-
1
-
-
36849040529
-
Albinterferon α-2b: A genetic fusion protein for the treatment of chronic hepatitis C
-
DOI 10.1038/nbt1364, PII NBT1364
-
GM Subramanian, M Fiscella, A Lamousé-Smith et al. Albinterferon α-2b: a genetic fusion protein for the treatment of chronic hepatitis C Nat Biotechnol 25 2007 1411 1419 (Pubitemid 350233139)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.12
, pp. 1411-1419
-
-
Subramanian, G.M.1
Fiscella, M.2
Lamouse-Smith, A.3
Zeuzem, S.4
McHutchison, J.G.5
-
2
-
-
65349102942
-
Development, characterization, and evaluation of a fusion protein of a novel glucagon-like peptide-1 (GLP-1) analog and human serum albumin in Pichia pastoris
-
Z Gao, G Bai, J Chen et al. Development, characterization, and evaluation of a fusion protein of a novel glucagon-like peptide-1 (GLP-1) analog and human serum albumin in Pichia pastoris. Biosci Biotechnol Biochem 73 2009 688 694
-
(2009)
Biosci Biotechnol Biochem
, vol.73
, pp. 688-694
-
-
Gao, Z.1
Bai, G.2
Chen, J.3
-
3
-
-
70350438004
-
The versatile MHC class I-related FcRn protects IgG and albumin from degradation: Implications for development of new diagnostics and therapeutics
-
JT Andersen, I Sandlie The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics Drug Metab Pharmacokinet 24 2009 318 332
-
(2009)
Drug Metab Pharmacokinet
, vol.24
, pp. 318-332
-
-
Andersen, J.T.1
Sandlie, I.2
-
4
-
-
62149133544
-
Fusion-proteins as biopharmaceuticals-applications and challenges
-
SR Schmidt Fusion-proteins as biopharmaceuticals-applications and challenges Curr Opin Drug Discov Devel 12 2009 284 295
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 284-295
-
-
Schmidt, S.R.1
-
5
-
-
67649843650
-
Strategies to extend plasma half-lives of recombinant antibodies
-
RE Kontermann Strategies to extend plasma half-lives of recombinant antibodies BioDrugs 23 2009 93 109
-
(2009)
BioDrugs
, vol.23
, pp. 93-109
-
-
Kontermann, R.E.1
-
6
-
-
33745508741
-
Perspective - FcRn transports albumin: Relevance to immunology and medicine
-
DOI 10.1016/j.it.2006.05.004, PII S1471490606001463
-
CL Anderson, C Chaudhury, J Kim et al. Perspective-FcRn transports albumin: relevance to immunology and medicine Trends Immunol 27 2006 343 348 (Pubitemid 43963476)
-
(2006)
Trends in Immunology
, vol.27
, Issue.7
, pp. 343-348
-
-
Anderson, C.L.1
Chaudhury, C.2
Kim, J.3
Bronson, C.L.4
Wani, M.A.5
Mohanty, S.6
-
7
-
-
84875534020
-
Real-time, label-free surface plasmon resonance (Biacore™) analysis of rIX-FP, a recombinant fusion protein linking coagulation factor IX with albumin, shows binding to FcRn comparable to plasma-derived human albumin-correlating with extended half-life in vivo
-
[Abstract PO-TU-019].
-
H Braley, V Tomasetig, S Zollner et al. Real-time, label-free surface plasmon resonance (Biacore™) analysis of rIX-FP, a recombinant fusion protein linking coagulation factor IX with albumin, shows binding to FcRn comparable to plasma-derived human albumin-correlating with extended half-life in vivo Haemophilia 18 Suppl 3 2012 30 [Abstract PO-TU-019].
-
(2012)
Haemophilia
, vol.18
, Issue.SUPPL. 3
, pp. 30
-
-
Braley, H.1
Tomasetig, V.2
Zollner, S.3
-
8
-
-
0036001387
-
Pharmaceutical strategies utilizing recombinant human serum albumin
-
DOI 10.1023/A:1015396825274
-
VT Chuang, U Kragh-Hansen, M Otagiri Pharmaceutical strategies utilizing recombinant human serum albumin Pharm Res 19 2002 569 577 (Pubitemid 34553662)
-
(2002)
Pharmaceutical Research
, vol.19
, Issue.5
, pp. 569-577
-
-
Tuan Giam Chuang, V.1
Kragh-Hansen, U.2
Otagiri, M.3
-
9
-
-
84855850311
-
Impact of albumin on drug delivery-New applications on the horizon
-
B Elsadek, F Kratz Impact of albumin on drug delivery-New applications on the horizon J Control Release 157 2012 4 28
-
(2012)
J Control Release
, vol.157
, pp. 4-28
-
-
Elsadek, B.1
Kratz, F.2
-
11
-
-
19944428668
-
Development of a long-acting insulin analog using albumin fusion technology
-
DOI 10.2337/diabetes.54.1.251
-
A Duttaroy, P Kanakaraj, BL Osborn et al. Development of a long-acting insulin analog using albumin fusion technology Diabetes 54 2005 251 258 (Pubitemid 40105120)
-
(2005)
Diabetes
, vol.54
, Issue.1
, pp. 251-258
-
-
Duttaroy, A.1
Kanakaraj, P.2
Osborn, B.L.3
Schneider, H.4
Pickeral, O.K.5
Chen, C.6
Zhang, G.7
Kaithamana, S.8
Singh, M.9
Schulingkamp, R.10
Crossan, D.11
Bock, J.12
Kaufman, T.E.13
Keavey, P.14
Carey-Barber, M.15
Krishnan, S.K.16
Garcia, A.17
Murphy, K.18
Siskind, J.K.19
McLean, M.A.20
Cheng, S.21
Ruben, S.22
Birse, C.E.23
Blondel, O.24
more..
