatitis C?

Author keywords

Chronic hepatitis C; Direct antiviral agents; Insulin resistance; Metabolic factors

Indexed keywords

ANTIVIRUS AGENT; BOCEPREVIR; INTERLEUKIN 28B; PEGINTERFERON ALPHA2A; PLACEBO; RIBAVIRIN; RIBAVIRIN PLUS METFORMIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TELAPREVIR; UNCLASSIFIED DRUG; VIRUS RNA; LIPID; METFORMIN; PEGINTERFERON; PIOGLITAZONE; SOFOSBUVIR;

EID: 84887531199     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i41.6947     Document Type: Article
Times cited : (11)

References (91)
  • 1
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • [PMID: 19207969 DOI10.1111/ j.1478-3231.2008.01934.x]
    • Lavanchy D. The global burden of hepatitis C. Liver Int 2009; 29 Suppl 1: 74-81 [PMID: 19207969 DOI: 10.1111/ j.1478-3231.2008.01934.x]
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 1 , pp. 74-81
    • Lavanchy, D.1
  • 2
    • 33845441692 scopus 로고    scopus 로고
    • Hepatitis C virus and liver transplantation
    • [PMID: 17164125 DOI: 10.1016/j.cld.2006.08.012]
    • Verna EC, Brown RS. Hepatitis C virus and liver transplantation. Clin Liver Dis 2006; 10: 919-940 [PMID: 17164125 DOI: 10.1016/j.cld.2006.08.012]
    • (2006) Clin Liver Dis , vol.10 , pp. 919-940
    • Verna, E.C.1    Brown, R.S.2
  • 3
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomized trial
    • [PMID: 1158374 DOI: 10.1016/ S0140-6736(01)06102-5]
    • Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial. Lancet 2001; 358: 958-965 [PMID: 1158374 DOI: 10.1016/ S0140-6736(01)06102-5]
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.9    Albrecht, J.K.10
  • 5
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
    • PEGASYS International Study Group, [PMID: 14996676 DOI: 10.7326/0003-4819-140-5-200403020-00010]
    • Hadziyannis SJ, Sette H, Morgan TR, Balan V, Diago M, Marcellin P, Ramadori G, Bodenheimer H, Bernstein D, Rizzetto M, Zeuzem S, Pockros PJ, Lin A, Ackrill AM, PEGASYS International Study Group. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004; 140: 346-355 [PMID: 14996676 DOI: 10.7326/0003-4819-140-5-200403020-00010]
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette, H.2    Morgan, T.R.3    Balan, V.4    Diago, M.5    Marcellin, P.6    Ramadori, G.7    Bodenheimer, H.8    Bernstein, D.9    Rizzetto, M.10    Zeuzem, S.11    Pockros, P.J.12    Lin, A.13    Ackrill, A.M.14
  • 7
    • 0043037223 scopus 로고    scopus 로고
    • High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    • [PMID: 12939590 DOI: 10.1053/ jhep.2003.50350]
    • Bressler BL, Guindi M, Tomlinson G, Heathcote J. High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Hepatology 2003; 38: 639-644 [PMID: 12939590 DOI: 10.1053/ jhep.2003.50350]
    • (2003) Hepatology , vol.38 , pp. 639-644
    • Bressler, B.L.1    Guindi, M.2    Tomlinson, G.3    Heathcote, J.4
  • 11
    • 0030018628 scopus 로고    scopus 로고
    • Increased prevalence of diabetes mellitus in patients with chronic hepatitis C virus infection
    • [PMID: 8678039]
    • Ozyilkan E, Arslan M. Increased prevalence of diabetes mellitus in patients with chronic hepatitis C virus infection. Am J Gastroenterol 1996; 91: 1480-1481 [PMID: 8678039]
    • (1996) Am J Gastroenterol , vol.91 , pp. 1480-1481
    • Ozyilkan, E.1    Arslan, M.2
  • 12
    • 33746365151 scopus 로고    scopus 로고
    • Glucose abnormalities in patients with hepatitis C virus infection: Epidemiology and pathogenesis
    • [PMID: 16644655 DOI: 10.2337/dc05-1995]
    • Lecube A, Hernández C, Genescà J, Simó R. Glucose abnormalities in patients with hepatitis C virus infection: Epidemiology and pathogenesis. Diabetes Care 2006; 29: 1140-1149 [PMID: 16644655 DOI: 10.2337/dc05-1995]
