Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

Chinese Journal of Integrative Medicine

Volumn 14, Issue 1, 2008, Pages 56-60

  Lu, Fu Rong ^a   Shen, Lin ^a   Qin, You ^a   Gao, Lan ^a   Li, Heng ^a   Dai, Yi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Sulfonylureas; Trigonella foenum graecum L.; Type 2 diabetes mellitus

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; GLUCOSE; HEMOGLOBIN A1C; PLACEBO; SAPONIN; SULFONYLUREA DERIVATIVE; TRIGONELLA FOENUM GRAECUM EXTRACT;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CLINICAL OBSERVATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; STOMACH DISCOMFORT; UREA NITROGEN BLOOD LEVEL;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; SAPONINS; SULFONYLUREA COMPOUNDS; TRIGONELLA;

EID: 41749109134     PISSN: 16720415     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11655-007-9005-3     Document Type: Article

References (14)

1. Pan CY, Jin WS. Epidemiology of type 2 diabetes mellitus. Chin J Endocrinol Metab (Chin) 2005;21(5) :5S1-5S5.
2. Xu MY, Lu GH, Chen MD, eds. Diabetes. Shanghai: Shanghai Scientific and Technical Publishers, 2003:304-305.
3. Neeraja A, Rajyalakshmi P. Hypoglycemic effect of processed fenugreek seed in humans. J Food Sci Technol 1996;33:427-431.
4. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1057-1058.
5. The Special Committee of Diabetes Mellitus, Chinese Association of the Integration of Traditional and Western Medicine. Standard for Diagnosis and Therapeutic Effect Evaluation of Diabetes Mellitus by Integrative Chinese and Western Medicine (Draft, Chin). Chin J Integr Med 2005;25(1):94-95.
6. Ministry of Health, P. R. China. Guiding Principle of Clinical Research on New Drugs of TCM. Vol 1. Beijing: People's Medical Publishing House, 1993:215-217.
7. Ferrannini E. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 1998;19:477-490.
8. Sharma RD, Sarkar A, Hazra DK, et al. Use of fenugreek
9. seed powder in the management of non-insulin dependent diabetes mellitus. Nutrit Res 1996;16:1331-1339.
10. Li LL, Zhang YM, Wang XF, et al. The study of TFGs extracts on type 2 diabetes mellitus mice and rats. J Xinjiang Med Univ (Chin) 2005;28(2):98-101 .
11. Ravtkumar P, Anuradha CV. Effect of fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats. Phytother Res 1999;13(3):197-201.
12. Preet A, Siddiqui MR, Taha A, et al. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biothemical abnormalities in diabetic rat ocular tissues. Mol Cell Biochem 2006;289:137-147.
13. Thakran S, Siddiqui MR, Baquer NZ. Trigonella foenum graecum seed powder protects against pathological abnormalities in tissues of diabetic rats. Mol Cell Biochem 2004;266:151-159.
14. Vijayakumar MV, Singh S, Chhipa RR. The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Br J Pharmacol 2005;146:41-48.