Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate

Bioscience Reports

Volumn 33, Issue 5, 2013, Pages 815-822

  Helmis, Christina ^a   Blechner, Christine ^a   Lin, Hongying ^a   Schweizer, Michaela ^a   Mayr, Georg W ^a   Nielsen, Peter ^a   Windhorst, Sabine ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

H1299 tumour cell; Inositol hexakisphosphate; Multiple inositol polyphosphate phosphatase (MINPP1)

Indexed keywords

CHROMIUM; IRON; PHYTIC ACID; COORDINATION COMPOUND; FERRITIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; CANCER CELL; CELL FRACTIONATION; CELL STRAIN CACO 2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; ELECTRON MICROSCOPE; H1299 CELL; HUMAN; HUMAN CELL; IRON TRANSPORT; LUNG CARCINOMA; LYSOSOME; PHAGOCYTOSIS; CACO 2 CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; DRUG EFFECT; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CHROMIUM; COORDINATION COMPLEXES; FERRITINS; HUMANS; IRON; LYSOSOMES; PHYTIC ACID; REACTIVE OXYGEN SPECIES;

EID: 84887048636     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20130079     Document Type: Article

References (17)

1. Veiga, N., Torres, J., Domínguez, S., Mederos, A., Irvine, R. F., Díaz, A. and Kremer, C. (2006) The behaviour of myo-inositol hexakisphosphate in the presence of magnesium(II) and calcium(II): protein-free soluble InsP6 is limited to 49 microM under cytosolic/nuclear conditions. J. Inorg. Biochem. 100, 1800-1810
2. Nelson, T. S. and Ferrara, L. W. (1968) Phytate phosphorus content of feed ingredients derived from plants. Poult. Sci. 47, 1372-1374
3. Jorquera, M. A., Crowley, D. E., Marschner, P., Greiner, R., Fernández, M. T., Romero, D., Menezes-Blackburn, D. and De La Luz Mora, M. (2011) Identification of β-propeller phytase-encoding genes in culturable Paenibacillus and Bacillus spp. from the rhizosphere of pasture plants on volcanic soils. FEMS Microbiol. Ecol. 75, 163-172
4. Windhorst, S., Lin, H., Blechner, C., Fanick, W., Brandt, L., Brehm, M. A. and Mayr, G. W. (2013) Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation. Biochem. J. 450, 115-125
5. Vucenik, I. and Shamsuddin, A. M. (2006) Protection against cancer by dietary IP6 and inositol. Nutr. Cancer 55, 109-125
6. Anderson, C. P., Shen, M., Eisenstein, R. S. and Leibold, EA. (2012) Mammalian iron metabolism and its control by iron regulatory proteins. Biochim. Biophys. Acta 1823, 1468-1483
7. Cheryan, M. (1980) Phytic acid interactions in food systems. Crit. Rev. Food Sci. Nutr. 13, 297-335
8. Hallberg, L., Rossander, L. and Skanberg, A. B. (1987) Phytates and the inhibitory effect of bran on iron absorption in man. Am. J. Clin. Nutr. 45, 988-996
9. Ma, Q., Kim, E. Y., Lindsay, E. A. and Han, O. (2011) Bioactive dietary polyphenols inhibit heme iron absorption in a dose-dependent manner in human intestinal Caco-2 cells. J. Food Sci. 76, H143-H150
10. Mayr, G. W. (1988) A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimens. Biochem. J. 254, 585-591
11. Bessis, M. C. and Breton-Gorius, J. (1962) Iron metabolism in the bone marrow as seen by electron microscopy: a critical review. Blood 19, 635-663
12. Ahlinder, L., Ekstrand-Hammarström, B., Geladi, P. and Osterlund, L. (2013) Large uptake of titania and iron oxide nanoparticles in the nucleus of lungepithelial cells as measured by Raman imaging and multivariate classification. Biophys. J. 105, 310-319
13. Theil, E. C. (2003) Ferritin: at the crossroads of iron and oxygen metabolism. J. Nutr. 133, 1549S-1553S
14. Hawkins, P. T., Poyner, D. R., Jackson, T. R., Letcher, A. J., Lander, D. A. and Irvine, R. F. (1993) Inhibition of iron-catalysed hydroxyl radical formation by inositolpolyphosphates: a possible physiological function for myo-inositol hexakisphosphate. Biochem. J. 294, 929-934
15. Mali, G., Sala, M., Ar Ccaron, On I., Kau Ccaron, I., Ccaron, V. C. and Kolar, J. (2006) Insight into the short-range structure of amorphous iron inositol hexaphosphate as provided by (31)P NMR and Fe X-ray absorption spectroscopy. J. Phys. Chem. B 110, 23060-23067
16. Sala, M., Makuc, D., Kolar, J., Plavec, J. and Bretti, P. B. (2011) Potentiometric and 31P NMR studies on inositol phosphates and their interaction with iron(III) ions. Carbohydr. Res. 346, 488-494
17. Bretti, C., Cigala, R. M., Lando, G., Milea, D. and Sammartano, S. (2012) Sequestering ability of phytate toward biologically and environmentally relevant trivalent metal cations. J. Agric. Food Chem. 60, 8075-8082