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Volumn 274, Issue 6, 2013, Pages 547-560

Electronic health records: New opportunities for clinical research

Author keywords

Clinical research; Electronic health records; Research ethics; Research techniques

Indexed keywords

CLINICAL RESEARCH; COMPARATIVE EFFECTIVENESS; DATA BASE; DRUG INDUSTRY; ELECTRONIC MEDICAL RECORD; GENOME; HUMAN; MANAGEMENT; MEDICAL RESEARCH; METHODOLOGY; PATIENT CARE; PRIORITY JOURNAL; RESEARCH ETHICS; REVIEW; STUDY DESIGN; WORKFLOW;

EID: 84887401594     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/joim.12119     Document Type: Review
Times cited : (248)

References (99)
  • 1
    • 84887408000 scopus 로고    scopus 로고
    • Towards 2020 Science' report. Available from:
    • 'Towards 2020 Science' report. Available from: http://research.microsoft.com/towards2020science. 2006.
    • (2006)
  • 2
    • 84864340298 scopus 로고    scopus 로고
    • Knowledge engineering for health: a new discipline required to bridge the "ICT gap" between research and healthcare
    • Beck T, Gollapudi S, Brunak S et al. Knowledge engineering for health: a new discipline required to bridge the "ICT gap" between research and healthcare. Hum Mutat 2012; 33: 797-802.
    • (2012) Hum Mutat , vol.33 , pp. 797-802
    • Beck, T.1    Gollapudi, S.2    Brunak, S.3
  • 3
    • 84887406281 scopus 로고    scopus 로고
    • Kairos Future. The Data Explosion and the Future of Health: What every decision-maker in the health and healthcare industries need to know about the coming revolution. Global Strategic Analysis Report.
    • Kairos Future. The Data Explosion and the Future of Health: What every decision-maker in the health and healthcare industries need to know about the coming revolution. Global Strategic Analysis Report. 2011.
    • (2011)
  • 4
    • 84870479826 scopus 로고    scopus 로고
    • Trustworthy reuse of health data: a transnational perspective
    • Geissbuhler A, Safran C, Buchan I et al. Trustworthy reuse of health data: a transnational perspective. Int J Med Informatics 2013; 82: 1-9.
    • (2013) Int J Med Informatics , vol.82 , pp. 1-9
    • Geissbuhler, A.1    Safran, C.2    Buchan, I.3
  • 5
    • 84861235431 scopus 로고    scopus 로고
    • Mining electronic health records: towards better research applications and clinical care
    • Jensen PB, Jensen LJ, Brunak S. Mining electronic health records: towards better research applications and clinical care. Nat Rev Genet 2012; 13: 395-405.
    • (2012) Nat Rev Genet , vol.13 , pp. 395-405
    • Jensen, P.B.1    Jensen, L.J.2    Brunak, S.3
  • 6
    • 84887402994 scopus 로고    scopus 로고
    • Electronic Health Record Systems for Clinical Research (EHR4CR). Available from:
    • Electronic Health Record Systems for Clinical Research (EHR4CR). Available from: http://www.ehr4cr.eu.
  • 7
    • 84878677956 scopus 로고    scopus 로고
    • Meeting meaningful use criteria and managing patient populations: a national survey of practicing physicians
    • Desroches CM, Audet AM, Painter M, Donelan K. Meeting meaningful use criteria and managing patient populations: a national survey of practicing physicians. Ann Intern Med 2013; 158: 791-9.
    • (2013) Ann Intern Med , vol.158 , pp. 791-799
    • Desroches, C.M.1    Audet, A.M.2    Painter, M.3    Donelan, K.4
  • 8
    • 41149088350 scopus 로고    scopus 로고
    • Definition, structure, content, use and impacts of electronic health records: a review of the research literature
    • Hayrinen K, Saranto K, Nykanen P. Definition, structure, content, use and impacts of electronic health records: a review of the research literature. Int J Med Informatics 2008; 77: 291-304.
    • (2008) Int J Med Informatics , vol.77 , pp. 291-304
    • Hayrinen, K.1    Saranto, K.2    Nykanen, P.3
  • 9
    • 84871882786 scopus 로고    scopus 로고
    • Methods and dimensions of electronic health record data quality assessment: enabling reuse for clinical research
    • Weiskopf NG, Weng C. Methods and dimensions of electronic health record data quality assessment: enabling reuse for clinical research. JAMIA 2013; 20: 144-51.
