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Volumn 41, Issue 11, 2013, Pages 2658-2667

Enhanced tissue regeneration potential of juvenile articular cartilage

Author keywords

adult; aging; articular cartilage; biology of cartilage; bovine; cartilage regeneration; cartilage repair; chondrocyte; gene expression; juvenile; knee; migration

Indexed keywords

GELATINASE A; GLYCOSAMINOGLYCAN;

EID: 84887197966     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546513502945     Document Type: Article
Times cited : (45)

References (45)
  • 1
    • 0034800545 scopus 로고    scopus 로고
    • In vitro generation of scaffold independent neocartilage
    • Adkisson HD, Gillis MP, Davis EC, et al. In vitro generation of scaffold independent neocartilage. Clin Orthop Relat Res. 2001 ; 391: 280-294
    • (2001) Clin Orthop Relat Res , vol.391 , pp. 280-294
    • Adkisson, H.D.1    Gillis, M.P.2    Davis, E.C.3
  • 2
    • 77954344675 scopus 로고    scopus 로고
    • The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage
    • Adkisson HD, Martin JA, Amendola RL, et al. The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med. 2010 ; 38 (7). 1324-1333
    • (2010) Am J Sports Med , vol.38 , Issue.7 , pp. 1324-1333
    • Adkisson, H.D.1    Martin, J.A.2    Amendola, R.L.3
  • 3
    • 0034966785 scopus 로고    scopus 로고
    • Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: A study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage
    • Aigner T, Hemmel M, Neureiter D, et al. Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum. 2001 ; 44 (6). 1304-1312
    • (2001) Arthritis Rheum , vol.44 , Issue.6 , pp. 1304-1312
    • Aigner, T.1    Hemmel, M.2    Neureiter, D.3
  • 4
    • 0020369710 scopus 로고
    • Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
    • Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell. 1982 ; 30 (1). 215-224
    • (1982) Cell , vol.30 , Issue.1 , pp. 215-224
    • Benya, P.D.1    Shaffer, J.D.2
  • 5
    • 0034740503 scopus 로고    scopus 로고
    • TGF-beta3-induced palatogenesis requires matrix metalloproteinases
    • Blavier L, Lazaryev A, Groffen J, et al. TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell. 2001 ; 12 (5). 1457-1466
    • (2001) Mol Biol Cell , vol.12 , Issue.5 , pp. 1457-1466
    • Blavier, L.1    Lazaryev, A.2    Groffen, J.3
  • 6
    • 80155177821 scopus 로고    scopus 로고
    • Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: In vitro matrix production
    • Bonasia DE, Martin JA, Marmotti A, et al. Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production. Am J Sports Med. 2011 ; 39 (11). 2355-2361
    • (2011) Am J Sports Med , vol.39 , Issue.11 , pp. 2355-2361
    • Bonasia, D.E.1    Martin, J.A.2    Marmotti, A.3
  • 7
    • 84855415972 scopus 로고    scopus 로고
    • Articular cartilage repair and the evolving role of regenerative medicine
    • Bos PK, van Melle ML, van Osch GJ. Articular cartilage repair and the evolving role of regenerative medicine. Open Access Surgery. 2010 ; 3: 109-122
    • (2010) Open Access Surgery , vol.3 , pp. 109-122
    • Bos, P.K.1    Van Melle, M.L.2    Van Osch, G.J.3
  • 8
    • 0031608434 scopus 로고    scopus 로고
    • Articular cartilage: Tissue design and chondrocyte-matrix interactions
    • Buckwalter JA, Mankin HJ. Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr Course Lect. 1998 ; 47: 477-486
    • (1998) Instr Course Lect , vol.47 , pp. 477-486
    • Buckwalter, J.A.1    Mankin, H.J.2
  • 9
    • 0037385014 scopus 로고    scopus 로고
    • The volume and morphology of chondrocytes within non-degenerate and degenerate human articular cartilage
    • Bush PG, Hall AC. The volume and morphology of chondrocytes within non-degenerate and degenerate human articular cartilage. Osteoarthritis Cartilage. 2003 ; 11 (4). 242-251
