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Volumn 208, Issue 7, 2013, Pages 1152-1160

Mixed pneumococcal-nontypeable haemophilus influenzae otitis media is a distinct clinical entity with unique epidemiologic characteristics and pneumococcal serotype distribution

Author keywords

chronic; mixed infections; non responsive; nontypeable H. influenzae; otitis media; recurrent; S. pneumoniae

Indexed keywords

ARTICLE; BACTERIAL COLONIZATION; BODY TEMPERATURE; CHILD; CHRONICITY; CONTROLLED STUDY; CROWDING (AREA); FEMALE; HAEMOPHILUS INFECTION; HAEMOPHILUS INFLUENZAE; HUMAN; ISRAEL; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MYRINGOTOMY; NONHUMAN; OTITIS MEDIA; PATIENT HISTORY OF SURGERY; PNEUMOCOCCAL INFECTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT INFECTION; SEROTYPE; STREPTOCOCCUS PNEUMONIAE; WINTER; BACTERIUM IDENTIFICATION; CHRONIC; CLASSIFICATION; COMPARATIVE STUDY; HETEROZYGOTE; INFANT; ISOLATION AND PURIFICATION; MICROBIOLOGY; NASOPHARYNX; NON-RESPONSIVE; NONTYPEABLE H. INFLUENZAE; PATHOLOGY; RECURRENT; S. PNEUMONIAE; SEROTYPING;

EID: 84887314613     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit289     Document Type: Article
Times cited : (41)

References (50)
  • 1
    • 0024339586 scopus 로고
    • Epidemiology of otitis media during the first seven years of life in children in greater Boston: A prospective, cohort study
    • Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: A prospective, cohort study. J Infect Dis 1989; 160:83-94
    • (1989) J Infect Dis , vol.160 , pp. 83-94
    • Teele, D.W.1    Klein, J.O.2    Rosner, B.3
  • 2
    • 67649562422 scopus 로고    scopus 로고
    • Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media
    • Barkai G, Leibovitz E, Givon-Lavi N, Dagan R. Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media. Pediatr Infect Dis J 2009; 28:466-71
    • (2009) Pediatr Infect Dis J , vol.28 , pp. 466-471
    • Barkai, G.1    Leibovitz, E.2    Givon-Lavi, N.3    Dagan, R.4
  • 3
    • 0033829550 scopus 로고    scopus 로고
    • Recurrent and persistent otitis media
    • Pichichero ME. Recurrent and persistent otitis media. Pediatr Infect Dis J 2000; 19:911-6
    • (2000) Pediatr Infect Dis J , vol.19 , pp. 911-916
    • Pichichero, M.E.1
  • 4
    • 53249113241 scopus 로고    scopus 로고
    • Pathogens causing recurrent and difficult-To-Treat acute otitis media 2003-2006
    • Pichichero ME, Casey JR, Hoberman A, Schwartz R. Pathogens causing recurrent and difficult-To-Treat acute otitis media, 2003-2006. Clin Pediatr (Phila) 2008; 47:901-6
    • (2008) Clin Pediatr (Phila , vol.47 , pp. 901-906
    • Pichichero, M.E.1    Casey, J.R.2    Hoberman, A.3    Schwartz, R.4
  • 5
    • 34347340669 scopus 로고    scopus 로고
    • Is bilateral acute otitis media clinically different than unilateral acute otitis media
    • Leibovitz E, Asher E, Piglansky L, et al. Is bilateral acute otitis media clinically different than unilateral acute otitis media Pediatr Infect Dis J 2007; 26:589-92
    • (2007) Pediatr Infect Dis J , vol.26 , pp. 589-592
    • Leibovitz, E.1    Asher, E.2    Piglansky, L.3
  • 6
    • 41649090060 scopus 로고    scopus 로고
    • Bacterial biofilms in otitis media: Evidence and relevance
    • Bakaletz LO. Bacterial biofilms in otitis media: Evidence and relevance. Pediatr Infect Dis J 2007; 26:S17-9
    • (2007) Pediatr Infect Dis J , vol.26
    • Bakaletz, L.O.1
  • 7
    • 72849151976 scopus 로고    scopus 로고
    • Acute otitis media caused by moraxella catarrhalis: Epidemiologic and clinical characteristics
