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Volumn 288, Issue 45, 2013, Pages 32777-32786

Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner

Author keywords

[No Author keywords available]

Indexed keywords

AFTER-TREATMENT; ALTERNATIVE ROUTES; AMMONIUM CHLORIDE; APOPTOTIC ACTIVITY; LONG-TERM INCUBATION; NUCLEAR TRANSLOCATIONS; PROTEASOME INHIBITORS; SPECIFIC INHIBITORS;

EID: 84887418168     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.480921     Document Type: Article
Times cited : (15)

References (36)
  • 1
    • 0029347062 scopus 로고
    • New insights into proteasome function: From archaebacteria to drug development
    • Goldberg, A. L., Stein, R., and Adams, J. (1995) New insights into proteasome function: from archaebacteria to drug development. Chem. Biol. 2, 503-508
    • (1995) Chem. Biol , vol.2 , pp. 503-508
    • Goldberg, A.L.1    Stein, R.2    Adams, J.3
  • 2
    • 0030016595 scopus 로고    scopus 로고
    • Structure and functions of the 20S and 26S proteasomes
    • Coux, O., Tanaka, K., and Goldberg, A. L. (1996) Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65, 801-847
    • (1996) Annu. Rev. Biochem , vol.65 , pp. 801-847
    • Coux, O.1    Tanaka, K.2    Goldberg, A.L.3
  • 4
    • 0037342895 scopus 로고    scopus 로고
    • Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines
    • Ling, Y. H., Liebes, L., Jiang, J. D., Holland, J. F., Elliott, P. J., Adams, J., Muggia, F. M., and Perez-Soler, R. (2003) Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin. Cancer Res. 9, 1145-1154
    • (2003) Clin. Cancer Res , vol.9 , pp. 1145-1154
    • Ling, Y.H.1    Liebes, L.2    Jiang, J.D.3    Holland, J.F.4    Elliott, P.J.5    Adams, J.6    Muggia, F.M.7    Perez-Soler, R.8
  • 5
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-κB inhibition
    • Cusack, J. C. Jr., Liu, R., Houston, M., Abendroth, K., Elliott, P. J., Adams, J., and Baldwin, A. S. Jr. (2001) Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-κB inhibition. Cancer Res. 61, 3535-3540
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3    Abendroth, K.4    Elliott, P.J.5    Adams, J.6    Baldwin Jr., A.S.7
  • 8
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima, T., Richardson, P., Chauhan, D., Palombella, V. J., Elliott, P. J., Adams, J., and Anderson, K. C. (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61, 3071-3076
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3    Palombella, V.J.4    Elliott, P.J.5    Adams, J.6    Anderson, K.C.7
  • 9
    • 14544303662 scopus 로고    scopus 로고
    • Proteasome inhibition as a novel therapeutic target in human cancer
    • Rajkumar, S. V., Richardson, P. G., Hideshima, T., and Anderson, K. C. (2005) Proteasome inhibition as a novel therapeutic target in human cancer. J. Clin. Oncol. 23, 630-639
    • (2005) J. Clin. Oncol , vol.23 , pp. 630-639
    • Rajkumar, S.V.1    Richardson, P.G.2    Hideshima, T.3    Anderson, K.C.4
  • 10
    • 39749136204 scopus 로고    scopus 로고
    • BCL-2 family regulation by the 20S proteasome inhibitor bortezomib
    • Fennell, D. A., Chacko, A., and Mutti, L. (2008) BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 27, 1189-1197
    • (2008) Oncogene , vol.27 , pp. 1189-1197
    • Fennell, D.A.1    Chacko, A.2    Mutti, L.3
  • 12
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-κB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo, J. B., Chen, Z., Dong, G., Yeh, N., Crowl Bancroft, C., Sausville, E., Adams, J., Elliott, P., and Van Waes, C. (2001) Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-κB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin. Cancer Res. 7, 1419-1428
