The SCIentinel study - prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS) - study protocol and interim feasibility data

BMC Neurology

Volumn 13, Issue , 2013, Pages

  Kopp, Marcel A ^a   Druschel, Claudia ^a   Meisel, Christian ^a   Liebscher, Thomas ^b   Prilipp, Erik ^b   Watzlawick, Ralf ^a   Cinelli, Paolo ^c   Niedeggen, Andreas ^b   Schaser, Klaus Dieter ^a   Wanner, Guido A ^c   Curt, Armin ^d   Lindemann, Gertraut ^d   Nugaeva, Natalia ^e   Fehlings, Michael G ^e   Vajkoczy, Peter ^a   Cabraja, Mario ^a   Dengler, Julius ^a   Ertel, Wolfgang ^a   Ekkernkamp, Axel ^b   Martus, Peter ^f   Volk, Hans Dieter ^a   Unterwalder, Nadine ^a   Kölsch, Uwe ^a   Brommer, Benedikt ^a   Hellmann, Rick C ^a   Ossami Saidy, Ramin R ^a   Laginha, Ines ^a   Prüss, Harald ^a   Failli, Vieri ^a   Dirnagl, Ulrich ^a   Schwab, Jan M ^a,b   more..

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Trauma Hospital Berlin   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

High dose methylprednisolone treatment; Immune paralysis; Infections; Lesion height dependency; Spinal cord injury

Indexed keywords

GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; METHYLPREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; AMERICAN SPINAL INJURY ASSOCIATION IMPAIRMENT SCALE; ARTICLE; BLOOD SAMPLING; CENTRAL NERVOUS SYSTEM; CYTOKINE PRODUCTION; GENE EXPRESSION; HUMAN; IMMUNE DEFICIENCY; IMMUNE DEPRESSION SYNDROME; IMMUNE SYSTEM; IMMUNOCOMPETENCE; IMMUNOMODULATION; IMMUNOPHENOTYPING; INFECTION; INJURY SEVERITY; INNATE IMMUNITY; LEUKOCYTE; LYMPHOCYTOPENIA; MONOCYTE; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SPINAL CORD INJURY; SPINE FRACTURE; SPINE SURGERY;

AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; DATABASES, FACTUAL; FEASIBILITY STUDIES; HUMANS; INTERNATIONALITY; LONGITUDINAL STUDIES; PROSPECTIVE STUDIES; SPINAL CORD INJURIES;

EID: 84887348788     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/1471-2377-13-168     Document Type: Article

References (33)

