Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: A clinical experience of 618 pancreatic cysts

Modern Pathology

Volumn 26, Issue 11, 2013, Pages 1478-1487

  Nikiforova, Marina N ^a   Khalid, Asif ^b   Fasanella, Kenneth E ^b   McGrath, Kevin M ^b   Brand, Randall E ^b   Chennat, Jennifer S ^b   Slivka, Adam ^b   Zeh, Herbert J ^b   Zureikat, Amer H ^b   Krasinskas, Alyssa M ^a   Ohori, N Paul ^a   Schoedel, Karen E ^a   Navina, Sarah ^a   Mantha, Geeta S ^a   Pai, Reetesh K ^a   Singhi, Aatur D ^a  

^a PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

intraductal papillary mucinous neoplasm; IPMN; KRAS; MCN; mucinous cystic neoplasm

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; GENOMIC DNA; K RAS PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CODON; CYST FLUID; CYSTADENOMA; CYSTIC NEOPLASM; CYTOPATHOLOGY; DIAGNOSTIC TEST ACCURACY STUDY; ENDOSCOPIC ECHOGRAPHY; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; FOLLOW UP; GRANULOSA CELL TUMOR; HUMAN; HUMAN TISSUE; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; MAJOR CLINICAL STUDY; MALE; MUCINOUS CYSTIC NEOPLASM; MUTATIONAL ANALYSIS; NEURILEMOMA; PANCREAS ADENOCARCINOMA; PANCREAS CYST; PANCREAS FOREGUT CYST; PANCREAS LYMPHOEPITHELIAL CYST; PANCREAS PSEUDOCYST; PANCREAS RETENTION CYST; PANCREATIC NEUROENDOCRINE TUMOR; POINT MUTATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SOLID PSEUDOPAPILLARY TUMOR; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, PANCREATIC DUCTAL; CELL DIFFERENTIATION; DNA MUTATIONAL ANALYSIS; ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASMS, CYSTIC, MUCINOUS, AND SEROUS; PANCREATIC CYST; PANCREATIC NEOPLASMS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; YOUNG ADULT;

EID: 84887053712     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.91     Document Type: Article

References (24)

1. Spinelli KS, Fromwiller TE, Daniel RA, et al. Cystic pancreatic neoplasms: observe or operate. Ann Surg 2004;239:651-657; discussion 7-9.
2. Laffan TA, Horton KM, Klein AP, et al. Prevalence of unsuspected pancreatic cysts on MDCT. AJR Am J Roentgenol 2008;191:802-807.
3. Kimura W, Nagai H, Kuroda A, et al. Analysis of small cystic lesions of the pancreas. Int J Pancreatol 1995;18:197-206. (Pubitemid 26023501)
4. Sohn TA, Yeo CJ, Cameron JL, et al. Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 2004;239:788-797; discussion 97-99.
5. Schnelldorfer T, Sarr MG, Nagorney DM, et al. Experience with 208 resections for intraductal papillary mucinous neoplasm of the pancreas. Arch Surg 2008; 143:639-646; discussion 46. (Pubitemid 352040228)
6. Hruban RH, Maitra A, Kern SE, et al. Precursors to pancreatic cancer. Gastroenterol Clin North Am 2007; 36:831-849; vi. (Pubitemid 350051704)
7. Matthaei H, Schulick RD, Hruban RH, et al. Cystic precursors to invasive pancreatic cancer. Nat Rev Gastroenterol Hepatol 2011;8:141-150.
8. Tanaka M, Fernandez-del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 2012;12:183-197.
9. Tanaka M, Chari S, Adsay V, et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006;6: 17-32.
10. Schoedel KE, Finkelstein SD, Ohori NP. K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas. Diagn Cytopathol 2006;34:605-608. (Pubitemid 44298560)
11. Khalid A, McGrath KM, Zahid M, et al. The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology. Clin Gastroenterol Hepatol 2005;3: 967-973. (Pubitemid 41415743)
12. Khalid A, Zahid M, Finkelstein SD, et al. Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc 2009;69:1095-1102.
13. Hruban RH, Pitman MB, Klimstra DS. Tumors of the Pancreas. American Registry of Pathology Washington, DC, 2007.
14. Shen J, Brugge WR, Dimaio CJ, et al. Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis. Cancer 2009;117:217-227.
15. Panarelli NC, Sela R, Schreiner AM, et al. Commercial molecular panels are of limited utility in the classification of pancreatic cystic lesions. Am J Surg Pathol 2012;36:1434-1443.
16. Toll AD, Kowalski T, Loren D, et al. The added value of molecular testing in small pancreatic cysts. JOP 2010;11:582-586.
17. Singhi AD, Chu LC, Tatsas AD, et al. Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. Am J Surg Pathol 2012;36:1666-1673.
18. Satoh K, Shimosegawa T, Moriizumi S, et al. K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas 1996;12:362-368.
19. Schonleben F, Allendorf JD, Qiu W, et al. Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas. Pancreas 2008;36:168-172.
20. Schonleben F, Qiu W, Bruckman KC, et al. BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Lett 2007;249:242-248. (Pubitemid 46452934)
21. Yoshizawa K, Nagai H, Sakurai S, et al. Clonality and K-ras mutation analyses of epithelia in intraductal papillary mucinous tumor and mucinous cystic tumor of the pancreas. Virchows Arch 2002;441: 437-443. (Pubitemid 35430457)
22. Jimenez RE, Warshaw AL, Z'Graggen K, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg 1999;230:501-509; discussion 9-11.
23. Wu J, Matthaei H, Maitra A, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med 2011;3:92ra66.
24. Wu J, Jiao Y, Dal Molin M, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitindependent pathways. Proc Natl Acad Sci USA 2011; 108:21188-21193.