    • (2006) Diabetes Care , vol.29 , pp. 1140-1149
    • Lecube, A.1    Hernández, C.2    Genescà, J.3    Simó, R.4
  • 13
    • 34547593683 scopus 로고    scopus 로고
    • Hepatitis C virus infection and the development of type 2 diabetes in a community-based longitudinal study
    • [PMID: 17496314 DOI: 10.1093/aje/kwm061]
    • Wang CS, Wang ST, Yao WJ, Chang TT, Chou P. Hepatitis C virus infection and the development of type 2 diabetes in a community-based longitudinal study. Am J Epidemiol 2007; 166: 196-203 [PMID: 17496314 DOI: 10.1093/aje/kwm061]
    • (2007) Am J Epidemiol , vol.166 , pp. 196-203
    • Wang, C.S.1    Wang, S.T.2    Yao, W.J.3    Chang, T.T.4    Chou, P.5
  • 16
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • [PMID: 11391523 DOI: 10.1053/ jhep.2001.24432]
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-1364 [PMID: 11391523 DOI: 10.1053/ jhep.2001.24432]
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 17
    • 21044456174 scopus 로고    scopus 로고
    • Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C
    • [PMID: 15951550 DOI: 10.1136/gut.2004.050302]
    • Fartoux L, Poujol-Robert A, Guéchot J, Wendum D, Poupon R, Serfaty L. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 2005; 54: 1003-1008 [PMID: 15951550 DOI: 10.1136/gut.2004.050302]
    • (2005) Gut , vol.54 , pp. 1003-1008
    • Fartoux, L.1    Poujol-Robert, A.2    Guéchot, J.3    Wendum, D.4    Poupon, R.5    Serfaty, L.6
  • 18
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance
    • [PMID: 14988838]
    • Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004; 126: 840-848 [PMID: 14988838]
    • (2004) Gastroenterology , vol.126 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3    Tsutsumi, T.4    Tsukamoto, K.5    Kimura, S.6    Moriya, K.7    Koike, K.8
  • 20
    • 33847016551 scopus 로고    scopus 로고
    • Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C
    • [PMID: 17258724 DOI: 10.1053/j.gastro.2006.11.045]
    • Huang Y, Feld JJ, Sapp RK, Nanda S, Lin JH, Blatt LM, Fried MW, Murthy K, Liang TJ. Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C. Gastroenterology 2007; 132: 733-744 [PMID: 17258724 DOI: 10.1053/j.gastro.2006.11.045]
    • (2007) Gastroenterology , vol.132 , pp. 733-744
    • Huang, Y.1    Feld, J.J.2    Sapp, R.K.3    Nanda, S.4    Lin, J.H.5    Blatt, L.M.6    Fried, M.W.7    Murthy, K.8    Liang, T.J.9
  • 21
    • 36349030379 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy
    • [PMID: 17668875 DOI: 10.1002/hep.21782]
    • Persico M, Capasso M, Persico E, Svelto M, Russo R, Spano D, Crocè L, La Mura V, Moschella F, Masutti F, Torella R, Tiribelli C, Iolascon A. Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy. Hepatology 2007; 46: 1009-1015 [PMID: 17668875 DOI: 10.1002/hep.21782]
    • (2007) Hepatology , vol.46 , pp. 1009-1015
    • Persico, M.1    Capasso, M.2    Persico, E.3    Svelto, M.4    Russo, R.5    Spano, D.6    Crocè, L.7    La Mura, V.8    Moschella, F.9    Masutti, F.10    Torella, R.11    Tiribelli, C.12    Iolascon, A.13
  • 23
    • 33847316067 scopus 로고    scopus 로고
    • Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2
    • [PMID: 17222321 DOI: 10.1111/j.1572-0241.2006.01038.x]
    • Kawaguchi T, Ide T, Taniguchi E, Hirano E, Itou M, Sumie S, Nagao Y, Yanagimoto C, Hanada S, Koga H, Sata M. Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2. Am J Gastroenterol 2007; 102: 570-576 [PMID: 17222321 DOI: 10.1111/j.1572-0241.2006.01038.x]
    • (2007) Am J Gastroenterol , vol.102 , pp. 570-576
