Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes

Environmental Toxicology and Pharmacology

Volumn 36, Issue 3, 2013, Pages 1253-1260

  Ko, Seok Chun ^a   Lee, Myoungsook ^b   Lee, Ji Hyeok ^a   Lee, Seung Hong ^c   Lim, Yunsook ^d   Jeon, You Jin ^a,e  

^a Jeju National University   (South Korea)

^b Sungshin Women's University   (South Korea)

^c Konkuk University   (South Korea)

^d Kyung Hee University   (South Korea)

^e Aqua Green Technology Co Ltd   (South Korea)

Author keywords

3T3 L1 preadipocytes; Adipogenesis; AMPK; Diekol; Ecklonia cava

Indexed keywords

ALGAL EXTRACT; CCAAT ENHANCER BINDING PROTEIN ALPHA; DIECKOL; FATTY ACID BINDING PROTEIN 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHLOROTANNIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ADIPOGENESIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; ECKLONIA CAVA; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; ISHIGE OKAMURAE; LIPID COMPOSITION; LIPID STORAGE; PADINA ARBORESCENS; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SARGASSUM THUNBERGII; SEAWEED; SIGNAL TRANSDUCTION; UNDARIA WRIGHTII; WESTERN BLOTTING;

3T3-L1 PREADIPOCYTES; ADIPOGENESIS; AMPK; DIEKOL; ECKLONIA CAVA;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; AZO COMPOUNDS; BENZOFURANS; BLOTTING, WESTERN; CELL DIFFERENTIATION; COLORING AGENTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FREEZE DRYING; MICE; PHAEOPHYTA; REAL-TIME POLYMERASE CHAIN REACTION; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84887227981     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2013.10.011     Document Type: Article

References (34)

