HDAC inhibition suppresses bladder cancer cell adhesion to collagen under flow conditions

Experimental Biology and Medicine

Volumn 238, Issue 11, 2013, Pages 1297-1304

  Juengel, Eva ^a   Santos, Sascha Meyer dos ^a   Schneider, Tanja ^a   Makarević, Jasmina ^a   Hudak, Lukasz ^a   Bartsch, Georg ^a   Haferkamp, Axel ^a   Wiesner, Christoph ^a   Blaheta, Roman A ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

bladder carcinoma; cell adhesion; integrin receptors; Valproic acid

Indexed keywords

ALPHA3 INTEGRIN; ALPHA5 INTEGRIN; BETA1 INTEGRIN; BETA3 INTEGRIN; BETA4 INTEGRIN; COLLAGEN; HISTONE DEACETYLASE; INTEGRIN RECEPTOR; VALPROIC ACID;

ARTICLE; BLADDER CANCER; CELL ADHESION; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; UPREGULATION; WESTERN BLOTTING;

BLADDER CARCINOMA; CELL ADHESION; INTEGRIN RECEPTORS; VALPROIC ACID;

CARCINOMA; CELL ADHESION; CELL LINE, TUMOR; COLLAGEN; FLOW CYTOMETRY; HISTONE DEACETYLASE INHIBITORS; HUMANS; INTEGRINS; UP-REGULATION; URINARY BLADDER NEOPLASMS; VALPROIC ACID;

EID: 84887204802     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213498975     Document Type: Article

References (27)

