Genetic characteristics of Neisseria meningitidis serogroup B strains carried by adolescents living in Milan, Italy: Implications for vaccine efficacy

Human Vaccines and Immunotherapeutics

Volumn 9, Issue 11, 2013, Pages 2296-2303

  Esposito, Susanna ^a   Zampiero, Alberto ^a   Terranova, Leonardo ^a   Montinaro, Valentina ^a   Scala, Alessia ^a   Ansuini, Valentina ^a   Principi, Nicola ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Invasive bacterial disease; Meningococcal vaccine; Meningococcus B; Meningococcus B vaccine; Neisseria meningitides

Indexed keywords

BACTERIAL VACCINE; MENINGOCOCCUS VACCINE;

ADOLESCENT; ADULT; AMINO ACID ANALYSIS; ANTIBODY RESPONSE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; ITALY; MALE; MENINGOCOCCEMIA; NEISSERIA MENINGITIDIS; NONHUMAN; NORMAL HUMAN; CLASSIFICATION; EPIDEMIOLOGY; GENETICS; GENOTYPE; HETEROZYGOTE; IMMUNOLOGY; ISOLATION AND PURIFICATION; MENINGOCOCCAL INFECTIONS; MICROBIOLOGY; MOLECULAR TYPING; NASOPHARYNX; YOUNG ADULT;

ADOLESCENT; CARRIER STATE; FEMALE; GENOTYPE; HUMANS; ITALY; MALE; MENINGOCOCCAL INFECTIONS; MENINGOCOCCAL VACCINES; MOLECULAR TYPING; NASOPHARYNX; NEISSERIA MENINGITIDIS, SEROGROUP B; YOUNG ADULT;

EID: 84887450287     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.25800     Document Type: Article

References (39)