    • (2013) JAMIA , vol.20 , pp. 144-151
    • Weiskopf, N.G.1    Weng, C.2
  • 10
    • 83055163886 scopus 로고    scopus 로고
    • Policy brief on the current status of certification of electronic Health Records in the US and Europe
    • De Moor G, O'Brien J, Fridsma D et al. Policy brief on the current status of certification of electronic Health Records in the US and Europe. Stud Health Technol Inform 2011; 170: 83-106.
    • (2011) Stud Health Technol Inform , vol.170 , pp. 83-106
    • De Moor, G.1    O'Brien, J.2    Fridsma, D.3
  • 11
    • 77955532493 scopus 로고    scopus 로고
    • Electronic health records. A systematic review on quality requirements
    • Hoerbst A, Ammenwerth E. Electronic health records. A systematic review on quality requirements. Methods Inf Med 2010; 49: 320-36.
    • (2010) Methods Inf Med , vol.49 , pp. 320-336
    • Hoerbst, A.1    Ammenwerth, E.2
  • 12
    • 79952555358 scopus 로고    scopus 로고
    • Quality and Certification of Electronic Health Records: an overview of current approaches from the US and Europe
    • Hoerbst A, Ammenwerth E. Quality and Certification of Electronic Health Records: an overview of current approaches from the US and Europe. Appl Clin Inform 2010; 1: 149-64.
    • (2010) Appl Clin Inform , vol.1 , pp. 149-164
    • Hoerbst, A.1    Ammenwerth, E.2
  • 13
    • 84887405567 scopus 로고    scopus 로고
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline for Good Clinical Practice (GCP)
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline for Good Clinical Practice (GCP), 2002.
    • (2002)
  • 14
    • 84880773391 scopus 로고    scopus 로고
    • Clinician perspectives on the quality of patient data used for clinical decision support: a qualitative study
    • McCormack JL, Ash JS. Clinician perspectives on the quality of patient data used for clinical decision support: a qualitative study. AMIA Annu Symp Proc 2012; 2012: 1302-9.
    • (2012) AMIA Annu Symp Proc , vol.2012 , pp. 1302-1309
    • McCormack, J.L.1    Ash, J.S.2
  • 15
    • 0033258236 scopus 로고    scopus 로고
    • Data quality and the electronic medical record: a role for direct parental data entry
    • Porter SC, Mandl KD. Data quality and the electronic medical record: a role for direct parental data entry. Proc AMIA Symp 1999: 354-8.
    • Proc AMIA Symp , vol.1999 , pp. 354-358
    • Porter, S.C.1    Mandl, K.D.2
  • 16
    • 84859155091 scopus 로고    scopus 로고
    • Qualitative and quantitative evaluation of EHR-integrated mobile patient questionnaires regarding usability and cost-efficiency
    • Fritz F, Balhorn S, Riek M, Breil B, Dugas M. Qualitative and quantitative evaluation of EHR-integrated mobile patient questionnaires regarding usability and cost-efficiency. Int J Med Informatics 2012; 81: 303-13.
    • (2012) Int J Med Informatics , vol.81 , pp. 303-313
    • Fritz, F.1    Balhorn, S.2    Riek, M.3    Breil, B.4    Dugas, M.5
  • 17
    • 79951644557 scopus 로고    scopus 로고
    • The impact of eHealth on the quality and safety of health care: a systematic overview
    • Black AD, Car J, Pagliari C et al. The impact of eHealth on the quality and safety of health care: a systematic overview. PLoS Med 2011; 8: e1000387.
    • (2011) PLoS Med , vol.8
    • Black, A.D.1    Car, J.2    Pagliari, C.3
  • 18
    • 84872248482 scopus 로고    scopus 로고
    • Using EHRs to integrate research with patient care: promises and challenges
    • Weng C, Appelbaum P, Hripcsak G et al. Using EHRs to integrate research with patient care: promises and challenges. JAMIA 2012; 19: 684-7.
    • (2012) JAMIA , vol.19 , pp. 684-687
    • Weng, C.1    Appelbaum, P.2    Hripcsak, G.3
  • 19
    • 80052312723 scopus 로고    scopus 로고
    • Secondary use of EHR: data quality issues and informatics opportunities
    • Botsis T, Hartvigsen G, Chen F, Weng C. Secondary use of EHR: data quality issues and informatics opportunities. AMIA Summits Transl Sci Proc 2010; 2010: 1-5.
