Central ghrelin treatment stimulates ACTH cells in normal-fed, food-restricted and high-fed rats: An immunohistomorphometric and hormonal study

Acta Histochemica

Volumn 115, Issue 8, 2013, Pages 858-864

  Milošević, Verica ^a   Ajdžanović, Vladimir ^a   Nešić, Dejan ^a   Starčević, Vesna ^a   Filipović, Branko ^a   Rakočević, Rastko ^a   Stevanović, Darko ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

ACTH; ACTH cells; Corticosterone; Ghrelin; Intracerebroventricular; Rats

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; GHRELIN; FAT INTAKE;

ACTH SECRETING CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CELL STIMULATION; CELL STRUCTURE; CELL VOLUME; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; ENERGY BALANCE; FEEDING BEHAVIOR; HYPOPHYSIS ADRENAL SYSTEM; IMMUNOHISTOCHEMISTRY; LIPID DIET; MALE; NONHUMAN; ORGAN WEIGHT; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; RAT; ANIMAL; CELL COUNT; CYTOLOGY; DRUG EFFECTS; FAT INTAKE; FOOD DEPRIVATION; HYPOPHYSIS; LOW CALORY DIET; METABOLISM; PHARMACOLOGY; PHYSIOLOGY; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL COUNT; DIET, REDUCING; DIETARY FATS; FOOD DEPRIVATION; GHRELIN; IMMUNOHISTOCHEMISTRY; MALE; PITUITARY GLAND; PITUITARY-ADRENAL SYSTEM; RATS; RATS, WISTAR;

EID: 84887187837     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2013.04.003     Document Type: Article

References (43)

