Screening a peptide library by DSC and SAXD: Comparison with the biological function of the parent proteins

PLoS ONE

Volumn 4, Issue 2, 2009, Pages

  Pérez Berná, Ana J ^a   Pabst, George ^b   Laggner, Peter ^b   Villalaín, José ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN E1; GLYCOPROTEIN E2; MEMBRANE FUSION PROTEIN; PEPTIDE LIBRARY; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN P7;

AMINO ACID SEQUENCE; ARTICLE; BUDDING; CELL VIABILITY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; FEASIBILITY STUDY; HEPATITIS C VIRUS; INTERMETHOD COMPARISON; NONHUMAN; PEPTIDE ANALYSIS; PHASE TRANSITION; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

HEPATITIS C VIRUS;

EID: 84887212411     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004356     Document Type: Article

References (42)

1. Chen SL, Morgan TR (2006) The natural history of hepatitis C virus (HCV) infection. Int J Med Sci 3: 47-52.
2. Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM (2004) Structural biology of hepatitis C virus. Hepatology 39: 5-19.
3. Tan SL, Pause A, Shi Y, Sonenberg N (2002) Hepatitis C therapeutics: current status and emerging strategies. Nat Rev Drug Discov 1: 867-881.
4. Qureshi SA (2007) Hepatitis C virus-biology, host evasion strategies, and promising new therapies on the horizon. Med Res Rev 27: 353-373.
5. Vauloup-Fellous C, Pene V, Garaud-Aunis J, Harper F, Bardin S, et al. (2006) Signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding but destabilizes the viral capsid. J Biol Chem 281: 27679-27692.
6. Pozzetto B, Bourlet T, Grattard F, Bonnevial L (1996) Structure, genomic organization, replication and variability of hepatitis C virus. Nephrol Dial Transplant 11 Suppl 4: 2-5.
7. Cha TA, Beall E, Irvine B, Kolberg J, Chien D, et al. (1992) At least five related, but distinct, hepatitis C viral genotypes exist. Proc Natl Acad Sci U S A 89: 7144-7148.
8. Lee SK, Park SO, Joe CO, Kim YS (2007) Interaction of HCV core protein with 14-3-3epsilon protein releases Bax to activate apoptosis. Biochem Biophys Res Commun 352: 756-762.
9. Irshad M, Dhar I (2006) Hepatitis C virus core protein: an update on its molecular biology, cellular functions and clinical implications. Med Princ Pract 15: 405-416.
10. Kunkel M, Watowich SJ (2004) Biophysical characterization of hepatitis C virus core protein: implications for interactions within the virus and host. FEBS Lett 557: 174-180.
11. Boulant S, Vanbelle C, Ebel C, Penin F, Lavergne JP (2005) Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features. J Virol 79: 11353-11365.
12. Bartosch B, Dubuisson J, Cosset FL (2003) Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J Exp Med 197: 633-642.
13. Op De Beeck A, Montserret R, Duvet S, Cocquerel L, Cacan R, et al. (2000) The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerization. J Biol Chem 275: 31428-31437.
14. Garry RF, Dash S (2003) Proteomics computational analyses suggest that hepatitis C virus E1 and pestivirus E2 envelope glycoproteins are truncated class II fusion proteins. Virology 307: 255-265.
15. Sakai A, Claire MS, Faulk K, Govindarajan S, Emerson SU, et al. (2003) The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences. Proc Natl Acad Sci U S A 100: 11646-11651.
16. Gonzalez ME, Carrasco L (2003) Viroporins. FEBS Lett 552: 28-34.
17. Steinmann E, Penin F, Kallis S, Patel AH, Bartenschlager R, et al. (2007) Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions. PLoS Pathog 3: e103.
18. Griffin SD, Beales LP, Clarke DS, Worsfold O, Evans SD, et al. (2003) The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett 535: 34-38.
