Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-α and TGF-β release by interacting with formyl-peptide receptors

International Journal of Immunopathology and Pharmacology

Volumn 26, Issue 3, 2013, Pages 647-662

  Prevete, N ^a   Rossi, F W ^a   Rivellese, F ^a   Lamacchia, D ^a   Pelosi, C ^a   Lobasso, A ^a   Necchi, V ^b   Solcia, E ^b   Fiocca, R ^c   Ceppa, P ^c   Staibano, S ^a   Mascolo, M ^a   D'Argenio, G ^a   Romano, M ^d   Ricci, V ^b   Marone, G ^a   De Paulis, Amato ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Eosinophils; FPRs; Helicobacter pylori; Hp(2 20)

Indexed keywords

BACTERIAL PROTEIN; FORMYLPEPTIDE RECEPTOR; INDOMETACIN; LACTATE DEHYDROGENASE; PROTEIN; PROTEIN FPR1; PROTEIN FPR2; PROTEIN FPR3; PROTEIN HP(2-20); TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EOSINOPHIL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE ACTIVATION; LEUKOCYTE MIGRATION; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; STOMACH BIOPSY; STOMACH EPITHELIUM; STOMACH INJURY; STOMACH MUCOSA; TISSUE REPAIR; TRANSMISSION ELECTRON MICROSCOPY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EOSINOPHIL COUNT; GASTRIC MUCOSA; IN VITRO STUDY; IN VIVO STUDY; INVESTIGATIVE PROCEDURES; LAMINA PROPRIA; PROTEIN INTERACTION;

ANIMALS; BACTERIAL PROTEINS; CASE-CONTROL STUDIES; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; EOSINOPHILS; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; INDOMETHACIN; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, LIPOXIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; STOMACH ULCER; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84887457129     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201302600308     Document Type: Article

References (30)

1. Lee JJ, Jacobsen EA, McGarry MP, Schleimer RP, Lee NA. Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy 2010; 40:563-75.
2. Powell N, Walker MM, Talley NJ. Gastrointestinal eosinophils in health, disease and functional disorders. Nat Rev Gastroenterol Hepatol 2010; 7:146-56.
3. Piazuelo MB, Camargo MC, Mera RM, et al. Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis. Hum Pathol 2008; 39:1360-69.
4. de Paulis A, Prevete N, Fiorentino I, et al. Basophils infiltrate human gastric mucosa at sites of Helicobacter pylori infection, and exhibit chemotaxis in response to H. pylori-derived peptide Hp(2-20). J Immunol 2004; 172:7734-43. (Pubitemid 38747641)
5. Ernst PB, Gold BD. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu Rev Microbiol 2000; 54:615-40.
6. Stenfeldt AL, Wenneras C. Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils. Immunology 2004; 112:605-14. (Pubitemid 39061486)
7. Lampinen M, Ronnblom A, Amin K, et al. Eosinophil granulocytes are activated during the remission phase of ulcerative colitis. Gut 2005; 54:1714-20. (Pubitemid 41697669)
8. de Paulis A, Prevete N, Rossi FW, et al. Helicobacter pylori Hp(2-20) promotes migration and proliferation of gastric epithelial cells by interacting with formyl peptide receptors in vitro and accelerates gastric mucosal healing in vivo. J Immunol 2009; 183:3761-69.
9. Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev 2009; 61:119-61.
10. Marone G, Florio G, Petraroli A, Triggiani M, de Paulis A. Human mast cells and basophils in HIV-1 infection. Trends Immunol 2001; 22:229-32. (Pubitemid 32667502)
11. Fiocca R, Villani L, Luinetti O, Gianatti A, Perego M, Alvisi C, Turpini F, Solcia E. Helicobacter colonization and histopathological profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer: a morphological approach to the study of ulcerogenesis in man. Virchows Arch A Pathol Anat Histopathol 1992; 420:489-98.
12. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996; 20:1161-81
13. Metso T, Venge P, Haahtela T, Peterson CG, Seveus L. Cell specific markers for eosinophils and neutrophils in sputum and bronchoalveolar lavage fluid of patients with respiratory conditions and healthy subjects. Thorax 2002; 57:449-51. (Pubitemid 34494159)
14. Necchi V, Candusso ME, Tava F, Luinetti O, Ventura U, Fiocca R, Ricci V, Solcia E. Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori. Gastroenterology 2007; 132:1009-23. (Pubitemid 46440875)
15. de Paulis A, Minopoli G, Arbustini E, de Crescenzo G, Dal Piaz F, Pucci P, Russo T, Marone G. Stem cell factor is localized in, released from, and cleaved by human mast cells. J Immunol 1999; 163:2799-808. (Pubitemid 29399208)
16. Triggiani M, Granata F, Balestrieri B, Petraroli A, Scalia G, Del Vecchio L, Marone G. Secretory phospholipases A2 activate selective functions in human eosinophils. J Immunol 2003; 170:3279-88. (Pubitemid 36302206)
17. de Paulis A, De Palma R, Di Gioia L, Carfora M, Prevete N, Tosi G, Accolla RS, Marone G. Tat protein is an HIV-1-encoded beta-chemokine homolog that promotes migration and up-regulates CCR3 expression on human Fc epsilon RI+ cells. J Immunol 2000; 165:7171-9. (Pubitemid 32001194)
18. Detoraki A, Staiano RI, Granata F, et al. Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol 2009; 123:1142-49.
19. de Paulis A, Montuori N, Prevete N, et al. Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2. J Immunol 2004; 173:5739-48 (Pubitemid 39392163)
20. de Paulis A, Prevete N, Fiorentino I, et al. Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J Immunol 2006; 177:7322-31. (Pubitemid 44715102)
21. de Paulis A, Annunziato F, Di Gioia L, Romagnani S, Carfora M, Beltrame C, Marone G, Romagnani P. Expression of the chemokine receptor CCR3 on human mast cells. Int Arch Allergy Immunol 2001; 124:146-50. (Pubitemid 32304787)
22. Lwin T, Melton SD, Genta RM. Eosinophilic gastritis: histopathological characterization and quantification of the normal gastric eosinophil content. Mod Pathol 2011; 24:556-63.
23. de Paulis A, Cirillo R, Ciccarelli A, Condorelli M, Marone G. FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human Fc epsilon RI+ cells. J Immunol 1991; 146:2374-81
24. Genovese A, Borgia G, Björck L, Petraroli A, de Paulis A, Piazza M, Marone G. Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human Fc epsilon RI+ cells through interaction with the kappa light chains of IgE. J Immunol 2003; 170:1854-61. (Pubitemid 36197402)
25. Bylund J, Christophe T, Boulay F, Nystrom T, Karlsson A, Dahlgren C. Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori. Antimicrob Agents Chemother 2001; 45:1700-704. (Pubitemid 32466337)
26. de Paulis A, Ciccarelli A, de Crescenzo G, Cirillo R, Patella V, Marone G. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. J Allergy Clin Immunol 1996; 98:152-64
27. Kay AB. Eosinophils and asthma. N Engl J Med 1991;324:1514-15.
28. Svensson L, Redvall E, Bjorn C, Karlsson J, Bergin AM, Rabiet MJ, Dahlgren C, Wenneras C. House dust mite allergen activates human eosinophils via formyl peptide receptor and formyl peptide receptor-like 1. Eur J Immunol 2007; 37:1966-77. (Pubitemid 47065132)
29. Devosse T, Guillabert A, D'Haene N, et al. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. J Immunol 2009; 182:4974-84.
30. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83:835-70. (Pubitemid 36828927)