    • Broides A, Dagan R, Greenberg D, Givon-Lavi N, Leibovitz E. Acute otitis media caused by Moraxella catarrhalis: Epidemiologic and clinical characteristics. Clin Infect Dis 2009; 49:1641-7
    • (2009) Clin Infect Dis , vol.49 , pp. 1641-1647
    • Broides, A.1    Dagan, R.2    Greenberg, D.3    Givon-Lavi, N.4    Leibovitz, E.5
  • 9
    • 16644392313 scopus 로고    scopus 로고
    • Haemophilus influenzae: A significant pathogen in acute otitis media
    • Leibovitz E, Jacobs MR, Dagan R. Haemophilus influenzae: A significant pathogen in acute otitis media. Pediatr Infect Dis J 2004; 23:1142-52
    • (2004) Pediatr Infect Dis J , vol.23 , pp. 1142-1152
    • Leibovitz, E.1    Jacobs, M.R.2    Dagan, R.3
  • 10
    • 80054797495 scopus 로고    scopus 로고
    • Multi-species bacterial biofilm and intracellular infection in otitis media
    • Thornton RB, Rigby PJ, Wiertsema SP, et al. Multi-species bacterial biofilm and intracellular infection in otitis media. BMC Pediatr 2011; 11:94
    • (2011) BMC Pediatr , vol.11 , pp. 94
    • Thornton, R.B.1    Rigby, P.J.2    Wiertsema, S.P.3
  • 11
    • 0032573876 scopus 로고    scopus 로고
    • Evidence of bacterial metabolic activity in culture-negative otitis media with effusion
    • Rayner MG, Zhang Y, Gorry MC, Chen Y, Post JC, Ehrlich GD. Evidence of bacterial metabolic activity in culture-negative otitis media with effusion. JAMA 1998; 279:296-9
    • (1998) JAMA , vol.279 , pp. 296-299
    • Rayner, M.G.1    Zhang, Y.2    Gorry, M.C.3    Chen, Y.4    Post, J.C.5    Ehrlich, G.D.6
  • 12
    • 20344372877 scopus 로고    scopus 로고
    • Long-Term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate
    • Brook I, Gober AE. Long-Term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate. J Med Microbiol 2005; 54:553-6
    • (2005) J Med Microbiol , vol.54 , pp. 553-556
    • Brook, I.1    Gober, A.E.2
  • 14
    • 79958146840 scopus 로고    scopus 로고
    • Microbiology of bronchoalveolar lavage fluid in children with acute nonresponding or recurrent community-Acquired pneumonia: Identification of nontypeable Haemophilus influenzae as a major pathogen
    • De Schutter I, De Wachter E, Crokaert F, et al. Microbiology of bronchoalveolar lavage fluid in children with acute nonresponding or recurrent community-Acquired pneumonia: Identification of nontypeable Haemophilus influenzae as a major pathogen. Clin Infect Dis 2011; 52:1437-44
    • (2011) Clin Infect Dis , vol.52 , pp. 1437-1444
    • De Schutter, I.1    De Wachter, E.2    Crokaert, F.3
  • 15
    • 0031908490 scopus 로고    scopus 로고
    • Hospitalizations for infectious diseases in Jewish and Bedouin children in southern Israel
    • Levy A, Fraser D, Vardi H, Dagan R. Hospitalizations for infectious diseases in Jewish and Bedouin children in southern Israel. Eur J Epidemiol 1998; 14:179-86
    • (1998) Eur J Epidemiol , vol.14 , pp. 179-186
    • Levy, A.1    Fraser, D.2    Vardi, H.3    Dagan, R.4
  • 16
    • 0033989601 scopus 로고    scopus 로고
    • Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children
    • Dagan R, Leibovitz E, Fliss DM, et al. Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children. Antimicrob Agents Chemother 2000; 44:43-50
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 43-50
    • Dagan, R.1    Leibovitz, E.2    Fliss, D.M.3
  • 17
    • 33745726952 scopus 로고    scopus 로고
    • Site-specific disease potential of individual Streptococcus pneumoniae serotypes in pediatric invasive disease, acute otitis media and acute conjunctivitis
