Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi

Critical Care Medicine

Volumn 41, Issue 11, 2013, Pages

  Harrois, Anatole ^a,b   Baudry, Nathalie ^a   Huet, Olivier ^b,c   Kato, Hiromi ^a   Lohez, Manuel ^d,e   Ziol, Marianne ^d,e   Duranteau, Jacques ^b   Vicaut, Eric ^a  

^a Laboratoire d'Etude de la Microcirculation   (France)

^b BICÊTRE HOSPITAL   (France)

^c MONASH UNIVERSITY   (Australia)

^d HÔPITAL JEAN VERDIER   (France)

^e UNIVERSITÉ PARIS 13   (France)

Author keywords

Hemorrhagic shock; Hypoxemia; Intestinal microcirculation; Multiple organ failure; Trauma

Indexed keywords

OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ERYTHROCYTE; EXPERIMENTAL STUDY; EXSANGUINATION; HEMORRHAGIC SHOCK; HYPOVOLEMIA; HYPOXEMIA; INTESTINE BLOOD FLOW; INTESTINE PERFUSION; INTESTINE VILLUS; LEUKOCYTE ADHERENCE; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; VENULE;

ANIMALS; ANOXIA; CELL ADHESION; HEMODYNAMICS; HUMANS; HYPOVOLEMIA; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED BALB C; MICROCIRCULATION; NEUTROPHILS; RANDOM ALLOCATION;

EID: 84887048962     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318292388d     Document Type: Article

References (36)

