Technical considerations for analyzing EMT-MET data from surgical samples

Cancer Letters

Volumn 341, Issue 1, 2013, Pages 105-110

  Aoyagi, Kazuhiko ^a   Tamaoki, Masashi ^a   Nishumura, Takao ^a   Sasaki, Hiroki ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Artificially induced EMT; Esophageal cancer; Expression profile; Surgical sample

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; TRANSCRIPTION FACTOR ZEB1;

BIOPSY; CANCER ADJUVANT THERAPY; CANCER RESEARCH; COMPARATIVE STUDY; DISEASE MARKER; ENDOSCOPIC BIOPSY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM; ESOPHAGUS CANCER; FN GENE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; IN VIVO STUDY; ISCHEMIA; MOUSE; NFKB1 GENE; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; SHORT SURVEY; TGFBR2 GENE; TWIST1 GENE; VIM GENE; ZEB1 GENE; ZEB2 GENE;

EID: 84887183981     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.08.001     Document Type: Review

References (25)

1. Kim C., Pik S., et al. Gene-expression-based prognostic assays for breast cancer. Nat. Rev. Clin. Oncol. 2010, 7:340-347.
2. Fordor S.P., Read J.L., Pirrung M.C., Stryer L., et al. Light-directed, spatially addressable parallel chemical synthesis. Science 1991, 251:767-773.
3. Lockhart D.J., Dong H., Byrne M.C., et al. Expression monitoring by hybridization to high-density ologonucleotide arrays. Nat. Biothechnol. 1996, 14:1675-1680.
4. DeRisi J., Penland L., Brown P.O., et al. Use of a cDNA microarray to analyze gene expression patterns in human cancer. Nat. Genet. 1996, 14:457-460.
5. Brown P.O., Botstein D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 1999, 21:33-37.
6. Ishikura S., Nihei K., Ohtsu A., et al. Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracicesophagus. J. Clin. Oncol. 2003, 21:2697-2702.
7. Tachimori Y., Kanamori N., Uemura N., et al. Salvage esophagectomy after high-dose chemoradiotherapy for esophageal squamous cell carcinoma. J. Thorac. Cardiovasc. Surg. 2009, 137:49-54.
8. Aoyagi K., Minashi K., Igaki H., et al. Artificially induced epithelial-mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research. PLoS ONE 2011, 6(4):e18196.
9. Ashida A., Boku N., Aoyagi K., et al. Expression profiling of esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy: clinical implications. Int. J. Oncol. 2006, 28:1345-1352.
10. Isohata N., Aoyagi K., Mabuchi T., et al. Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int. J. Cancer 2009, 125:1212-1221.
11. Sano M., Aoyagi K., Takahashi H., et al. Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis. Int. J. Oncol. 2010, 36:321-330.
12. Yang J., Weinberg R.A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell. 2008, 14:818-829.
13. Thiery J.P., Acloque H., Huang R.Y., et al. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
14. Aoyagi K., Tatsuta T., Nishigaki M., et al. A faithful method for PCR-mediated global mRNA amplification and its integration into microarray analysis on laser-captured cells. Biochem. Biophys. Res. Commun. 2003, 300:915-920.
15. Yang M.H., Wu M.Z., Chiou S.H., et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat. Cell Biol. 2008, 10:295-305.
16. Gort E.H., van Haaften G., Verlaan I., et al. The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha. Oncogene 2008, 27:1501-1510.
17. Peinado H., del Carmen M., La Cruz I.-D., et al. A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression. EMBO J. 2005, 24:3446-3458.
18. Katoh M., Katoh M. Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. Int. J. Oncol. 2009, 34:1737-1742.
19. Eoin P.C., Edurne B., Katrina M.C., et al. Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity. Proc. Natl. Acad. Sci. USA 2006, 103:18154-18159.
20. Chengyin M., Sean F.E., David H.S., et al. NF-κB and epithelial to mesenchymal transition of cancer. J. Cell Biochem. 2008, 104:733-744.
21. Cormac T.T., Eoin P.C. The role of NF-κB in hypoxia-induced gene expression. Hypoxia and consequences. Ann. NY Acad. Sci. 2009, 1177:178-184.
22. Luthra R.R., Wu T.-T., Luthra M.G., et al. Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoprerative chemoradiation. J. Clin. Oncol. 2006, 24:259-267.
23. Duong C., Greenawalt D.M., Kowalczyk A., et al. Pretreatment gene expression profiles can be used to predict response to neoadjuvant chemoradiotherapy in esophageal cancer. Ann. Surg. Oncol. 2007, 14:3602-3609.
24. Izzo J.G., Wu X., Wu T.-T., et al. Therapy-induced expression of NF-κB portends poor prognosis in patients with localized esophageal cancer undergoing preoperative chemoradiation. Dis. Esophagus 2009, 22:127-132.
25. Maher S.G., Gillham C.M., Duggan S.P., et al. Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer. Ann. Surg. 2009, 250:729-737.