Red ginseng extract inhibits the expression of MCP-1 and iNOS in Helicobacter pylori-infected gastric epithelial cells by suppressing the activation of NADPH oxidase and Jak2/Stat3

Journal of Ethnopharmacology

Volumn 150, Issue 2, 2013, Pages 761-764

  Cho, Soon Ok ^a   Lim, Joo Weon ^a   Kim, Hyeyoung ^a  

^a Yonsei University   (South Korea)

Author keywords

Gastric epithelial cells; Helicobacter pylori; iNOS; MCP 1; Panax ginseng C.A. Meyer; Red ginseng extract (RGE)

Indexed keywords

GINSENG EXTRACT; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE 2; MONOCYTE CHEMOTACTIC PROTEIN 1; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN P47; PROTEIN P47 PHOX; PROTEIN P67; PROTEIN P67 PHOX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; EPITHELIUM CELL; GINSENG; HELICOBACTER INFECTION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TRANSPORT; RED GINSENG; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM;

HELICOBACTER PYLORI; PANAX GINSENG;

GASTRIC EPITHELIAL CELLS; HELICOBACTER PYLORI; INOS; MCP-1; PANAX GINSENG C.A. MEYER; RED GINSENG EXTRACT (RGE);

CELL LINE; CHEMOKINE CCL2; EPITHELIAL CELLS; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; JANUS KINASE 2; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE II; PANAX; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; STAT3 TRANSCRIPTION FACTOR;

EID: 84887488863     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.09.013     Document Type: Article

References (19)

1. J.Y. Ban, S.W. Kang, J.S. Lee, J.H. Chung, Y.G. Ko, and H.S. Choi Korean red ginseng protects against neuronal damage induced by transient focal ischemia in rats Experimental and Therapeutic Medicine 3 2012 693 698
2. B. Cha, J.W. Lim, K.H. Kim, and H. Kim HSP90β interacts with Rac1 to activate NADPH oxidase in Helicobacter pylori-infected gastric epithelial cells International Journal of Biochemistry and Cell Biology 42 2010 1455 1461
3. B. Cha, J.W. Lim, K.H. Kim, and H. Kim 15-deoxy-D12,14-prostaglandin J2 suppresses RANTES expression by inhibiting NADPH oxidase activation in Helicobacter pylori-infected gastric epithelial cells Journal of Physiology and Pharmacology 62 2011 167 174
4. S.O. Cho, J.W. Lim, K.H. Kim, and H. Kim Diphenyleneiodonium inhibits the activation of mitogen-activated protein kinases and the expression of monocyte chemoattractant protein-1 in Helicobacter pylori-infected gastric epithelial AGS cells Inflammation Research 60 2011 501 507
5. P. Dell'Albani, R. Santangelo, L. Torrisi, V.G. Nicoletti, J. de Vellis, and A.M. Giuffrida Stella JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures Journal of Neuroscience Research 65 2001 417 424
6. M. Funakoshi-Tago, K. Tago, Y. Sato, S. Tominaga, and T. Kasahara JAK2 is an important signal transducer in IL-33-induced NF-κB activation Cell Signaling 23 2011 363 370
7. S.H. Jang, J.W. Lim, T. Morio, and H. Kim Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells Free Radical Biology and Medicine 52 2012 607 615
8. J.S. Jung, D.H. Kim, and H.S. Kim Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways Biochemical Biophysical Research Communication 397 2010 323 328
9. M. Mochizuki, Y.C. Yoo, K. Matsuzawa, K. Sato, I. Saiki, S. Tono-oka, K. Samukawa, and I. Azuma Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)-and 20(S) - ginsenoside-Rg3, of red ginseng Biological and Pharmaceutical Bulletin 18 1995 1197 1202
10. E.K. Park, M.K. Choo, M.J. Han, and D.H. Kim Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities International Archives of Allergy and Immunology 133 2004 113 120
11. S. Park, M. Yeo, J.H. Jin, K.M. Lee, S.S. Kim, S.Y. Choi, and K.B. Hahm Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells Digestive Diseases and Sciences 52 2007 973 982
12. G. Rieder, J.A. Hofmann, R.A. Hatz, M. Stolte, and G.A. Enders Up-regulation of inducible nitric oxide synthase in Helicobacter pylori-associated gastritis may represent an increased risk factor to develop gastric carcinoma of the intestinal type International Journal of Medical Microbiology 293 2003 403 412
13. J.H. Seo, J.W. Lim, H. Kim, and K.H. Kim Helicobacter pylori in a Korean isolate activates mitogen-activated protein kinases, AP-1, and NF-κB and induces chemokine expression in gastric epithelial AGS cells Laboratory Investigation 84 2004 49 62
14. T. Shimoyama, S.M. Everett, M.F. Dixon, A.T. Axon, and J.E. Crabtree Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis Journal of Clinical Pathology 51 1998 765 770
15. A.T. Smolinski, and J.J. Pestka Modulation of lipopolysaccharide- induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin, ginsenoside Rb1 and parthenolide Food and Chemical Toxicology 41 1999 1381 1390
16. S. Teshima, S. Tsunawaki, and K. Rokutan Helicobacter pylori lipopolysaccharide enhances the expression of NADPH oxidase components in guinea pig gastric mucosal cells FEBS Letters 452 1999 243 246
17. X. Wang, Q. Liu, A. Ihsan, L. Huang, M. Dai, H. Hao, G. Cheng, Z. Liu, Y. Wang, and Z. Yuan JAK/STAT pathway plays a critical role in proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin Toxicological Sciences 127 2012 412 424
18. X.S. Xie, H.S. Liu, M. Yang, C. Zuo, Y. Deng, and J.M. Fan Ginsenoside Rb1, a panoxadiol saponin against oxidative damage and renal interstitial fibrosis in rats with unilateral ureteral obstruction Chinese Journal of Integrated Medicine 15 2009 133 140
19. X Zhang, Y Yang, R Zhu, J Bai, Y Tian, X Li, Z Peng, Y He, L Chen, D Fang, W Chen, Q Zou, X Mao, and R. Wang Helicobacter pylori induces the expression of Hath1 in gastric epithelial cells via interleukin-8/STAT3 phosphorylation while suppressing Hes1 Journal of Cellular Biochemisry 113 2012 3740 3751