    • Kawaguchi, T.1    Ide, T.2    Taniguchi, E.3    Hirano, E.4    Itou, M.5    Sumie, S.6    Nagao, Y.7    Yanagimoto, C.8    Hanada, S.9    Koga, H.10    Sata, M.11
  • 25
    • 77950950837 scopus 로고    scopus 로고
    • Reduction of insulin resistance with effective clearance of hepatitis C infection: Results from the HALT-C trial
    • Halt-C Trial Group, [PMID: 20156586 DOI: 10.1016/j.cgh.2010.01.022]
    • Delgado-Borrego A, Jordan SH, Negre B, Healey D, Lin W, Kamegaya Y, Christofi M, Ludwig DA, Lok AS, Chung RT, Halt-C Trial Group. Reduction of insulin resistance with effective clearance of hepatitis C infection: results from the HALT-C trial. Clin Gastroenterol Hepatol 2010; 8: 458-462 [PMID: 20156586 DOI: 10.1016/j.cgh.2010.01.022]
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 458-462
    • Delgado-Borrego, A.1    Jordan, S.H.2    Negre, B.3    Healey, D.4    Lin, W.5    Kamegaya, Y.6    Christofi, M.7    Ludwig, D.A.8    Lok, A.S.9    Chung, R.T.10
  • 28
    • 84868203343 scopus 로고    scopus 로고
    • Sustained virological response prevents the development of insulin resistance in patients with chronic hepatitis C
    • [PMID: 22619107 DOI: 10.1002/ hep.25867]
    • Aghemo A, Prati GM, Rumi MG, Soffredini R, D'Ambrosio R, Orsi E, De Nicola S, Degasperi E, Grancini V, Colombo M. Sustained virological response prevents the development of insulin resistance in patients with chronic hepatitis C. Hepatology 2012; 56: 1681-1687 [PMID: 22619107 DOI: 10.1002/ hep.25867]
    • (2012) Hepatology , vol.56 , pp. 1681-1687
    • Aghemo, A.1    Prati, G.M.2    Rumi, M.G.3    Soffredini, R.4    D'Ambrosio, R.5    Orsi, E.6    De Nicola, S.7    Degasperi, E.8    Grancini, V.9    Colombo, M.10
  • 32
    • 70350124913 scopus 로고    scopus 로고
    • Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor
    • [PMID: 19751943 DOI: 10.1016/j.virol.2009.]
    • Owen DM, Huang H, Ye J, Gale M. Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor. Virology 2009; 394: 99-108 [PMID: 19751943 DOI: 10.1016/j.virol.2009.]
    • (2009) Virology , vol.394 , pp. 99-108
    • Owen, D.M.1    Huang, H.2    Ye, J.3    Gale, M.4
  • 34
    • 84867704490 scopus 로고    scopus 로고
    • Entry of hepatitis C virus into the cell: A therapeutic target
    • [PMID: 22969220 DOI: 10.3748/ wjg.v18.i33.4481]
    • Del Campo JA, Rojas Á, Romero-Gómez M. Entry of hepatitis C virus into the cell: a therapeutic target. World J Gastroenterol 2012; 18: 4481-4485 [PMID: 22969220 DOI: 10.3748/ wjg.v18.i33.4481]
    • (2012) World J Gastroenterol , vol.18 , pp. 4481-4485
    • Del Campo, J.A.1    Rojas, A.2    Romero-Gómez, M.3
  • 36
    • 0034893193 scopus 로고    scopus 로고
    • Changes in serum lipoprotein profile during interferon therapy in chronic hepatitis C
    • [PMID: 11513192 DOI: 10.1111/ j.1572-0241.2001.04055.x]
    • Naeem M, Bacon BR, Mistry B, Britton RS, Di Bisceglie AM. Changes in serum lipoprotein profile during interferon therapy in chronic hepatitis C. Am J Gastroenterol 2001; 96: 2468-2472 [PMID: 11513192 DOI: 10.1111/ j.1572-0241.2001.04055.x]
    • (2001) Am J Gastroenterol , vol.96 , pp. 2468-2472
    • Naeem, M.1    Bacon, B.R.2    Mistry, B.3    Britton, R.S.4    Di Bisceglie, A.M.5
  • 37
    • 14844283411 scopus 로고    scopus 로고
    • Changes in serum lipid concentrations in patients with chronic hepatitis C virus positive hepatitis responsive or non-responsive to interferon therapy
    • [PMID: 15683422 DOI: 10.1111/j.1440-1746.2004.03526.x]