    • (2010) AMIA Summits Transl Sci Proc , vol.2010 , pp. 1-5
    • Botsis, T.1    Hartvigsen, G.2    Chen, F.3    Weng, C.4
  • 20
    • 84875125416 scopus 로고    scopus 로고
    • Evaluation of data completeness in the electronic health record for the purpose of patient recruitment into clinical trials: a retrospective analysis of element presence
    • Kopcke F, Trinczek B, Majeed RW et al. Evaluation of data completeness in the electronic health record for the purpose of patient recruitment into clinical trials: a retrospective analysis of element presence. BMC Med Inform Decis Mak 2013; 13: 37.
    • (2013) BMC Med Inform Decis Mak , vol.13 , pp. 37
    • Kopcke, F.1    Trinczek, B.2    Majeed, R.W.3
  • 21
    • 84862283766 scopus 로고    scopus 로고
    • A pragmatic framework for single-site and multisite data quality assessment in electronic health record-based clinical research
    • Kahn MG, Raebel MA, Glanz JM, Riedlinger K, Steiner JF. A pragmatic framework for single-site and multisite data quality assessment in electronic health record-based clinical research. Med Care 2012; 50(Suppl): S21-9.
    • (2012) Med Care , vol.50 , Issue.SUPPL
    • Kahn, M.G.1    Raebel, M.A.2    Glanz, J.M.3    Riedlinger, K.4    Steiner, J.F.5
  • 22
    • 84875774711 scopus 로고    scopus 로고
    • Continuous innovation: developing and using a clinical database with new technology for patient-centred care-the case of the Swedish quality register for arthritis
    • Ovretveit J, Keller C, Hvitfeldt Forsberg H, Essen A, Lindblad S, Brommels M. Continuous innovation: developing and using a clinical database with new technology for patient-centred care-the case of the Swedish quality register for arthritis. Int J Qual Health Care 2013; 25: 118-24.
    • (2013) Int J Qual Health Care , vol.25 , pp. 118-124
    • Ovretveit, J.1    Keller, C.2    Hvitfeldt, F.H.3    Essen, A.4    Lindblad, S.5    Brommels, M.6
  • 24
    • 84887408577 scopus 로고    scopus 로고
    • EN ISO 13606-1:2012, Health informatics - Electronic health record communication - Part 1 - Reference model, International Organization for Standardization, Geneva 2008 and CEN - The European Committee for Standardization, Brussels
    • EN ISO 13606-1:2012, Health informatics - Electronic health record communication - Part 1 - Reference model, International Organization for Standardization, Geneva 2008 and CEN - The European Committee for Standardization, Brussels, 2012.
    • (2012)
  • 26
    • 29244445108 scopus 로고    scopus 로고
    • HL7 clinical document architecture, release 2
    • Dolin RH, Alschuler L, Boyer S et al. HL7 clinical document architecture, release 2. JAMIA 2006; 13: 30-9.
    • (2006) JAMIA , vol.13 , pp. 30-39
    • Dolin, R.H.1    Alschuler, L.2    Boyer, S.3
  • 27
    • 72249103918 scopus 로고    scopus 로고
    • HL7 template model and EN/ISO 13606 archetype object model - a comparison
    • Bointner K, Duftschmid G. HL7 template model and EN/ISO 13606 archetype object model - a comparison. Stud Health Technol Inform 2009; 150: 249.
    • (2009) Stud Health Technol Inform , vol.150 , pp. 249
    • Bointner, K.1    Duftschmid, G.2
  • 29
    • 83055179482 scopus 로고    scopus 로고
    • Representing knowledge, data and concepts for EHRS using DCM
    • Goossen W. Representing knowledge, data and concepts for EHRS using DCM. Stud Health Technol Inform 2011; 169: 774-8.
    • (2011) Stud Health Technol Inform , vol.169 , pp. 774-778
    • Goossen, W.1
  • 30
    • 84887401232 scopus 로고    scopus 로고
    • Clinical Data Interchange Standards Consortium (CDISC) Study Design Model in XML (SDM-XML). Available from:
    • Clinical Data Interchange Standards Consortium (CDISC) Study Design Model in XML (SDM-XML). Available from: http://www.cdisc.org/stuff/contentmgr/files/0/8c85b168e80d6834ded59339b55fdbc7/misc/cdisc_sdm_xml_1.0.pdf.
  • 31
    • 84887405272 scopus 로고    scopus 로고
    • Clinical Data Interchange Standards Consortium (CDISC) Protocol Representation Model (PRM). Available from:
    • Clinical Data Interchange Standards Consortium (CDISC) Protocol Representation Model (PRM). Available from: http://www.cdisc.org/protocol.