1. An L., Pang Y.W., Gao H.M., Tao L., Miao K., Wu Z.H., Tian J.H. Heterologous expression of C. elegans fat-1 decreases the n-6/n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells. Biochem. Biophys. Res. Commun. 2012, 428:405-410.
2. Ahn J., Lee H., Kim S., Park J., Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem. Biophys. Res. Commun. 2008, 373:545-549.
3. 2-mediated DNA damage. Eur. Food Res. Technol. 2007, 226:71-79.
4. Evans M., Lin X., Odle J., MCIntosh M. Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. J. Nutr. 2002, 132:450-455.
5. Farmer S.R. Regulation of PPARγ activity during adipogenesis. Int. J. Obes. 2005, 29:13-16.
6. Ghosh C., Chung H.Y., Nandre R.M., Lee J.H., Jeon T.I., Kim I.S., Yang S.H., Hwang S.G. An active extract of Ulmuspumila inhibits adipogenesis through regulation of cell cycle progression in 3T3-L1 cells. Food Chem. Toxicol. 2012, 50:2009-2015.
7. Giri S., Rattan R., Haq E., Khan M., Yasmin R., Won J.S., Key L., Singh A.K., Singh I. AICAR inhibits adipocyte differentiation in 3T3-L1 and restores metabolic alteractions in diet-induced obesity mice model. Nutr. Metab. 2006, 3:31-50.
8. Guo X., Liao K. Analysis of gene expression profile during 3T3-L1 preadipocyte differentiation. Gene 2000, 251:45-53.
9. Ha D.H., Trung T.H., Phuong T.T., Yim N., Chen Q.C., Bae K.H. The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells. Bioorg. Med. Chem. Lett. 2010, 20:6076-6081.
10. Heo S.J., Park E.J., Lee K.W., Jeon Y.J. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour. Technol. 2005, 96:613-1623.
11. Halliwell B., Gutteridge J.M.C. Antioxidant defenses. Free Radicals in Biology and Medicine 1999, 105-199. Oxford Science Publications, Oxford. B. Halliwell, J.M.C. Gutteridge (Eds.).
12. Herberg L., Doppen W., Major E., Gries F.A. Dietary-induced hypertrophic-hyperplastic obesity mice. J. Lipid Res. 1974, 15:580-585.
13. Jeon T., Hwang S.G., Hirai S., Matsui T., Yano H., Kawada T., Lim B.O., Park D.K. Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sci. 2004, 17:3195-3203.
14. Kang M.C., Ahn G., Yang X., Kim K.N., Kang S.M., Lee S.H., Ko S.C., Ko J.Y., Kim D., Kim Y.T., Jee Y., Park S.J., Jeon Y.J. Hepatoprotective effects of dieckol-rich phlrorotannins from Eckonia cava, brown seaweed, against ethanol induced liver damage in BALB/c mice. Food Chem. Toxicol. 2012, 50:1986-1991.
15. Kang M.C., Wijesinghe W.A.J.P., Lee S.H., Kang S.M., Ko S.C., Yang X., Kang N., Jeon B.T., Kim J., Jeon Y.J. Dieckol isolated from brown seaweed Ecklonia cava attenuates type II diabetes in db/db mouse model. Food Chem. Toxicol. 2013, 53:294-298.
16. Kang S.I., Ko H.C., Shin H.S., Kim H.M., Hong Y.S., Lee N.H., Kim S.J. Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes. Biochem. Biophys. Res. Commun. 2011, 409:769-774.
17. Kim C.K., Kim M., Oh S.D., Lee S.M., Sun B.G.S., Choi G.S., Kim S.K., Bae H., Kang C., Min B.I. Effects of Atractylodes macrocephala Koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity. J. Ethnopharmacol. 2011, 137:396-402.
18. Kim S.K., Kong C.S. Anti-adipogenic effect of dioxinodehydoeckol via AMPK activation in 3T3-L1 adipocytes. Chem. Biol. Interact. 2010, 186:24-29.
19. Kim K.J., Lee O.H., Lee B.Y. Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes. Life Sci. 2010, 86:791-797.
20. Kang K.A., Lee K.H., Chae S., Zhang R., Jung M.S., Lee Y., Kim S.Y., Kim H.S., Joo H.G., Park J.W., Ham Y.M., Lee N.H., Hyun J.W. Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. FEBS Lett. 2005, 579:6295-6304.
21. Kessler R.C., Davis R.B., Foster D.F., Van Rompay M.I., Walters E.E., Wilkey S.A., Kaptchuk T.J., Eisenberg D.M. Long-term trends in the use of complementary and alternative medical therapies in the United States. Ann. Intern. Med. 2001, 135:262-268.
22. Lee S.H., Park M.H., Heo S.J., Kang S.M., Ko S.C., Han J.S., Jeon Y.J. Dieckol isolated from Ecklonia cava inhibits glucosidase and amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. Food Chem. Toxicol. 2010, 48:2633-2637.
23. Lee Y.K., Lee W.S., Hwang J.T., Kwon D.Y., Surh Y.J., Park O.J. Curcumin exerts antidifferentiation effect through AMPKα-PPARγ in 3T3-L1 adipocytes and antiproliferatory effect through AMPKα-COX-2 in cancer cells. J. Agric. Food Chem. 2009, 57:305-310.
24. Lieberman L.S. Dietary, evolutionary, and modernizing influences on the prevalence of type 2 diabetes. Eur. J. Pharmacol. 2003, 659:193-198.
25. Moon H.S., Lee H.G., Choi Y.J., Kim T.G., Cho C.S. Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity. Chem. Biol. Interact. 2007, 167:85-98.
26. Nakayama T., Takahashi M., Fukuyama Y., Kinzyo Z. An anti-plasmin inhibitor, eckol, isolated from the brown alga Ecklonia kurome OKAMURA. Agric. Biol. Chem. 1989, 63:3025-3030.
27. Otto T.C., Lane M.D. Adipose development: from stem cell to adipocyte. Crit. Rev. Biochem. Mol. Biol. 2005, 40:22-242.
28. Sakurai N., Mochizuki K., Kameji H., Shimada M., Goda T. (-)-Epigallocatechin gllate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation. Nutrition 2009, 25:1047-1056.
29. Sugiura Y., Matsuda K., Yamada Y., Nishikawa M., Shioya K., Katsuzaki H., Imai K., Amano H. Isolation of a new anti-allergic phlorotannin, phlorofucofuroeckol-B, from an edible brown alga, Eiseniaarborea. Biosci. Biotechnol. Biochem. 2006, 70:2807-2811.
30. Unger R.H. The hyperleptinemia of obesity-regulator of caloric surpluses. Cell 2004, 117:145-146.
31. Wijesinghe W.A.J.P., Ko S.C., Jeon Y.J. Effect of phlorotannins isolated from Ecklonia cava on antiotensin I-converting enzyme (ACE) inhibitory activity. Nutr. Res. Pract. 2011, 5:93-100.
32. White U.A., Stephens J.M. Transcriptional factors that promote formation of white adipose tissue. Mol. Cell Endocrinol. 2010, 318:10-14.
33. Winder W.W., Thomson D.M. Cellular energy sensing and signaling by AMP-activated protein kinase. Cell Biochem. Biophys. 2007, 47:332-347.
34. Wang Y.W., Jones P.J. Conjugated linolic acid and obesity control: efficacy and mechanisms. Int. Obes. Relat. Metab. Disord. 2004, 28:941-955.