    • Hamamoto S, Uchida Y, Wada T, Moritani M, Sato S, Hamamoto N, Ishihara S, Watanabe M, Kinoshita Y. Changes in serum lipid concentrations in patients with chronic hepatitis C virus positive hepatitis responsive or non-responsive to interferon therapy. J Gastroenterol Hepatol 2005; 20: 204-208 [PMID: 15683422 DOI: 10.1111/j.1440-1746.2004.03526.x]
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 204-208
    • Hamamoto, S.1    Uchida, Y.2    Wada, T.3    Moritani, M.4    Sato, S.5    Hamamoto, N.6    Ishihara, S.7    Watanabe, M.8    Kinoshita, Y.9
  • 38
    • 77953553818 scopus 로고    scopus 로고
    • Hyperinsulinaemia reduces the 24-h virological response to PEG-interferon therapy in patients with chronic hepatitis C and insulin resistance
    • [PMID: 19878535 DOI: 10.1111/ j.1365-2893.2009.01204.x]
    • Bortoletto G, Scribano L, Realdon S, Marcolongo M, Mirandola S, Franceschini L, Bonisegna S, Noventa F, Plebani M, Martines D, Alberti A. Hyperinsulinaemia reduces the 24-h virological response to PEG-interferon therapy in patients with chronic hepatitis C and insulin resistance. J Viral Hepat 2010; 17: 475-480 [PMID: 19878535 DOI: 10.1111/ j.1365-2893.2009.01204.x]
    • (2010) J Viral Hepat , vol.17 , pp. 475-480
    • Bortoletto, G.1    Scribano, L.2    Realdon, S.3    Marcolongo, M.4    Mirandola, S.5    Franceschini, L.6    Bonisegna, S.7    Noventa, F.8    Plebani, M.9    Martines, D.10    Alberti, A.11
  • 39
    • 71549129264 scopus 로고    scopus 로고
    • Insulin resistance predicts rapid virological response in non-diabetic, non-cirrhotic genotype 1 HCV patients treated with peginterferon alpha-2b plus ribavirin
    • [PMID: 19695729 DOI: 10.1016/j.jhep.2009.07.008]
    • Grasso A, Malfatti F, De Leo P, Martines H, Fabris P, Toscanini F, Anselmo M, Menardo G. Insulin resistance predicts rapid virological response in non-diabetic, non-cirrhotic genotype 1 HCV patients treated with peginterferon alpha-2b plus ribavirin. J Hepatol 2009; 51: 984-990 [PMID: 19695729 DOI: 10.1016/j.jhep.2009.07.008]
    • (2009) J Hepatol , vol.51 , pp. 984-990
    • Grasso, A.1    Malfatti, F.2    De Leo, P.3    Martines, H.4    Fabris, P.5    Toscanini, F.6    Anselmo, M.7    Menardo, G.8
  • 40
    • 78650155207 scopus 로고    scopus 로고
    • The homeostasis model assessment of the insulin resistance score is not predictive of a sustained virological response in chronic hepatitis C patients
    • Italian Hepatitis C Cohort Study Collaborative Group, [PMID: 20840397 DOI: 10.1111/j.1478-3231.2010.02343.x]
    • Fattovich G, Covolo L, Pasino M, Perini E, Rossi L, Brocco G, Guido M, Cristofori C, Belotti C, Puoti M, Gaeta GB, Santantonio T, Raimondo G, Bruno R, Minola E, Negro F, Donato F, Italian Hepatitis C Cohort Study Collaborative Group. The homeostasis model assessment of the insulin resistance score is not predictive of a sustained virological response in chronic hepatitis C patients. Liver Int 2011; 31: 66-74 [PMID: 20840397 DOI: 10.1111/j.1478-3231.2010.02343.x]
    • (2011) Liver Int , vol.31 , pp. 66-74
    • Fattovich, G.1    Covolo, L.2    Pasino, M.3    Perini, E.4    Rossi, L.5    Brocco, G.6    Guido, M.7    Cristofori, C.8    Belotti, C.9    Puoti, M.10    Gaeta, G.B.11    Santantonio, T.12    Raimondo, G.13    Bruno, R.14    Minola, E.15    Negro, F.16    Donato, F.17
  • 41
    • 77956343048 scopus 로고    scopus 로고
    • Insulin resistance predicts rapid virologic response to peginterferon/ribavirin combination therapy in hepatitis C genotype 4 patients
    • [PMID: 20234345 DOI: 10.1038/ajg.2010.110]
    • Khattab M, Eslam M, Sharwae MA, Shatat M, Ali A, Hamdy L. Insulin resistance predicts rapid virologic response to peginterferon/ribavirin combination therapy in hepatitis C genotype 4 patients. Am J Gastroenterol 2010; 105: 1970-1977 [PMID: 20234345 DOI: 10.1038/ajg.2010.110]