  • 32
    • 84887411020 scopus 로고    scopus 로고
    • Clinical Data Interchange Standards Consortium (CDISC) Operational Data Model (ODM). Available from:
    • Clinical Data Interchange Standards Consortium (CDISC) Operational Data Model (ODM). Available from: http://www.cdisc.org/odm.
  • 33
    • 84887408129 scopus 로고    scopus 로고
    • Clinical Data Interchange Standards Consortium (CDISC) Clinical Data Acquisition Standards Harmonization (CDASH). Available from:
    • Clinical Data Interchange Standards Consortium (CDISC) Clinical Data Acquisition Standards Harmonization (CDASH). Available from: http://www.cdisc.org/CDASH.
  • 35
    • 68349123424 scopus 로고    scopus 로고
    • Healthcare standards development. The value of nurturing collaboration
    • quiz 1-2.
    • Hammond WE, Jaffe C, Kush RD. Healthcare standards development. The value of nurturing collaboration. J AHIMA 2009; 80: 44-50; quiz 1-2.
    • (2009) J AHIMA , vol.80 , pp. 44-50
    • Hammond, W.E.1    Jaffe, C.2    Kush, R.D.3
  • 36
    • 33644856806 scopus 로고    scopus 로고
    • Data interchange standards in healthcare IT-computable semantic interoperability: now possible but still difficult, do we really need a better mousetrap?
    • Mead CN. Data interchange standards in healthcare IT-computable semantic interoperability: now possible but still difficult, do we really need a better mousetrap? J Healthc Inf Manag 2006; 20: 71-8.
    • (2006) J Healthc Inf Manag , vol.20 , pp. 71-78
    • Mead, C.N.1
  • 37
    • 84887410663 scopus 로고    scopus 로고
    • Semantic Interoperability for Better Health and Safer Healthcare. Deployment and Research Roadmap for Europe.
    • Semantic Interoperability for Better Health and Safer Healthcare. Deployment and Research Roadmap for Europe. 2009.
    • (2009)
  • 38
    • 84887403913 scopus 로고    scopus 로고
    • Integrating the Healthcare Enterprise (IHE). Available from:
    • Integrating the Healthcare Enterprise (IHE). Available from: http://www.ihe.net.
  • 39
    • 84887408936 scopus 로고    scopus 로고
    • IHE Quality, Research and Public Health (QRPH) domain. Available from:
    • IHE Quality, Research and Public Health (QRPH) domain. Available from: http://www.ihe.net/Quality_Research_and_Public_Health.
  • 40
    • 37849007693 scopus 로고    scopus 로고
    • caCORE version 3: implementation of a model driven, service-oriented architecture for semantic interoperability
    • Komatsoulis GA, Warzel DB, Hartel FW et al. caCORE version 3: implementation of a model driven, service-oriented architecture for semantic interoperability. J Biomed Inform 2008; 41: 106-23.
    • (2008) J Biomed Inform , vol.41 , pp. 106-123
    • Komatsoulis, G.A.1    Warzel, D.B.2    Hartel, F.W.3
  • 42
    • 84859889070 scopus 로고    scopus 로고
    • A collaborative framework for representation and harmonization of clinical study data elements using semantic MediaWiki
    • Jiang G, Solbrig HR, Iberson-Hurst D, Kush RD, Chute CG. A collaborative framework for representation and harmonization of clinical study data elements using semantic MediaWiki. AMIA Summits Transl Sci Proc 2010; 2010: 11-5.
    • (2010) AMIA Summits Transl Sci Proc , vol.2010 , pp. 11-15
    • Jiang, G.1    Solbrig, H.R.2    Iberson-Hurst, D.3    Kush, R.D.4    Chute, C.G.5
  • 43
    • 84875615265 scopus 로고    scopus 로고
    • The ISO/IEC 11179 norm for metadata registries: does it cover healthcare standards in empirical research?
    • Ngouongo SM, Lobe M, Stausberg J. The ISO/IEC 11179 norm for metadata registries: does it cover healthcare standards in empirical research? J Biomed Inform 2013; 46: 318-27.
    • (2013) J Biomed Inform , vol.46 , pp. 318-327
    • Ngouongo, S.M.1    Lobe, M.2    Stausberg, J.3
  • 44
    • 84887409183 scopus 로고    scopus 로고
    • Scalable, Standard based Interoperability Framework for Sustainable Proactive Post Market Safety Studies (SALUS). Available from:
    • Scalable, Standard based Interoperability Framework for Sustainable Proactive Post Market Safety Studies (SALUS). Available from: http://www.salusproject.eu.