    • (2001) Clin. Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3    Yeh, N.4    Crowl Bancroft, C.5    Sausville, E.6    Adams, J.7    Elliott, P.8    Van Waes, C.9
  • 13
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A. S. Jr. (1996) The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683
    • (1996) Annu. Rev. Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 14
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes, P. J., and Karin, M. (1997) Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336, 1066-1071
    • (1997) N. Engl. J. Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 15
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., May, M. J., and Kopp, E. B. (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260
    • (1998) Annu. Rev. Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 17
    • 0035173922 scopus 로고    scopus 로고
    • Anti-inflammatory effect of adenovirus-mediated IκBα overexpression in respiratory epithelial cells
    • Park, G. Y., Le, S., Park, K. H., Le, C. T., Kim, Y. W., Han, S. K., Shim, Y. S., and Yoo, C. G. (2001) Anti-inflammatory effect of adenovirus-mediated IκBα overexpression in respiratory epithelial cells. Eur. Respir. J. 18, 801-809
    • (2001) Eur. Respir. J , vol.18 , pp. 801-809
    • Park, G.Y.1    Le, S.2    Park, K.H.3    Le, C.T.4    Kim, Y.W.5    Han, S.K.6    Shim, Y.S.7    Yoo, C.G.8
  • 18
    • 0034657795 scopus 로고    scopus 로고
    • Anti-inflammatory effect of heat shock protein induction is related to stabilization of IκBα through preventing IκB kinase activation in respiratory epithelial cells
    • Yoo, C. G., Lee, S., Lee, C. T., Kim, Y. W., Han, S. K., and Shim, Y. S. (2000) Anti-inflammatory effect of heat shock protein induction is related to stabilization of IκBα through preventing IκB kinase activation in respiratory epithelial cells. J. Immunol. 164, 5416-5423
    • (2000) J. Immunol , vol.164 , pp. 5416-5423
    • Yoo, C.G.1    Lee, S.2    Lee, C.T.3    Kim, Y.W.4    Han, S.K.5    Shim, Y.S.6
  • 19
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151-175
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3    Agrawal, D.K.4    Aliev, G.5
  • 20
    • 4043050142 scopus 로고    scopus 로고
    • The heat-shock-induced suppression of the IκB/NF-κB cascade is due to inactivation of upstream regulators of IκBα through insolubilization
    • Lee, K. H., Hwang, Y. H., Lee, C. T., Kim, Y. W., Han, S. K., Shim, Y. S., and Yoo, C. G. (2004) The heat-shock-induced suppression of the IκB/NF-κB cascade is due to inactivation of upstream regulators of IκBα through insolubilization. Exp. Cell Res. 299, 49-56
    • (2004) Exp. Cell Res , vol.299 , pp. 49-56
    • Lee, K.H.1    Hwang, Y.H.2    Lee, C.T.3    Kim, Y.W.4    Han, S.K.5    Shim, Y.S.6    Yoo, C.G.7
  • 21
    • 25444530592 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3β functions to specify gene-specific, NF-κB-dependent transcription
    • Steinbrecher, K. A., Wilson, W., 3rd., Cogswell, P. C., and Baldwin, A. S. (2005) Glycogen synthase kinase 3β functions to specify gene-specific, NF-κB-dependent transcription. Mol. Cell. Biol. 25, 8444-8455
    • (2005) Mol. Cell. Biol , vol.25 , pp. 8444-8455
    • Steinbrecher, K.A.1    Wilson III, W.2    Cogswell, P.C.3    Baldwin, A.S.4
  • 22