    • (2003) Osteoarthritis Cartilage , vol.11 , Issue.4 , pp. 242-251
    • Bush, P.G.1    Hall, A.C.2
  • 10
    • 54949135803 scopus 로고    scopus 로고
    • Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage
    • Byers BA, Mauck RL, Chiang IE, Tuan RS. Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage. Tissue Eng Part A. 2008 ; 14 (11). 1821-1834
    • (2008) Tissue Eng Part A , vol.14 , Issue.11 , pp. 1821-1834
    • Byers, B.A.1    Mauck, R.L.2    Chiang, I.E.3    Tuan, R.S.4
  • 11
    • 0032910459 scopus 로고    scopus 로고
    • Age-related decrease in proteoglycan synthesis of human articular chondrocytes: The role of nonenzymatic glycation
    • DeGroot J, Verzijl N, Bank RA, et al. Age-related decrease in proteoglycan synthesis of human articular chondrocytes: the role of nonenzymatic glycation. Arthritis Rheum. 1999 ; 42 (5). 1003-1009
    • (1999) Arthritis Rheum , vol.42 , Issue.5 , pp. 1003-1009
    • Degroot, J.1    Verzijl, N.2    Bank, R.A.3
  • 12
    • 0038005018 scopus 로고    scopus 로고
    • DAVID: Database for Annotation, Visualization, and Integrated Discovery
    • Dennis G, Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003 ; 4 (5). 3
    • (2003) Genome Biol , vol.4 , Issue.5 , pp. 3
    • Dennis, G.1    Sherman, B.T.2    Hosack, D.A.3
  • 13
    • 27144473960 scopus 로고    scopus 로고
    • Aggrecan, aging and assembly in articular cartilage
    • Dudhia J. Aggrecan, aging and assembly in articular cartilage. Cell Mol Life Sci. 2005 ; 62 (19-20). 2241-2256
    • (2005) Cell Mol Life Sci , vol.62 , Issue.1920 , pp. 2241-2256
    • Dudhia, J.1
  • 14
    • 0030024311 scopus 로고    scopus 로고
    • Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
    • Fosang AJ, Last K, Knauper V, et al. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Lett. 1996 ; 380 (1-2). 17-20
    • (1996) FEBS Lett , vol.380 , Issue.12 , pp. 17-20
    • Fosang, A.J.1    Last, K.2    Knauper, V.3
  • 15
    • 82355181393 scopus 로고    scopus 로고
    • Transforming growth factor-beta 3 stimulates cartilage matrix elaboration by human marrow-derived stromal cells encapsulated in photocrosslinked carboxymethylcellulose hydrogels: Potential for nucleus pulposus replacement
    • Gupta MS, Cooper ES, Nicoll SB. Transforming growth factor-beta 3 stimulates cartilage matrix elaboration by human marrow-derived stromal cells encapsulated in photocrosslinked carboxymethylcellulose hydrogels: potential for nucleus pulposus replacement. Tissue Eng Part A. 2011 ; 17 (23-24). 2903-2910
    • (2011) Tissue Eng Part A , vol.17 , Issue.2324 , pp. 2903-2910
    • Gupta, M.S.1    Cooper, E.S.2    Nicoll, S.B.3
  • 16
    • 72649099116 scopus 로고    scopus 로고
    • Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner
    • Huang AH, Stein A, Tuan RS, Mauck RL. Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Tissue Eng Part A. 2009 ; 15 (11). 3461-3472
    • (2009) Tissue Eng Part A , vol.15 , Issue.11 , pp. 3461-3472
    • Huang, A.H.1    Stein, A.2    Tuan, R.S.3    Mauck, R.L.4
  • 17
    • 0029351142 scopus 로고
    • Of the structure and disease of articulating cartilages
    • Hunter W. Of the structure and disease of articulating cartilages. Clin Orthop Relat Res. 1995 ; 317: 3-6
    • (1995) Clin Orthop Relat Res , vol.317 , pp. 3-6
    • Hunter, W.1
  • 18
    • 0035947766 scopus 로고    scopus 로고
    • Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration
    • Kajita M, Itoh Y, Chiba T, et al. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol. 2001 ; 153 (5). 893-904
    • (2001) J Cell Biol , vol.153 , Issue.5 , pp. 893-904
    • Kajita, M.1    Itoh, Y.2    Chiba, T.3
  • 19
    • 0030898796 scopus 로고    scopus 로고
    • The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction
    • Knauper V, Cowell S, Smith B, et al. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J Biol Chem. 1997 ; 272 (12). 7608-7616
