Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4)

Biochemical Pharmacology

Volumn 86, Issue 11, 2013, Pages 1531-1540

  Wang, Chunmei ^a   Lin, Wenwei ^a,b   Playa, Hilaire ^a   Sun, Shan ^a   Cameron, Keyuna ^a   Buolamwini, John K ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Dipyridamole analogs; Equilibrative nucleoside transporters; Human equilibrative nucleoside transporter 4; Structure activity relationships

Indexed keywords

2,6 DI(N MONOHYDROXYETHYL); ADENOSINE; CAMPTOTHECIN; DIPYRIDAMOLE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2; HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4; PYRIMIDINE DERIVATIVE; PYRIMIDO[5,4 DEXTRO]PYRIMIDINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DESIGN; DRUG DEVELOPMENT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

DIPYRIDAMOLE ANALOGS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS; HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4; STRUCTURE-ACTIVITY RELATIONSHIPS;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; DIPYRIDAMOLE; DRUG DESIGN; EQUILIBRATIVE NUCLEOSIDE TRANSPORT PROTEINS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; NUCLEOSIDE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TRANSFECTION;

EID: 84887458738     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.063     Document Type: Article

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