    • 4644316230 scopus 로고    scopus 로고
    • Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine- induced apoptosis
    • Denlinger, C. E., Rundall, B. K., Keller, M. D., and Jones, D. R. (2004) Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine- induced apoptosis. Ann. Thorac. Surg. 78, 1207-1214
    • (2004) Ann. Thorac. Surg , vol.78 , pp. 1207-1214
    • Denlinger, C.E.1    Rundall, B.K.2    Keller, M.D.3    Jones, D.R.4
  • 23
    • 33746840548 scopus 로고    scopus 로고
    • Proteasome inhibitors induce death but activate NF-κB on endometrial carcinoma cell lines and primary culture explants
    • Dolcet, X., Llobet, D., Encinas, M., Pallares, J., Cabero, A., Schoenenberger, J. A., Comella, J. X., and Matias-Guiu, X. (2006) Proteasome inhibitors induce death but activate NF-κB on endometrial carcinoma cell lines and primary culture explants. J. Biol. Chem. 281, 22118-22130
    • (2006) J. Biol. Chem , vol.281 , pp. 22118-22130
    • Dolcet, X.1    Llobet, D.2    Encinas, M.3    Pallares, J.4    Cabero, A.5    Schoenenberger, J.A.6    Comella, J.X.7    Matias-Guiu, X.8
  • 24
    • 1642538959 scopus 로고    scopus 로고
    • Proteasome inhibitors induce inhibitory κb (IκB) kinase activation, IκBα degradation, and nuclear factor κb activation in HT-29 cells
    • Németh, Z. H., Wong, H. R., Odoms, K., Deitch, E. A., Szabó, C., Vizi, E. S., and Haskó, G. (2004) Proteasome inhibitors induce inhibitory κB (IκB) kinase activation, IκBα degradation, and nuclear factor κB activation in HT-29 cells. Mol. Pharmacol. 65, 342-349
    • (2004) Mol. Pharmacol , vol.65 , pp. 342-349
    • Németh, Z.H.1    Wong, H.R.2    Odoms, K.3    Deitch, E.A.4    Szabó, C.5    Vizi, E.S.6    Haskó, G.7
  • 25
    • 0031570757 scopus 로고    scopus 로고
    • Calpain contributes to silica-induced IκB-α degradation and nuclear factor-κB activation
    • Chen, F., Lu, Y., Kuhn, D. C., Maki, M., Shi, X., Sun, S. C., and Demers, L. M. (1997) Calpain contributes to silica-induced IκB-α degradation and nuclear factor-κB activation. Arch. Biochem. Biophys. 342, 383-388
    • (1997) Arch. Biochem. Biophys , vol.342 , pp. 383-388
    • Chen, F.1    Lu, Y.2    Kuhn, D.C.3    Maki, M.4    Shi, X.5    Sun, S.C.6    Demers, L.M.7
  • 26
    • 0031594708 scopus 로고    scopus 로고
    • Novel IκBα proteolytic pathway in WEHI231 immature B cells
    • Miyamoto, S., Seufzer, B. J., and Shumway, S. D. (1998) Novel IκBα proteolytic pathway in WEHI231 immature B cells. Mol. Cell. Biol. 18, 19-29
    • (1998) Mol. Cell. Biol , vol.18 , pp. 19-29
    • Miyamoto, S.1    Seufzer, B.J.2    Shumway, S.D.3
  • 27
    • 0029736796 scopus 로고    scopus 로고
    • Bcl-2 and CrmA have different effects on transformation, apoptosis and the stability of IκB-α in chicken spleen cells transformed by temperature-sensitive v-Rel oncoproteins
    • White, D. W., and Gilmore, T. D. (1996) Bcl-2 and CrmA have different effects on transformation, apoptosis and the stability of IκB-α in chicken spleen cells transformed by temperature-sensitive v-Rel oncoproteins. Oncogene 13, 891-899
    • (1996) Oncogene , vol.13 , pp. 891-899
    • White, D.W.1    Gilmore, T.D.2
  • 28
    • 0031595780 scopus 로고    scopus 로고
    • IκB is a substrate for a selective pathway of lysosomal proteolysis
    • Cuervo, A. M., Hu, W., Lim, B., and Dice, J. F. (1998) IκB is a substrate for a selective pathway of lysosomal proteolysis. Mol. Biol. Cell 9, 1995-2010
    • (1998) Mol. Biol. Cell , vol.9 , pp. 1995-2010
