Upregulation of IL-17A, CXCL9 and CXCL10 in Early-Stage Granulomas Induced by Mycobacterium bovis in Cattle

Transboundary and Emerging Diseases

Volumn 60, Issue 6, 2013, Pages 525-537

  Aranday Cortes, E ^a   Bull, N C ^a   Villarreal Ramos, B ^a   Gough, J ^a   Hicks, D ^a   Ortiz Peláez, Á ^a   Vordermeier, H M ^a   Salguero, F J ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

Cytokine; Laser capture microdissection; Mycobacterium bovis; QPCR; Tuberculosis

Indexed keywords

BOS; BOVINAE; MYCOBACTERIUM BOVIS;

BACTERIAL RNA; BIOLOGICAL MARKER; CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 17;

ANIMAL; ARTICLE; BIOSYNTHESIS; BOVINE TUBERCULOSIS; CATTLE; GENETICS; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; METABOLISM; MYCOBACTERIUM BOVIS; PATHOLOGY; QPCR; REAL TIME POLYMERASE CHAIN REACTION; TUBERCULOSIS; UPREGULATION;

CYTOKINE; LASER CAPTURE MICRODISSECTION; MYCOBACTERIUM BOVIS; QPCR; TUBERCULOSIS;

ANIMALS; BIOLOGICAL MARKERS; CATTLE; CHEMOKINE CXCL10; CHEMOKINE CXCL9; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-17; MYCOBACTERIUM BOVIS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, BACTERIAL; TUBERCULOSIS, BOVINE; UP-REGULATION;

EID: 84887195768     PISSN: 18651674     EISSN: 18651682     Source Type: Journal    
DOI: 10.1111/j.1865-1682.2012.01370.x     Document Type: Article

References (37)

