Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: A meta-analysis of individual patient data

Pediatrics

Volumn 119, Issue 3, 2007, Pages 579-585

  Rovers, Maroeska M ^a,f   Glasziou, Paul ^b   Appelman, Cees L ^a   Burke, Peter ^b   McCormick, David P ^c   Damoiseaux, Roger A ^a   Little, Paul ^d   Le Saux, Nicole ^e   Hoes, Arno W ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c University of Texas Medical Branch School of Medicine   (United States)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Acute otitis media; Meta analysis; Prognosis

Indexed keywords

ANTIBIOTIC AGENT;

ACUTE OTITIS MEDIA; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DISEASE COURSE; DISEASE DURATION; FEVER; HUMAN; META ANALYSIS; PAIN; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SYSTEMATIC REVIEW;

ACUTE DISEASE; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; FEVER; FOLLOW-UP STUDIES; HUMANS; INFANT; MALE; OTITIS MEDIA; PAIN; RANDOMIZED CONTROLLED TRIALS; RECURRENCE; RISK FACTORS; TIME FACTORS;

EID: 33947178800     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2006-2092     Document Type: Article

References (43)

1. Freid VM, Mukuc DM, Rooks RN. Ambulatory health care visits by children: principal diagnosis and place of visit. Vital Health Stat 13. 1998;(137):1-23
2. Schilder AG, Lok W, Rovers MM. International perspectives on management of acute otitis media: a qualitative review. Int J Pediatr Otorhinolaryngol. 2004;68:29-36
3. Glasziou PP, Del Mar CB, Sanders SL, Hayem M. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2004;(1):CD000219
4. Marcy M, Takata G, Shekelle P, et al. Management of Acute Otitis Media: Evidence Report 15. Rockville, MD: Agency for Healthcare Research and Quality; 2001. AHRQ publication 01-E010.
5. Rosenfeld RM, Vertrees JE, Carr J, et al. Clinical efficacy of antimicrobial drugs for acute otitis media: meta-analysis of 5400 children from thirty-three randomized trials. J Pediatr. 1994;124:355-367
6. Ghaffar F, Friedland IR, Katz K, et al. Increased carriage of resistant non-pneumococcal α-hemolytic streptococci after antibiotic therapy. J Pediatr. 1999;135:618-623
7. Dagan R. Treatment of acute otitis media: challenges in the era of antibiotic resistance. Vaccine. 2000;19(suppl 1):S9-S16
8. Little P, Williamson I, Warner G, Gantley M, Kinmonth AI. Reattendance and complications in a randomized trial of prescribing strategies for sore throat: the medicalising effect of prescribing antibiotics. BMJ. 1997;315:350-352
9. Little P, Gould C, Moore M, Warner G, Dunleavey J, Williamson I. Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial. BMJ. 2002;325:22
10. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49:1373-1379
11. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-560
12. Hosmer DW, Lemeshow S. Applied Logistic Regression. New York, NY: John Wiley; 1989:140-145
13. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristics (ROC) curve. Radiology. 1982;143:29-36
14. Greenland S, Finkle WD. A critical look at methods for handling missing covariates in epidemiologic regression analyses. Am J Epidemiol. 1995;142:1255-1264
15. Harrell FE, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15:361-387
16. de Chaput Saintonge DM, Levine DF, Savage IT, et al. Trial of three-day and ten-day courses of amoxycillin in otitis media. BMJ (Clin Res Ed). 1982;284:1078-1081
17. Engelhard D, Strauss N, Jorczak-Sarni L, Cohen D, Sacjs TG, Shapiro M. Randomised study of myringotomy, amoxycillin/ clavulanate, or both for acute otitis media in infants. Lancet. 1989;2:141-143
18. Ostfeld E, Segal J, Kaufstein M, Gelernter I. Management of acute otitis media without primary administration of systemic antimicrobial agents. In: Lim DJ, Bluestone CD, Klein JO, Nelson JD, eds. International Symposium on Recent Advances in Otitis Media. Toronto, Ontario, Canada: Decker; 1987:235-239
19. Rudberg RD. Acute otitis media: comparative therapeutic results of sulphonamide and penicillin administered in various forms. Acta Otolaryngol. 1954;113(suppl):1-79
20. Ruohola A, Heikkinen T, Meurman O, Puhakka T, Lindblad N, Ruuskanen O. Antibiotic treatment of acute otorrhea through tympanostomy tube: randomized double-blind placebo-controlled study with daily follow-up. Pediatrics. 2003;111:1061-1067