    • Shouval DS, Greenberg D, Givon-Lavi N, Porat N, Dagan R. Site-specific disease potential of individual Streptococcus pneumoniae serotypes in pediatric invasive disease, acute otitis media and acute conjunctivitis. Pediatr Infect Dis J 2006; 25:602-7
    • (2006) Pediatr Infect Dis J , vol.25 , pp. 602-607
    • Shouval, D.S.1    Greenberg, D.2    Givon-Lavi, N.3    Porat, N.4    Dagan, R.5
  • 18
    • 33947178800 scopus 로고    scopus 로고
    • Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: A meta-Analysis of individual patient data
    • Rovers MM, Glasziou P, Appelman CL, et al. Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: A meta-Analysis of individual patient data. Pediatrics 2007; 119:579-85
    • (2007) Pediatrics , vol.119 , pp. 579-585
    • Rovers, M.M.1    Glasziou, P.2    Appelman, C.L.3
  • 19
    • 33750021118 scopus 로고    scopus 로고
    • Antibiotics for acute otitis media: A meta-Analysis with individual patient data
    • Rovers MM, Glasziou P, Appelman CL, et al. Antibiotics for acute otitis media: A meta-Analysis with individual patient data. Lancet 2006; 368:1429-35
    • (2006) Lancet , vol.368 , pp. 1429-1435
    • Rovers, M.M.1    Glasziou, P.2    Appelman, C.L.3
  • 21
    • 84855391731 scopus 로고    scopus 로고
    • Seasonality and determinants of moderate and severe copd exacerbations in the torch study
    • Jenkins CR, Celli B, Anderson JA, et al. Seasonality and determinants of moderate and severe COPD exacerbations in the TORCH study. Eur Respir J 2012; 39:38-45
    • (2012) Eur Respir J , vol.39 , pp. 38-45
    • Jenkins, C.R.1    Celli, B.2    Anderson, J.A.3
  • 22
    • 77956911922 scopus 로고    scopus 로고
    • Coinfection with haemophilus influenzae promotes pneumococcal biofilm formation during experimental otitis media and impedes the progression of pneumococcal disease
    • Weimer KE, Armbruster CE, Juneau RA, Hong W, Pang B, Swords WE. Coinfection with Haemophilus influenzae promotes pneumococcal biofilm formation during experimental otitis media and impedes the progression of pneumococcal disease. J Infect Dis 2010; 202: 1068-75
    • (2010) J Infect Dis , vol.202 , pp. 1068-1075
    • Weimer, K.E.1    Armbruster, C.E.2    Juneau, R.A.3    Hong, W.4    Pang, B.5    Swords, W.E.6
  • 24
    • 79957995270 scopus 로고    scopus 로고
    • Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal children
    • Jacoby P, Carville KS, Hall G, et al. Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal children. Pediatr Infect Dis J 2011; 30:480-5
    • (2011) Pediatr Infect Dis J , vol.30 , pp. 480-485
    • Jacoby, P.1    Carville, K.S.2    Hall, G.3
  • 25
    • 41649106350 scopus 로고    scopus 로고
    • The burden and outcome of respiratory tract infection in australian and aboriginal children
    • Leach AJ, Morris PS. The burden and outcome of respiratory tract infection in Australian and aboriginal children. Pediatr Infect Dis J 2007; 26:S4-7
    • (2007) Pediatr Infect Dis J , vol.26
    • Leach, A.J.1    Morris, P.S.2
  • 26
    • 0027404760 scopus 로고
    • Protracted secretory otitis media. The impact of familial factors and day-care center attendance
    • Rasmussen F. Protracted secretory otitis media. The impact of familial factors and day-care center attendance. Int J Pediatr Otorhinolaryngol 1993; 26:29-37
    • (1993) Int J Pediatr Otorhinolaryngol , vol.26 , pp. 29-37
    • Rasmussen, F.1
  • 28
    • 34848856744 scopus 로고    scopus 로고
    • The dynamics of bacteria in the middle ear during the course of acute otitis media with tympanostomy tube otorrhea