1. Stephens DS, Greenwood B, Brandtzaeg P. Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 2007; 369: 2196-210; PMID: 17604802; http://dx.doi.org/10.1016/S0140-6736(07)61016-2 (Pubitemid 46977462)
2. Bruge J, Bouveret-Le Cam N, Danve B, Rougon G, Schulz D. Clinical evaluation of a group B meningococcal N-propionylated polysaccharide conjugate vaccine in adult, male volunteers. Vaccine 2004; 22: 1087-96; PMID: 15 0 0 3 6 35; http://dx.doi.org/10.1016/j.vaccine.2003.10.005 (Pubitemid 38296650)
3. Finne J, Bitter-Suermann D, Goridis C, Finne U. An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues. J Immunol 1987; 138: 4402-7; PMID: 3108388 (Pubitemid 17090418)
4. Nedelec J, Boucraut J, Garnier JM, Bernard D, Rougon G. Evidence for autoimmune antibodies directed against embryonic neural cell adhesion molecules (N-CAM) in patients with group B meningitis. J Neuroimmunol 1990; 29: 49-56; PMID: 2211988; http://dx.doi.org/10.1016/0165-5728(90)90146-E (Pubitemid 20283781)
5. Holst J, Martin D, Arnold R, Huergo CC, Oster P, O'Hallahan J, et al. Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis. Vaccine 2009; 27(Suppl 2):B3-12; PMID: 19481313; http://dx.doi.org/10.1016/j.vaccine.2009.04.071
6. To n d e l l a ML, Popovic T, Rosenstein NE, Lake DB, Carlone GM, Mayer LW, et al.; The Active Bacterial Core Surveillance Team. Distribution of Neisseria meningitidis serogroup B serosubtypes and serotypes circulating in the United States. J Clin Microbiol 2000; 38: 3323-8; PMID: 10970378
7. Sette A, Rappuoli R. Reverse vaccinology: developing vaccines in the era of genomics. Immunity 2010; 33: 530-41; PMID: 21029963; http://dx.doi.org/10. 1016/j.immuni.2010.09.017
8. Serruto D, Bottomley MJ, Ram S, Giuliani MM, Rappuoli R. The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens. Vacci ne 2012; 30(Suppl 2):B87-97; PMID: 22607904; http://dx.doi.org/10.1016/j.vaccine.2012.01. 033
9. Feavers IM, Pizza M. Meningococcal protein antigens and vaccines. Vaccine 2009; 27(Suppl 2):B42-50; PMID: 19 4 81315; http://dx.doi.org/10.1016/j. vaccine.2009.05.001
10. Gossger N, Snape MD, Yu LM, Finn A, Bona G, Esposito S, et al.; European MenB Vaccine Study Group. Immunogenicity and tolerability of recombinant serogroup B meningococcal vaccine administered with or without routine infant vaccinations according to different immunization schedules: a randomized controlled trial. JAMA 2012; 307: 573-82; PMID: 22318278; http://dx.doi.org/10. 1001/jama.2012.85
11. Vesikari T, Esposito S, Prymula R, Ypma E, Kohl I, To n e a t t o D, et al.; EU Meningococcal B Infant Vaccine Study group. Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with routine infant and child vaccinations: results of two randomised trials. Lancet 2013; 381: 825-35; PMID: 23324563; http://d x. d oi.or g/10.1016/S 014 0 - 673 6 (12 ) 61961-8
12. Marshall HS, Richmond PC, Nissen MD, Jiang Q, Anderson AS, Jansen KU, et al. Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 months: a phase 1 randomized-controlled clinical trial. Pediatr Infect Dis J 2012; 31: 1061-8; PMID: 22718089
13. Caugant DA, Maiden MCJ. Meningococcal carriage and disease-population biology and evolution. Vacci ne 2009; 27(Suppl 2):B64-70; PMID: 19464092; http://dx.doi.org/10.1016/j. vaccine.2009.04.061
14. Anderson AS, Hao L, Jiang Q, Harris SL, Jones TR, Perez JL, et al. Potential impact of the bivalent rLP2806 vaccine on Neisseria meningitidis carriage and invasive serogroup B disease. Hum Vaccin Immunother 2012; 9; PMID: 23249817
15. Christensen H, May M, Bowen L, Hickman M, Trot ter CL. Meningococcal carriage by age: a systematic review and meta-analysis. Lancet Infect Dis 2010; 10: 853-61; PMID: 21075057; http://dx.doi.org/10.1016/S1473-3099(10)70251-6
16. Ala'aldeen DA, Oldfeld NJ, Bidmos FA, Abouseada NM, Ahmed NW, Tu r n e r DP, et al. Carriage of meningococci by university students, United Kingdom. Emerg Infect Dis 2 011; 17: 1762-3; PMID: 21888817; http://dx.doi.org/10.3201/e i d170 9.10176 2
17. Istituto Superiore di Sanità. Dati di sorveglianza delle malattie batteriche invasive aggiornati al 18 dicembre 2012 Available at: http://www.simi.iss.it/fles/Report-MBI.pdf. Accessed: 31 January 2013.
18. Lucidarme J, Comanducci M, Findlow J, Gray SJ, Kaczmarski EB, Guiver M, et al. Characterization of fHbp, nhba (gna2132), nadA, porA, and sequence type in group B meningococcal case isolates collected in England and Wales during January 2008 and potential coverage of an investigational group B meningococcal vaccine. Clin Vaccine Immunol 2010; 17: 919-29; PMID: 20375242; http://dx.doi.org/10.1128/CVI.00027-10
19. Seib KL, Brunelli B, Brogioni B, Palumbo E, Bambini S, Muzzi A, et al. Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies. Infect Immun 2011; 79: 970-81; PMID: 21149595; http://dx.doi.org/10.1128/I A I.0 0 891-10