    • (1997) J Biol Chem , vol.272 , Issue.12 , pp. 7608-7616
    • Knauper, V.1    Cowell, S.2    Smith, B.3
  • 20
    • 0030037395 scopus 로고    scopus 로고
    • Cellular mechanisms for human procollagenase-3 (MMP-13) activation: Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme
    • Knauper V, Will H, Lopez-Otin C, et al. Cellular mechanisms for human procollagenase-3 (MMP-13) activation: evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem. 1996 ; 271 (29). 17124-17131
    • (1996) J Biol Chem , vol.271 , Issue.29 , pp. 17124-17131
    • Knauper, V.1    Will, H.2    Lopez-Otin, C.3
  • 21
    • 77955565285 scopus 로고    scopus 로고
    • Regeneration of the articular surface of the rabbit synovial joint by cell homing: A proof of concept study
    • Lee CH, Cook JL, Mendelson A, et al. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet. 2010 ; 376 (9739). 440-448
    • (2010) Lancet , vol.376 , Issue.9739 , pp. 440-448
    • Lee, C.H.1    Cook, J.L.2    Mendelson, A.3
  • 22
    • 33746682471 scopus 로고    scopus 로고
    • The chondrocyte: Biology and clinical application
    • Lin Z, Willers C, Xu J, Zheng MH. The chondrocyte: biology and clinical application. Tissue Eng. 2006 ; 12 (7). 1971-1984
    • (2006) Tissue Eng , vol.12 , Issue.7 , pp. 1971-1984
    • Lin, Z.1    Willers, C.2    Xu, J.3    Zheng, M.H.4
  • 23
    • 33745011909 scopus 로고    scopus 로고
    • Minced cartilage without cell culture serves as an effective intraoperative cell source for cartilage repair
    • Lu Y, Dhanaraj S, Wang Z, et al. Minced cartilage without cell culture serves as an effective intraoperative cell source for cartilage repair. J Orthop Res. 2006 ; 24: 1261-1270
    • (2006) J Orthop Res , vol.24 , pp. 1261-1270
    • Lu, Y.1    Dhanaraj, S.2    Wang, Z.3
  • 24
    • 40849118160 scopus 로고    scopus 로고
    • Transforming growth factor beta3 increases chondrocyte proliferation and decreases apoptosis in murine cricoid cartilage in vitro
    • Martinez-Alvernia EA, Rudnick JA, Mankarious LA. Transforming growth factor beta3 increases chondrocyte proliferation and decreases apoptosis in murine cricoid cartilage in vitro. Otolaryngol Head Neck Surg. 2008 ; 138 (4). 435-440
    • (2008) Otolaryngol Head Neck Surg , vol.138 , Issue.4 , pp. 435-440
    • Martinez-Alvernia, E.A.1    Rudnick, J.A.2    Mankarious, L.A.3
  • 25
    • 77049105235 scopus 로고    scopus 로고
    • Membrane-based cultures generate scaffold-free neocartilage in vitro: Influence of growth factors
    • Mayer-Wagner S, Schiergens TS, Sievers B, et al. Membrane-based cultures generate scaffold-free neocartilage in vitro: influence of growth factors. Tissue Eng Part A. 2010 ; 16 (2). 513-521
    • (2010) Tissue Eng Part A , vol.16 , Issue.2 , pp. 513-521
    • Mayer-Wagner, S.1    Schiergens, T.S.2    Sievers, B.3
  • 26
    • 56549121683 scopus 로고    scopus 로고
    • Differential gene expression associated with postnatal equine articular cartilage maturation
    • Mienaltowski MJ, Huang L, Stromberg AJ, MacLeod JN. Differential gene expression associated with postnatal equine articular cartilage maturation. BMC Musculoskelet Disord. 2008 ; 9: 149
    • (2008) BMC Musculoskelet Disord , vol.9 , pp. 149
    • Mienaltowski, M.J.1    Huang, L.2    Stromberg, A.J.3    Macleod, J.N.4
  • 27
    • 34247568901 scopus 로고    scopus 로고
    • Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis
    • Mitsuyama H, Healey RM, Terkeltaub RA, et al. Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis. Osteoarthritis Cartilage. 2007 ; 15 (5). 559-565
    • (2007) Osteoarthritis Cartilage , vol.15 , Issue.5 , pp. 559-565
    • Mitsuyama, H.1    Healey, R.M.2    Terkeltaub, R.A.3
  • 28
    • 78650548314 scopus 로고    scopus 로고
    • Strategies for prevention of scars: What can we learn from fetal skin?
