Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit

Shock

Volumn 31, Issue 6, 2009, Pages 586-591

  Nakamura, Akiko ^a,b   Wada, Hideo ^b,c   Ikejiri, Makoto ^b   Hatada, Tsuyoshi ^b   Sakurai, Hiroyuki ^b   Matsushima, Yoshiko ^a   Nishioka, Junji ^a   Maruyama, Kazuo ^b   Isaji, Shuji ^b   Takeda, Taichi ^b   Nobori, Tsutomu ^b  

^a MIE UNIVERSITY HOSPITAL   (Japan)

^b MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bacterial infection; Blood culture; Fungal infection; Polymerase chain reaction; Procalcitonin

Indexed keywords

C REACTIVE PROTEIN; FUNGAL DNA; PROCALCITONIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BACTEREMIA; BACTERIAL INFECTION; BLOOD CULTURE; CALCITONIN BLOOD LEVEL; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FEMALE; FUNGUS; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; SEPSIS;

AGED; BACTEREMIA; BACTERIAL INFECTIONS; C-REACTIVE PROTEIN; CALCITONIN; DNA, BACTERIAL; DNA, FUNGAL; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROTEIN PRECURSORS;

EID: 68049106352     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31819716fa     Document Type: Article

References (27)

1. Jensen JU, Heslet L, Jensen TH, Espersen K, Steffensen P, Tvede M: Procalcitonin increase in early identification of critically ill patients at high risk of mortality. Crit Care Med 34:2596-2602, 2006.
2. Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C: Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med 31:2742-2751, 2003.
3. Alberti C, Brun-Buisson C, Chevret S, Antonelli M, Goodman SV, Martin C, Moreno R, Ochagavia AR, Palazzo M, Werdan K, et al.: Systemic inflammatory response and progression to severe sepsis in critically ill infected patients. Am J Respir Crit Care Med 171:461-468, 2005.
4. Herzum I, Renz H: Inflammatory markers in SIRS, sepsis and septic shock. Curr Med Chem 15:581-587, 2008.
5. Rau BM, Kemppainen EA, Gumbs AA, Büchler MW, Wegscheider K, Bassi C, Puolakkainen PA, Beger HG: Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): a prospective international multicenter study. Ann Surg 245:745-754, 2007.
6. Becker KL, Nylen ES, White JC, Muller BC, Snider RH Jr: Clinical review 167: procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab 89:1512-1525, 2004.
7. Meisner M, Müller V, Khakpour Z, Toegel E, Redl H: Induction of procalcitonin and proinflammatory cytokines in an anhepatic baboon endotoxin shock model. Shock 19:187-190, 2003.
8. Müller B, Christ-Crain M: Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators. Eur Respir J 30:556-573, 2007.
9. Christ-Crain M, Müller B: Procalcitonin in bacterial infections - hype, hope, more or less? Swiss Med Wkly 135:451-460, 2005.
10. Nylen ES, O'Neill W, Jordan MH, Snider RH, Moore CF, Lewis M, Silva OL, Becker KL: Serum procalcitonin as an index of inhalation injury in burns. Horm Metab Res 24:439-443, 1992.
11. Whang KT, Steinwald PM, White JC, Nylen ES, Snider RH, Simon GL, Goldberg RL, Becker KL: Serum calcitonin precursors in sepsis and systemic inflammation. J Clin Endocrinol Metab 83:3296-3301, 1998.
12. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C: High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341:515-518, 1993.
13. Krüger S, Ewig S, Marre R, Papassotiriou J, Richter K, von Baum H, Suttorp N, Welte T; CAPNETZ Study Group: Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes. Eur Respir J 31:349-355, 2008.
14. Buchman TG, Rossier M, Merz WG, Charache P: Detection of surgical pathogens by in vitro DNA amplification. Part I. Rapid identification of Candida albicans by in vitro amplification of a fungus-specific gene. Surgery 108:338-346, 1990.
15. Shin JH, Nolte FS, Morrison CJ: Rapid identification of Candida species in blood cultures by a clinically useful PCR method. J Clin Microbiol 35:1454-1459, 1997.
16. de Aguirre L, Hurst SF, Choi JS, Shin JH, Hinrikson HP, Morrison CJ: Rapid differentiation of Aspergillus species from other medically important opportunistic molds and yeasts by PCR-enzyme immunoassay. J Clin Microbiol 42:3495-3504, 2004.
17. Fenollar F, Raoult D: Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria. Int J Antimicrob Agents 30(Suppl 1):S7-S15, 2007.
18. Ammann RA, Zucol F, Aebi C, Niggli FK, Kühne T, Nadal D: Real-time broad-range PCR versus blood culture. A prospective pilot study in pediatric cancer patients with fever and neutropenia. Support Care Cancer 15:637-641, 2007.
19. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, Müller B: Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 363:600-607, 2004.
20. Makimura K, Murayama S, Yamaguchi H: Detection of wide range of medically important fungi by the polymerase chain reaction. J Clin Microbiol 40:358-364, 1994.
21. Sprengart ML, Fatscher HP, Fuchs E: The initiation of translation in E. coli: apparent base pairing between the 16srRNA and downstream sequences of the mRNA. Nucleic Acids Res 18:1719-1723, 1990.
22. Goldstein BJ, Mushlin AI: Use of a single thyroxine test to evaluate ambulatory medical patients for suspected hypothyroidism. J Gen Intern Med 2:20-24, 1987.
23. Becker KL, Snider R, Nylen ES: Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med 36:941-952, 2008.
24. Echániz-Quintana A, Pita-Fernández S, Otero-Ferreiro A, Suárez-López F, Gómez-Gutiérrez M, Guerrero-Espejo A: Risk factors associated with invasive fungal infection in orthotopic liver transplantation. Med Clin Med Clin (Barc) 122:444-448, 2004.
25. Said A, Safdar N, Lucey MR, Knechtle SJ, D'Alessandro A, Musat A, Pirsch J, Kalayoglu M, Maki DG: Infected bilomas in liver transplant recipients, incidence, risk factors and implications for prevention. Am J Transplant 4:574-582, 2004.
26. Karp JE, Merz WG, Charache P: Response to empiric amphotericin B during antileukemic therapy-induced granulocytopenia. Rev Infect Dis 13:592-599, 1991.
27. Rantakokko-Jalava K, Nikkari S, Jalava J, Eerola E, Skurnik M, Meurman O, Ruuskanen O, Alanen A, Kotilainen E, Toivanen P, et al.: Direct amplification of rRNA genes in diagnosis of bacterial infections. J Clin Microbiol 38:32-39, 2000.