Transgenic Mammary Epithelial Osteopontin (Spp1) Expression Induces Proliferation and Alveologenesis

Genes and Cancer

Volumn 4, Issue 5-6, 2013, Pages 201-212

  Hubbard, Neil E ^a   Chen, Qian J ^a   Sickafoose, Laura K ^a   Wood, Meghan B ^a   Gregg, Jeffrey P ^b   Abrahamsson, Ninnie M ^a   Engelberg, Jesse A ^a   Walls, Judith E ^a   Borowsky, Alexander D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

flow cytometry; involution; lobulogenesis; mammary gland; organoid culture; osteopontin

Indexed keywords

OSTEOPONTIN;

ALVEOLOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; CANCER GROWTH; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; FEMALE; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; LACTATION; MAMMARY GLAND; MORPHOGENESIS; MOUSE; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METABOLISM; TUMOR INVASION;

EID: 84887440201     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601913496813     Document Type: Article

References (30)

1. Sweeney EE,McDaniel RE,Maximov PY,Fan P,Jordan VC.Models and mechanisms of acquired antihormone resistance in breast cancer: significant clinical progress despite limitations.Horm Mol Biol Clin Investig. 2012;9:143-63.
2. Borowsky A.Special considerations in mouse models of breast cancer.Breast Dis. 2007;28:29-38.
3. Borowsky AD.Choosing a mouse model: experimental biology in context-the utility and limitations of mouse models of breast cancer.Cold Spring Harb Perspect Biol. 2011;3:a009670.
4. Hassiotou F,Geddes D.Anatomy of the human mammary gland: current status of knowledge.Clin Anat. 2013;26:29-48.
5. Colak D,Nofal A,Albakheet A, et al.Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women. PLoS One. 2013;8:e63204.
6. Shevde LA,Das S,Clark DW,Samant RS.Osteopontin: an effector and an effect of tumor metastasis.Curr Mol Med. 2010;10:71-81.
7. Rittling SR,Novick KE.Osteopontin expression in mammary gland development and tumorigenesis.Cell Growth Differ. 1997;8:1061-9.
8. Nagatomo T,Ohga S,Takada H, et al.Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period.Clin Exp Immunol. 2004;138:47-53.
9. Brown LF,Berse B,Van de Water L, et al.Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.Mol Biol Cell. 1992;3:1169-80.
10. Nemir M,Bhattacharyya D,Li X,Singh K,Mukherjee AB,Mukherjee BB.Targeted inhibition of osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency.J Biol Chem. 2000;275:969-76.
11. Tuck AB,Chambers AF.The role of osteopontin in breast cancer: clinical and experimental studies.J Mammary Gland Biol Neoplasia. 2001;6:419-29.
12. El-Tanani MK,Yuen HF,Shi Z, et al.Osteopontin can act as an effector for a germline mutation of BRCA1 in malignant transformation of breast cancer-related cells.Cancer Sci. 2010;101:1354-60.
13. Wai PY,Kuo PC.Osteopontin: regulation in tumor metastasis.Cancer Metastasis Rev. 2008;27:103-18.
14. Hartung F,Weber GF.RNA blood levels of osteopontin splice variants are cancer markers.Springerplus. 2013;2:110.
15. Mirza M,Shaughnessy E,Hurley JK, et al.Osteopontin-c is a selective marker of breast cancer. Int J Cancer. 2008;122:889-97.
16. Jessen KA,Liu SY,Tepper CG, et al.Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontin.Breast Cancer Res. 2004;6:R157-69.
17. Mailleux AA,Overholtzer M,Schmelzle T,Bouillet P,Strasser A,Brugge JS.BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.Dev Cell. 2007;12:221-34.
18. Streuli CH,Bailey N,Bissell MJ.Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.J Cell Biol. 1991;115:1383-95.
19. Bill HM,Knudsen B,Moores SL, et al.Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells.Mol Cell Biol. 2004;24:8586-99.
20. Eades G,Yao Y,Yang M,Zhang Y,Chumsri S,Zhou Q.miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells.J Biol Chem. 2011;286:25992-6002.
21. Foroni C,Broggini M,Generali D,Damia G.Epithelial-mesenchymal transition and breast cancer: role, molecular mechanisms and clinical impact.Cancer Treat Rev. 2011;38:689-97.
22. Thiery JP,Acloque H,Huang RY,Nieto MA.Epithelial-mesenchymal transitions in development and disease.Cell. 2009;139:871-90.
23. Damonte P,Gregg JP,Borowsky AD,Keister BA,Cardiff RD.EMT tumorigenesis in the mouse mammary gland.Lab Invest. 2007;87:1218-26.
24. Anborgh PH,Mutrie JC,Tuck AB,Chambers AF.Role of the metastasis-promoting protein osteopontin in the tumour microenvironment.J Cell Mol Med. 2010;14:2037-44.
25. Guy CT,Cardiff RD,Muller WJ.Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.Mol Cell Biol. 1992;12:954-61.
26. Rasmussen S,Young L,Smith GMethods in mammary gland biology and breast cancer research. Ip MAsch B, ed. New York: Kluwer Academic/Plenum; 2000:75-85.
27. Maglione JE,McGoldrick ET,Young LJ, et al.Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes.Mol Cancer Ther. 2004;3:941-53.
28. Walter T,Shattuck DW,Baldock R, et al.Visualization of image data from cells to organisms. Nat Methods. 2010;7:S26-41.
29. Zudaire E,Gambardella L,Kurcz C,Vermeren S.A computational tool for quantitative analysis of vascular networks.PLoS One. 2011;6:e27385.
30. Simian M,Hirai Y,Navre M,Werb Z,Lochter A,Bissell MJ.The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells.Development. 2001;128:3117-31.