Prevalence of thrombophilia according to age at the first manifestation of venous thromboembolism: Results from the MAISTHRO registry

British Journal of Haematology

Volumn 163, Issue 5, 2013, Pages 655-665

  Weingarz, Lea ^a   Schwonberg, Jan ^a   Schindewolf, Marc ^a   Hecking, Carola ^a   Wolf, Zsuzsanna ^a   Erbe, Matthias ^a   Weber, Adele ^a   Lindhoff Last, Edelgard ^a   Linnemann, Birgit ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Age; Screening; Thrombophilia; Unprovoked DVT; Venous thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN;

ADULT; AGE; AGED; ARTICLE; CHILD; COHORT ANALYSIS; FACTOR V LEIDEN GENE; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RISK FACTOR; SCHOOL CHILD; SCREENING TEST; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

AGE; SCREENING; THROMBOPHILIA; UNPROVOKED DVT; VENOUS THROMBOEMBOLISM;

ACTIVATED PROTEIN C RESISTANCE; ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ANTIPHOSPHOLIPID SYNDROME; CHILD; CONTRACEPTIVES, ORAL; CROSS-SECTIONAL STUDIES; FACTOR V; FEMALE; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; PREVALENCE; PROMOTER REGIONS, GENETIC; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; PROTHROMBIN; REGISTRIES; THROMBOPHILIA; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84887520301     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12575     Document Type: Article

References (46)

