Gold(I)-catalyzed cascade approach for the synthesis of tryptamine-based polycyclic privileged scaffolds as α1-adrenergic receptor antagonists

Journal of Organic Chemistry

Volumn 78, Issue 21, 2013, Pages 10802-10811

  Li, Zeng ^a   Li, Jing ^b   Yang, Nan ^a   Chen, Ying ^b   Zhou, Yu ^a   Ji, Xun ^a   Zhang, Lei ^a   Wang, Jinfang ^a   Xie, Xin ^b   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTORS; C-C BONDS; HIGH YIELD; ONE POT; PRIVILEGED STRUCTURES; SELECTIVITY RATIO; TARGET MOLECULE; TRYPTAMINES;

CATALYSIS; ENZYME INHIBITION; SCAFFOLDS;

GOLD;

10 CHLORO 2,13B DIMETHYL 7,8,13,13B TETRAHYDRO 5H BENZO[1,2]INDOLIZINO[8,7 B]INDOLE; 10 METHOXY 13B METHYL 7,8,13,13B TETRAHYDRO 5H BENZO[1,2]INDOLIZINO[8,7 B]INDOLE; 10 METHOXY 2,13B DIMETHYL 7,8,13,13B TETRAHYDRO 5H BENZO[1,2]INDOLIZINO[8,7 B]INDOLE; 10,13B DIMETHYL 7,8,13,13B TETRAHYDRO 5H BENZO[1,2]INDOLIZINO[8,7 B]INDOLE; 11 CHLORO 14B METHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 11 METHOXY 14B METHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 11,14B DIMETHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 13B METHYL 7,8,13,13B TETRAHYDRO 5H BENZO[1,2]INDOLIZINO[8,7 B]INDOLE; 14B METHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 2 METHOXY 14B METHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 2,11 DIMETHOXY 14B METHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 2,13B DIMETHYL 7,8,13,13B TETRAHYDRO 5H BENZO[1,2]INDOLIZINO[8,7 B]INDOLE; 3 CHLORO 11 METHOXY 14B METHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 3 CHLORO 11,14B DIMETHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; 3 CHLORO 14B METHYL 5,6,8,9,14,14B HEXAHYDROINDOLO[2',3':3,4]PYRIDO[2,1 A]ISOQUINOLINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; GOLD; INDOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; SILODOSIN; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYSIS; BIOLOGICAL ACTIVITY; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; ONE POT SYNTHESIS;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; GOLD; INHIBITORY CONCENTRATION 50; TRYPTAMINES;

EID: 84887097576     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo4017887     Document Type: Article

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