    • Ruohola A, Meurman O, Nikkari S, Skottman T, Heikkinen T, Ruuskanen O. The dynamics of bacteria in the middle ear during the course of acute otitis media with tympanostomy tube otorrhea. Pediatr Infect Dis J 2007; 26:892-6
    • (2007) Pediatr Infect Dis J , vol.26 , pp. 892-896
    • Ruohola, A.1    Meurman, O.2    Nikkari, S.3    Skottman, T.4    Heikkinen, T.5    Ruuskanen, O.6
  • 29
    • 77958186705 scopus 로고    scopus 로고
    • Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling
    • doi:10.1128/mBio.00102.10
    • Armbruster CE, Hong W, Pang B, et al. Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. MBio 2010; 3:e00102-10. doi:10.1128/mBio.00102.10
    • (2010) MBio , vol.3
    • Armbruster, C.E.1    Hong, W.2    Pang, B.3
  • 30
    • 33745890309 scopus 로고    scopus 로고
    • Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media
    • Hall-Stoodley L, Hu FZ, Gieseke A, et al. Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA 2006; 296:202-11
    • (2006) JAMA , vol.296 , pp. 202-211
    • Hall-Stoodley, L.1    Hu, F.Z.2    Gieseke, A.3
  • 31
    • 33846805494 scopus 로고    scopus 로고
    • Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media
    • Hong W, Mason K, Jurcisek J, Novotny L, Bakaletz LO, Swords WE. Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media. Infect Immun 2007; 75:958-65
    • (2007) Infect Immun , vol.75 , pp. 958-965
    • Hong, W.1    Mason, K.2    Jurcisek, J.3    Novotny, L.4    Bakaletz, L.O.5    Swords, W.E.6
  • 32
    • 79751519055 scopus 로고    scopus 로고
    • Divergent mechanisms for passive pneumococcal resistance to beta-lactam antibiotics in the presence of Haemophilus influenzae
    • Weimer KE, Juneau RA, Murrah KA, et al. Divergent mechanisms for passive pneumococcal resistance to beta-lactam antibiotics in the presence of Haemophilus influenzae. J Infect Dis 2011; 203:549-55
    • (2011) J Infect Dis , vol.203 , pp. 549-555
    • Weimer, K.E.1    Juneau, R.A.2    Murrah, K.A.3
  • 33
    • 82655183579 scopus 로고    scopus 로고
    • Regulation of virulence gene expression resulting from Streptococcus pneumoniae and nontypeable Haemophilus influenzae interactions in chronic disease
    • Cope EK, Goldstein-Daruech N, Kofonow JM, et al. Regulation of virulence gene expression resulting from Streptococcus pneumoniae and nontypeable Haemophilus influenzae interactions in chronic disease. PLoS One 2011; 6:e28523
    • (2011) PLoS One , vol.6
    • Cope, E.K.1    Goldstein-Daruech, N.2    Kofonow, J.M.3
  • 34
    • 0038555738 scopus 로고    scopus 로고
    • Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype-And clone-specific differences in invasive disease potential
    • Brueggemann AB, Griffiths DT, Meats E, Peto T, Crook DW, Spratt BG. Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype-And clone-specific differences in invasive disease potential. J Infect Dis 2003; 187:1424-32
    • (2003) J Infect Dis , vol.187 , pp. 1424-1432
    • Brueggemann, A.B.1    Griffiths, D.T.2    Meats, E.3    Peto, T.4    Crook, D.W.5    Spratt, B.G.6
  • 35
    • 0347511930 scopus 로고    scopus 로고
    • Ability of pneumococcal serotypes and clones to cause acute otitis media: Implications for the prevention of otitis media by conjugate vaccines
    • Hanage WP, Auranen K, Syrjanen R, et al. Ability of pneumococcal serotypes and clones to cause acute otitis media: Implications for the prevention of otitis media by conjugate vaccines. Infect Immun 2004; 72:76-81
    • (2004) Infect Immun , vol.72 , pp. 76-81
    • Hanage, W.P.1    Auranen, K.2    Syrjanen, R.3