21. van Buchem F, Peeters M, van't Hof M. Acute otitis media: a new treatment strategy. BMJ. 1985;290:1033-1037
22. Halsted C, Lepow ML, Balassanian N, Emmerich J, Wolinsky E. Otitis media: clinical observation, microbiology and evaluation of therapy. Am J Dis Child. 1968;115:542-551
23. Howie VM, Ploussard JH. Efficacy of fixed combination antibiotics versus separate components in otitis media: effectiveness of erythromycin estolate, triple sulfonamide, ampicillin, erythromycin estolate-triple sulfonamide, and placebo in 280 patients with acute otitis media under two and one-half years of age. Clin Pediatr (Phila). 1972;11:205-214
24. Laxdal OE, Merida J, Jones RHT. Treatment of acute otitis media: a controlled study of 142 children. CMAJ. 1970;102:263-268
25. Appelman CL, Claessen JQ, Touw-Otten FW, Hordijk GJ, de Melker RA. Co-amoxiclav in recurrent acute otitis media: placebo controlled study. BMJ. 1991;303:1450-1452
26. Burke P, Bain J, Robinson D, Dunleavey J. Acute red ear in children: controlled trial of non-antibiotic treatment in general practice. BMJ. 1991;303:558-562
27. Damoiseaux RA, van Balen FA, Hoes AW, Verheij TJ, de Melker RA. Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years. BMJ. 2000;320:350-354
28. Little P, Gould C, Williamson I, Moore M, Warner G, Dunleavey J. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. BMJ. 2001;322:336-342
29. Le Saux N, Gaboury I, Baird M, et al. A randomized, double-blind, placebo-controlled noninferiority trial of amoxicillin for clinically diagnosed acute otitis media in children 6 months to 5 years of age. CMAJ. 2005;172:335-341
30. McCormick DP, Chonmaitree T, Pittman C, et al. Nonsevere acute otitis media: a clinical trial comparing outcomes of watchful waiting versus immediate antibiotic treatment. Pediatrics. 2005;115:1455-1465
31. Mygind N, Meistrup-Larsen K-I, Thomsen J, Thomsen VF, Josefsson K, Sorensen H. Penicillin in acute otitis media: a double-blind placebo-controlled trial. Clin Otolaryngol. 1981;6:5-13
32. Thalin A, Densert O, Larsson A, Lyden E, Ripa T. Is penicillin necessary in the treatment of acute otitis media? In: Proceedings of the International Conference on Acute and Secretory Otitis Media, Jerusalem. Amsterdam, Netherlands: Kugler Publications; 1985:441-446
33. van Buchem FL, Dunk JHM, van't Hof MA. Therapy of acute otitis media: myringotomy, antibiotics or neither? A double-blind study in children. Lancet. 1981;2:883-887
34. Kaleida PH, Casselhrant ML, Rockette HE, et al. Amoxicillin or myringotomy or both for acute otitis media: results of a randomized clinical trial. Pediatrics. 1991;87:466-474
35. Oxman AD, Clarke MJ, Stewart LA. From science to practice: meta-analysis using individual patient data are needed. JAMA. 1995;274:845-846
36. Westert GP, Schellevis FG, de Bakker DH, Groenewegen PP, Bensing JM, van der Zee J. Monitoring health inequalities through general practice: the Second Dutch National Survey of General Practice. Eur J Public Health. 2005;15:59-65
37. Marchetti F, Ronfani L, Nibali SC, Tamburlini G, Italian Study Group on Acute Otitis Media. Delayed prescription may reduce the use of antibiotics for acute otitis media: a prospective observational study in primary care. Arch Pediatr Adolesc Med. 2005;159:679-684
38. Rijkers GT, Sanders EAM, Breuekels MA, Zegers BJM. Responsiveness of infants to capsular polysaccharides: impact for vaccine development. Rev Med Microbiol. 1996;7:3-12
39. Suzuki C, Balaban C, Sando I, et al. Postnatal development of eustachian tube: a computer-aided 3-D reconstruction and measurement study. Acta Otolaryngol (Stockh). 1998;118:837-843
40. Niemela M, Uhari M, Lautala P, Huggare J. Association of recurrent acute otitis media with nasopharynx dimensions in children. J Laryngol Otol. 1994;108:299-302
41. American Academy of Family Physicians, American Academy of Pediatrics. Diagnosis and management of acute otitis media. Available at: www.aafp.org/x26481.xml. Accessed January 1, 2007
42. Dutch College of General Practitioners. Practice guideline "acute otitis media." Available at: http://nhg.artsennet.nl/ upload/104/ guidelines2/E09.htm. Accessed January 1, 2007
43. Scottish Intercollegiate Guidelines Network. Diagnosis and management of childhood otitis media in primary care. Available at: www.sign.ac.uk/guidelines/ fulltext/66. Accessed January 1, 2007