Altered expression of β1 integrins in renal carcinoma cell lines exposed to the differentiation inducer valproic acid

International Journal of Molecular Medicine

Volumn 18, Issue 2, 2006, Pages 347-354

  Oertl, Anton ^a   Relja, Borna ^a   Makarevic, Jasmina ^a   Weich, Eva ^a   Höfler, Sonja ^a   Jones, Jon ^a   Jonas, Dietger ^a   Bratzke, Hansjürgen ^a   Baer, Patrick C ^a   Blaheta, Roman A ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Adhesion; Integrins; Proliferation; Renal cell carcinoma; Valproic acid

Indexed keywords

ALPHA INTEGRIN; BETA1 INTEGRIN; ENZYME INHIBITOR; VALPROIC ACID;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DISEASE COURSE; DOSE RESPONSE; DRUG EFFECT; EPITHELIUM CELL; GENETICS; HUMAN; KIDNEY CARCINOMA; KIDNEY PROXIMAL TUBULE; KIDNEY TUMOR; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ANTIGENS, CD29; CARCINOMA, RENAL CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELLS, CULTURED; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; INTEGRIN ALPHA CHAINS; KIDNEY NEOPLASMS; KIDNEY TUBULES, PROXIMAL; VALPROIC ACID;

EID: 34748864211     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.18.2.347     Document Type: Article

References (21)

1. Guo W and Giancotti FG: Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5: 816-826, 2004.
2. Brenner W, Benzing F, Gudejko-Thiel J, Fischer R, Farber G, Hengstler JG, Seliger B and Thuroff JW: Regulation of β1 integrin expression by PKCε in renal cancer cells. Int J Oncol 25: 1157-1163, 2004.
3. Bockhorn M, Roberge S, Sousa C, Jain RK and Munn LL: Differential gene expression in metastasizing cells shed from kidney tumors. Cancer Res 64: 2469-2473, 2004.
4. Rissanen J, Korhonen M, Lehto VP and Virtanen I: Laminin alpha1 chain in human renal cell carcinomas and integrin-mediated adhesion of renal cell carcinoma cells to human laminin isoforms. J Pathol 200: 157-167, 2003. (Pubitemid 36748024)
5. Jenq W, Cooper DR and Ramirez G: Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells. Connect Tissue Res 34: 161-174, 1996.
6. Markovic-Lipkovski J, Brasanac D, Muller GA and Muller CA: Cadherins and integrins in renal cell carcinoma: an immunohistochemical study. Tumori 87: 173-178, 2001.
7. Tomita Y, Saito T, Saito K, Oite T, Shimizu F and Sato S: Possible significance of VLA-4 (alpha 4 beta 1) for hematogenous metastasis of renal-cell cancer. Int J Cancer 60: 753-758, 1995.
8. Anastassiou G, Duensing S, Steinhoff G, Kirchner H, Ganser A and Atzpodien J: In vivo distribution of integrins in renal cell carcinoma: integrin-phenotype alteration in different degrees of tumor differentiation and VLA-2 involvement in tumor metastasis. Cancer Biother 10: 287-292, 1995.
9. Gilcrease MZ, Truong L and Brown RW: Correlation of very late activation integrin and CD44 expression with extrarenal invasion and metastasis of renal cell carcinomas. Hum Pathol 27: 1355-1360, 1996.
10. Baer PC, Nockher WA, Haase W and Scherberich JE: Isolation of proximal and distal tubule cells from human kidney by immunomagnetic separation. Kidney Int 52: 1321-1331, 1997.
11. Baer PC, Scherberich JE, Bereiter-Hahn J and Geiger H: Induction of RANTES, HLA-DR, and intercellular adhesion molecule-1 on highly purified distal tubular cells from human kidney. Transplantation 69: 2456-2459, 2000.
12. Davidowitz EJ, Schoenfeld AR and Burk RD: VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling. Mol Cell Biol 21: 865-874, 2001.
13. Levy P, Robin H, Bertrand F, Kornprobst M and Capeau J: Butyrate-treated colonic Caco-2 cells exhibit defective integrin-mediated signaling together with increased apoptosis and differentiation. J Cell Physiol 197: 336-347, 2003.
14. Klein G, Langegger M, Timpl R and Ekblom P: Role of laminin A chain in the development of epithelial cell polarity. Cell 55: 331-341, 1988.
15. Engl T, Makarevic J, Relja B, Natsheh I, Muller I, Beecken WD, Jonas D and Blaheta RA: Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: impact on tumor recurrence and malignancy. BMC Cancer 5: 4, 2005. (Pubitemid 40180315)
16. Dedhar S, Saulnier R, Nagle R and Overall CM: Specific alterations in the expression of alpha 3 beta 1 and alpha 6 beta 4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane. Clin Exp Metastasis 11: 391-400, 1993.
17. Giancotti FG and Ruoslahti E: Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60: 849-859, 1990.
18. Kuwada SK, Kuang J and Li X: Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. J Biol Chem 280: 19027-19035, 2005.
19. Mongan NP and Gudas LJ: Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells. Mol Cancer Ther 4: 477-486, 2005.
20. Catalano MG, Fortunati N, Pugliese M, Costantino L, Poli R, Bosco O and Boccuzzi G: Valproic acid induces apoptosis and cell cycle arrest in poorly differentiated thyroid cancer cells. J Clin Endocrinol Metab 90: 1383-1389, 2005.
21. Li XN, Shu Q, Su JM, Perlaky L, Blaney SM and Lau CC: Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. Mol Cancer Ther 4: 1912-1922, 2005.