    • (2010) Am J Gastroenterol , vol.105 , pp. 1970-1977
    • Khattab, M.1    Eslam, M.2    Sharwae, M.A.3    Shatat, M.4    Ali, A.5    Hamdy, L.6
  • 42
    • 79959945801 scopus 로고    scopus 로고
    • Meta-analysis: Insulin resistance and sustained virological response in hepatitis C
    • [PMID: 21623851 DOI: 10.1111/j.1365-2036.2011.04716.x]
    • Eslam M, Aparcero R, Kawaguchi T, Del Campo JA, Sata M, Khattab MA, Romero-Gomez M. Meta-analysis: insulin resistance and sustained virological response in hepatitis C. Aliment Pharmacol Ther 2011; 34: 297-305 [PMID: 21623851 DOI: 10.1111/j.1365-2036.2011.04716.x]
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 297-305
    • Eslam, M.1    Aparcero, R.2    Kawaguchi, T.3    Del Campo, J.A.4    Sata, M.5    Khattab, M.A.6    Romero-Gomez, M.7
  • 43
    • 79960824576 scopus 로고    scopus 로고
    • Impact of insulin resistance on sustained response in HCV patients treated with pegylated interferon and ribavirin: A meta-analysis
    • [PMID: 21703195 DOI: 10.1016/ j.jhep.2011.03.010]
    • Deltenre P, Louvet A, Lemoine M, Mourad A, Fartoux L, Moreno C, Henrion J, Mathurin P, Serfaty L. Impact of insulin resistance on sustained response in HCV patients treated with pegylated interferon and ribavirin: a meta-analysis. J Hepatol 2011; 55: 1187-1194 [PMID: 21703195 DOI: 10.1016/ j.jhep.2011.03.010]
    • (2011) J Hepatol , vol.55 , pp. 1187-1194
    • Deltenre, P.1    Louvet, A.2    Lemoine, M.3    Mourad, A.4    Fartoux, L.5    Moreno, C.6    Henrion, J.7    Mathurin, P.8    Serfaty, L.9
  • 44
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • [PMID: 3899825 DOI: 10.1007/BF00280883]
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419 [PMID: 3899825 DOI: 10.1007/BF00280883]
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 45
    • 0035081231 scopus 로고    scopus 로고
    • Clinical significance of the insulin resistance index as assessed by homeostasis model assessment
    • [PMID: 11403106 DOI: 10.1507/endocrj.48.81]
    • Ikeda Y, Suehiro T, Nakamura T, Kumon Y, Hashimoto K. Clinical significance of the insulin resistance index as assessed by homeostasis model assessment. Endocr J 2001; 48: 81-86 [PMID: 11403106 DOI: 10.1507/endocrj.48.81]
    • (2001) Endocr J , vol.48 , pp. 81-86
    • Ikeda, Y.1    Suehiro, T.2    Nakamura, T.3    Kumon, Y.4    Hashimoto, K.5
  • 46
    • 42249093870 scopus 로고    scopus 로고
    • Metabolic syndrome pandemic
    • [PMID: 18174459 DOI: 10.1161/ATVBAHA.107.151092]
    • Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008; 28: 629-636 [PMID: 18174459 DOI: 10.1161/ATVBAHA.107.151092]
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 629-636
    • Grundy, S.M.1
  • 47
    • 84859209957 scopus 로고    scopus 로고
    • Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome
    • [PMID: 22277808 DOI: 10.1016/j.dld.2011.12.006]
    • Fattovich G, Baroni GS, Pasino M, Pierantonelli I, Covolo L, Ieluzzi D, Passigato N, Tonon A, Faraci MG, Guido M, Negro F. Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome. Dig Liver Dis 2012; 44: 419-425 [PMID: 22277808 DOI: 10.1016/j.dld.2011.12.006]
    • (2012) Dig Liver Dis , vol.44 , pp. 419-425
    • Fattovich, G.1    Baroni, G.S.2    Pasino, M.3    Pierantonelli, I.4    Covolo, L.5    Ieluzzi, D.6    Passigato, N.7    Tonon, A.8    Faraci, M.G.9    Guido, M.10    Negro, F.11
  • 48
    • 33745560465 scopus 로고    scopus 로고
    • Impact of obesity on treatment of chronic hepatitis C
