Reassessing the reliability of the salivary cortisol assay for the diagnosis of Cushing syndrome

Journal of International Medical Research

Volumn 41, Issue 5, 2013, Pages 1387-1394

  Zhang, Qian ^a   Dou, Jingtao ^a   Gu, Weijun ^a   Yang, Guoqing ^a   Lu, Juming ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Cushing syndrome; diagnosis; hypercortisolism; midnight cortisol level; pseudo Cushing syndrome

Indexed keywords

HYDROCORTISONE;

CONTROLLED STUDY; CUSHING SYNDROME; CUSHINGOID SYNDROME; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; HORMONE DETERMINATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; MEASUREMENT; RELIABILITY; REPEAT PROCEDURE; REVIEW; SALIVA ANALYSIS; SALIVA LEVEL; SENSITIVITY AND SPECIFICITY;

CUSHING SYNDROME; DIAGNOSIS; HYPERCORTISOLISM; MIDNIGHT CORTISOL LEVEL; PSEUDO-CUSHING SYNDROME;

BIOLOGICAL MARKERS; CIRCADIAN RHYTHM; CUSHING SYNDROME; DATABASES, BIBLIOGRAPHIC; HUMANS; HYDROCORTISONE; LUMINESCENT MEASUREMENTS; RADIOIMMUNOASSAY; REPRODUCIBILITY OF RESULTS; SALIVA; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84887270019     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060513498017     Document Type: Review

References (28)

1. National Organization for Rare Disorders, USA. Cushing syndrome (available at: http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/126/viewFullReport).
2. Raff H,Raff JL,Findling JW.Late-night salivary cortisol as a screening test for Cushing's syndrome.J Clin Endocrinol Metab. 1998;83:2681-2686.
3. Ellis E,Chin PK,Hunt PJ, et al.Is late-night salivary cortisol a better screening test for possible cortisol excess than standard screening tests in obese patients with Type 2 diabetes?.N Z Med J. 2012;125:47-58.
4. Sakihara S,Kageyama K,Oki Y, et al.Evaluation of plasma, salivary, and urinary cortisol levels for diagnosis of Cushing's syndrome.Endocr J. 2010;57:331-337.
5. Carrozza C,Corsello SM,Paragliola RM, et al.Clinical accuracy of midnight salivary cortisol measured by automated electrochemiluminescence immunoassay method in Cushing's syndrome.Ann Clin Biochem. 2010;47:228-232.
6. Raff H.Utility of salivary cortisol measurements in Cushing's syndrome and adrenal insufficiency.J Clin Endocrinol Metab. 2009;94:3647-3655.
7. Erickson D,Singh RJ,Sathananthan A, et al.Late-night salivary cortisol for diagnosis of Cushing's syndrome by liquid chromatography/tandem mass spectrometry assay.Clin Endocrinol (Oxf). 2012;76:467-472.
8. León-Justel A,Mangas MA,Infante Fontán R, et al.Budget impact of using midnight salivary cortisol in the diagnosis of hypercortisolism.Clin Chim Acta. 2011;412:2248-2253.
9. Friedman TC,Ghods DE,Shahinian HK, et al.High prevalence of normal tests assessing hypercortisolism in subjects with mild and episodic Cushing's syndrome suggests that the paradigm for diagnosis and exclusion of Cushing's syndrome requires multiple testing.Horm Metab Res. 2010;42:874-881.
10. Mullan K,Black N,Thiraviaraj A, et al.Is there value in routine screening for Cushing's syndrome in patients with diabetes?.J Clin Endocrinol Metab. 2010;95:2262-2265.
11. Gagliardi L,Chapman IM,O'Loughlin P, et al.Screening for subclinical Cushing's syndrome in type 2 diabetes mellitus: low false-positive rates with nocturnal salivary cortisol.Horm Metab Res. 2010;42:280-284.
12. Beko G,Varga I,Glaz E, et al.Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods.Clin Chim Acta. 2010;411:364-367.
13. Carroll T,Raff H,Findling JW.Late-night salivary cortisol for the diagnosis of Cushing syndrome: a meta-analysis.Endocr Pract. 2009;15:335-342.
14. Ludescher B,Leitlein G,Schaefer JE, et al.Changes of body composition in bulimia nervosa: increased visceral fat and adrenal gland size.Psychosom Med. 2009;71:93-97.
15. Nunes ML,Vattaut S,Corcuff JB, et al.Late-night salivary cortisol for diagnosis of overt and subclinical Cushing's syndrome in hospitalized and ambulatory patients.J Clin Endocrinol Metab. 2009;94:456-462.
16. Cardoso EM,Arregger AL,Tumilasci OR, et al.Diagnostic value of salivary cortisol in Cushing's syndrome (CS).Clin Endocrinol (Oxf). 2009;70:516-521.
17. Nieman LK,Biller BM,Findling JW, et al.The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.J Clin Endocrinol Metab. 2008;93:1526-1540.
18. Kidambi S,Raff H,Findling JW.Limitations of nocturnal salivary cortisol and urine free cortisol in the diagnosis of mild Cushing's syndrome.Eur J Endocrinol. 2007;157:725-731.
19. Baid SK,Sinaii N,Wade M, et al.Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism.J Clin Endocrinol Metab. 2007;92:3102-3107.
20. Yaneva M,Mosnier-Pudar H,Dugué MA, et al.Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes.J Clin Endocrinol Metab. 2004;89:3345-3351.
21. Papanicolaou DA,Mullen N,Kyrou I, et al.Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome.J Clin Endocrinol Metab. 2002;87:4515-4521.
22. Putignano P,Toja P,Dubini A, et al.Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing's syndrome.J Clin Endocrinol Metab. 2003;88:4153-4157.
23. Viardot A,Huber P,Puder JJ, et al.Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test.J Clin Endocrinol Metab. 2005;90:5730-5736.
24. Zerikly RK,Amiri L,Faiman C, et al.Diagnostic characteristics of late-night salivary cortisol using liquid chromatography-tandem mass spectrometry.J Clin Endocrinol Metab. 2010;95:4555-4559.
25. Newell-Price J,Trainer P,Perry L, et al.A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome.Clin Endocrinol (Oxf). 1995;43:545-550.
26. Bornstein SR.Predisposing factors for adrenal insufficiency.New Engl J Med. 2009;360:2328-2339.
27. Arnaldi G,Angeli A,Atkinson AB, et al.Diagnosis and complications of Cushing's syndrome: a consensus statement.J Clin Endocrinol Metab. 2003;88:5593-5602.
28. Yanovski JA,Cutler GB.Glucocorticoid action and the clinical features of Cushing syndrome.Endocrinol Metab Clin North Am. 1994;23:487-509.