1. Baglin, T., Gray, E., Greaves, M., Hunt, B.J., Keeling, D., Machin, S., Mackie, I., Makris, M., Nokes, T., Perry, D., Tait, R.C., Walker, I. & Watson, H. (2010) Clinical guidelines for testing for heritable thrombophilia. British Journal of Haematology, 149, 209-220.
2. Blaettler, W., Gerlach, H., Hach-Wunderle, V., Konstantinides, S., Noppeney, T., Pillny, M., Riess, H., Schellong, S., Stiegler, H. & Wildberger, J.E. (2010) Interdisziplinäre S2-Leitlinie: Diagnostik und Therapie der Venenthrombose und der Lungenembolie. VASA, 39, 1-39.
3. Brandt, J.T., Triplett, D.A., Alving, B. & Scharrer, I. (1995) Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thrombosis and Haemostasis, 74, 1185-1190.
4. Brouwer, J.L., Lijfering, W.M., ten Kate, M.K., Kluin-Nelemans, H.C., Veeger, N.J. & van der Meer, J. (2009) High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin. Thrombosis and Haemostasis, 101, 93-99.
5. Chong, L.Y., Fenu, E., Stansby, G., Hodgkinson, S., on behalf of the Guideline Development Group. (2012) Management of venous thromboembolic diseases and the role of thrombophilia testing: summary of NICE guidance. British Medical Journal, 344, e3979.
6. Christiansen, S.C., Cannegieter, S.C., Koster, T., Vandenbroucke, J.P. & Rosendaal, F.R. (2005) Thrombophilia, clinical factors, and recurrent venous thrombotic events. JAMA, 293, 2352-2361.
7. Cohn, D.M. & Middeldorp, S. (2008) Early termination of the multicentre randomised clinical trial to evaluate the benefit of testing for thrombophilia following a first venous thromboembolism: the NOSTRADAMUS study. Nederlands Tijdschrift voor Geneeskunde, 152, 2093-2094.
8. Cohn, D.M., Vansenne, F., Kaptein, A.A., De Borgie, J.M. & Middeldorp, S. (2008) The psychological impact of testing for thrombophilia: a systematic review. Journal of Thrombosis and Haemostasis, 6, 1099-1104.
9. Cohn, D., Vansenne, F., de Borgie, C. & Middeldorp, S. (2009) Thrombophilia testing for prevention of recurrent venous thromboembolism. Cochrane Database Systematic Review, 1, pCD007069.
10. Conlan, M.G., Folsom, A.R., Finch, A., Davis, C.E., Sorlie, P., Marcucci, G. & Wu, K.K. (1993) Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thrombosis and Haemostasis, 70, 380-385.
11. Coppens, M., van Mourik, J.A., Eckmann, C.M., Bueller, H.R. & Middeldorp, S. (2007) Current pratice of testing for thrombophilia in The Netherlands. Journal of Thrombosis and Haemostasis, 5, 1979-1981.
12. Cushman, M., Glynn, R.J., Goldhaber, S.Z., Moll, S., Bauer, K.A., Deitcher, S., Shrivastava, S. & Ridker, P.M. (2006) Hormonal factors and risk of recurrent venous thrombosis: the Prevention of Recurrent Venous Thromboembolism trial. Journal of Thrombosis and Haemostasis, 4, 2199-2203.
13. De Stefano, V., Rossi, E., Paciaroni, K. & Leone, G. (2002) Screening for inherited thrombophilia: indications and therapeutic implications. Haematologica, 87, 1095-1108.
14. Engbers, M.J., van Hylckama Vlieg, A. & Rosendaal, F.R. (2010) Venous thrombosis in the elderly: incidence, risk factors and risk groups. Journal of Thrombosis and Haemostasis, 8, 2105-2112.
15. Folsom, A.R., for the LITE investigators. (2007) Update on factor V Leiden association with venous thromboembolism in the LITE study. Blood, 109, 1336-1337.
16. Folsom, A.R., Cushman, M., Tsai, M.Y., Heckbert, S.R. & Aleksic, N. (2002) Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism. American Journal of Hematology, 71, 285-290.
17. Hansson, P.O., Sörbo, J. & Eriksson, H. (2000) Recurrent venous thromboembolism after deep venous thrombosis: incidence and risk factors. Archives of Internal Medicine, 160, 769-774.
18. Heit, J.A., Sobell, J.L., Li, H. & Sommer, S.S. (2005) The incidence of venous thromboembolism among factor V Leiden carriers: a community-based cohort study. Journal of Thrombosis and Haemostasis, 3, 305-311.
19. Ho, W.K., Hankey, G.J., Quinlan, D.J. & Eikelboom, J.W. (2006) Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systemic review. Archives of Internal Medicine, 166, 729-736.
20. Jenkens, P.V., Rawley, O., Smith, O.P. & O'Donnell, J.S. (2012) Elevated factor VIII levels and risk of venous thromboembolism. British Journal of Haematology, 157, 653-663.
21. Kearon, C., Akl, E.A., Comerota, A.J., Prandoni, P., Bounameaux, H., Goldhaber, S.Z., Nelson, M.E., Wells, P.S., Gould, M.K., Dentali, F., Crowther, M. & Kahn, S.R. (2012) Antithrombotic therapy for VTE disease. Antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest, 141(Suppl. 2), e419S-e494S.
22. Kyrle, P.A., Minar, E., Bialonczyk, C., Hirschl, M., Weltermann, A. & Eichinger, S. (2004) The risk of recurrent venous thromboembolism in men and women. New England Journal of Medicine, 350, 2558-2563.
23. Lindhoff-Last, E. & Luxembourg, B. (2008) Evidence-based indications for thrombophilia screening. VASA, 37, 19-30.
24. Linnemann, B., Zgouras, D., Schindewolf, M., Schwonberg, J., Jarosch-Preusche, M. & Lindhoff-Last, E. (2008) Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry. Blood Coagulation & Fibrinolysis, 19, 159-165.