1. Thuret S, Moon LD, Gage FH. Therapeutic interventions after spinal cord injury. Nat Rev Neurosci 2006, 7(8):628-643. 10.1038/nrn1955, 16858391.
2. DeVivo MJ, Kartus PL, Stover SL, Rutt RD, Fine PR. Cause of death for patients with spinal cord injuries. Arch Intern Med 1989, 149(8):1761-1766. 10.1001/archinte.1989.00390080043011, 2669663.
3. Soden RJ, Walsh J, Middleton JW, Craven ML, Rutkowski SB, Yeo JD. Causes of death after spinal cord injury. Spinal Cord 2000, 38(10):604-610. 10.1038/sj.sc.3101080, 11093321.
4. Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 2005, 6(10):775-786.
5. Riegger T, Conrad S, Liu K, Schluesener HJ, Adibzahdeh M, Schwab JM. Spinal cord injury-induced immune depression syndrome (SCI-IDS). Eur J Neurosci 2007, 25(6):1743-1747. 10.1111/j.1460-9568.2007.05447.x, 17432962.
6. Riegger T, Conrad S, Schluesener HJ, Kaps HP, Badke A, Baron C, Gerstein J, Dietz K, Abdizahdeh M, Schwab JM. Immune depression syndrome following human spinal cord injury (SCI): a pilot study. Neuroscience 2009, 158(3):1194-1199. 10.1016/j.neuroscience.2008.08.021, 18790013.
7. Riegger T, Schluesener HJ, Kaps HP, Badke A, Baron C, Gerstein J, Dietz K, Abdizahdeh M, Schwab JM. Hematologic cellular inflammatory response following human spinal cord injury. Acta Neuropathol 2003, 106:392.
8. Campagnolo DI, Keller SE, DeLisa JA, Glick TJ, Sipski ML, Schleifer SJ. Alteration of immune system function in tetraplegics. A pilot study. Am J Phys Med Rehabil 1994, 73(6):387-393. 10.1097/00002060-199411000-00003, 7993612.
9. Cruse JM, Lewis RE, Bishop GR, Kliesch WF, Gaitan E, Britt R. Decreased immune reactivity and neuroendocrine alterations related to chronic stress in spinal cord injury and stroke patients. Pathobiology 1993, 61(3-4):183-192.
10. Lucin KM, Sanders VM, Jones TB, Malarkey WB, Popovich PG. Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation. Exp Neuro 2007, 207(1):75-84.
11. Furlan JC, Krassioukov AV, Fehlings MG. Hematologic abnormalities within the first week after acute isolated traumatic cervical spinal cord injury: a case-control cohort study. Spine (Phila Pa 1976) 2006, 31(23):2674-2683. 10.1097/01.brs.0000244569.91204.01, 17077735.
12. Failli V, Kopp MA, Gericke C, Martus P, Klingbeil S, Brommer B, Laginha I, Chen Y, DeVivo MJ, Dirnagl U, et al. Functional neurological recovery after spinal cord injury is impaired in patients with infections. Brain 2012, 135(Pt 11):3238-3250.
13. Strohmeyer JC, Blume C, Meisel C, Doecke WD, Hummel M, Hoeflich C, Thiele K, Unbehaun A, Hetzer R, Volk HD. Standardized immune monitoring for the prediction of infections after cardiopulmonary bypass surgery in risk patients. Cytometry B Clin Cytom 2003, 53(1):54-62.
14. Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel C, Kiefer P, Weber SU, Hedwig-Geissing M, Kreuzfelder E, Tschentscher P, et al. Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study. Clin Chem 2005, 51(12):2341-2347. 10.1373/clinchem.2005.052639, 16214828.
15. Haeusler KG, Schmidt WU, Fohring F, Meisel C, Helms T, Jungehulsing GJ, Nolte CH, Schmolke K, Wegner B, Meisel A, et al. Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovasc Dis 2008, 25(1-2):50-58.
16. Meisel C, Hoflich C, Volk HD. Immune monitoring in SIRS and sepsis based on the PIRO model. Dtsch Med Wochenschr 2008, 133(45):2332-2336. 10.1055/s-0028-1100924, 18958829.
17. Held KS, Steward O, Blanc C, Lane TE. Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection. Exp Neuro 2010, 226(1):242-253.
18. Campagnolo DI, Dixon D, Schwartz J, Bartlett JA, Keller SE. Altered innate immunity following spinal cord injury. Spinal Cord 2008, 46(7):477-481. 10.1038/sc.2008.4, 2562915, 18268516.