1. Ajdžanović V., Šošić-Jurjević B., Filipović B., Trifunović S., Brkić D., Sekulić M., et al. Genistein affects the morphology of pituitary ACTH cells and decreases circulating levels of ACTH and corticosterone in middle-aged male rats. Biol Res 2009, 42:13-23.
2. Andrew R., Phillips D.I., Walker B.R. Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 1998, 83:1806-1809.
3. Bornstein S.R., Uhlmann K., Haidan A., Ehrhart-Bornstein M., Scherbaum W.A. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes 1997, 46:1235-1238.
4. Briggs D.I., Andrews Z.B. Metabolic status regulates ghrelin function on energy homeostasis. Neuroendocrinology 2011, 93:48-57.
5. Bulló M., García-Lorda P., Megias I., Salas-Salvadó J. Systemic inflammation, adipose tissue tumor necrosis factor and leptin expression. Obes Res 2003, 11:525-531.
6. Casanueva F.F., Dieguez C. Growth hormone secretagogues: physiological role and clinical utility. Trends Endocrinol Metab 1999, 10:30-38.
7. Chang C.H., Rickes E.L., Marsilio F., McGuire L., Cosgrove S., Taylor J., et al. Activity of a novel nonpeptidyl growth hormone secretagogue, L-700,653, in swine. Endocrinology 1995, 136:1065-1071.
8. Childs G.V. Multipotential pituitary cells that contain adrenocorticotropin (ACTH) and other pituitary hormones. Trends Endocrinol Metab 1991, 2:112-117.
9. Clark R.G., Thomas G.B., Mortensen D.L., Won W.B., Ma Y.H., Tomlinson E.E., et al. Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat. Endocrinology 1997, 138:4316-4323.
10. Dallman M.F., Akana S.F., Bhatnagar S., Bell M.E., Choi S., Chu A., et al. Starvation: early signals, sensors, and sequelae. Endocrinology 1999, 140:4015-4023.
11. Elias K.A., Ingle G.S., Burnier J.P., Hammonds R.G., McDowell R.S., Rawson T.E., et al. In vitro characterization of four novel classes of growth hormone-releasing peptide. Endocrinology 1995, 136:5694-5699.
12. Ghigo E., Arvat E., Camanni F. Growth hormone secretagogues as corticotrophin-releasing factors. Growth Horm IGF Res 1998, 8:145-148.
13. Ghigo E., Arvat E., Muccioli G., Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol 1997, 136:445-460.
14. Girault E.M., Yi C.X., Fliers E., Kalsbeek A. Orexins, feeding, and energy balance. Prog Brain Res 2012, 198:47-64.
15. Hickey G., Jacks T., Judith F., Taylor J., Schoen W.R., Krupa D., et al. Efficacy and specificity of L-692,429, a novel nonpeptidyl growth hormone secretagogue, in beagles. Endocrinology 1994, 134:695-701.
16. Hickey G.J., Drisko J., Faidley T. Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585. J Endocrinol 1996, 148:371-380.
17. Horvath T.L., Diano S., Sotonyi P., Heiman M., Tschöp M. Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 2001, 142:4163-4169.
18. Jacks T., Hickey G., Judith F., Taylor J., Chen H., Krupa D., et al. Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. J Endocrinol 1994, 143:399-406.
19. Kok P., Kok S.W., Buijs M.M., Westenberg J.J., Roelfsema F., Frölich M., et al. Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment. Am J Physiol Endocrinol Metab 2004, 287:E848-E856.
20. Korbonits M., Grossman A.B. Growth hormone-releasing peptide and its analogues: novel stimuli to growth hormone release. Trends Endocrinol Metab 1995, 6:43-49.
21. Malendowicz L.K., Rucinski M., Belloni A.S., et al. Leptin and the regulation of the hypothalamic-pituitary-adrenal axis. Int Rev Cytol 2007, 263:63-102.
22. Malendowicz L.K. Sex differences in adrenocortical structure and function. I. The effects of postpubertal gonadectomy and gonadal hormone replacement on nuclear volume of adrenocortical cells in the rat. Cell Tissue Res 1974, 151:525-536.
23. Milošević V., Ajdžanović V., Bogojević D., Medigović I., Ivanović-Matić S., Martinović V., et al. Effect of chronic food restriction on immunopositive ACTH cells in peripubertal female rats. Gen Physiol Biophys 2011, 30:321-324.
24. Milošević V., Stevanović D., Nešić D., Šošić-Jurjević B., Ajdžanović V., Starčević V., et al. Central effects of ghrelin on the adrenal cortex: a morphological and hormonal study. Gen Physiol Biophys 2010, 29:194-202.
25. Mozid A.M., Tringali G., Forsling M.L., Hendricks M.S., Ajodha S., Edwards R., et al. Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin. Horm Metab Res 2003, 35:455-459.
26. Newman G.R., Jasani B., Williams E.D. Multiple hormone storage by cells of the human pituitary. J Histochem Cytochem 1989, 37:1183-1192.
27. Nowak K.W., Pierzchala-Koziec K., Tortorella C., Nussdorfer G.G., Malendowicz L.K. Effects of prolonged leptin infusion on rat pituitary-adrenocortical function. Int J Mol Med 2002, 9:61-64.
28. Roelfsema F., Kok P., Frolich M., Pereira A.M., Pijl H. Disordered and increased adrenocorticotropin secretion with diminished adrenocorticotropin potency in obese in premenopausal women. J Clin Endocrinol Metab 2009, 94:2991-2997.
29. Rucinski M., Ziolkowska A., Tyczewska M., Malendowicz L.K. Expression of prepro-ghrelin and related receptor genes in the rat adrenal gland and evidences that ghrelin exerts a potent stimulating effect on corticosterone secretion by cultured rat adrenocortical cells. Peptides 2009, 30:1448-1455.
30. Saito M., Nishimura K., Kato H. Modifications of circadian cortisol rhythm by cyclic and continuous total enteral nutrition. J Nutr Sci Vitaminol (Tokyo) 1989, 35:639-647.
31. Shin A.C., MohanKumar S.M., Sirivelu M.P., Claycombe K.J., Haywood J.R., Fink G.D., et al. Chronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats. Int J Obes (Lond) 2010, 34:1218-1226.
32. Smith R.G., Cheng K., Schoen W.R., et al. A nonpeptidyl growth hormone secretagogue. Science 1993, 260:1640-1643.
33. Starčević V., Milošević V., Brkić B., Severs W. Effects of centrally applied somatostatin on pituitary adrenocorticotropes in female rats. Pharmacology 2000, 60:203-207.
34. Starčević V.P., Morrow B.A., Farner L.A., Keil L.C., Severs W.B. Long-term recording of cerebrospinal fluid pressure in freely behaving rats. Brain Res 1988, 462:112-117.
35. Sternberger L.A., Hardy P.H.J., Cuculius J.J., Meyer H.G. The unlabelled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 1970, 18:315-333.
36. Stevanović D., Milošević V., Starčević V.P., Severs W.B. The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats. Life Sci 2007, 80:867-872.
37. Stevanović D., Nešić D., Milošević V., Starčević V., Severs W.B. Consummatory behavior and metabolic indicators after central ghrelin injections in rats. Regul Peptides 2008, 147:52-59.
38. Stevanović D., Starčević V., Vilimanovich U., Nešić D., Vučićević L., Misirkić M., et al. Immunomodulatory actions of central ghrelin in diet-induced energy imbalance. Brain Behav Immun 2012, 26:150-158.
39. Thomas G.B., Fairhall K.M., Robinson I.C. Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats. Endocrinology 1997, 138:1585-1591.
40. Weibel E.R. Stereological Methods, vol. 1. Practical Methods for Biological Morphometry 1979, Academic Press, New York, pp. 1-415.
41. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
42. Wren A.M., Small C.J., Fribbens C.V., Neary N.M., Ward H.L., Seal L.J., et al. The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Neuroendocrinology 2002, 76:316-324.
43. Xu Y., Elmquist J.K., Fukuda M. Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci 2011, 1243:1-14.