  • 36
    • 84864569507 scopus 로고    scopus 로고
    • Pneumococcal interactions with epithelial cells are crucial for optimal biofilm formation and colonization in vitro and in vivo
    • Marks LR, Parameswaran GI, Hakansson AP. Pneumococcal interactions with epithelial cells are crucial for optimal biofilm formation and colonization in vitro and in vivo. Infect Immun 2012; 80:2744-60
    • (2012) Infect Immun , vol.80 , pp. 2744-2760
    • Marks, L.R.1    Parameswaran, G.I.2    Hakansson, A.P.3
  • 37
    • 77949894979 scopus 로고    scopus 로고
    • Biofilm formation by Streptococcus pneumoniae isolates from paediatric patients
    • Tapiainen T, Kujala T, Kaijalainen T, et al. Biofilm formation by Streptococcus pneumoniae isolates from paediatric patients. APMIS 2010; 118:255-60
    • (2010) APMIS , vol.118 , pp. 255-260
    • Tapiainen, T.1    Kujala, T.2    Kaijalainen, T.3
  • 38
    • 33751119902 scopus 로고    scopus 로고
    • Biofilm formation by Streptococcus pneumoniae: Role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion
    • Moscoso M, Garcia E, Lopez R. Biofilm formation by Streptococcus pneumoniae: Role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion. J Bacteriol 2006; 188:7785-95
    • (2006) J Bacteriol , vol.188 , pp. 7785-7795
    • Moscoso, M.1    Garcia, E.2    Lopez, R.3
  • 39
    • 78751574169 scopus 로고    scopus 로고
    • Contribution of serotype and genetic background to biofilm formation by Streptococcus pneumoniae
    • Camilli R, Pantosti A, Baldassarri L. Contribution of serotype and genetic background to biofilm formation by Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis 2011; 30:97-102
    • (2011) Eur J Clin Microbiol Infect Dis , vol.30 , pp. 97-102
    • Camilli, R.1    Pantosti, A.2    Baldassarri, L.3
  • 40
    • 79956295462 scopus 로고    scopus 로고
    • Antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae isolates from elderly patients with pneumonia and acute exacerbation of chronic obstructive pulmonary disease
    • Perez-Trallero E, Marimon JM, Larruskain J, Alonso M, Ercibengoa M. Antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae isolates from elderly patients with pneumonia and acute exacerbation of chronic obstructive pulmonary disease. Antimicrob Agents Chemother 2011; 55:2729-34
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2729-2734
    • Perez-Trallero, E.1    Marimon, J.M.2    Larruskain, J.3    Alonso, M.4    Ercibengoa, M.5
  • 41
    • 37849017710 scopus 로고    scopus 로고
    • Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilms
    • Starner TD, Shrout JD, Parsek MR, Appelbaum PC, Kim G. Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilms. Antimicrob Agents Chemother 2008; 52:137-45
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 137-145
    • Starner, T.D.1    Shrout, J.D.2    Parsek, M.R.3    Appelbaum, P.C.4    Kim, G.5
  • 42
    • 77955978715 scopus 로고    scopus 로고
    • Association of serotype with risk of death due to pneumococcal pneumonia: A meta-Analysis
    • Weinberger DM, Harboe ZB, Sanders EA, et al. Association of serotype with risk of death due to pneumococcal pneumonia: A meta-Analysis. Clin Infect Dis 2010; 51:692-9
    • (2010) Clin Infect Dis , vol.51 , pp. 692-699
    • Weinberger, D.M.1    Harboe, Z.B.2    Sanders, E.A.3
  • 43
    • 79960857148 scopus 로고    scopus 로고
    • Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition
    • Sharma SK, Casey JR, Pichichero ME. Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition. J Infect Dis 2011; 204:645-53
