Artificially induced epithelial-mesenchymal transition in surgical subjects: Its implications in clinical and basic cancer research

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Aoyagi, Kazuhiko ^a   Minashi, Keiko ^c   Igaki, Hiroyasu ^b   Tachimori, Yuji ^b   Nishimura, Takao ^a   Hokamura, Norikazu ^b   Ashida, Akio ^a   Daiko, Hiroyuki ^c   Ochiai, Atsushi ^c   Muto, Manabu ^d   Ohtsu, Atsushi ^c   Yoshida, Teruhiko ^a   Sasaki, Hiroki ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; BASIC RESEARCH; CANCER ADJUVANT THERAPY; CANCER CELL; CANCER RESEARCH; CLINICAL ARTICLE; CLINICAL RESEARCH; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; ESOPHAGUS BIOPSY; ESOPHAGUS CANCER; ESOPHAGUS MUCOSA; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; ISCHEMIA; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PREDICTION; PROGNOSIS; SURGICAL PATIENT; SURGICAL SAMPLE; TISSUE NECROSIS; TISSUE SECTION; BIOPSY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; NEOPLASM; PATHOLOGY; SURGERY;

BIOPSY; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION PROFILING; HUMANS; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SURGICAL PROCEDURES, OPERATIVE;

EID: 79955451022     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018196     Document Type: Article

References (29)

1. Kim C, Pik S, (2010) Gene-expression-based prognostic assays for breast cancer. Nat Rev Clin Oncol 7: 340-347.
2. Fordor SP, Read JL, Pirrung MC, Stryer L, Lu AT, et al. (1991) Light-directed, spatially addressable parallel chemical synthesis. Science 251: 767-773.
3. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, et al. (1996) Expression monitoring by hybridization to high-density ologonucleotide arrays. Nat Biothechnol 14: 1675-1680.
4. DeRisi J, Penland L, Brown PO, Bittner ML, Meltzer PS, et al. (1996) Use of a cDNA microarray to analyze gene expression patterns in human cancer. Nat Genet 14: 457-460.
5. Brown PO, Botstein D, (1999) Exploring the new world of the genome with DNA microarrays. Nat Genet 21: 33-37.
6. Ishikura S, Nihei K, Ohtsu A, Boku N, Hironaka S, et al. (2003) Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracicesophagus. J Clin Oncol 21: 2697-2702.
7. Tachimori Y, Kanamori N, Uemura N, Hokamura N, Igaki H, et al. (2009) Salvage esophagectomy after high-dose chemoradiotherapy for esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg 137: 49-54.
8. Ashida A, Boku N, Aoyagi K, Sato H, Tsubosa Y, et al. (2006) Expression profiling of esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy: clinical implications. Int J Oncol 28: 1345-1352.
9. Isohata N, Aoyagi K, Mabuchi T, Daiko H, Fukaya M, et al. (2009) Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int J Cancer 125: 1212-1221.
10. Sano M, Aoyagi K, Takahashi H, Kawamura T, Mabuchi T, et al. (2010) Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis. Int J Oncol 36: 321-330.
11. Yang J, Weinberg RA, (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829.
12. Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
13. Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, et al. (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 10: 295-305.
14. Gort EH, van Haaften G, Verlaan I, Groot AJ, Plasterk RH, et al. (2008) The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha. Oncogene 27: 1501-1510.
15. Peinado H, del Carmen M, La Cruz I-D, Olmeda D, Csiszar K, et al. (2005) A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression. EMBO J 24: 3446-3458.
16. Katoh M, Katoh M, (2009) Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. Int J Oncol 34: 1737-1742.
17. Eoin PC, Edurne B, Katrina MC, Amandine G, Kathleen TF, et al. (2006) Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NF"Insert&Symbol,"kB activity. Proc Natl Acad Sci USA 103: 18154-18159.
18. Chengyin M, Sean FE, David HS, Gail ES, (2008) NF-κB and epithelial to mesenchymal transition of cancer. J Cell Biochem 104: 733-744.
19. Cormac TT, Eoin PC, (2009) The role of NF-κB in hypoxia-induced gene expression. Hypoxia and consequences. Ann NY Acad Sci 1177: 178-184.
20. Luthra R, Wu T-T, Luthra MG, Izzo J, Lopez-Alvarez E, et al. (2006) Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preopererative chemoradiation. J Clin Oncol 24: 259-267.
21. Duong C, Greenawalt DM, Kowalczyk A, Ciavarella ML, Raskutti G, et al. (2007) Pretreatment gene expression profiles can be used to predict response to neoadjuvant chemoradiotherapy in esophageal cancer. Ann Surg Oncol 14: 3602-3609.
22. Izzo JG, Wu X, Wu T-T, Huang P, Lee JS, et al. (2009) Therapy-induced expression of NF-κB portends poor prognosis in patients with localized esophageal cancer undergoing preoperative chemoradiation. Dis Esophagus 22: 127-132.
23. Maher SG, Gillham CM, Duggan SP, Smyth PC, Miller N, et al. (2009) Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer. Ann Surg 250: 729-737.
24. Aoyagi K, Tatsuta T, Nishigaki M, Akimoto S, Tanabe C, et al. (2003) A faithful method for PCR-mediated global mRNA amplification and its integration into microarray analysis on laser-captured cells. Biochem Biophys Res Commun 300: 915-920.
25. Fukaya M, Isohata N, Ohta H, Aoyagi K, Ochiya T, et al. (2006) Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology 131: 14-29.
26. Nakamura N, Kobayashi K, Nakamoto M, Kohno T, Sasaki H, et al. (2006) Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma. Oncogene 25: 4245-4255.
27. Nishigaki M, Aoyagi K, Danjoh I, Fukaya M, Yanagihara K, et al. (2005) Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res 65: 2115-2124.
28. Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, et al. (2007) GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-β-dependent apoptotic signalling. Oncogene 26: 6488-6498.
29. Eisen MB, Spellman PT, Brown PO, Botstein D, (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95: 14863-14868.