19. Kliesch WF, Cruse JM, Lewis RE, Bishop GR, Brackin B, Lampton JA. Restoration of depressed immune function in spinal cord injury patients receiving rehabilitation therapy. Paraplegia 1996, 34(2):82-90. 10.1038/sc.1996.14, 8835031.
20. Marino RJ, Ditunno JF, Donovan WH, Maynard F. Neurologic recovery after traumatic spinal cord injury: data from the model spinal cord injury systems. Arch Phys Med Rehabil 1999, 80(11):1391-1396. 10.1016/S0003-9993(99)90249-6, 10569432.
21. Burgdörfer H, Heidler H, Madersbacher H, Kutzenberger J, Palmtag H, Pannek J, Sauerwein D, Stöhrer M, Arbeitskreis Urologische Rehabilitation Querschnittgelähmter, vol. 4 Manual Neuro-Urologie und Querschnittlähmung. Leitlinien zur urologischen Betreuung Querschnittgelähmter. Überarbeitete Auflage, 4 2007, Überarbeitete Auflage, Arbeitskreis Urologische Rehabilitation Querschnittgelähmter, vol. 4.
22. Mann G, Hankey GJ, Cameron D. Swallowing function after stroke: prognosis and prognostic factors at 6 months. Stroke 1999, 30(4):744-748. 10.1161/01.STR.30.4.744, 10187872.
23. Marino RJ, Barros T, Biering-Sorensen F, Burns SP, Donovan WH, Graves DE, Haak M, Hudson LM, Priebe MM. International standards for neurological classification of spinal cord injury. J Spinal Cord Med 2003, 26(Suppl 1):S50-S56.
24. Kirshblum SC, Waring W, Biering-Sorensen F, Burns SP, Johansen M, Schmidt-Read M, Donovan W, Graves D, Jha A, Jones L, et al. Reference for the 2011 revision of the international standards for neurological classification of spinal cord injury. J Spinal Cord Med 2011, 34(6):547-554. 10.1179/107902611X13186000420242, 3232637, 22330109.
25. Davis C, Wu X, Li W, Fan H, Reddy M. Stability of immunophenotypic markers in fixed peripheral blood for extended analysis using flow cytometry. J Immunol Methods 2011, 363(2):158-165. 10.1016/j.jim.2010.09.029, 20875824.
26. Ng AA, Lee BT, Teo TS, Poidinger M, Connolly JE. Optimal cellular preservation for high dimensional flow cytometric analysis of multicentre trials. J Immunol Methods 2012, 385(1-2):79-89.
27. Harms H, Prass K, Meisel C, Klehmet J, Rogge W, Drenckhahn C, Gohler J, Bereswill S, Gobel U, Wernecke KD, et al. Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLoS One 2008, 3(5):e2158. 10.1371/journal.pone.0002158, 2373885, 18478129.
28. Landelle C, Lepape A, Voirin N, Tognet E, Venet F, Bohe J, Vanhems P, Monneret G. Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med 2010, 36(11):1859-1866. 10.1007/s00134-010-1962-x, 20652682.
29. Zhang Y, Guan Z, Reader B, Shawler T, Mandrekar-Colucci S, Huang K, Weil Z, Bratasz A, Well J, Powell ND, et al. Autonomic dysreflexia causes chronic immune suppression after spinal cord injury. J Neurosci 2013, 33(32):12970-12981. 10.1523/JNEUROSCI.1974-13.2013, 23926252.
30. Bao F, Bailey CS, Gurr KR, Bailey SI, Rosas-Arellano MP, Brown A, Dekaban GA, Weaver LC. Human spinal cord injury causes specific increases in surface expression of beta integrins on leukocytes. J Neurotrauma 2011, 28(2):269-280. 10.1089/neu.2010.1618, 21142687.
31. Cameron AP, Rodriguez GM, Schomer KG. Systematic review of urological followup after spinal cord injury. J Urol 2012, 187(2):391-397. 10.1016/j.juro.2011.10.020, 22177149.
32. Ronco E, Denys P, Bernede-Bauduin C, Laffont I, Martel P, Salomon J, Bussel B, Guillemot D, Gaillard JL. Diagnostic criteria of urinary tract infection in male patients with spinal cord injury. Neurorehabil Neural Repair 2011, 25(4):351-358. 10.1177/1545968310383432, 21131625.
33. Zorner B, Blanckenhorn WU, Dietz V, Group E-SS, Curt A. Clinical algorithm for improved prediction of ambulation and patient stratification after incomplete spinal cord injury. J Neurotrauma 2010, 27(1):241-252. 10.1089/neu.2009.0901, 19645527.