Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins

Molecular Immunology

Volumn 57, Issue 2, 2014, Pages 236-246

  Saifer, Mark G P ^a   Williams, L David ^a   Sobczyk, Monika A ^a   Michaels, Shawnya J ^a   Sherman, Merry R ^a  

^a Mountain View Pharmaceuticals Inc   (United States)

Author keywords

Anti PEG; Backbone specific; Methoxy specific; Monoclonal; Poly(ethylene glycol); Polyclonal

Indexed keywords

ETHYLENE DERIVATIVE; HYDROXYPOLY(ETHYLENE GLYCOL); IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MACROGOL; METHOXYPOLY(ETHYLENE GLYCOL); METHOXYPOLY(ETHYLENE GLYCOL) ANTIBODY; MONOCLONAL ANTIBODY; OLIGOMER; OXYETHYLENE; POLYCLONAL ANTIBODY; POLYMER; RABBIT ANTISERUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONJUGATE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROPHOBICITY; IMMUNE RESPONSE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL;

20KDA MPEG-KLH; 5KDA MPEG-KLH; AAALAC; ALBUMIN; ANTI-PEG; ANTI-PEG ANTIBODIES; ANTI-PEGS; ASSOCIATION FOR THE ASSESSMENT AND ACCREDITATION OF LABORATORY ANIMAL CARE; BACKBONE-SPECIFIC; D(50); DILUTION OF SERUM THAT CORRESPONDS TO 50% OF MAXIMAL BINDING IN A DIRECT ELISA; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETO-TEG; H AND L CHAINS; HEAVY AND LIGHT IMMUNOGLOBULIN CHAINS; HO-PEG; HUMAN SERUM ALBUMIN; HYDROXYPEG; IACUC; IC(50); IFN-Α; INHIBITOR CONCENTRATION THAT REDUCES BINDING TO 50% OF MAXIMAL BINDING IN A COMPETITIVE ELISA; INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE; INTERFERON-Α; KEYHOLE LIMPET HEMOCYANIN; KLH; MAB; MAU/MIN; METHOXY-SPECIFIC; MILLI-ABSORBANCE UNITS PER MINUTE; MONOCLONAL; MONOCLONAL ANTIBODY; MONOMETHOXYPOLY(ETHYLENE GLYCOL); MPEG; MPEG-KLH; MTEG; N-BUO-TEG; NPC; P-NITROPHENYLCARBONATE; P-NITROPHENYLCHLOROFORMATE; PEG; PEG20K-KLH; PNPCOCL; POLY(ETHYLENE GLYCOL); POLYCLONAL; PORCINE CU-ZN SUPEROXIDE DISMUTASE; REFRACTIVE INDEX; RELATIVE STANDARD DEVIATION=S.D./MEAN; RI; RSD; SOD; TEG DIOL AND TETRAEG ARE DEFINED IN TABLE 1; ULTRAVIOLET ABSORBANCE. CROWN ETHER; UV;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; HUMANS; POLYETHYLENE GLYCOLS; PROTEINS; RABBITS;

EID: 84887193611     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2013.07.014     Document Type: Article

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