1. Algood, H. M. S., J. Chan, and J. A. L. Flynn, 2003: Chemokines and tuberculosis. Cytokine Growth Factor Rev. 14, 467-477.
2. Aranday-Cortes, E., P. J. Hogarth, D. A. Kaveh, A. O. Whelan, B. Villarreal-Ramos, A. Lalvani, and H. M. Vordermeier, 2012: Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers. PLoS ONE 7, e30626.
3. Bai, X., S. E. Wilson, K. Chmura, N. E. Feldman, and E. D. Chan, 2004: Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. Tuberculosis (Edinb.) 84, 375-385.
4. Blanco, F. C., M. V. Bianco, V. Meikle, S. Garbaccio, L. Vagnoni, M. Forrellad, L. I. Klepp, A. A. Cataldi, and F. Bigi, 2011: Increased IL-17 expression is associated with pathology in a bovine model of tuberculosis. Tuberculosis (Edinb.) 91, 57-63.
5. Boddu-Jasmine, H. C., J. Witchell, M. Vordermeier, A. Wangoo, and M. Goyal, 2008: Cytokine mRNA expression in cattle infected with different dosages of Mycobacterium bovis. Tuberculosis (Edinb.) 88, 610-615.
6. Bold, T. D., and J. D. Ernst, 2009: Who benefits from granulomas, mycobacteria or host? Cell 136, 17-19.
7. Chan, J., Y. Xing, R. S. Magliozzo, and B. R. Bloom, 1992: Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 175, 1111-1122.
8. Dhiman, R., M. Indramohan, P. F. Barnes, R. C. Nayak, P. Paidipally, L. V. Rao, and R. Vankayalapati, 2009: IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion. J. Immunol. 183, 6639-6645.
9. Egen, J. G., A. G. Rothfuchs, C. G. Feng, M. A. Horwitz, A. Sher, and R. N. Germain, 2011: Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity 34, 807-819.
10. Hernandez-Pando, R., T. Schon, E. H. Orozco, J. Serafin, and I. Estrada-Garcia, 2001: Expression of inducible nitric oxide synthase and nitrotyrosine during the evolution of experimental pulmonary tuberculosis. Exp. Toxicol. Pathol. 53, 257-265.
11. Hicks, D. J., L. Johnson, S. M. Mitchell, J. Gough, W. A. Cooley, R. M. La Ragione, Y. I. Spencer, and A. Wangoo, 2006: Evaluation of zinc salt based fixatives for preserving antigenic determinants for immunohistochemical demonstration of murine immune system cell markers. Biotech. Histochem. 81, 23-30.
12. Irving, J. A., G. Cain, A. Parr, M. Howard, B. Angus, and A. R. Cattan, 1996: OCT embedded sections of pathological specimens as a source of high quality RNA for reverse transcriptase/polymerase chain reaction. J. Clin. Pathol. 49, 258-259.
13. Johnson, L., J. Gough, Y. Spencer, G. Hewinson, M. Vordermeier, and A. Wangoo, 2006: Immunohistochemical markers augment evaluation of vaccine efficacy and disease severity in bacillus Calmette-Guerin (BCG) vaccinated cattle challenged with Mycobacterium bovis. Vet. Immunol. Immunopathol. 111, 219-229.
14. Liebana, E., L. Johnson, J. Gough, P. Durr, K. Jahans, R. Clifton-Hadley, Y. Spencer, R. G. Hewinson, and S. H. Downs, 2008: Pathology of naturally occurring bovine tuberculosis in England and Wales. Vet. J. 176, 354-360.
15. Livak, K. J., and T. D. Schmittgen, 2001: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
16. Ly, L. H., M. I. Russell, and D. N. McMurray, 2007: Microdissection of the cytokine milieu of pulmonary granulomas from tuberculous guinea pigs. Cell. Microbiol. 9, 1127-1136.
17. Ly, L. H., M. I. Russell, and D. N. McMurray, 2008: Cytokine profiles in primary and secondary pulmonary granulomas of Guinea pigs with tuberculosis. Am. J. Respir. Cell Mol. Biol. 38, 455-462.
18. Neill, S. D., J. M. Pollock, D. B. Bryson, and J. Hanna, 1994: Pathogenesis of Mycobacterium bovis infection in cattle. Vet. Microbiol. 40, 41-52.
19. Okamoto Yoshida, Y., M. Umemura, A. Yahagi, R. L. O'Brien, K. Ikuta, K. Kishihara, H. Hara, S. Nakae, Y. Iwakura, and G. Matsuzaki, 2010: Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J. Immunol. 184, 4414-4422.
20. Okamoto, M., K. Hiura, G. Ohe, Y. Ohba, K. Terai, T. Oshikawa, S. Furuichi, H. Nishikawa, K. Moriyama, H. Yoshida, and M. Sato, 2000: Mechanism for bone invasion of oral cancer cells mediated by interleukin-6 in vitro and in vivo. Cancer 89, 1966-1975.
21. Paige, C., and W. R. Bishai, 2010: Penitentiary or penthouse condo: the tuberculous granuloma from the microbe's point of view. Cell. Microbiol. 12, 301-309.
22. Palmer, M. V., W. R. Waters, and T. C. Thacker, 2007: Lesion development and immunohistochemical changes in granulomas from cattle experimentally infected with Mycobacterium bovis. Vet. Pathol. 44, 863-874.
23. Pollock, J. M., D. A. Pollock, D. G. Campbell, R. M. Girvin, A. D. Crockard, S. D. Neill, and D. P. Mackie, 1996: Dynamic changes in circulating and antigen-responsive T-cell subpopulations post-Mycobacterium bovis infection in cattle. Immunology 87, 236-241.
24. Pollock, J. M., J. McNair, M. D. Welsh, R. M. Girvin, H. E. Kennedy, D. P. Mackie, and S. D. Neill, 2001: Immune responses in bovine tuberculosis. Tuberculosis (Edinb.) 81, 103-107.
25. Southey, A., E. Costello, and E. Gormley, 2002: Detection of Mycobacterium bovis infection and production of interleukin-2 by in vitro stimulation of badger lymphocytes. Vet. Immunol. Immunopathol. 87, 73-78.
26. Stenger, S., R. J. Mazzaccaro, K. Uyemura, S. Cho, P. F. Barnes, J. P. Rosat, A. Sette, M. B. Brenner, S. A. Porcelli, B. R. Bloom, and R. L. Modlin, 1997: Differential effects of cytolytic T cell subsets on intracellular infection. Science 276, 1684-1687.
27. Thacker, T. C., M. V. Palmer, and W. R. Waters, 2007: Associations between cytokine gene expression and pathology in Mycobacterium bovis infected cattle. Vet. Immunol. Immunopathol. 119, 204-213.
28. Ulrichs, T., G. A. Kosmiadi, V. Trusov, S. Jorg, L. Pradl, M. Titukhina, V. Mishenko, N. Gushina, and S. H. Kaufmann, 2004: Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung. J. Pathol. 204, 217-228.
29. Van Rhijn, I., J. Godfroid, A. Michel, and V. Rutten, 2008: Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models. Microbes Infect. 10, 711-715.
30. Vidyarani, M., P. Selvaraj, S. Raghavan, and P. R. Narayanan, 2009: Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis. Exp. Mol. Pathol. 86, 69-73.
31. Volkman, H. E., T. C. Pozos, J. Zheng, J. Davis, J. F. Rawls, and L. Ramakrishnan, 2010: Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. Science 327, 466.
32. Vordermeier, H. M., M. A. Chambers, P. J. Cockle, A. O. Whelan, J. Simmons, and R. G. Hewinson, 2002: Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis. Infect. Immun. 70, 3026-3032.
33. Wangoo, A., L. Johnson, J. Gough, R. Ackbar, S. Inglut, D. Hicks, Y. Spencer, G. Hewinson, and M. Vordermeier, 2005: Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells. J. Comp. Pathol. 133, 223-234.
34. Welsh, M. D., R. T. Cunningham, D. M. Corbett, R. M. Girvin, J. McNair, R. A. Skuce, D. G. Bryson, and J. M. Pollock, 2005: Influence of pathological progression on the balance between cellular and humoral immune responses in bovine tuberculosis. Immunology 114, 101-111.
35. Widdison, S., M. Watson, and T. J. Coffey, 2009: Correlation between lymph node pathology and chemokine expression during bovine tuberculosis. Tuberculosis (Edinb.) 89, 417-422.
36. Zeng, G., C. Y. Chen, D. Huang, S. Yao, R. C. Wang, and Z. W. Chen, 2011: Membrane-bound IL-22 after de novo production in tuberculosis and anti-Mycobacterium tuberculosis effector function of IL-22+ CD4+ T cells. J. Immunol. 187, 190-199.
37. Zhu, G., H. Xiao, V. P. Mohan, K. Tanaka, S. Tyagi, F. Tsen, P. Salgame, and J. Chan, 2003: Gene expression in the tuberculous granuloma: analysis by laser capture microdissection and real-time PCR. Cell. Microbiol. 5, 445-453.