Negative regulation of the peptidylarginine deiminase type IV promoter by NF-κB in human myeloid cells

Gene

Volumn 533, Issue 1, 2014, Pages 123-131

  Abbas, Ali K ^a   Le, Kevin ^a   Pimmett, Virginia L ^a   Bell, David A ^a   Cairns, Ewa ^a   DeKoter, Rodney P ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

Arthritis; Autoimmune diseases; DNA transcription; Neutrophil; NF B transcription factor; Protein citrullination

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; PEPTIDYLARGININE DEIMINASE TYPE IV; PROTEIN ARGININE DEIMINASE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOINFORMATICS; BIOLOGICAL ACTIVITY; BONE MARROW CELL; CELL LINEAGE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PHYLOGENY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

5′ RACE; 5′ RAPID AMPLIFICATION OF CDNA ENDS; ACPA; ANTI-CITRULLINATED PROTEIN/PEPTIDE ANTIBODY; ARTHRITIS; AUTOIMMUNE DISEASES; CHIP; CHROMATIN IMMUNOPRECIPITATION; DNA TRANSCRIPTION; EDTA; ETHYLENEDIAMINETETRAACETIC ACID; GAPDH; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE; IGG; IL8; IMMUNOGLOBULIN G; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LPS; NET; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP; NF-ΚB; NF-ΚB TRANSCRIPTION FACTOR; NUCLEAR FACTOR-KAPPA B; PAD4; PEPTIDYLARGININE DEIMINASE TYPE IV; PROTEIN CITRULLINATION; RA; REVERSE TRANSCRIPTASE QUANTITATIVE POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RT-QPCR; SDS; SODIUM DODECYL SULFATE; TNF-Α; TUMOR NECROSIS FACTOR ALPHA;

ANIMALS; BASE SEQUENCE; BINDING SITES; CHROMATIN IMMUNOPRECIPITATION; DNA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HL-60 CELLS; HUMANS; HYDROLASES; MICE; MOLECULAR SEQUENCE DATA; MYELOID CELLS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 84887223289     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.09.108     Document Type: Article

References (46)