  • 45
    • 84883797927 scopus 로고    scopus 로고
    • Providing semantic interoperability between clinical care and clinical research domains
    • doi: 10.1109/TITB.2012.2219552
    • Laleci G, Yuksel M, Dogac A. Providing semantic interoperability between clinical care and clinical research domains. IEEE J Biomed Health Inform 2012; doi: 10.1109/TITB.2012.2219552
    • (2012) IEEE J Biomed Health Inform
    • Laleci, G.1    Yuksel, M.2    Dogac, A.3
  • 46
    • 84870514214 scopus 로고    scopus 로고
    • The Electronic Healthcare Record for Clinical Research (EHR4CR) information model and terminology
    • Ouagne D, Hussain S, Sadou E, Jaulent MC, Daniel C. The Electronic Healthcare Record for Clinical Research (EHR4CR) information model and terminology. Stud Health Technol Inform 2012; 180: 534-8.
    • (2012) Stud Health Technol Inform , vol.180 , pp. 534-538
    • Ouagne, D.1    Hussain, S.2    Sadou, E.3    Jaulent, M.C.4    Daniel, C.5
  • 48
    • 84887408340 scopus 로고    scopus 로고
    • Opinion 03/2013 of Article 29 data protection working party on "purpose limitation" adopted on 2 April 2013.
    • Opinion 03/2013 of Article 29 data protection working party on "purpose limitation" adopted on 2 April 2013.
  • 50
    • 84882449721 scopus 로고    scopus 로고
    • Broad consent versus dynamic consent in biobank research: is passive participation an ethical problem?
    • Steinsbekk KS, Myskja BK, Solberg B. Broad consent versus dynamic consent in biobank research: is passive participation an ethical problem? Eur J Hum Genet 2013; 21: 897-902.
    • (2013) Eur J Hum Genet , vol.21 , pp. 897-902
    • Steinsbekk, K.S.1    Myskja, B.K.2    Solberg, B.3
  • 51
    • 84887406909 scopus 로고    scopus 로고
    • Directive 95/46/EC of the European Parliament and of the Council of 24 October 1995 on the protection of individuals with regard to the processing of personal data and on the free movement of such data. Article 13 para 2; article 32 para 3. Available from:
    • Directive 95/46/EC of the European Parliament and of the Council of 24 October 1995 on the protection of individuals with regard to the processing of personal data and on the free movement of such data. Article 13 para 2; article 32 para 3. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31995L0046:en:HTML.
  • 52
    • 84887408890 scopus 로고    scopus 로고
    • Directive 95/46/EC of the European Parliament and of the Council of 24 October 1995 on the protection of individuals with regard to the processing of personal data and on the free movement of such data. Recitals 28 & 29; Article 6 para 1(b).Available from:
    • Directive 95/46/EC of the European Parliament and of the Council of 24 October 1995 on the protection of individuals with regard to the processing of personal data and on the free movement of such data. Recitals 28 & 29; Article 6 para 1(b).Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31995L0046:en:HTML.
  • 53
    • 77957594024 scopus 로고    scopus 로고
    • Broken premises of privacy: responding to the surprising failure of anonymization
    • Ohm P. Broken premises of privacy: responding to the surprising failure of anonymization. UCLA Law Rev 2010; 57: 1701.
    • (2010) UCLA Law Rev , vol.57 , pp. 1701
    • Ohm, P.1
  • 54
    • 84887402527 scopus 로고    scopus 로고
    • Communication from the European Commission on the precautionary principle, COM (2000) 1. Available from:
    • Communication from the European Commission on the precautionary principle, COM (2000) 1. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:52000DC0001:EN:NOT
  • 55
    • 84887406686 scopus 로고    scopus 로고
    • Eurobarometer. Data Protection in the European Union. Data controllers' perceptions. Analytical Report.
    • Eurobarometer. Data Protection in the European Union. Data controllers' perceptions. Analytical Report. 2008.
    • (2008)
  • 59
    • 84887401440 scopus 로고    scopus 로고
    • ARGUS. EESnet-project. Statistics Netherlands
    • μ-ARGUS. EESnet-project. Statistics Netherlands, 2008.
    • (2008)
  • 60
    • 84887406212 scopus 로고    scopus 로고
    • Implementing the Post Randomisation method to the Individual Sample of Anonymised Records (SAR) from the 2001 Census. Statistical Disclosure Control Centre Methodology Group, Office for National Statistics
    • Gross B, Guiblin P, Merrett K. Implementing the Post Randomisation method to the Individual Sample of Anonymised Records (SAR) from the 2001 Census. Statistical Disclosure Control Centre Methodology Group, Office for National Statistics, 2004.
