The added value of molecular testing in small pancreatic cysts

Journal of the Pancreas

Volumn 11, Issue 6, 2010, Pages 582-586

  Toll, Adam D ^a   Kowalski, Thomas ^a   Loren, David ^a   Bibbo, Marluce ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Molecular biology; Pancreatic cyst

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DNA;

ADULT; AGED; ARTICLE; ASPIRATION BIOPSY; CYST ASPIRATION; CYTOLOGY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DNA DETERMINATION; ENDOSCOPIC ECHOGRAPHY; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE K RAS; PANCREAS CYST; PANCREATICODUODENECTOMY; RETROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOPSY, FINE-NEEDLE; CARCINOEMBRYONIC ANTIGEN; CYST FLUID; ENDOSONOGRAPHY; FEMALE; GENES, RAS; HUMANS; MALE; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; PANCREATIC CYST; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 78449310839     PISSN: None     EISSN: 15908577     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Brugge WR, Lauwers GY, Sahani D, Castillo CF, Warshaw AL. Cystic neoplasms of the pancreas. N Engl J Med 2004; 351:1218-1226. [PMID 15371579]
2. Khalid A, Brugge WR. ACG practice guidelines for the diagnosis and management of neoplastic pancreatic cysts. Am J Gastroenterol 2007; 102: 2339-2349. [PMID: 17764489]
3. Hutchins G, Draganov PV. Diagnostic evaluation of pancreatic cystic malignancies. Surg Clin North Am 2010; 90:399-410. [PMID 20362794]
4. Brugge WR, Lewandrowski K, Lee-Lewandrowski E, Centeno BA, Szydlo T, Regan S, et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 2004; 126:1330-1336. [PMID: 15131794]
5. Federle MP, McGrath KM. Cystic neoplasms of the pancreas. Gastroenterol Clin North Am 2007; 36:365-376. [PMID: 17533084]
6. Khalid A, Zahid M, Finkelstein SD, LeBlanc JK, Kaushik N, Ahmad N, et al. Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc 2009; 69:1095-1102. [PMID: 19152896]
7. Khalid A, McGrath K, Zahid M, Wilson M, Brody D, Swalsky P, et al. The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology. Clin Gastroenterol Hepatol 2005; 3:967-973. [PMID 16234041]
8. Sawhney MS, Devarajan S, O'Farrel P, Cury MS, Kundu R, Vollmer CM, Brown A, et al. Comparison of carcinoembryonic antigen and molecular analysis in pancreatic cyst fluid. Gastrointest Endosc 2009; 69:1106-1110. [PMID: 19249035]
9. Al-Haddad M, Raimondo M, Woodward T, Krishna M, Pungpapong S, Noh K, Wallace MB. Safety and efficacy of cytology brushings versus standard FNA in evaluating cystic lesions of the pancreas: a pilot study. Gastrointest Endosc 2007; 65:894-898. [PMID 17210151]
10. Schoedel K, Finkelstein S, Ohori N. K-ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas. Diagn Cytopathol 2006; 34:605-608. [PMID 16900481]
11. Sreenarasimhaiah J, Lara LF, Jazrawi SF, Barnett CC, Tang SJ. A comparative analysis of pancreatic cyst fluid CEA and histology with DNA mutational analysis in the detection of mucin producing or malignant cysts. JOP. J Pancreas (Online) 2009; 10:163-168. [PMID: 19287110]
12. Shen J, Brugge WR, DiMaio CJ, Pitman MB. Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis. Cancer Cytopathol 2009; 117:217-227. [PMID 19415731]
13. Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006; 6:17-32. [PMID 16327281]
14. Grobmyer SR, Cance WG, Copeland EM, Vogel SB, Hochwald SN. Is there an indication for initial conservative management of pancreatic cystic lesions? J Surg Oncol 2009; 100:372-374. [PMID 19267387]
15. Goh BK, Tan YM, Chung YF, Chow PK, Cheow PC, Thng CH, et al. Pancreatic cysts: a proposed management algorithm based on current evidence. Am J Surg 2007; 193:749-755. [PMID 17512290]
16. Allen PJ, D'Angelica M, Gonen M, Jacques DP, Coit DG, Jarnagin WR, DeMatteo R, et al. A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients. Ann Surg 2006; 244:572-582. [PMID 16998366]
17. DeWitt J, McGreevy K, Schmidt CM, Brugge WR. EUS-guided ethanol versus saline solution lavage for pancreatic cysts: a randomized, double-blinded study. Gastrointest Endosc 2009; 70:710-723. [PMID: 19577745]
18. Ho KY, Brugge WR, EUS 2008 Working Group. EUS 2008 Working Group document: evaluation of EUS-guided pancreatic-cyst ablation. Gastrointest Endosc 2009; 69(Suppl 2):S22-S27. [PMID: 19179162]