Stimulating effects of quercetin and phenamil on differentiation of human dental pulp cells

European Journal of Oral Sciences

Volumn 121, Issue 6, 2013, Pages 559-565

  Kim, Jong Gil ^a   Son, Kyung M ^a   Park, Hee C ^a   Zhu, Tingting ^a   Kwon, Ji H ^a   Yang, Hyeong Cheol ^a  

^a Seoul National University   (South Korea)

Author keywords

Dental pulp cells; Differentiation; Odontogenicity; Phenamil; Quercetin

Indexed keywords

ALKALINE PHOSPHATASE; AMILORIDE; ANTIOXIDANT; DENTIN SIALOPHOSPHOPROTEIN; DRUG DERIVATIVE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCALCIN; PHENAMIL; PHOSPHOPROTEIN; QUERCETIN; SCLEROPROTEIN; SIALOGLYCOPROTEIN;

ARTICLE; BLOOD; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DENTAL PULP CELLS; DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; HUMAN; METABOLISM; ODONTOGENICITY; OSTEOBLAST; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOOTH DEVELOPMENT; TOOTH PULP;

DENTAL PULP CELLS; DIFFERENTIATION; ODONTOGENICITY; PHENAMIL; QUERCETIN;

ALKALINE PHOSPHATASE; AMILORIDE; ANTIOXIDANTS; CELL DIFFERENTIATION; CELLS, CULTURED; DENTAL PULP; DENTINOGENESIS; EXTRACELLULAR MATRIX PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; HUMANS; MAP KINASE SIGNALING SYSTEM; OSTEOBLASTS; OSTEOCALCIN; PHOSPHOPROTEINS; QUERCETIN; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIALOGLYCOPROTEINS;

EID: 84887401911     PISSN: 09098836     EISSN: 16000722     Source Type: Journal    
DOI: 10.1111/eos.12086     Document Type: Article

References (27)

1. Nakashima M. Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J Dent Res 1994; 73: 1515-1522.
2. Sloan AJ, Rutherford RB, Smith AJ. Stimulation of the rat dentine-pulp complex by bone morphogenetic protein-7 in vitro. Arch Oral Biol 2000; 45: 173-177.
3. Li Y, Lü X, Sun X, Bai S, Li S, Shi J. Odontoblast-like cell differentiation and dentin formation induced with TGF-β1. Arch Oral Biol 2011; 56: 1221-1229.
4. Prouillet C, Mazière J-C, Mazière C, Wattel A, Brazier M, Kamel S. Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol 2004; 67: 1307-1313.
5. Yang L, Takai H, Utsunomiya T, Li X, Li Z, Wang Z, Wang S, Sasaki Y, Yamamoto H, Ogata Y. Kaempferol stimulates bone sialoprotein gene transcription and new bone formation. J Cell Biochem 2010; 110: 1342-1355.
6. Heim M, Frank O, Kampmann G, Sochocky N, Pennimpede T, Fuchs P, Hunziker W, Weber P, Martin I, Bendik I. The Phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells. Endocrinology 2004; 145: 848-859.
7. Guo AJ, Choi RC, Cheung AW, Chen VP, Xu SL, Dong TT, Chen JJ, Tsim KW. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/β-catenin signaling pathway. J Biol Chem 2012; 287: 6958.
8. Kim JM, Lee S-U, Kim YS, Min YK, Kim SH. Baicalein stimulates osteoblast differentiation via coordinating activation of MAP kinases and transcription factors. J Cell Biochem 2008; 104: 1906-1917.
9. Nakayama Y, Takahashi K, Noji S, Muto K, Nishijima K, Taniguchi S. Functional modes of retinoic acid in mouse osteoblastic clone MC3T3-E1, proved as a target cell for retinoic acid. FEBS Lett 1990; 261: 93-96.
10. Park KW, Waki H, Kim W-K, Davies BSJ, Young SG, Parhami F, Tontonoz P. The small molecule phenamil induces osteoblast differentiation and mineralization. Mol Cell Biol 2009; 29: 3905-3914.
11. Lo KW, Ulery BD, Kan HM, Laurencin CT. Evaluating the feasibility of utilizaing the small molecule phenamil as a novel biofactor for bone regenerative engineering. J Tissue Eng Regen Med. doi: 10.1002/term.1573. [Epub ahead of print].
12. Ohishi M, Horibe M, Ikedo D, Miyazaki M, Ohishi K, Kataoka M, Kido J, Nagata T. Effect of retinoic acid on osteopontin expression in rat clonal dental pulp cells. J Endod 1999; 25: 683-685.
13. Huang XF, Yuan SJ, Yang C. Effects of total flavonoids from Drynaria fortunei on the proliferation and osteogenic differentiation of rat dental pulp stem cells. Mol Med Rep 2012; 6: 547-552.
14. Kim NR, Lim B-S, Park HC, Son KM, Yang H-C. Effects of N-acetylcysteine on TEGDMA- and HEMA-induced suppression of osteogenic differentiation of human osteosarcoma MG63 cells. J Biomed Mater Res B Appl Biomater 2011; 98B: 300-307.
15. Kim NR, Park HC, Kim I, Lim B-S, Yang H-C. In vitro cytocompatibility of N-acetylcysteine-supplemented dentin bonding agents. J Endod 2010; 36: 1844-1850.
16. 2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines. Cell Biol Toxicol 2006; 22: 39-46.
17. Qu Q, Perälä-Heape M, Kapanen A, Dahllund J, Salo J, Väänänen HK, Härkönen PL. Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture. Bone 1998; 22: 201-209.
18. Qu Q, Härkönen PL, Väänänen HK. Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture. J Cell Biochem 1999; 73: 500-507.
19. Kousteni S, Han L, Chen J-R, Almeida M, Plotkin LI, Bellido T, Manolagas SC. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest 2003; 111: 1651-1664.
20. ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO J 1998; 17: 2008-2018.
21. Lai C-F, Chaudhary L, Fausto A, Halstead LR, Ory DS, Avioli LV, Cheng SL. Erk is essential for growth, differentiation, integrin expression and cell function in human osteoblastic cells. J Biol Chem 2001; 276: 14443-14450.
22. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, Franceschi RT. Bone morphogenic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 2002; 17: 101-110.
23. S-Y Lee, S-Y Kim, S-H Park, J-J Kim, J-H Jang, E-C Kim Effects of recombinant dentin sialoprotein in dental pulp cells. J Dent Res 2012; 91: 407-412.
24. Karanxba L, Park S-J, Son W-J, Nör JE, Min K-S. Combined effects of simvastatin and enamel matrix derivative on odontoblastic differentiation of human dental pulp cells. J Endod 2013; 39: 76-82.
25. Jukić S, Prpić-Mehičić G, Talan-Hranilovć J, Miletić I, Šegović S, Anić I. Estrogen receptors in human pulp tissue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95: 340-344.
26. Qin W, Yang F, Deng R, Li D, Song Z, Tian Y, Wang R, Jing J, Lin Z. Smad 1/5 is involved in bone morphorgenic protein-2-induced odontoblastic differentiation in human dental pulp cells. J Endod 2012; 38: 66-71.
27. Washio A, Kitamura C, Morotomi T, Terashita M, Nishihara T. Possible involvement of smad signaling pathways in induction of odontoblastic properties in KN-3 cells by bone morphogenic proteins-2: A growth factor to induce dentin regeneration. Int J Dent 2012; 2012: 258469.