Therapy-induced expression of NF-kappa;B portends poor prognosis in patients with localized esophageal cancer undergoing preoperative chemoradiation

Diseases of the Esophagus

Volumn 22, Issue 2, 2009, Pages 127-132

  Izzo, J G ^a   Wu, X ^a   Wu, T T ^b   Huang, P ^a   Lee, J S ^a   Liao, Z ^a   Lee, J H ^c   Bhutani, M S ^c   Hofstetter, W ^c   Maru, D ^b   Hung, M C ^c   Ajani, Jaffer A ^c  

^a Department of Experimental Therapeutics ^*  (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Chemoradiation resistance; Esophageal cancer; NF B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLATINUM COMPLEX; TAXANE DERIVATIVE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL ARTICLE; DISEASE FREE SURVIVAL; ESOPHAGUS CANCER; ESOPHAGUS RESECTION; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; OVERALL SURVIVAL; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADENOCARCINOMA; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; MALE; NF-KAPPA B; PROGNOSIS;

EID: 60549104629     PISSN: 11208694     EISSN: 14422050     Source Type: Journal    
DOI: 10.1111/j.1442-2050.2008.00884.x     Document Type: Article

References (28)

1. Pohl H, Welch H G. The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst 2005; 97: 142-6.
2. Tepper J, Krasna M, Niedzwiecki D etal. Superiority of trimodality therapy to surgery alone in esophageal cancer: Results of CALGB 9781. J Clin Oncol 2008; 26: 1086-92.
3. Bosset J F, Gignoux M, Triboulet J P et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med 1997; 337: 161-7.
4. Urba S G, Orringer M B, Turrisi A, Iannettoni M, Forastiere A, Strawderman M. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001; 19: 305-13.
5. Walsh T N, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy T P. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996; 335: 462-7.
6. Kleinberg L, Forastiere A A. Chemoradiation in the management of esophageal cancer. J Clin Oncol 2007; 25: 4110-7.
7. Rice T W, Blackstone E H, Rybicki L A et al. Refining esophageal cancer staging. J Thorac Cardiovasc Surg 2003; 125: 1103-13.
8. Karin M, Cao Y, Greten F R, Li Z W. NF-kappaB in cancer: From innocent bystander to major culprit. Nat Rev 2002; 2: 301-10.
9. Hayden M S, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004; 18: 2195-224.
10. Cusack J C Jr, Liu R, Baldwin A S Jr. Inducible chemoresistance to 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation. Cancer Res 2000; 60: 2323-30.
11. Bottero V, Busuttil V, Loubat A et al. Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: A brake to apoptosis in HeLa human carcinoma cells. Cancer Res 2001; 61: 7785-91.
12. Bourgarel-Rey V, Vallee S, Rimet O et al. Involvement of nuclear factor kappaB in c-Myc induction by tubulin polymerization inhibitors. Mol Pharmacol 2001; 59: 1165-70.
13. Mabuchi S, Ohmichi M, Nishio Y et al. Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models. J Biol Chem 2004; 279: 23477-85.
14. Nakanishi C, Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev 2005; 5: 297-309.
15. Wang H E, Wu H C, Kao S J et al. Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-kappaB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell. Biochem Pharmacol 2005; 69: 617-26.
16. Wang W, Cassidy J. Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells. Br J Cancer 2003; 88: 624-9.
17. Russell J S, Tofilon P J. Radiation-induced activation of nuclear factor-kappaB involves selective degradation of plasma membrane-associated I(kappa)B(alpha). Mol Biol Cell 2002; 13: 3431-40.
18. Brach M A, Hass R, Sherman M L, Gunji H, Weichselbaum R, Kufe D. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest 1991; 88: 691-5.
19. Izzo J G, Correa A M, Wu T T et al. Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma. Mol Cancer Ther 2006; 5: 2844-50.
20. Izzo J G, Malhotra U, Wu T T et al. Association of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinoma. J Clin Oncol 2006; 24: 748-54.
21. Izzo J G, Malhotra U, Wu T T et al. Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression. Cancer Epidemiol Biomarkers Prev 2007; 16: 1200-5.
22. Sharom F J. ABC multidrug transporters: Structure, function, and role in chemoresistance. Pharmacogenomics 2008; 9: 105-27.
23. Perez-Tomas R. Multidrug resistance: Retrospect and prospect in anti-cancer drug treatment. Curr Med Chem 2006; 13: 1859-76.
24. Kuo M T. Roles of multidrug resistance genes in breast cancer chemoresistance. Adv Exp Med Biol 2007; 608: 23-30.
25. Calcagno A M, Kim I W, Wu C P, Shukla S, Ambudkar S V. ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions. Curr Drug Deliv 2007; 4: 324-33.
26. Luthra R, Luthra M G, Izzo J et al. Biomarkers of response to preoperative chemoradiation in esophageal cancers. Semin Oncol 2006; 33 (6 Suppl. 11): S2-5.
27. Lyng H, Landsverk K S, Kristiansen E et al. Response of malignant B lymphocytes to ionizing radiation: Gene expression and genotype. Int J Cancer 2005; 115: 935-42.
28. Aggarwal B, Shishodia S, Takada Y et al. Curcumin suppresses the paclitaxel-induced nuclear factor-kappa B pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 2005; 11: 7490-8.