Porcine endogenous retrovirus infection changes the expression of inflammation-related genes in lipopolysaccharide-stimulated human dermal fibroblasts

Annals of Transplantation

Volumn 18, Issue 1, 2013, Pages 576-586

  Kimsa, Magdalena C ^a   Strzałka Mrozik, Barbara ^a   Kimsa, Małgorzata W ^a   Kruszniewska Rajs, Celina ^a   Gola, Joanna ^a   Adamska, Jolanta ^a   Rajs, Antoni ^a   Mazurek, Urszula ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Inflammation; Lipopolysaccharide; Oligonucleotide microarray; Porcine endogenous retrovirus; Quantitative PCR; Xenotransplantation

Indexed keywords

BETA1 INTERFERON; BETA1A INTERFERON; CHEMOKINE RECEPTOR CXCR2; DEATH RECEPTOR 3; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 12P35; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 25; INTERLEUKIN 27; INTERLEUKIN 32; INTERLEUKIN 33; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENDOGENOUS RETROVIRUS; FLUORESCENCE; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; MICROARRAY ANALYSIS; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RETROVIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; UPREGULATION; VIRUS INFECTIVITY; VIRUS LOAD;

ANIMALS; DNA, VIRAL; ENDOGENOUS RETROVIRUSES; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; RETROVIRIDAE INFECTIONS; SWINE;

EID: 84887250423     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: 10.12659/AOT.889310     Document Type: Article

References (54)