1. Arita K., Hashimoto H., Shimizu T., Nakashima K., Yamada M., Sato M. Structural basis for Ca(2+)-induced activation of human PAD4. Nat. Struct. Mol. Biol. 2004, 11:777-783.
2. Asaga H., Nakashima K., Senshu T., Ishigami A., Yamada M. Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils. J. Leukoc. Biol. 2001, 70:46-51.
3. Barton A., et al. A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. Arthritis Rheum. 2004, 50:1117-1121.
4. Bax M., van Heemst J., Huizinga T.W., Toes R.E. Genetics of rheumatoid arthritis: what have we learned?. Immunogenetics 2011, 63:459-466.
5. Bonizzi G., Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004, 25:280-288.
6. Brink M., et al. Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum. 2013, 65:899-910.
7. Brinkmann V., et al. Neutrophil extracellular traps kill bacteria. Science 2004, 303:1532-1535.
8. Cao S., Zhang X., Edwards J.P., Mosser D.M. NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J. Biol. Chem. 2006, 281:26041-26050.
9. Chang X., et al. Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis. Rheumatology (Oxford) 2005, 44:40-50.
10. Chen F.E., Kempiak S., Huang D.B., Phelps C., Ghosh G. Construction, expression, purification and functional analysis of recombinant NFκB p50:p65 heterodimer. Protein Eng. 1999, 12:423-428.
11. Elsharkawy A.M., Oakley F., Lin F., Packham G., Mann D.A., Mann J. The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. J. Hepatol. 2010, 53:519-527.
12. + T cells. J. Biol. Chem. 2004, 279:8460-8468.
13. Guolong Z., Ghosh S. Molecular mechanisms of NF-B activation induced by bacterial lipopolysaccharide through Toll-like receptors. J. Endotoxin Res. 2000, 6:453-457.
14. Harney S.M., Meisel C., Sims A.M., Woon P.Y., Wordsworth B.P., Brown M.A. Genetic and genomic studies of PADI4 in rheumatoid arthritis. Rheumatology (Oxford) 2005, 44:869-872.
15. Hemmers S., Teijaro J.R., Arandjelovic S., Mowen K.A. PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection. PLoS ONE 2011, 6:10.
16. Israël A., et al. TNF Stimulates Expression of Mouse MHC Class I Genes 1989.
17. Iwamoto T., et al. Association between PADI4 and rheumatoid arthritis: a meta-analysis. Rheumatology (Oxford) 2006, 45:804-807.
18. Jawaheer D., et al. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am. J. Hum. Genet. 2001, 68:927-936.
19. Kang H.B., Kim Y.E., Kwon H.J., Sok D.E., Lee Y. Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3. Stem Cells Dev. 2007, 16:615-623.
20. Kolfenbach J.R., et al. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis Rheum. 2010, 62:2633-2639.
21. Kuryłowicz A., Nauman J. The role of nuclear factor-κB in the development of autoimmune diseases: a link between genes and environment. Acta Biochim. Pol. 2008, 55:629-647.
22. Lapponi M.J., et al. Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 2013, 345:430-437.
23. Li Q., Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2002, 2:725-734.
24. Li P., Li M., Lindberg M.R., Kennett M.J., Xiong N., Wang Y. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 2010, 207:1853-1862.
25. Liu Y.L., Chiang Y.H., Liu G.Y., Hung H.C. Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4). PLoS ONE 2011, 6:e21314.
26. Loots G.G. Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons. Science 2000, 288:136-140.
27. Loots G.G., Ovcharenko I., Pachter L., Dubchak I., Rubin E.M. rVista for comparative sequence-based discovery of functional transcription factor binding sites. Genome Res. 2002, 12:832-839.
28. Lundberg K., et al. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res. Ther. 2005, 7:R458-R467.
29. Oeckinghaus A., Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb. Perspect. Biol. 2009, 1:a000034.
30. Plaksin D., Baeuerle P.A., Eisenbach L. KBF1 (p50 NF-kB homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells. J. Exp. Med. 1993, 177:1651-1662.
31. Rantapaa-Dahlqvist S., et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003, 48:2741-2749.
32. Rohrbach A.S., Slade D.J., Thompson P.R., Mowen K.A. Activation of PAD4 in NET formation. Front. Immunol. 2012, 3:360.
33. Suzuki A., et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat. Genet. 2003, 34:395-402.
34. Suzuki A., Yamada R., Yamamoto K. Citrullination by peptidylarginine deiminase in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 2007, 1108:323-339.
35. Tak P.P., Firestein G.S. NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 2001, 107:7-11.
36. Udalova I.A., Mott R., Field D., Kwiatkowski D. Quantitative prediction of NF-kappa B DNA-protein interactions. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:8167-8172.
37. Urban C.F., Reichard U., Brinkmann V., Zychlinsky A. Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. Cell. Microbiol. 2006, 8:668-676.
38. van Boekel M.A., Vossenaar E.R., van den Hoogen F.H., van Venrooij W.J. Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res. 2002, 4:87-93.
39. van Gaalen F.A., et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum. 2004, 50:709-715.
40. Vossenaar E.R. Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann. Rheum. Dis. 2004, 63:373-381.
41. Vossenaar E.R., et al. Citrullination of synovial proteins in murine models of rheumatoid arthritis. Arthritis Rheum. 2003, 48:2489-2500.
42. Wang Y., et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 2004, 306:279-283.
43. Wang Y., et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J. Cell Biol. 2009, 184:205-213.
44. Wegner N., et al. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol. Rev. 2010, 233:34-54.
45. Willis V.C., et al. N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J. Immunol. 2011, 186:4396-4404.
46. Wong D., et al. Extensive characterization of NF-kappaB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits. Genome Biol. 2011, 12:R70.