1. Goebell PJ,Vom Dorp F,Rödel C,Frohneberg D,Thüroff JW,Jocham D,Stief C,Roth S,Knüchel R,Schmidt KW,Kausch I,Zaak D,Wiesner C,Miller K,Sauer R,Rübben H.Noninvasive and invasive bladder cancer: diagnostics and treatment.Urologe A. 2006;45:873-84.
2. Ozawa A,Tanji N,Kikugawa T,Sasaki T,Yanagihara Y,Miura N,Yokoyama M.Inhibition of bladder tumour growth by histone deacetylase inhibitor.BJU Int. 2010;105:1181-6.
3. Xu XS,Wang L,Abrams J,Wang G.Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer.J Hematol Oncol. 2011;4:17-17.
4. Qu W,Kang YD,Zhou MS,Fu LL,Hua ZH,Wang LM.Experimental study on inhibitory effects of histone deacetylase inhibitor MS-275 and TSA on bladder cancer cells.Urol Oncol. 2010;28:648-54.
5. Buckley MT,Yoon J,Yee H,Chiriboga L,Liebes L,Ara G,Qian X,Bajorin DF,Sun TT,Wu XR,Osman I.The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo.J Transl Med. 2007;5:49-49.
6. Niegisch G, Knievel J, Koch A, Hader C, Fischer U, Albers P and Schulz WA. Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers. Urol Oncol 2012; in press.
7. Vallo S,Xi W,Hudak L,Juengel E,Tsaur I,Wiesner C,Haferkamp A,Blaheta RA.HDAC inhibition delays cell cycle progression of human bladder cancer cells in vitro.Anticancer Drugs. 2011;22:1002-9.
8. Savage B,Ginsberg MH,Ruggeri ZM.Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow.Blood. 1999;94:2704-15.
9. Meyer dos Santos S,Klinkhardt U,Schneppenheim R,Harder S.Using ImageJ for the quantitative analysis of flow-based adhesion assays in real-time under physiologic flow conditions.Platelets. 2010;21:60-6.
10. Gontero P,Banisadr S,Frea B,Brausi M.Metastasis markers in bladder cancer: a review of the literature and clinical considerations.Eur Urol. 2004;46:296-311.
11. Liebert M,Washington R,Stein J,Wedemeyer G,Grossman HB.Expression of the VLA beta 1 integrin family in bladder cancer.Am J Pathol. 1994;144:1016-22.
12. Laidler P,Gil D,Pituch-Noworolska A,Cioczyk D,Ksiazek D,Przybyo M,Lityñska A.Expression of beta1-integrins and N-cadherin in bladder cancer and melanoma cell lines.Acta Biochim Pol. 2000;47:1159-70.
13. Oertl A,Relja B,Makarevic J,Weich E,Höfler S,Jones J,Jonas D,Bratzke H,Baer PC,Blaheta RA.Altered expression of beta1 integrins in renal carcinoma cell lines exposed to the differentiation inducer valproic acid.Int J Mol Med. 2006;18:347-54.
14. Wedel S,Hudak L,Seibel JM,Makareviæ J,Juengel E,Tsaur I,Wiesner C,Haferkamp A,Blaheta RA.Impact of combined HDAC and mTOR inhibition on adhesion, migration and invasion of prostate cancer cells.Clin Exp Metastasis. 2011;28:479-91.
15. Heyder C,Gloria-Maercker E,Hatzmann W,Niggemann B,Zänker KS,Dittmar T.Role of the beta1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells.Clin Exp Metastasis. 2005;22:99-106.
16. Lityńska A,Przybylo M,Pocheć E,Laidler P.Adhesion properties of human bladder cell lines with extracellular matrix components: the role of integrins and glycosylation.Acta Biochim Pol. 2002;49:643-50.
17. Saito T,Kimura M,Kawasaki T,Sato S,Tomita Y.Correlation between integrin alpha 5 expression and the malignant phenotype of transitional cell carcinoma.Br J Cancer. 1996;73:327-31.
18. Chakraborty A,White SM,Guha S.Granulocyte colony-stimulating receptor promotes beta1-integrin-mediated adhesion and invasion of bladder cancer cells.Urology. 2006;68:208-13.
19. Zhang CJ,Shen ZJ,Pan CW,Zhong S,Li T,Zhang MG.Engagement of integrin â1 induces resistance of bladder cancer cells to mitomycin-C.Urology. 2012;79:638-43.
20. Engl T,Makareviæ J,Relja B,Natsheh I,Müller I,Beecken WD,Jonas D,Blaheta RA.Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: impact on tumor recurrence and malignancy.BMC Cancer. 2005;5:4-4.
21. Hudak L, Tezeeh P, Wedel S, Makareviæ J, Juengel E, Tsaur I, Bartsch G, Wiesner C, Haferkamp A and Blaheta RA. Low dosed interferon alpha augments the anti-tumor potential of histone deacetylase inhibition on prostate cancer cell growth and invasion. Prostate 2012; 72:1719-35.
22. Mai A,Veltel S,Pellinen T,Padzik A,Coffey E,Marjomäki V,Ivaska J.Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration.J Cell Biol. 2011;194:291-306.
23. Stupack DG,Puente XS,Boutsaboualoy S,Storgard CM,Cheresh DA.Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins.J Cell Biol. 2001;155:459-70.
24. Kaur S,Kenny HA,Jagadeeswaran S,Zillhardt MR,Montag AG,Kistner E,Yamada SD,Mitra AK,Lengyel E.{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.Am J Pathol. 2009;175:2184-96.
25. Mialhe A,Louis J,Pasquier D,Rambeaud JJ,Seigneurin D.Expression of three cell adhesion molecules in bladder carcinomas: correlation with pathological features.Anal Cell Pathol. 1997;13:125-36.
26. Kim SY,Bachman NJ,Nair TS,Goldsmith S,Liebert M,Grossman HB,Lomax MI,Carey TE.Beta 4 integrin transfection of UM-UC-2 (human bladder carcinoma) cells: stable expression of a spontaneous cytoplasmic truncation mutant with rapid loss of clones expressing intact beta 4.Cancer Res. 1997;57:38-42.
27. Harabayashi T,Kanai Y,Yamada T,Sakamoto M,Ochiai A,Kakizoe T,Koyanagi T,Hirohashi S.Reduction of integrin beta4 and enhanced migration on laminin in association with intraepithelial spreading of urinary bladder carcinomas.J Urol. 1999;161:1364-71.