19. Patargias G, Zitzmann N, Dwek R, Fischer WB (2006) Protein-protein interactions: modeling the hepatitis C virus ion channel p7. J Med Chem 49: 648-655.
20. Carrere-Kremer S, Montpellier-Pala C, Cocquerel L, Wychowski C, Penin F, et al. (2002) Subcellular localization and topology of the p7 polypeptide of hepatitis C virus. J Virol 76: 3720-3730.
21. Perez-Berna AJ, Guillen J, Moreno MR, Bernabeu A, Pabst G, et al. (2008) Identification of the Membrane-active Regions of Hepatitis C Virus p7 Protein: BIOPHYSICAL CHARACTERIZATION OF THE LOOP REGION. J Biol Chem 283: 8089-8101.
22. Perez-Berna AJ, Veiga AS, Castanho MA, Villalain J (2008) Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2. J Viral Hepat 15: 346-356.
23. Perez-Berna AJ, Moreno MR, Guillen J, Bernabeu A, Villalain J (2006) The membrane-active regions of the hepatitis C virus E1 and E2 envelope glycoproteins. Biochemistry 45: 3755-3768.
24. Epand RM, Epand RF, Martin I, Ruysschaert JM (2001) Membrane interactions of mutated forms of the influenza fusion peptide. Biochemistry 40: 8800-8807.
25. Sapir A, Avinoam O, Podbilewicz B, Chernomordik LV (2008) Viral and developmental cell fusion mechanisms: conservation and divergence. Dev Cell 14: 11-21.
26. Perez-Fons L, Aranda FJ, Guillen J, Villalain J, Micol V (2006) Rosemary (Rosmarinus officinalis) diterpenes affect lipid polymorphism and fluidity in phospholipid membranes. Arch Biochem Biophys 453: 224-236.
27. Rappolt M, Hodzic A, Sartori B, Ollivon M, Laggner P (2008) Conformational and hydrational properties during the L(beta)- to L(alpha)- and L(alpha)- to H(II)-phase transition in phosphatidylethanolamine. Chem Phys Lipids.
28. Epand RM (1998) Lipid polymorphism and protein-lipid interactions. Biochim Biophys Acta 1376: 353-368.
29. Luzzati V, Tardieu A, Gulik-Krzywicki T (1968) Polymorphism of lipids. Nature 217: 1028-1030.
30. Killian JA, de Kruijff B (1985) Importance of hydration for gramicidin-induced hexagonal HII phase formation in dioleoylphosphatidylcholine model membranes. Biochemistry 24: 7890-7898.
31. Pabst G (2006) Global properties of biomimetic membranes: Perspectives on molecular features. Biophysical Reviews and Letters 1: 57-84.
32. Kielian M, Rey FA (2006) Virus membrane-fusion proteins: more than one way to make a hairpin. Nat Rev Microbiol 4: 67-76.
33. Schibli DJ, Weissenhorn W (2004) Class I and class II viral fusion protein structures reveal similar principles in membrane fusion. Mol Membr Biol 21: 361-371.
34. Peisajovich SG, Shai Y (2003) Viral fusion proteins: multiple regions contribute to membrane fusion. Biochim Biophys Acta 1614: 122-129.
35. Chernomordik LV, Kozlov MM (2003) Protein-lipid interplay in fusion and fission of biological membranes. Annu Rev Biochem 72: 175-207.
36. Chernomordik LV, Zimmerberg J, Kozlov MM (2006) Membranes of the world unite! J Cell Biol 175: 201-207.
37. Bartosch B, Cosset FL (2006) Cell entry of hepatitis C virus. Virology 348: 1-12.
38. Helle F, Goffard A, Morel V, Duverlie G, McKeating J, et al. (2007) The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein. J Virol 81: 8101-8111.
39. Roingeard P, Hourioux C (2008) Hepatitis C virus core protein, lipid droplets and steatosis. J Viral Hepat 15: 157-164.
40. Böttcher CSF, Van Gent CM, Fries C (1961) A rapid and sensitive sub-micro phosphorus determination. Anal Chim Acta 1061: 203-204.
41. Edelhoch H (1967) Spectroscopic determination of tryptophan and tyrosine in proteins. Biochemistry 6: 1948-1954.
42. Laggner P (1994) X-ray diffraction on biomembranes with emphasis on lipid moiety. Subcell Biochem 23: 451-491.