    • [PMID: 16729327 DOI: 10.1002/hep.21239]
    • Charlton MR, Pockros PJ, Harrison SA. Impact of obesity on treatment of chronic hepatitis C. Hepatology 2006; 43: 1177-1186 [PMID: 16729327 DOI: 10.1002/hep.21239]
    • (2006) Hepatology , vol.43 , pp. 1177-1186
    • Charlton, M.R.1    Pockros, P.J.2    Harrison, S.A.3
  • 49
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • [PMID: 19585655 DOI: 10.1002/ hep.23046]
    • Marra F, Bertolani C. Adipokines in liver diseases. Hepatology 2009; 50: 957-969 [PMID: 19585655 DOI: 10.1002/ hep.23046]
    • (2009) Hepatology , vol.50 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 50
    • 33645114359 scopus 로고    scopus 로고
    • Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
    • [PMID: 16299039 DOI: 10.1136/gut.2005.069674]
    • Walsh MJ, Jonsson JR, Richardson MM, Lipka GM, Purdie DM, Clouston AD, Powell EE. Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut 2006; 55: 529-535 [PMID: 16299039 DOI: 10.1136/gut.2005.069674]
    • (2006) Gut , vol.55 , pp. 529-535
    • Walsh, M.J.1    Jonsson, J.R.2    Richardson, M.M.3    Lipka, G.M.4    Purdie, D.M.5    Clouston, A.D.6    Powell, E.E.7
  • 52
    • 41849143415 scopus 로고    scopus 로고
    • Baseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis C
    • [PMID: 17498221 DOI: 10.1111/j.1440-1746.2007.04911.x]
    • Economou M, Milionis H, Filis S, Baltayiannis G, Christou L, Elisaf M, Tsianos E. Baseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis C. J Gastroenterol Hepatol 2008; 23: 586-591 [PMID: 17498221 DOI: 10.1111/j.1440-1746.2007.04911.x]
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 586-591
    • Economou, M.1    Milionis, H.2    Filis, S.3    Baltayiannis, G.4    Christou, L.5    Elisaf, M.6    Tsianos, E.7
  • 53
    • 77956634475 scopus 로고    scopus 로고
    • Associations between serum lipids and hepatitis C antiviral treatment efficacy
    • Virahep-C Study Group, [PMID: 20690192 DOI: 10.1002/hep.23796]
    • Ramcharran D, Wahed AS, Conjeevaram HS, Evans RW, Wang T, Belle SH, Yee LJ, Virahep-C Study Group. Associations between serum lipids and hepatitis C antiviral treatment efficacy. Hepatology 2010; 52: 854-863 [PMID: 20690192 DOI: 10.1002/hep.23796]
    • (2010) Hepatology , vol.52 , pp. 854-863
    • Ramcharran, D.1    Wahed, A.S.2    Conjeevaram, H.S.3    Evans, R.W.4    Wang, T.5    Belle, S.H.6    Yee, L.J.7
  • 54
    • 84862671711 scopus 로고    scopus 로고
    • Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: Evidence for an association with interferon sensitivity
    • [PMID: 22414761 DOI: 10.1016/j.jhep.2012.02.017]
    • Sheridan DA, Bridge SH, Felmlee DJ, Crossey MM, Thomas HC, Taylor-Robinson SD, Toms GL, Neely RD, Bassendine MF. Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: evidence for an association with interferon sensitivity. J Hepatol 2012; 57: 32-38 [PMID: 22414761 DOI: 10.1016/j.jhep.2012.02.017]
    • (2012) J Hepatol , vol.57 , pp. 32-38
    • Sheridan, D.A.1    Bridge, S.H.2    Felmlee, D.J.3    Crossey, M.M.4    Thomas, H.C.5    Taylor-Robinson, S.D.6    Toms, G.L.7    Neely, R.D.8    Bassendine, M.F.9
  • 60
    • 80053238945 scopus 로고    scopus 로고
    • Aerobic exercise improves insulin resistance and decreases body fat and serum levels of leptin in patients with hepatitis C virus
    • [PMID: 21707884 DOI: 10.1111/j.1872-034X.2011.00833.x]
    • Konishi I, Hiasa Y, Tokumoto Y, Abe M, Furukawa S, Toshimitsu K, Matsuura B, Onji M. Aerobic exercise improves insulin resistance and decreases body fat and serum levels of leptin in patients with hepatitis C virus. Hepatol Res 2011; 41: 928-935 [PMID: 21707884 DOI: 10.1111/j.1872-034X.2011.00833.x]