    • Namazi MR, Fallahzadeh MK, Schwartz RA. Strategies for prevention of scars: what can we learn from fetal skin?. Int J Dermatol. 2011 ; 50 (1). 85-93
    • (2011) Int J Dermatol , vol.50 , Issue.1 , pp. 85-93
    • Namazi, M.R.1    Fallahzadeh, M.K.2    Schwartz, R.A.3
  • 29
    • 0031909614 scopus 로고    scopus 로고
    • Spontaneous repair of superficial defects in articular cartilage in a fetal lamb model
    • Namba RS, Meuli M, Sullivan KM, et al. Spontaneous repair of superficial defects in articular cartilage in a fetal lamb model. J Bone Joint Surg Am. 1998 ; 80 (1). 4-10
    • (1998) J Bone Joint Surg Am , vol.80 , Issue.1 , pp. 4-10
    • Namba, R.S.1    Meuli, M.2    Sullivan, K.M.3
  • 30
    • 70349446494 scopus 로고    scopus 로고
    • Transforming growth factor beta-3 bound with sulfate polysaccharide in synthetic extracellular matrix enhanced the biological activities for neocartilage formation in vivo
    • Park JS, Woo DG, Yang HN, et al. Transforming growth factor beta-3 bound with sulfate polysaccharide in synthetic extracellular matrix enhanced the biological activities for neocartilage formation in vivo. J Biomed Mater Res A. 2009 ; 91 (2). 408-415
    • (2009) J Biomed Mater Res A , vol.91 , Issue.2 , pp. 408-415
    • Park, J.S.1    Woo, D.G.2    Yang, H.N.3
  • 31
    • 0029880393 scopus 로고    scopus 로고
    • The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes: A role in osteoarthritis
    • Reboul P, Pelletier JP, Tardif G, et al. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes: a role in osteoarthritis. J Clin Invest. 1996 ; 97 (9). 2011-2019
    • (1996) J Clin Invest , vol.97 , Issue.9 , pp. 2011-2019
    • Reboul, P.1    Pelletier, J.P.2    Tardif, G.3
  • 32
    • 22444448450 scopus 로고    scopus 로고
    • Current strategies for articular cartilage repair
    • Redman SN, Oldfield SF, Archer CW. Current strategies for articular cartilage repair. Eur Cell Mater. 2005 ; 14 (9). 23-32
    • (2005) Eur Cell Mater , vol.14 , Issue.9 , pp. 23-32
    • Redman, S.N.1    Oldfield, S.F.2    Archer, C.W.3
  • 34
    • 31544478045 scopus 로고    scopus 로고
    • Conditioning of cartilage during normal activities is an important factor in the development of osteoarthritis
    • Seedhom BB. Conditioning of cartilage during normal activities is an important factor in the development of osteoarthritis. Rheumatology (Oxford). 2006 ; 45 (2). 146-149
    • (2006) Rheumatology (Oxford) , vol.45 , Issue.2 , pp. 146-149
    • Seedhom, B.B.1
  • 35
    • 1942508193 scopus 로고    scopus 로고
    • Membrane-type 1 matrix metalloproteinase and cell migration
    • Seiki M, Mori H, Kajita M, et al. Membrane-type 1 matrix metalloproteinase and cell migration. Biochem Soc Symp. 2003 ; (70). 253-262
    • (2003) Biochem Soc Symp , Issue.70 , pp. 253-262
    • Seiki, M.1    Mori, H.2    Kajita, M.3
  • 36
    • 84855172998 scopus 로고    scopus 로고
    • Mesenchymal stem cell-based tissue engineering for chondrogenesis
    • Seo S, Na K. Mesenchymal stem cell-based tissue engineering for chondrogenesis. J Biomed Biotechnol. 2011 ; 2011: 806891
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 806891
    • Seo, S.1    Na, K.2
  • 37
    • 0029918461 scopus 로고    scopus 로고
    • Fetal chondral homografts in the repair of articular cartilage defects
    • Specchia N, Gigante A, Falciglia F, Greco F. Fetal chondral homografts in the repair of articular cartilage defects. Bull Hosp Jt Dis. 1996 ; 54 (4). 230-235
    • (1996) Bull Hosp Jt Dis , vol.54 , Issue.4 , pp. 230-235