25. Luxembourg, B., Schmitt, J., Humpich, M., Glowatzki, M., Seifried, E. & Lindhoff-Last, E. (2009) Intrinsic clotting factors in dependency of age, sex, body mass index, and oral contraceptives: definition and risk of elevated clotting factor levels. Blood Coagulation & Fibrinolysis, 20, 524-534.
26. Machin, S.J. (2003) Pros and cons of thrombophilia testing: cons. Journal of Thrombosis and Haemostasis, 1, 412-413.
27. Mateo, J., Oliver, A., Borrell, M., Sala, N., Fontcuberta, J., the EMET group. (1997) Laboratory evaluation and clinical characteristics of 2 132 consecutive unselected patients with venous thromboembolism - results of the Spanish multicentric study on thrombophilia (EMET-Study). Thrombosis and Haemostasis, 77, 444-451.
28. McRae, S., Tran, H., Schulman, S., Ginsberg, J. & Kearon, C. (2006) Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis. Lancet, 368, 371-378.
29. Middeldorp, S. & van Hylckama Vlieg, A. (2008) Does thrombophilia testing help in the clinical management of patients? British Journal of Haematology, 143, 321-335.
30. Miyakis, S., Lockshin, M.D., Atsumi, T., Branch, D.W., Brey, R.L., Cervera, R., Derksen, R.H., de Groot, P.G., Koike, T., Meroni, P.L., Reber, G., Shoenfeld, Y., Tincani, A., Vlachoyiannopoulos, P.G. & Krilis, S.A. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis and Haemostasis, 4, 295-306.
31. Monreal, M., del Campo, R. & Papadakis, E. (2012) Thrombophilia and venous thromboembolism: RIETE Experience. Best Practice & Research. Clinical Haematology, 25, 285-294.
32. Naess, I.A., Christiansen, S.C., Romundstad, P., Cannegieter, S.C., Rosendaal, F.R. & Hammerstrom, J. (2007) Incidence and mortality of venous thrombosis: a population-based study. Journal of Thrombosis and Haemostasis, 5, 692-699.
33. Paschoa, A.F. & Guillaumon, A.T. (2006) Impact of screening on thrombophilia for patients with venous thrombosis. International Angiology, 25, 52-59.
34. Pengo, V., Tripodi, A., Reber, G., Rand, J.H., Ortel, T.L., Galli, M., de Groot, P.G., Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the Internation Society on Thrombosis and Haemostasis. (2009) Update of the Guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. Journal of Thrombosis and Haemostasis, 7, 1737-1740.
35. Pengo, V., Ruffatti, A., Legnani, C., Gresele, P., Barcellona, D., Erba, N., Testa, S., Marongiu, F., Bison, E., Denas, G., Banzato, A., Padayattil Jose, S. & Iliceto, S. (2010) Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. Journal of Thrombosis and Haemostasis, 8, 237-242.
36. Pernod, G., Biron-Andreani, C., Morange, P.E., Boehlen, F., Constans, J., Couturaud, F., Crouet, L., Jude, B., Lecompte, T., Le Gal, G., Trillot, N., Wahl, D., for the French group on haemostasis and thrombosis and the French Society of vascular medicine. (2009) Recommendations on testing for thrombophilia in venous thromboembolic disease: a French consensus guideline. Journal des Maladies Vasculaires, 34, 156-203.
37. Pottier, P., Cormier, G., Truchaud, F. & Planchon, B. (2005) Efficiency of systematic thrombophilia screening in idiopathic venous thrombosis: a prospective study in internal medicine. Clinical and Applied Thrombosis/Hemostasis, 11, 243-251.
38. Rosendaal, F.R. (1999) Venous thrombosis: a multicausal disease. Lancet, 353, 1167-1173.
39. Rosendaal, F.R., van Hylckama Vlieg, A. & Doggen, C.J. (2007) Venous thrombosis in the elderly. Journal of Thrombosis and Haemostasis, 5, 310-317.
40. Segal, J.B., Brotmann, D.J., Necochea, A.J., Emadi, A., Samal, L., Wilson, L.M., Crim, M.T. & Bass, E.B. (2009) Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systemic review. JAMA, 301, 2472-2485.
41. Simpson, E.L., Stevenson, M.D., Rawdin, A. & Papaioannou, D. (2009) Thrombophilia testing in people with venous thromboembolism: systemic review and cost-effectiveness analysis. Health Technology Assessment, 13, 1-91.
42. Souto, J.C., Almasy, L., Borrell, M., Gari, M., Martinez, E., Mateo, J., Stone, W.H., Blangero, J. & Fontcuberta, J. (2000) Genetic determinants of hemostasis phenotypes in Spanish families. Circulation, 101, 1546-1551.
43. Tsai, A.W., Cushman, M., Rosamond, W.D., Heckbert, S.R., Polka, J.F. & Folsom, A.R. (2002) Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Archives of Internal Medicine, 162, 1182-1189.
44. Vossen, C.Y., Conard, J., Fontcuberta, J., Makris, M., van der Meer, F.J., Pabinger, I., Palareti, G., Preston, F.E., Scharrer, I., Souto, J.C., Svensson, P., Walker, I.D. & Rosendaal, F.R. (2005) Risk of a first venous thrombotic event in carriers of a familial defect. The European Prospective Cohort on Thrombophilia (EPCOT). Journal of Thrombosis and Haemostasis, 3, 459-464.
45. Wu, O., Robertson, L., Twaddle, S., Lowe, G.D., Clark, P., Greaves, M., Walker, I.D., Langhorne, P., Brenkel, I., Regan, L. & Greer, I. (2006) Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technology Assessment, 10, 1-110.
46. Zhu, T., Martinez, I. & Emmerich, J. (2009) Venous thromboembolism. Risk factors for recurrence. Arteriosclerosis, Thrombosis, and Vascular Biology, 29, 298-310.