    • Cuervo, A.M.1    Hu, W.2    Lim, B.3    Dice, J.F.4
  • 29
    • 77952340703 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IκB(α) degradation
    • Li, C., Chen, S., Yue, P., Deng, X., Lonial, S., Khuri, F. R., and Sun, S. Y. (2010) Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IκB(α) degradation. J. Biol. Chem. 285, 16096-16104
    • (2010) J. Biol. Chem , vol.285 , pp. 16096-16104
    • Li, C.1    Chen, S.2    Yue, P.3    Deng, X.4    Lonial, S.5    Khuri, F.R.6    Sun, S.Y.7
  • 30
    • 0036020941 scopus 로고    scopus 로고
    • NF-κB as a therapeutic target in cancer
    • Orlowski, R. Z., and Baldwin, A. S., Jr. (2002) NF-κB as a therapeutic target in cancer. Trends Mol. Med. 8, 385-389
    • (2002) Trends Mol. Med , vol.8 , pp. 385-389
    • Orlowski, R.Z.1    Baldwin Jr., A.S.2
  • 31
    • 0242664121 scopus 로고    scopus 로고
    • IκB kinase-independent IκBα degradation pathway: Functional NF-κB activity and implications for cancer therapy
    • Tergaonkar, V., Bottero, V., Ikawa, M., Li, Q., and Verma, I. M. (2003) IκB kinase-independent IκBα degradation pathway: functional NF-κB activity and implications for cancer therapy. Mol. Cell. Biol. 23, 8070-8083
    • (2003) Mol. Cell. Biol , vol.23 , pp. 8070-8083
    • Tergaonkar, V.1    Bottero, V.2    Ikawa, M.3    Li, Q.4    Verma, I.M.5
  • 32
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble, B. W., and Woodgett, J. R. (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116, 1175-1186
    • (2003) J. Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 33
    • 0038044650 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3β-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor κb signaling
    • Sanchez, J. F., Sniderhan, L. F., Williamson, A. L., Fan, S., Chakraborty- Sett, S., and Maggirwar, S. B. (2003) Glycogen synthase kinase 3β-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor κB signaling. Mol. Cell. Biol. 23, 4649-4662
    • (2003) Mol. Cell. Biol , vol.23 , pp. 4649-4662
    • Sanchez, J.F.1    Sniderhan, L.F.2    Williamson, A.L.3    Fan, S.4    Chakraborty- Sett, S.5    Maggirwar, S.B.6
  • 34
    • 24644518476 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-α
    • Eto, M., Kouroedov, A., Cosentino, F., and Lüscher, T. F. (2005) Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-α. Circulation 112, 1316-1322
    • (2005) Circulation , vol.112 , pp. 1316-1322
    • Eto, M.1    Kouroedov, A.2    Cosentino, F.3    Lüscher, T.F.4
  • 35
    • 4544341116 scopus 로고    scopus 로고
    • Genetic deletion of glycogen synthase kinase-3β abrogates activation of IκBα kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    • Takada, Y., Fang, X., Jamaluddin, M. S., Boyd, D. D., and Aggarwal, B. B. (2004) Genetic deletion of glycogen synthase kinase-3β abrogates activation of IκBα kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J. Biol. Chem. 279, 39541-39554
    • (2004) J. Biol. Chem , vol.279 , pp. 39541-39554
    • Takada, Y.1    Fang, X.2    Jamaluddin, M.S.3    Boyd, D.D.4    Aggarwal, B.B.5
  • 36
    • 0036081578 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase- 3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes
    • Schwabe, R. F., and Brenner, D. A. (2002) Role of glycogen synthase kinase- 3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G204-G211
    • (2002) Am. J. Physiol. Gastrointest. Liver Physiol , vol.283
    • Schwabe, R.F.1    Brenner, D.A.2


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