Knockdown of DEPTOR inhibits cell proliferation and increases chemosensitivity to melphalan in human multiple myeloma RPMI-8226 cells via inhibiting PI3K/AKT activity

Journal of International Medical Research

Volumn 41, Issue 3, 2013, Pages 584-595

  Zhang, Hao Ran ^a   Chen, Jun Min ^a   Zeng, Zhi Yong ^a   Que, Wen Zhong ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; DEP domain containing mTOR interacting protein (DEPTOR); melphalan; Multiple myeloma; phosphatidylinositol 3 kinase v akt murine thymoma viral oncogene homologue 1 (PI3K AKT); proliferation

Indexed keywords

BINDING PROTEIN; CASPASE 3; DEP DOMAIN CONTAINING MTOR INTERACTING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MELPHALAN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL LEVEL; CELL PROLIFERATION; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPTOR GENE; DRUG CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOLECULAR MECHANICS; MULTIPLE MYELOMA; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TREATMENT RESPONSE; WESTERN BLOTTING;

APOPTOSIS; DEP DOMAIN CONTAINING MTOR-INTERACTING PROTEIN (DEPTOR); MELPHALAN; MULTIPLE MYELOMA; PHOSPHATIDYLINOSITOL 3-KINASE/V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOGUE 1 (PI3K/AKT); PROLIFERATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MELPHALAN; MULTIPLE MYELOMA; PHOSPHATIDYLINOSITOL 3-KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84887380745     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060513480920     Document Type: Article

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