    • (2004)
    • Gross, B.1    Guiblin, P.2    Merrett, K.3
  • 61
    • 0041848377 scopus 로고    scopus 로고
    • A polynomial algorithm for optimal univariate microaggregation
    • Hansen SL, Mukherjee S. A polynomial algorithm for optimal univariate microaggregation. Knowl Data Eng 2003; 15: 1043-4.
    • (2003) Knowl Data Eng , vol.15 , pp. 1043-1044
    • Hansen, S.L.1    Mukherjee, S.2
  • 62
    • 84887411800 scopus 로고    scopus 로고
    • t-closeness: Privacy Preserving Data Mining.
    • Arnab Bhattacharya RG. t-closeness: Privacy Preserving Data Mining. 2009.
    • (2009)
    • Arnab Bhattacharya, R.G.1
  • 63
    • 84863050103 scopus 로고    scopus 로고
    • Slicing: a new approach for privacy preserving data publishing
    • Li TC, Li NH, Zhang J, Molloy I. Slicing: a new approach for privacy preserving data publishing. Knowl Data Eng 2012; 24: 561-74.
    • (2012) Knowl Data Eng , vol.24 , pp. 561-574
    • Li, T.C.1    Li, N.H.2    Zhang, J.3    Molloy, I.4
  • 65
    • 69549114557 scopus 로고    scopus 로고
    • A globally optimal k-anonymity method for the de-identification of health data
    • El Emam K, Dankar FK, Issa R et al. A globally optimal k-anonymity method for the de-identification of health data. JAMIA 2009; 16: 670-82.
    • (2009) JAMIA , vol.16 , pp. 670-682
    • El Emam, K.1    Dankar, F.K.2    Issa, R.3
  • 66
    • 54249150466 scopus 로고    scopus 로고
    • An Anonymity Model Achievable Via Microaggregation
    • In: Jonker W, Petkovic M, eds. Heidelberg, Berlin: Springer-Verlag
    • Domingo-Ferrer J, Sebe F, Solanas A. An Anonymity Model Achievable Via Microaggregation. In: Jonker W, Petkovic M, eds. Secure Data Management. Heidelberg, Berlin: Springer-Verlag, 2008; 5159: 209-18.
    • (2008) Secure Data Management , vol.5159 , pp. 209-218
    • Domingo-Ferrer, J.1    Sebe, F.2    Solanas, A.3
  • 68
    • 4344559647 scopus 로고    scopus 로고
    • Protecting privacy when disclosing information: k-anonymity and its enforcement through generalization and suppression.
    • Samarati P, Sweeney L. Protecting privacy when disclosing information: k-anonymity and its enforcement through generalization and suppression. Proceedings of the IEEE Symposium on Research in Security and Privacy 1998: 384-93.
    • (1998) Proceedings of the IEEE Symposium on Research in Security and Privacy , pp. 384-393
    • Samarati, P.1    Sweeney, L.2
  • 69
    • 38049087648 scopus 로고    scopus 로고
    • Generating microdata with p-sensitive k-anonymity property
    • Truta TM, Campan A, Meyer P. Generating microdata with p-sensitive k-anonymity property. Sec Data Manag Proc 2007; 4721: 124-41.
    • (2007) Sec Data Manag Proc , vol.4721 , pp. 124-141
    • Truta, T.M.1    Campan, A.2    Meyer, P.3
  • 71
    • 84887408039 scopus 로고    scopus 로고
    • Center for Data Protection (CDP). Available from:
    • Center for Data Protection (CDP). Available from: http://www.privacypeople.org.
  • 72
    • 84887409330 scopus 로고    scopus 로고
    • Privacy-Preserving Data Mining.
    • Aggarwal C, Philips Y. Privacy-Preserving Data Mining. 2008.
    • (2008)
    • Aggarwal, C.1    Philips, Y.2
  • 73
    • 84887407546 scopus 로고    scopus 로고
    • Enforcing "Sticky" Security Policies throughout a Distributed Application.
    • Chadwick D, Lievens S. Enforcing "Sticky" Security Policies throughout a Distributed Application.
    • Chadwick, D.1    Lievens, S.2
  • 74
    • 84887403594 scopus 로고    scopus 로고
    • Consent in a Trial and Care Environment (CONTRACT). Available from:
    • Consent in a Trial and Care Environment (CONTRACT). Available from: http://www.contract-fp7.eu.
