A Novel Actin mRNA Splice Variant Regulates ACTG1 Expression

PLoS Genetics

Volumn 9, Issue 10, 2013, Pages

  Drummond, Meghan C ^a,b   Friderici, Karen H ^a  

^a Michigan State University   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOPLASMIC GAMMA ACTIN 1; MESSENGER RNA; NUCLEOTIDE; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; DIAPHRAGM; DOWN REGULATION; EXON; GENETIC CONSERVATION; GENETIC SIMILARITY; GENETIC VARIABILITY; HEART MUSCLE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; MOUSE; MUSCLE CELL; MYOBLAST; MYOTUBE; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; NUCLEOTIDE SEQUENCE; PREDICTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA TRANSLATION; SEQUENCE ANALYSIS; SKELETAL MUSCLE; SPECIES DIFFERENCE; STOP CODON; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ACTINS; ALTERNATIVE SPLICING; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CODON, NONSENSE; CYTOPLASM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; MUSCLE, SKELETAL; PROTEIN ISOFORMS; RNA, MESSENGER;

EID: 84887275487     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003743     Document Type: Article

References (34)

1. Erba HP, Gunning P, Kedes L, (1986) Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes. Nucleic Acids Res 14: 5275-5294.
2. Lloyd C, Gunning P, (2002) beta- and gamma-actin genes differ in their mechanisms of down-regulation during myogenesis. J Cell Biochem 84: 335-342.
3. Rubenstein PA, Spudich JA, (1977) Actin microheterogeneity in chick embryo fibroblasts. Proc Natl Acad Sci U S A 74: 120-123.
4. Storti RV, Coen DM, Rich A, (1976) Tissue-specific forms of actin in the developing chick. Cell 8: 521-527.
5. Belyantseva IA, Perrin BJ, Sonnemann KJ, Zhu M, Stepanyan R, et al. (2009) Gamma-actin is required for cytoskeletal maintenance but not development. Proc Natl Acad Sci U S A 106: 9703-9708.
6. Sonnemann KJ, Fitzsimons DP, Patel JR, Liu Y, Schneider MF, et al. (2006) Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy. Dev Cell 11: 387-397.
7. DePonti-Zilli L, Seiler-Tuyns A, Paterson BM, (1988) A 40-base-pair sequence in the 3′ end of the beta-actin gene regulates beta-actin mRNA transcription during myogenesis. Proc Natl Acad Sci U S A 85: 1389-1393.
8. Lewis BP, Green RE, Brenner SE, (2003) Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci U S A 100: 189-192.
9. McGlincy NJ, Smith CW, (2008) Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense? Trends Biochem Sci 33: 385-393.
10. Lareau LF, Green RE, Bhatnagar RS, Brenner SE, (2004) The evolving roles of alternative splicing. Curr Opin Struct Biol 14: 273-282.
11. Zhang Z, Xin D, Wang P, Zhou L, Hu L, et al. (2009) Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay. BMC Biol 7: 23.
12. Casadei L, Vallorani L, Gioacchini AM, Guescini M, Burattini S, et al. (2009) Proteomics-based investigation in C2C12 myoblast differentiation. Eur J Histochem 53: 261-268.
13. Kislinger T, Gramolini AO, Pan Y, Rahman K, MacLennan DH, et al. (2005) Proteome dynamics during C2C12 myoblast differentiation. Mol Cell Proteomics 4: 887-901.
14. Hofmann WA, Arduini A, Nicol SM, Camacho CJ, Lessard JL, et al. (2009) SUMOylation of nuclear actin. J Cell Biol 186: 193-200.
15. Kudryashova E, Kudryashov D, Kramerova I, Spencer MJ, (2005) Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin. Journal of Molecular Biology 354: 413-424.
16. Carter MS, Doskow J, Morris P, Li S, Nhim RP, et al. (1995) A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro. J Biol Chem 270: 28995-29003.
17. Lloyd C, Gunning P, (1993) Noncoding regions of the gamma-actin gene influence the impact of the gene on myoblast morphology. J Cell Biol 121: 73-82.
18. Lamba JK, Adachi M, Sun D, Tammur J, Schuetz EG, et al. (2003) Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. Hum Mol Genet 12: 99-109.
19. Noensie EN, Dietz HC, (2001) A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition. Nat Biotechnol 19: 434-439.
20. Green RE, Lewis BP, Hillman RT, Blanchette M, Lareau LF, et al. (2003) Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes. Bioinformatics 19 Suppl 1: i118-121.
21. Pan Q, Saltzman AL, Kim YK, Misquitta C, Shai O, et al. (2006) Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev 20: 153-158.
22. Melamud E, Moult J, (2009) Stochastic noise in splicing machinery. Nucleic Acids Res 37: 4873-4886.
23. Hyvonen MT, Uimari A, Vepsalainen J, Khomutov AR, Keinanen TA, et al. (2012) Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase. Amino Acids 42: 485-493.
24. De Rosa M, Morelli G, Cesaro E, Duraturo F, Turano M, et al. (2007) Alternative splicing and nonsense-mediated mRNA decay in the regulation of a new adenomatous polyposis coli transcript. Gene 395: 8-14.
25. Urano E, Miyauchi K, Ichikawa R, Futahashi Y, Komano J, (2012) Regulation of cyclin T1 expression and function by an alternative splice variant that skips exon 7 and contains a premature termination codon. Gene 505: 1-8.
26. Ochs MJ, Sorg BL, Pufahl L, Grez M, Suess B, et al. (2012) Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay. PLoS One 7: e31363.
27. Ng SY, Gunning P, Eddy R, Ponte P, Leavitt J, Shows T, Kedes L, (1985) Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes. Mol Cell Biol 5 (10) (): 2720-2732.
28. Kee AJ, Schevzov G, Nair-Shalliker V, Robinson CF, Vrhovski, et al. (2004) Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy. J Cell Biol 166: 685-696.
29. Schevzov G, Fath T, Vrhovski B, Vlahovich N, Rajan S, et al. (2008) Divergent Regulation of the Sarcomere and the Cytoskeleton. J Biol Chem 283: 275-283.
30. Soergel DAW, Lareau LF, Brenner SE (2006) Regulation of Gene Expression by Coupling of Alternative Splicing and NMD. In: Maquat LE, editor. Nonsense-Mediated mRNA Decay. Austin, Tx: Landes Bioscience.
31. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409: 860-921.
32. Lyubimova A, Bershadsky AD, Ben-Ze'ev A, (2000) Autoregulation of actin synthesis requires the 3 ′-UTR of actin mRNA and protects cells from actin overproduction. J Cell Biochem 76: 1-12.
33. Gallego ME, Gattoni R, Stevenin J, Marie J, Expert-Bezancon A, (1997) The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A. EMBO J 16: 1772-1784.
34. Goers ES, Purcell J, Voelker RB, Gates DP, Berglund JA, (2010) MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing. Nucleic Acids Res 38: 2467-2484.