Extending the pharmacokinetic half-life of coagulation factors by fusion to recombinant albumin

Thrombosis and Haemostasis

Volumn 110, Issue 5, 2013, Pages 931-939

  Metzner, Hubert J ^a   Pipe, Steven W ^b   Weimer, Thomas ^a   Schulte, Stefan ^a  

^a CSL BEHRING GMBH   (Germany)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Albumin fusion; Coagulation factor IX; Coagulation factor VIIa; Half life extension

Indexed keywords

ALBIGLUTIDE; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 9 CONCENTRATE; CHOLINESTERASE; FC RECEPTOR; GLUCAGON LIKE PEPTIDE 1; HYBRID PROTEIN; PHENPROCOUMON; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RECOMBINANT BLOOD CLOTTING FACTOR 9; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT HUMAN SERUM ALBUMIN; VON WILLEBRAND FACTOR;

AREA UNDER THE CURVE; BLEEDING TIME; BLOOD CLOTTING TIME; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; HEMOPHILIA A; HEMOPHILIA B; HUMAN; NEUTROPENIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATIENT COMPLIANCE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SINGLE DRUG DOSE;

ALBUMIN FUSION; COAGULATION FACTOR IX; COAGULATION FACTOR VIIA; HALF-LIFE EXTENSION;

ALBUMINS; ANIMALS; FACTOR IX; FACTOR VIIA; HEMOPHILIA A; HUMANS; MEDICATION ADHERENCE; PROTEIN ENGINEERING; QUALITY OF LIFE; RECOMBINANT FUSION PROTEINS;

EID: 84887009302     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-03-0213     Document Type: Review

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