1. Kauvar DS, Wade CE: The epidemiology and modern management of traumatic hemorrhage: US and international perspectives. Crit Care 2005; 9(Suppl 5):S1-S9
2. Dunham CM, Siegel JH, Weireter L, et al: Oxygen debt and metabolic acidemia as quantitative predictors of mortality and the severity of the ischemic insult in hemorrhagic shock. Crit Care Med 1991; 19:231-243
3. Rixen D, Raum M, Holzgraefe B, et al; Shock and Trauma Study Group: A pig hemorrhagic shock model: Oxygen debt and metabolic acidemia as indicators of severity. Shock 2001; 16:239-244
4. Rixen D, Siegel JH: Bench-to-bedside review: Oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock. Crit Care 2005; 9:441-453
5. Douzinas EE, Andrianakis I, Livaditi O, et al: The level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic inflammatory response: An experimental study. BMC Physiol 2008; 8:15
6. Scalia R, Armstead VE, Minchenko AG, et al: Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion. J Exp Med 1999; 189:931-938
7. Akgür FM, Brown MF, Zibari GB, et al: Role of superoxide in hemorrhagic shock-induced P-selectin expression. Am J Physiol Heart Circ Physiol 2000; 279:H791-H797
8. Childs EW, Udobi KF, Wood JG, et al: In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. Shock 2002; 18:423-427
9. van Meurs M, Wulfert FM, Jongman RM, et al: Hemorrhagic shockinduced endothelial cell activation in a spontaneous breathing and a mechanical ventilation hemorrhagic shock model is induced by a proinflammatory response and not by hypoxia. Anesthesiology 2011; 115:474-482
10. Zhang Q, Raoof M, Chen Y, et al: Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464:104-107
11. Baudry N, Danialou G, Boczkowski J, et al: In vivo study of the effect of systemic hypoxia on leukocyte-endothelium interactions. Am J Respir Crit Care Med 1998; 158:477-483
12. Wood JG, Johnson JS, Mattioli LF, et al: Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation. J Appl Physiol 1999; 87:1734-1740
13. Steiner DR, Gonzalez NC, Wood JG: Leukotriene B(4) promotes reactive oxidant generation and leukocyte adherence during acute hypoxia. J Appl Physiol 2001; 91:1160-1167
14. Casillan AJ, Gonzalez NC, Johnson JS, et al: Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. J Appl Physiol 2003; 94:2313-2322
15. Deitch EA, Xu D, Kaise VL: Role of the gut in the development of injury- and shock induced SIRS and MODS: The gut-lymph hypothesis, a review. Front Biosci 2006; 11:520-528
16. Duranteau J, Sitbon P, Vicaut E, et al: Assessment of gastric mucosal perfusion during simulated hypovolemia in healthy volunteers. Am J Respir Crit Care Med 1996; 154(6 Part 1):1653-1657
17. Dubin A, Pozo MO, Ferrara G, et al: Systemic and microcirculatory responses to progressive hemorrhage. Intensive Care Med 2009; 35:556-564
18. Gutierrez G, Palizas F, Doglio G, et al: Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992; 339:195-199
19. Pathan N, Burmester M, Adamovic T, et al: Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease. Am J Respir Crit Care Med 2011; 184:1261-1269
20. Tamion F, Richard V, Lyoumi S, et al: Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock. Am J Physiol 1997; 273(2 Part 1):G314-G321
21. Reino DC, Pisarenko V, Palange D, et al: Trauma hemorrhagic shockinduced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS One 2011; 6:e14829
22. Krejci V, Hiltebrand L, Banic A, et al: Continuous measurements of microcirculatory blood flow in gastrointestinal organs during acute haemorrhage. Br J Anaesth 2000; 84:468-475
23. Vajda K, Szabó A, Boros M: Heterogeneous microcirculation in the rat small intestine during hemorrhagic shock: Quantification of the effects of hypertonic-hyperoncotic resuscitation. Eur Surg Res 2004; 36:338-344
24. Nakajima Y, Baudry N, Duranteau J, et al: Microcirculation in intestinal villi: A comparison between hemorrhagic and endotoxin shock. Am J Respir Crit Care Med 2001; 164(8 Part 1):1526-1530
25. Fruchterman TM, Spain DA, Wilson MA, et al: Complement inhibition prevents gut ischemia and endothelial cell dysfunction after hemorrhage/ resuscitation. Surgery 1998; 124:782-791
26. Fang X, Tang W, Sun S, et al: Comparison of buccal microcirculation between septic and hemorrhagic shock. Crit Care Med 2006; 34(12 Suppl):S447-S453
27. Butcher EC, Weissman IL: Direct fluorescent labeling of cells with fluorescein or rhodamine isothiocyanate. I. Technical aspects. J Immunol Methods 1980; 37:97-108
28. Sarelius IH, Duling BR: Direct measurement of microvessel hematocrit, red cell flux, velocity, and transit time. Am J Physiol 1982; 243:H1018-H1026
29. Chiu CJ, McArdle AH, Brown R, et al: Intestinal mucosal lesion in lowflow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 1970; 101:478-483
30. Zuurbier CJ, Emons VM, Ince C: Hemodynamics of anesthetized ventilated mouse models: Aspects of anesthetics, fluid support, and strain. Am J Physiol Heart Circ Physiol 2002; 282:H2099-H2105
31. Dalkara T, Irikura K, Huang Z, et al: Cerebrovascular responses under controlled and monitored physiological conditions in the anesthetized mouse. J Cereb Blood Flow Metab 1995; 15:631-638
32. Langdown AJ, Marshall JM: Analysis of responses observed in mesenteric microcirculation of the rat during systemic hypoxia. J Physiol 1995; 482(Part 3):669-677
33. Robinson NB, Chi EY, Robertson HT: Ventilation-perfusion relationships after hemorrhage and resuscitation: An inert gas analysis. J Appl Physiol 1983; 54:1131-1140
34. Zakaria el R, Li N, Matheson PJ, et al: Cellular edema regulates tissue capillary perfusion after hemorrhage resuscitation. Surgery 2007; 142:487-496
35. Mazzoni MC, Borgström P, Intaglietta M, et al: Capillary narrowing in hemorrhagic shock is rectified by hyperosmotic saline-dextran reinfusion. Circ Shock 1990; 31:407-418
36. Pascual JL, Ferri LE, Seely AJ, et al: Hypertonic saline resuscitation of hemorrhagic shock diminishes neutrophil rolling and adherence to endothelium and reduces in vivo vascular leakage. Ann Surg 2002; 236:634-642