1. Mueller NJ, Takeuchi Y, Mattiuzzo G, Scobie L: Microbial safety in xenotransplantation. Curr Opin Organ Transplant, 2011; 16: 201-6
2. Costa Vallés C, Máñez Mendiluce R: Transgenic organs and xenotransplants. Adv Exp Med Biol, 2012; 741: 73-88
3. Scalea J, Hanecamp I, Robson SC, Yamada K: T-cell-mediated immunological barriers to xenotransplantation. Xenotransplantation, 2012; 19: 23-30
4. Cooper DK: A brief history of cross-species organ transplantation. Proc (Bay Univ Med Cent), 2012; 25: 49-57
5. Liu G, Li Z, Pan M et al: Genetic prevalence of porcine endogenous retrovirus in Chinese experimental miniature pigs. Transplant Proc, 2011; 43: 2762-69
6. Bartosch B, Stefanidis D, Myers R et al: Evidence and consequence of porcine endogenous retrovirus recombination. J Virol, 2004; 78: 13880-90
7. Feghali CA, Wright TM: Cytokines in acute and chronic inflammation. Front Biosci, 1997; 2: d12-26
8. Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S: The pro-and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta, 2011; 1813: 878-88
9. Leeson MC, Fujihara Y, Morrison DC: Evidence for lipopolysaccharide as the predominant proinflammatory mediator in supernatants of antibiotic-treated bacteria. Infect Immun, 1994; 62: 4975-80
10. Tardif F, Ross G, Rouabhia M: Gingival and dermal fibroblasts produce interleukin-1 beta converting enzyme and interleukin-1 beta but not interleukin-18 even after stimulation with lipopolysaccharide. J Cell Physiol, 2004; 198: 125-32
11. Antal-Szalmás P: Evaluation of CD14 in host defence. Eur J Clin Invest, 2000; 30: 167-79
12. Tabeta K, Yamazaki K, Akashi S et al: Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts. Infect Immun, 2000; 68: 3731-35
13. Putnins EE, Sanaie A, Wu Q, Firth JD: Induction of Keratinocyte Growth Factor 1 Expression by Lipopolysaccharide Is Regulated by CD-14 and Toll-Like Receptors 2 and 4. Infect Immun, 2002; 70: 6541-48
14. Wang J, Hori K, Ding J et al: Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. J Cell Physiol, 2011; 226: 1265-73
15. Sorrell JM, Caplan AI: Fibroblast heterogeneity: more than skin deep. Cell Sci, 2004; 117: 667-75
16. Sorrell JM, Caplan AI: Fibroblasts-a diverse population at the center of it all. Int Rev Cell. Mol Biol, 2009; 276: 161-214
17. Smith RS, Smith TJ, Blieden TM, Phipps RP: Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol, 1997; 151(2): 317-22
18. Saalbach A, Klein C, Sleeman J et al: Dermal fibroblasts induce maturation of dendritic cells. J Immunol, 2007; 178(8): 4966-74
19. Garkavenko O, Croxson MC, Irgang M J et al: Monitoring for Presence of Potentially Xenotic Viruses in Recipients of Pig Islet Xenotransplantation. J Clin Microbiol, 2004; 42: 5353-56
20. Wang HH, Wang YJ, Liu HL et al: Detection of PERV by polymerase chain reaction and its safety in bioartificial liver support system. World J Gastroenterol, 2006; 12: 1287-91
21. Specke V, Tacke SJ, Boller K et al: Porcine endogenous retroviruses: in vitro host range and attempts to establish small animal models. J Gen Virol, 2001; 82: 837-44
22. Li Z, Ping Y, Shengfu L et al: Variation of host cell tropism of porcine endogenous retroviruses expressed in chinese Banna minipig inbred. Intervirology, 2006; 49: 185-91
23. Cyganek-Niemiec A, Strzalka-Mrozik B, Pawlus-Lachecka L et al: Degradation effect of diepoxide fixation on porcine endogenous retrovirus DNA in heart valves: molecular aspects. Int J Artif Organs, 2012; 35: 25-33
24. Kimsa M, Strzalka-Mrozik B, Kimsa M et al: Quantitative estimation of porcine endogenous retrovirus release from PK15 cells. Pol J Microbiol, 2012; 61: 211-15
25. Strzalka-Mrozik B, Stanik-Walentek A, Kapral M et al: Differential expression of transforming growth factor-b isoforms in bullous keratopathy corneas. Mol Vis, 2010; 16: 161-66
26. Yoo D, Giulivi A: Xenotransplantation and the potential risk of xenogeneic transmission of porcine viruses. Can J Vet Res, 2000; 64: 193-203
27. Denner J: Porcine endogenous retroviruses (PERVs) and xenotransplantation: screening for transmission in several clinical trials and in experimental models using non-human primates. Ann Transplant, 2003; 8(3): 39-48
28. Sypniewski D, Bednarek I, Matczyńska D et al: Modulation of porcine endogenous retroviruses (PERVs) expression in vitro by shRNA in the presence of cyclosporine A and dexamethasone. Ann Transplant, 2012; 17(4): 92-107
29. Jónsson SR, LaRue RS, Stenglein MD et al: The restriction of zoonotic PERV transmission by human APOBEC3G. PLoS One, 2007; 2(9): e893
30. Takeuchi Y, Patience C, Magre S et al: Host Range and Interference Studies of Three Classes of Pig Endogenous Retrovirus. J Virol, 1998; 72: 9986-91
31. Blusch JH, Patience C, Takeuchi Y et al: Infection of Nonhuman Primate Cells by Pig Endogenous Retrovirus. J Virol, 2000; 74: 7687-90
32. Patience C, Takeuchi Y, Weiss RA: Infection of human cells by an endogenous retrovirus of pigs. Nat Med, 1997; 3: 282-86
33. Kim JH, Choi EY, Jung ES et al: Characterization of Clones of Human Cell Line Infected with Porcine Endogenous Retrovirus (PERV) from Porcine Cell Line, PK15. Infect Chemother, 2009; 41: 1-8
34. Coussens LM, Werb Z: Inflammation and Cancer. Nature, 2002; 420: 860-67
35. Tisato V, Cozzi E: Xenotransplantation: an overview of the field. Methods Mol Biol, 2012; 885: 1-16
36. Nagler A, Or R, Nisman B et al: Elevated inflammatory cytokine levels in bone marrow graft rejection. Transplantation, 1995; 60: 943-48
37. Holzknecht ZE, Platt JL: The fine cytokine line between graft acceptance and rejection. Nat Med, 2000; 6: 497-98
38. Krieg AM, Gourley MF, Klinman DM et al: Heterogeneous expression and coordinate regulation of endogenous retroviral sequences in human peripheral blood mononuclear cells. AIDS Res Hum Retroviruses, 1992; 8: 1991-98
39. Larsson E, Venables P, Andersson AC et al: Tissue and differentiation specific expression on the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line. Leukemia, 1997; 11: 142-44
40. Fishman JA, Rubin RH: Infection in organtransplant recipients. N Engl J Med, 1998; 338: 1741-51
41. Simard S, Maurais E, Gilbert C, Tremblay MJ: LPS reduces HIV-1 replication in primary human macrophages partly through an endogenous production of type I interferons. Clin Immunol, 2008; 127(2): 198-205
42. Kornbluth RS, Oh PS, Munis JR et al: Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro. J Exp Med, 1989; 169(3): 1137-51
43. Doyle S, Vaidya S, O'Connell R et al: IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity, 2002; 17(3): 251-63
44. Kedzierska K, Crowe SM, Turville S, Cunningham AL: The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages. Rev Med Virol, 2003; 13(1): 39-56
45. Brenchley JM, Price DA, Schacker TW et al: Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med, 2006; 12 (12): 1365-71
46. Cunningham DA, Dos Santos Cruz GJ, Fernández-Suárez XM et al: Activation of primary porcine endothelial cells induces release of porcine endogenous retroviruses. Transplantation, 2004; 77: 1071-79
47. McIntyre MC, Kannan B, Solano-Aguilar GI et al: Detection of porcine endogenous retrovirus in cultures of freshly isolated porcine bone marrow cells. Xenotransplantation, 2003; 10: 337-42
48. Wolf J, Weinberger B, Arnold CR et al: The effect of chronological age on the inflammatory response of human fibroblasts. Exp Gerontol, 2012; 47: 749-53
49. Diaz JA, Booth AJ, Lu G et al: Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant, 2009; 9: 1773-83
50. Zhao X, Boenisch O, Yeung M et al: Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance. Am J Transplant, 2012; 12: 90-101
51. Saethre M, Schneider MK, Lambris JD et al: Cytokine secretion depends on Galalpha(1,3) Gal expression in a pig-to-human whole blood model. J Immunol, 2008; 180: 6346-53
52. Chae JI, Shim JH, Lee KS et al: Downregulation of immune response by the human cytokines Interleukin-32 alpha and beta in cell-mediated rejection. Cell Immunol, 2010; 264: 47-53
53. Santoni FA, Hartley O, Luban J: Deciphering the code for retroviral integration target site selection. PLoS Comput Biol, 2010; 6: e1001008
54. Moalic Y, Blanchard Y, Félix H, Jestin A: Porcine endogenous retrovirus integration sites in the human genome: features in common with those of murine leukemia virus. J Virol, 2006; 80: 10980-88