20. Brunelli B, Del Tordello E, Palumbo E, Biolchi A, Bambini S, Comanducci M, et al. Infuence of sequence variability on bactericidal activity sera induced by Factor H binding protein variant 1.1. Vacci ne 2 011; 29: 1072-81; PMID: 2113 0753; http://dx.doi.org/10.1016/j.vaccine.2010.11.064
21. Elias J, Schouls LM, van de Pol I, Keijzers WC, Martin DR, Glennie A, et al. Vaccine preventability of meningococcal clone, Greater Aachen Region, Germany. Emerg Infect Dis 2010; 16: 465-72; PMID: 20202422; http://dx.doi.org/ 10.3201/eid1603.091102
22. Racloz VN, Luiz SJ. The elusive meningococcal meningitis serogroup: a systematic review of serogroup B epidemiology. BMC Infect Dis 2010; 10: 175; PMID: 20565757; http://dx.doi.org/10.118 6/1471-233 4-10-175
23. Mot hibeli K M, du Plessis M, von Gottberg A, Mu r phy E, Hoiseth SK, Zlotnick G, et al. Distribution of factor H binding protein beyond serogroup B: variation among fve serogroups of invasive Neisseria meningitidis in South Africa. Vaccine 2011; 29: 2187-92; PMID: 2114 4918; http://dx.doi.org/10.1016/j. vaccine.2010.11.072
24. Comanducci M, Bambini S, Caugant DA, Mora M, Brunelli B, Capecchi B, et al. NadA diversity and carriage in Neisseria meningitidis. Infect Immun 2004; 72: 4 2 17-23; PMID: 15 2 1 3 1 6 6; http://dx.doi.org/10.1128/IAI.72.7.4217- 4223.2004 (Pubitemid 38821936)
25. Jiang HQ, Hoiseth SK, Harris SL, McNeil LK, Zhu D, Tan C, et al. Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease. Vaccine 2010; 28: 6086-93; PMID: 20 619376; http://dx.doi.org/10.1016/j.vaccine.2010.06.083
26. Davenport V, Groves E, Horton RE, Hobbs CG, Guthrie T, Findlow J, et al. Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B. J Infect Dis 2008; 198: 731-40; PMID: 18636953; http://dx.doi.org/10.1086/590669
27. Guiver M, Borrow R, Marsh J, Gray SJ, Kaczmarski EB, Howells D, et al. Evaluation of the Applied Biosystems automated Taqman polymerase chain reaction system for the detection of meningococcal DNA. FEMS Immunol Med Microbiol 2000; 28: 173-9; PMID: 10799809; http://dx.doi. or g/10.1111/j.15 74 - 6 9 5 X. 2 0 0 0.t b 0147 3. x (Pubitemid 30224639)
28. Jordens JZ, Williams JN, Jones GR, Heckels JE. Detection of meningococcal carriage by culture and PCR of throat swabs and mouth gargles. J Clin Microbiol 2002; 40: 75-9; PMID: 11773095; http://dx.doi.org/10.1128/JCM.40.1.75-79.2002 (Pubitemid 34027603)
29. Maiden MC, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, et al. Multilocus sequence typing: a portable approach to the identifcation of clones wit hin populations of pathogenic microorganisms. Proc Natl Acad Sci U S A 1998; 95: 3140-5; PMID: 9501229; http://dx.doi.org/10.1073/pnas.95.6.3140 (Pubitemid 28135868)
30. Tippmann HF. Analysis for free: comparing programs for sequence analysis. Brief Bioinform 2004; 5: 82-7; PMID: 151533 0 8; http://dx.doi.org/10.1093/bib/ 5.1.82
31. Francisco AP, Bugalho M, Ramirez M, Carriço JA. Global optimal eBURST analysis of multilocus typing data using a graphic matroid approach. BMC Bioinformatics 2009; 10: 152; PMID: 19450271; http://dx.doi.org/10.1186/1471- 2105-10-152
32. Ta mu ra K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2 011; 28: 2 731-9; PMID: 215 4 6 353; http://dx.doi.org/10.1093/molbev/msr121
33. Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 19 8 7; 4: 406-25; PMID: 3 4 47 015
34. Bambini S, Muzzi A, Olcen P, Rappuoli R, Pizza M, Comanducci M. Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus. Vaccine 2009; 27: 2794-803; PMID: 19428890; http://dx.doi.org/10.1016/j. vaccine.2009.02.098
35. Murphy E, Andrew L, Lee KL, Dilts DA, Nunez L, Fink PS, et al. Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis. J Infect Dis 2009; 200: 379-89; PMID: 1953 4597; http://dx.doi.org/10.1086/600141
36. Sacchi CT, Lemos A P, Brandt ME, Whitney AM, Melles CE, Solari CA, et al. Proposed standardization of Neisseria meningitidis PorA variable-region typing nomenclature. Clin Diagn Lab Immunol 1998; 5: 845-55; PMID: 9801347 (Pubitemid 28519264)
37. Clarke SC, Diggle MA, Mölling P, Unemo M, Olcén P. Analysis of PorA variable region 3 in meningococci: implications for vaccine policy? Vaccine 2003; 21: 2468-73; PMID: 12744880; http://dx.doi.org/10.1016/S0264- 410X(03)00033-1 (Pubitemid 36561338)
38. de Filippis I, Gopalan V, Huyen Y. PorA VR3 Typing Database: a web-based resource for the determination of PorA VR3 alleles of Neisseria meningitidis. Infect Genet Evol 2011; 11: 248-9; PMID: 20801234; http://dx.doi.org/10.1016/j. meegid.2010.08.011
39. Lucidarme J, Comanducci M, Findlow J, Gray SJ, Kaczmarski EB, Guiver M, et al. Characterization of fHbp, nhba (gna2132), nadA, porA, sequence type (ST), and genomic presence of IS1301 in group B meningococcal ST269 clonal complex isolates from England and Wales. J Clin Microbiol 2009; 47: 3577-85; PMID: 19759227; http://dx.doi.org/10.1128/JCM.00936-09