    • (2011) J Infect Dis , vol.204 , pp. 645-653
    • Sharma, S.K.1    Casey, J.R.2    Pichichero, M.E.3
  • 44
    • 84857636427 scopus 로고    scopus 로고
    • Effect of early carriage of Streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy
    • van den Biggelaar AH, Pomat WS, Phuanukoonnon S, et al. Effect of early carriage of Streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy. Pediatr Infect Dis J 2012; 31:243-8
    • (2012) Pediatr Infect Dis J , vol.31 , pp. 243-248
    • Van Den Biggelaar, A.H.1    Pomat, W.S.2    Phuanukoonnon, S.3
  • 45
    • 0034063425 scopus 로고    scopus 로고
    • Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children
    • Black S, Shinefield H, Fireman B, et al. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis J 2000; 19:187-95
    • (2000) Pediatr Infect Dis J , vol.19 , pp. 187-195
    • Black, S.1    Shinefield, H.2    Fireman, B.3
  • 46
    • 4043085508 scopus 로고    scopus 로고
    • The seven-valent pneumococcal conjugate vaccine reduces tympanostomy tube placement in children
    • Palmu AA, Verho J, Jokinen J, Karma P, Kilpi TM. The seven-valent pneumococcal conjugate vaccine reduces tympanostomy tube placement in children. Pediatr Infect Dis J 2004; 23:732-8
    • (2004) Pediatr Infect Dis J , vol.23 , pp. 732-738
    • Palmu, A.A.1    Verho, J.2    Jokinen, J.3    Karma, P.4    Kilpi, T.M.5
  • 47
    • 80052838685 scopus 로고    scopus 로고
    • Pneumococcal vaccination in children at risk of developing recurrent acute otitis media-A randomized study
    • Gisselsson-Solen M, Melhus A, Hermansson A. Pneumococcal vaccination in children at risk of developing recurrent acute otitis media-A randomized study. Acta Paediatr 2011; 100:1354-8
    • (2011) Acta Paediatr , vol.100 , pp. 1354-1358
    • Gisselsson-Solen, M.1    Melhus, A.2    Hermansson, A.3
  • 48
    • 38849184289 scopus 로고    scopus 로고
    • Trends in acute otitis mediarelated health care utilization by privately insured young children in the united states, 19972004
    • Zhou F, Shefer A, Kong Y, Nuorti JP. Trends in acute otitis mediarelated health care utilization by privately insured young children in the United States, 1997-2004. Pediatrics 2008; 121:253-60
    • (2008) Pediatrics , vol.121 , pp. 253-260
    • Zhou, F.1    Shefer, A.2    Kong, Y.3    Nuorti, J.P.4
  • 49
    • 79959744337 scopus 로고    scopus 로고
    • The impact of the heptavalent pneumococcal conjugate vaccine on the epidemiology of acute otitis media complicated by otorrhea
    • Stamboulidis K, Chatzaki D, Poulakou G, et al. The impact of the heptavalent pneumococcal conjugate vaccine on the epidemiology of acute otitis media complicated by otorrhea. Pediatr Infect Dis J 2011; 30:551-5
    • (2011) Pediatr Infect Dis J , vol.30 , pp. 551-555
    • Stamboulidis, K.1    Chatzaki, D.2    Poulakou, G.3
  • 50
    • 84890063154 scopus 로고    scopus 로고
    • Incidence dynamics of culture-proven otitis media 4 years before and 3 years after introduction of pneumococcal conjugate vaccines (pcvs) in southern israel [abstract 508
    • San Diego, CA, 17-21 October 2012
    • Dagan R, Givon-Lavi N, Leibovitz E, Greenberg D. Incidence dynamics of culture-proven otitis media 4 years before and 3 years after introduction of pneumococcal conjugate vaccines (PCVs) in southern Israel [abstract 508]. Presented at: IDWeek 2012, San Diego, CA, 17-21 October 2012
    • (2012) Presented at: IDWeek
    • Dagan, R.1    Givon-Lavi, N.2    Leibovitz, E.3    Greenberg, D.4


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