  • 75
    • 84887406881 scopus 로고    scopus 로고
    • Enabling information re-use by linking clinical research and care (EURECA). Available from:
    • Enabling information re-use by linking clinical research and care (EURECA). Available from: http://eurecaproject.eu
  • 76
    • 84861961454 scopus 로고    scopus 로고
    • BRIDGING THE GAP BETWEEN CLINICAL RESEARCH AND CARE - Approaches to Semantic Interoperability, Security & Privacy. Proceedings of the International Conference on Health Informatics: -
    • Vdovjak R, Claerhout B, Bucur A. BRIDGING THE GAP BETWEEN CLINICAL RESEARCH AND CARE - Approaches to Semantic Interoperability, Security & Privacy. Proceedings of the International Conference on Health Informatics 2012: 281-6
    • (2012) , pp. 281-286
    • Vdovjak, R.1    Claerhout, B.2    Bucur, A.3
  • 77
    • 84879388805 scopus 로고    scopus 로고
    • Integrating scientific and real-world evidence within and beyond the drug development process
    • Epstein RS, Sidorov J, Lehner JP, Salimi T. Integrating scientific and real-world evidence within and beyond the drug development process. J Comp Eff Res 2012; 1(Suppl. 1): 9-13.
    • (2012) J Comp Eff Res , vol.1 , Issue.SUPPL. 1 , pp. 9-13
    • Epstein, R.S.1    Sidorov, J.2    Lehner, J.P.3    Salimi, T.4
  • 78
    • 38949160468 scopus 로고    scopus 로고
    • Weighing the outcomes: the emergent healthcare value era, its consequences, and what drug firms need to do about it
    • Russo MJ, Balekdjian D. Weighing the outcomes: the emergent healthcare value era, its consequences, and what drug firms need to do about it. Nat Biotechnol 2008; 26: 173-82.
    • (2008) Nat Biotechnol , vol.26 , pp. 173-182
    • Russo, M.J.1    Balekdjian, D.2
  • 79
    • 84886944480 scopus 로고    scopus 로고
    • A framework for pharmaceutical value-based innovations
    • Salimi T, Lehner JP, Epstein RS, Tunis SR. A framework for pharmaceutical value-based innovations. J Comp Eff Res 2012; 1(Suppl. 1): 3-7.
    • (2012) J Comp Eff Res , vol.1 , Issue.SUPPL. 1 , pp. 3-7
    • Salimi, T.1    Lehner, J.P.2    Epstein, R.S.3    Tunis, S.R.4
  • 80
    • 84887410760 scopus 로고    scopus 로고
    • EFPIA. The Pharmaceutical Industry in Figures. Key Data 2009. Update.
    • EFPIA. The Pharmaceutical Industry in Figures. Key Data 2009. Update. 2009; 1-27.
    • (2009) , pp. 1-27
  • 81
    • 84886909337 scopus 로고    scopus 로고
    • Case report from the EHR4CR Project - A European survey on electronic health record systems for clinical research
    • Kalra D, Schmidt A, Potts HWW, Dupont D, Sundgren M, De Moor G. Case report from the EHR4CR Project - A European survey on electronic health record systems for clinical research. Health Conn 2011; 1: 108-13.
    • (2011) Health Conn , vol.1 , pp. 108-113
    • Kalra, D.1    Schmidt, A.2    Potts, H.W.W.3    Dupont, D.4    Sundgren, M.5    De Moor, G.6
  • 82
    • 84886945185 scopus 로고    scopus 로고
    • Integrating new approaches for clinical development: translational research and relative effectiveness
    • Lehner JP, Epstein RS, Salimi T. Integrating new approaches for clinical development: translational research and relative effectiveness. J Comp Eff Res 2012; 1(Suppl. 1): 15-21.
    • (2012) J Comp Eff Res , vol.1 , Issue.SUPPL. 1 , pp. 15-21
    • Lehner, J.P.1    Epstein, R.S.2    Salimi, T.3
  • 83
    • 84879365103 scopus 로고    scopus 로고
    • R&D transformation and value-based innovation
    • Epstein RS. R&D transformation and value-based innovation. J Comp Eff Res 2012; 1(Suppl. 1): 1-2.
    • (2012) J Comp Eff Res , vol.1 , Issue.SUPPL. 1 , pp. 1-2
    • Epstein, R.S.1
  • 84
    • 27644565865 scopus 로고    scopus 로고
    • Can electronic medical record systems transform health care? Potential health benefits, savings, and costs
    • Hillestad R, Bigelow J, Bower A et al. Can electronic medical record systems transform health care? Potential health benefits, savings, and costs. Health Aff 2005; 24: 1103-17.