    • (2011) Hepatol Res , vol.41 , pp. 928-935
    • Konishi, I.1    Hiasa, Y.2    Tokumoto, Y.3    Abe, M.4    Furukawa, S.5    Toshimitsu, K.6    Matsuura, B.7    Onji, M.8
  • 61
    • 84873746608 scopus 로고    scopus 로고
    • A 24-week dietary and physical activity lifestyle intervention reduces hepatic insulin resistance in the obese with chronic hepatitis C
    • [PMID: 23278982 DOI: 10.1111/ liv.12041]
    • Pattullo V, Duarte-Rojo A, Soliman W, Vargas-Vorackova F, Sockalingam S, Fantus IG, Allard J, Heathcote J. A 24-week dietary and physical activity lifestyle intervention reduces hepatic insulin resistance in the obese with chronic hepatitis C. Liver Int 2013; 33: 410-419 [PMID: 23278982 DOI: 10.1111/ liv.12041]
    • (2013) Liver Int , vol.33 , pp. 410-419
    • Pattullo, V.1    Duarte-Rojo, A.2    Soliman, W.3    Vargas-Vorackova, F.4    Sockalingam, S.5    Fantus, I.G.6    Allard, J.7    Heathcote, J.8
  • 62
    • 33645129025 scopus 로고    scopus 로고
    • Does a lower insulin resistance affect antiviral therapy response in patients suffering from HCV related chronic hepatitis?
    • [PMID: 16531544]
    • Tarantino G, Conca P, Ariello M, Mastrolia M. Does a lower insulin resistance affect antiviral therapy response in patients suffering from HCV related chronic hepatitis? Gut 2006; 55: 585 [PMID: 16531544]
    • (2006) Gut , vol.55 , pp. 585
    • Tarantino, G.1    Conca, P.2    Ariello, M.3    Mastrolia, M.4
  • 64
    • 77950602195 scopus 로고    scopus 로고
    • Pioglitazone improves virological response to peginterferon alpha-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance
    • [PMID: 19919569 DOI: 10.1111/j.1478-3231.2009.02171.x]
    • Khattab M, Emad M, Abdelaleem A, Eslam M, Atef R, Shaker Y, Hamdy L. Pioglitazone improves virological response to peginterferon alpha-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance. Liver Int 2010; 30: 447-454 [PMID: 19919569 DOI: 10.1111/j.1478-3231.2009.02171.x]
    • (2010) Liver Int , vol.30 , pp. 447-454
    • Khattab, M.1    Emad, M.2    Abdelaleem, A.3    Eslam, M.4    Atef, R.5    Shaker, Y.6    Hamdy, L.7
  • 65
    • 46349099383 scopus 로고    scopus 로고
    • Pioglitazone in chronic hepatitis C not responding to pegylated interferon-alpha and ribavirin
    • Swiss Association for the Study of the Liver (SASL), [PMID: 18555553]
    • Overbeck K, Genné D, Golay A, Negro F, Swiss Association for the Study of the Liver (SASL). Pioglitazone in chronic hepatitis C not responding to pegylated interferon-alpha and ribavirin. J Hepatol 2008; 49: 295-298 [PMID: 18555553]
    • (2008) J Hepatol , vol.49 , pp. 295-298
    • Overbeck, K.1    Genné, D.2    Golay, A.3    Negro, F.4
  • 66
    • 60049101298 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of ppar-gamma agonist pioglitazone given in combination with peginterferon and ribavirin in patients with genotype-1 chronic hepatitis C
    • Conjeevaram H, Burant CF, McKenna B, Harsh D, Kang H, Das AK, Everett L, White D, Lok ASF. A randomized, double-blind, placebo-controlled study of ppar-gamma agonist pioglitazone given in combination with peginterferon and ribavirin in patients with genotype-1 chronic hepatitis C. Hepatology 2008; 48 Suppl 1: 384A
    • (2008) Hepatology , vol.48 , Issue.SUPPL. 1
    • Conjeevaram, H.1    Burant, C.F.2    McKenna, B.3    Harsh, D.4    Kang, H.5    Das, A.K.6    Everett, L.7    White, D.8    Lok, A.S.F.9
  • 67
    • 84864348299 scopus 로고    scopus 로고
    • Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin
    • [PMID: 22334369 DOI: 10.1002/hep.25661]