    • Specchia, N.1    Gigante, A.2    Falciglia, F.3    Greco, F.4
  • 38
    • 48549089299 scopus 로고    scopus 로고
    • Barley grain maturation and germination: Metabolic pathway and regulatory network commonalities and differences highlighted by new MapMan/PageMan profiling tools
    • Sreenivasulu N, Usadel B, Winter A, et al. Barley grain maturation and germination: metabolic pathway and regulatory network commonalities and differences highlighted by new MapMan/PageMan profiling tools. Plant Physiol. 2008 ; 146 (4). 1738-1758
    • (2008) Plant Physiol , vol.146 , Issue.4 , pp. 1738-1758
    • Sreenivasulu, N.1    Usadel, B.2    Winter, A.3
  • 39
    • 0028907318 scopus 로고
    • Mechanism of cell surface activation of 72-kDa type IV collagenase: Isolation of the activated form of the membrane metalloprotease
    • Strongin AY, Collier I, Bannikov G, et al. Mechanism of cell surface activation of 72-kDa type IV collagenase: isolation of the activated form of the membrane metalloprotease. J Biol Chem. 1995 ; 270 (10). 5331-5338
    • (1995) J Biol Chem , vol.270 , Issue.10 , pp. 5331-5338
    • Strongin, A.Y.1    Collier, I.2    Bannikov, G.3
  • 40
    • 67649112375 scopus 로고    scopus 로고
    • TGF-beta3: A potential biological therapy for enhancing chondrogenesis
    • Tang QO, Shakib K, Heliotis M, et al. TGF-beta3: a potential biological therapy for enhancing chondrogenesis. Expert Opin Biol Ther. 2009 ; 9 (6). 689-701
    • (2009) Expert Opin Biol Ther , vol.9 , Issue.6 , pp. 689-701
    • Tang, Q.O.1    Shakib, K.2    Heliotis, M.3
  • 41
    • 0142103359 scopus 로고    scopus 로고
    • Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk
    • Tuli R, Tuli S, Nandi S, et al. Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J Biol Chem. 2003 ; 278 (42). 41227-41236
    • (2003) J Biol Chem , vol.278 , Issue.42 , pp. 41227-41236
    • Tuli, R.1    Tuli, S.2    Nandi, S.3
  • 42
    • 84887147186 scopus 로고    scopus 로고
    • Toronto, ON, Canada: Millennium Research Group, A Decision Resources Inc Co;
    • Vankessel D US Markets for Orthopedic Biomaterials 2011. Toronto, ON, Canada: Millennium Research Group, A Decision Resources Inc Co ; 2010 :
    • (2010) US Markets for Orthopedic Biomaterials 2011
    • Vankessel, D.1
  • 43
    • 0017723046 scopus 로고
    • Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture
    • von der Mark K, Gauss V, von der Mark H, Muller P. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature. 1977 ; 267 (5611). 531-532
    • (1977) Nature , vol.267 , Issue.5611 , pp. 531-532
    • Von Der Mark, K.1    Gauss, V.2    Von Der Mark, H.3    Muller, P.4
  • 44
    • 79960838436 scopus 로고    scopus 로고
    • The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system
    • Wiercinska E, Naber HP, Pardali E, et al. The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system. Breast Cancer Res Treat. 2011 ; 128 (3). 657-666
    • (2011) Breast Cancer Res Treat , vol.128 , Issue.3 , pp. 657-666
    • Wiercinska, E.1    Naber, H.P.2    Pardali, E.3
  • 45
    • 0035216630 scopus 로고    scopus 로고
    • Compressive properties and function-composition relationships of developing bovine articular cartilage
    • Williamson AK, Chen AC, Sah RL. Compressive properties and function-composition relationships of developing bovine articular cartilage. J Orthop Res. 2001 ; 19 (6). 1113-1121
    • (2001) J Orthop Res , vol.19 , Issue.6 , pp. 1113-1121
    • Williamson, A.K.1    Chen, A.C.2    Sah, R.L.3


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