    • (2005) Health Aff , vol.24 , pp. 1103-1117
    • Hillestad, R.1    Bigelow, J.2    Bower, A.3
  • 86
    • 84887410266 scopus 로고    scopus 로고
    • i2b2 initiative. Available from:
    • i2b2 initiative. Available from: https://www.i2b2.org/
  • 87
    • 84887409758 scopus 로고    scopus 로고
    • eMERGE network. Available from:
    • eMERGE network. Available from: https://emerge.mc.vanderbilt.edu.
  • 88
    • 84887411964 scopus 로고    scopus 로고
    • Kaiser RPGEH Program. Available from:
    • Kaiser RPGEH Program. Available from: http://www.dor.kaiser.org/external/dorexternal/rpgeh.
  • 89
    • 84887404348 scopus 로고    scopus 로고
    • Million Veteran Program. Available from:
    • Million Veteran Program. Available from: http://www.research.va.gov/mvp/default.cfm.
  • 90
    • 84887402244 scopus 로고    scopus 로고
    • The Stanford Translational Research Integrated Database Environment (STRIDE). Available from:
    • The Stanford Translational Research Integrated Database Environment (STRIDE). Available from: https://clinicalinformatics.stanford.edu/research/stride.html.
  • 91
    • 84887403511 scopus 로고    scopus 로고
    • i4health network. Available from:
    • i4health network. Available from: http://www.i4health.eu.
  • 92
    • 84887403307 scopus 로고    scopus 로고
    • European Medical Information Framework (EMIF). Available from:
    • European Medical Information Framework (EMIF). Available from: http://www.imi.europa.eu/content/emif.
  • 93
    • 84887403684 scopus 로고    scopus 로고
    • European Translational Information and Knowledge Management Services (eTRIKS). Available from:
    • European Translational Information and Knowledge Management Services (eTRIKS). Available from: http://www.etriks.org.
  • 94
    • 84887407209 scopus 로고    scopus 로고
    • Integrative Cancer Research Through Innovative Biomedical Infrastructures (INTEGRATE). Available from:
    • Integrative Cancer Research Through Innovative Biomedical Infrastructures (INTEGRATE). Available from: http://www.fp7-integrate.eu.
  • 95
    • 84887403945 scopus 로고    scopus 로고
    • A Next-Generation, Secure Linked Data Medical Information Space For Semantically-Interconnecting Electronic Health Records and Clinical Trials Systems Advancing Patients Safety In Clinical Research (Linked2Safety). Available from:
    • A Next-Generation, Secure Linked Data Medical Information Space For Semantically-Interconnecting Electronic Health Records and Clinical Trials Systems Advancing Patients Safety In Clinical Research (Linked2Safety). Available from: http://www.linked2safety-project.eu.
  • 96
    • 84887411181 scopus 로고    scopus 로고
    • Translational Research and Patient Safety in Europe (TRANSFoRm). Available from:
    • Translational Research and Patient Safety in Europe (TRANSFoRm). Available from: http://www.transformproject.eu.
  • 97
    • 70450142818 scopus 로고    scopus 로고
    • Amsterdam,The Netherlands, Self Published, ISBN 978-2-8399-0580-0, 2009.
    • Osterwalder A, Pigneur Y. Business Model Generation. Amsterdam, The Netherlands, Self Published, 2009. ISBN 978-2-8399-0580-0, 2009.
    • (2009) Business Model Generation
    • Osterwalder, A.1    Pigneur, Y.2
  • 98
    • 84887404941 scopus 로고    scopus 로고
    • The Business Model: Theoretical Roots, Recent Developments and Future Research. Working Paper WP-862, IESE Business School, University of Navarra:
    • Zott C, Amit R, Massa L. The Business Model: Theoretical Roots, Recent Developments and Future Research. Working Paper WP-862, IESE Business School, University of Navarra 2010: 1-45.
    • (2010) , pp. 1-45
    • Zott, C.1    Amit, R.2    Massa, L.3
  • 99
    • 84887410665 scopus 로고    scopus 로고
    • Creating and delivering your value proposition: managing customer experience for profit. Kogan Page.
    • Barnes C, Blake H, Pinder D. Creating and delivering your value proposition: managing customer experience for profit. Kogan Page. 2009.
    • (2009)
    • Barnes, C.1    Blake, H.2    Pinder, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.