    • Harrison SA, Hamzeh FM, Han J, Pandya PK, Sheikh MY, Vierling JM. Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin. Hepatology 2012; 56: 464-473 [PMID: 22334369 DOI: 10.1002/hep.25661]
    • (2012) Hepatology , vol.56 , pp. 464-473
    • Harrison, S.A.1    Hamzeh, F.M.2    Han, J.3    Pandya, P.K.4    Sheikh, M.Y.5    Vierling, J.M.6
  • 68
    • 84858432382 scopus 로고    scopus 로고
    • A practical guide for the use of boceprevir and telaprevir for the treatment of hepatitis C
    • [PMID: 22404758 DOI10.1111/j.1365-2893.2012.01590.x]
    • Jacobson IM, Pawlotsky JM, Afdhal NH, Dusheiko GM, Forns X, Jensen DM, Poordad F, Schulz J. A practical guide for the use of boceprevir and telaprevir for the treatment of hepatitis C. J Viral Hepat 2012; 19 Suppl 2: 1-26 [PMID: 22404758 DOI: 10.1111/j.1365-2893.2012.01590.x]
    • (2012) J Viral Hepat , vol.19 , Issue.SUPPL. 2 , pp. 1-26
    • Jacobson, I.M.1    Pawlotsky, J.M.2    Afdhal, N.H.3    Dusheiko, G.M.4    Forns, X.5    Jensen, D.M.6    Poordad, F.7    Schulz, J.8
  • 69
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • PROVE1 Study Team, [PMID: 19403902 DOI: 10.1056/ NEJMoa0806104]
    • McHutchison JG, Everson GT, Gordon SC, Jacobson IM, Sulkowski M, Kauffman R, McNair L, Alam J, Muir AJ, PROVE1 Study Team. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009; 360: 1827-1838 [PMID: 19403902 DOI: 10.1056/ NEJMoa0806104]
    • (2009) N Engl J Med , vol.360 , pp. 1827-1838
    • McHutchison, J.G.1    Everson, G.T.2    Gordon, S.C.3    Jacobson, I.M.4    Sulkowski, M.5    Kauffman, R.6    McNair, L.7    Alam, J.8    Muir, A.J.9
  • 78
    • 84866060640 scopus 로고    scopus 로고
    • Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-naive patients infected with HCV genotype 1
    • [PMID: 22387529 DOI: 10.1136/ gutjnl-2011-300749]
    • Serfaty L, Forns X, Goeser T, Ferenci P, Nevens F, Carosi G, Drenth JP, Lonjon-Domanec I, DeMasi R, Picchio G, Beumont M, Marcellin P. Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-naive patients infected with HCV genotype 1. Gut 2012; 61: 1473-1480 [PMID: 22387529 DOI: 10.1136/ gutjnl-2011-300749]
    • (2012) Gut , vol.61 , pp. 1473-1480
    • Serfaty, L.1    Forns, X.2    Goeser, T.3    Ferenci, P.4    Nevens, F.5    Carosi, G.6    Drenth, J.P.7    Lonjon-Domanec, I.8    DeMasi, R.9    Picchio, G.10    Beumont, M.11    Marcellin, P.12
  • 81
    • 79960821870 scopus 로고    scopus 로고
    • Insulin resistance does not predict a response to pegylated interferon plus ribavirin in chronic hepatitis C patients: A sub-analysis of the MIST study
    • [DOI10.1016/ S0168-8278(10)60293-0]
    • Prati GM, Rumi MG, Aghemo A, D'Ambrosio R, De Nicola S, Olgiati L, Donato MF, Colombo M. Insulin resistance does not predict a response to pegylated interferon plus ribavirin in chronic hepatitis C patients: a sub-analysis of the MIST study. J Hepatol 2010; 52 Suppl1: S122 [DOI: 10.1016/ S0168-8278(10)60293-0]
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Prati, G.M.1    Rumi, M.G.2    Aghemo, A.3    D'Ambrosio, R.4    De Nicola, S.5    Olgiati, L.6    Donato, M.F.7    Colombo, M.8
  • 91
    • 84879606466 scopus 로고    scopus 로고
    • New horizons in hepatitis C antiviral therapy with direct-acting antivirals
    • [PMID: 23467911 DOI: 10.1002/hep.26371]
    • Aghemo A, De Francesco R. New horizons in hepatitis C antiviral therapy with direct-acting antivirals. Hepatology 2013; 58: 428-438 [PMID: 23467911 DOI: 10.1002/hep.26371]
    • (2013) Hepatology , vol.58 , pp. 428-438
    • Aghemo, A.1    De Francesco, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.