Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity

Radiotherapy and Oncology

Volumn 108, Issue 3, 2013, Pages 548-553

  Burrows, Natalie ^a   Telfer, Brian ^a   Brabant, Georg ^b   Williams, Kaye J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Medizinische Klinik i   (Germany)

Author keywords

GDC 0941; HIF 1; Metastasis; PI3K; Radiotherapy; Rho GTPases

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PICTILISIB; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IMMUNOFLUORESCENCE; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RADIATION INDUCED METASTASIS; RADIATION INJURY; THYROID CARCINOMA; WESTERN BLOTTING; XENOGRAFT;

GDC-0941; HIF-1; METASTASIS; PI3K; RADIOTHERAPY; RHO-GTPASES;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; INDAZOLES; MICE; NEOPLASM METASTASIS; PHOSPHATIDYLINOSITOL 3-KINASES; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SULFONAMIDES; THYROID NEOPLASMS;

EID: 84887016335     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.06.027     Document Type: Article

References (21)

1. N.L. Busaidy, and M.E. Cabanillas Differentiated thyroid cancer: management of patients with radioiodine nonresponsive disease J Thyroid Res 2012 2012 618985
2. M.K. Jones Management of papillary and follicular thyroid cancer J R Soc Med 95 2002 325 326
3. M. Vorster, and M.M. Sathekge Detection of extensive metastases from anaplastic thyroid cancer by F-18 FDG-PET/CT Open Nucl Med J 3 2011 1 6
4. N. Burrows, M. Babur, J. Resch, S. Ridsdale, M. Mejin, and E.J. Rowling GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxiainducible factor-1alpha (HIF-1alpha) pathways J Clin Endocrinol Metab 96 2011 E1934 E1943
5. J.E. Paes, and M.D. Ringel Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia Endocrinol Metab Clin North Am 37 2008 375 387 [viii-ix]
6. B.H. Jiang, and L.Z. Liu PI3K/PTEN signaling in angiogenesis and tumorigenesis Adv Cancer Res 102 2009 19 65
7. M. Qiao, J.D. Iglehart, and A.B. Pardee Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation Cancer Res 67 2007 5293 5299
8. L. Larue, and A. Bellacosa Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways Oncogene 24 2005 7443 7454
9. C. Wild-Bode, M. Weller, A. Rimner, J. Dichgans, and W. Wick Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma Cancer Res 61 2001 2744 2750
10. A.C. Pickhard, J. Margraf, A. Knopf, T. Stark, G. Piontek, and C. Beck Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways BMC Cancer 11 2011 388
11. M. Jo, R.D. Lester, V. Montel, B. Eastman, S. Takimoto, and S.L. Gonias Reversibility of epithelialmesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling J Biol Chem 284 2009 22825 22833
12. B.K. Park, X. Zeng, and R.I. Glazer Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells Cancer Res 61 2001 7647 7653
13. R.J. Cain, and A.J. Ridley Phosphoinositide 3-kinases in cell migration Biol Cell 101 2009 13 29
14. V.G. Walker, A. Ammer, Z. Cao, A.C. Clump, B.H. Jiang, and L.C. Kelley PI3K activation is required for PMA-directed activation of cSrc by AFAP-110 Am J Physiol Cell Physiol 293 2007 C119 C132
15. H.R. Reiske, S.C. Kao, L.A. Cary, J.L. Guan, J.F. Lai, and H.C. Chen Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration J Biol Chem 274 1999 12361 12366
16. M. Campbell, and E.R. Trimble Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII Circ Res 96 2005 197 206
17. N. Burrows, J. Resch, R.L. Cowen, R. von Wasielewski, C. Hoang-Vu, and C.M. West Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas Endocr Relat Cancer 17 2010 61 72
18. K.J. Williams, B.A. Telfer, A.M. Shannon, M. Babur, I.J. Stratford, and S.R. Wedge Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit Mol Cancer Ther 6 2007 599 606
19. P. Workman, E.O. Aboagye, F. Balkwill, A. Balmain, G. Bruder, and D.J. Chaplin Guidelines for the welfare and use of animals in cancer research Br J Cancer 102 2010 1555 1577
20. L. Liu, Y. Luo, L. Chen, T. Shen, B. Xu, and W. Chen Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity J Biol Chem 285 2010 38362 38373
21. I. Eke, and N. Cordes Radiobiology goes 3D: how ECM and cell morphology impact on cell survival after irradiation Radiother Oncol 99 2011 271 278