Evaluation of drug delivery profiles in geometric three-layered tablets with various mechanical properties, in vitro-in vivo drug release, and Raman imaging

Journal of Controlled Release

Volumn 172, Issue 3, 2013, Pages 763-772

  Choi, Du Hyung ^a   Kim, Ki Hyun ^b   Park, Jun Sang ^c   Jeong, Seong Hoon ^b   Park, Kinam ^d  

^a Pusan National University   (South Korea)

^b Dongguk University   (South Korea)

^c GL PharmTech Corporation   (South Korea)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Diffusion; Geometric tablet; Mechanical properties; Multi layered tablet; Raman imaging; Rheology

Indexed keywords

DRUG RELEASE MECHANISM; FORMULATION DEVELOPMENT; GEOMETRIC CHARACTERISTICS; GEOMETRIC TABLET; HUMAN PHARMACOKINETICS; MECHANICAL CHARACTERISTICS; MULTI-LAYERED TABLETS; RAMAN IMAGING;

DIFFUSION; DRUG DELIVERY; GEOMETRY; MECHANICAL PROPERTIES; PHARMACOKINETICS; POLYMERS; RAMAN SPECTROSCOPY; RHEOLOGY;

DRUG PRODUCTS;

MAGNESIUM STEARATE; POLYMER; SODIUM CHLORIDE; TAMSULOSIN;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED DRUG RELEASE; DISSOLUTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG HALF LIFE; DRUG MIGRATION; DRUG SOLUBILITY; ELASTICITY; GEOMETRY; HUMAN; HYDROGEN BOND; MATRIX TABLET; MAXIMUM PLASMA CONCENTRATION; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RAMAN SPECTROMETRY; TABLET; TABLET THICKNESS; THREE LAYERED TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION; VISCOUS MODULUS; WATER ABSORPTION; WATER TRANSPORT; YOUNG MODULUS;

DIFFUSION; GEOMETRIC TABLET; MECHANICAL PROPERTIES; MULTI-LAYERED TABLET; RAMAN IMAGING; RHEOLOGY;

CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DRUG CARRIERS; EQUIPMENT DESIGN; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RHEOLOGY; SPECTRUM ANALYSIS, RAMAN; TABLETS; WATER;

EID: 84887183797     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.08.301     Document Type: Article

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