-
12
-
-
0030942608
-
Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin
-
S Syed, PD Schuyler, M Kulczycky et al. Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin Blood 89 1997 3243 3252 (Pubitemid 27229809)
-
(1997)
Blood
, vol.89
, Issue.9
, pp. 3243-3252
-
-
Syed, S.1
Schuyler, P.D.2
Kulczycky, M.3
Sheffield, W.P.4
-
13
-
-
67650526845
-
Efficacy and safety of albinterferon alfa-2b in combination with ribavirin in treatment-naive, chronic hepatitis C genotype 1 (CHC G1) patients
-
[Abstract 1041].
-
S Zeuzem, M Sulkowski, E Lawitz et al. Efficacy and safety of albinterferon alfa-2b in combination with ribavirin in treatment-naive, chronic hepatitis C genotype 1 (CHC G1) patients J Hepatol 50 Suppl 1 2009 S378 [Abstract 1041].
-
(2009)
J Hepatol
, vol.50
, Issue.SUPPL. 1
, pp. 378
-
-
Zeuzem, S.1
Sulkowski, M.2
Lawitz, E.3
-
14
-
-
67650511381
-
Efficacy and safety results of albinterferon alfa-2b in combination with ribavirin in interferon-alfa treatment naive patients with genotype 2 or 3 chronic hepatitis C
-
[Abstract 1042].
-
D Nelson, Y Benhamou, WL Chuang et al. Efficacy and safety results of albinterferon alfa-2b in combination with ribavirin in interferon-alfa treatment naive patients with genotype 2 or 3 chronic hepatitis C J Hepatol 50 Suppl 1 2009 S378 [Abstract 1042].
-
(2009)
J Hepatol
, vol.50
, Issue.SUPPL. 1
, pp. 378
-
-
Nelson, D.1
Benhamou, Y.2
Chuang, W.L.3
-
15
-
-
2342628432
-
Effect of albumin fusion on the biodistribution of interleukin-2
-
DOI 10.1007/s00262-003-0454-z
-
Z Yao, W Dai, J Perry et al. Effect of albumin fusion on the biodistribution of interleukin-2 Cancer Immunol Immunother 53 2004 404 410 (Pubitemid 38657253)
-
(2004)
Cancer Immunology, Immunotherapy
, vol.53
, Issue.5
, pp. 404-410
-
-
Yao, Z.1
Dai, W.2
Perry, J.3
Brechbiel, M.W.4
Sung, C.5
-
16
-
-
20944431599
-
Pharmacokinetics and in vitro and in vivo anti-tumor response of an interleukin-2-human serum albumin fusion protein in mice
-
RJ Melder, BL Osborn, T Riccobene et al. Pharmacokinetics and in vitro and in vivo anti-tumor response of an interleukin-2-human serum albumin fusion protein in mice Cancer Immunol Immunother 54 2005 535 547
-
(2005)
Cancer Immunol Immunother
, vol.54
, pp. 535-547
-
-
Melder, R.J.1
Osborn, B.L.2
Riccobene, T.3
-
17
-
-
44849117242
-
Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin
-
YJ Huang, PM Lundy, A Lazaris et al. Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin BMC Biotechnol 8 2008 50
-
(2008)
BMC Biotechnol
, vol.8
, pp. 50
-
-
Huang, Y.J.1
Lundy, P.M.2
Lazaris, A.3
-
18
-
-
0033758789
-
Pharmacokinetics of recombinant activated factor VII (rFVIIa)
-
E Erhardtsen Pharmacokinetics of recombinant activated factor VII (rFVIIa) Semin Thromb Hemost 26 2000 385 391
-
(2000)
Semin Thromb Hemost
, vol.26
, pp. 385-391
-
-
Erhardtsen, E.1
-
19
-
-
53449102958
-
Use of albumin fusion technology to prolong the half-life of recombinant factor VIIa
-
S Schulte Use of albumin fusion technology to prolong the half-life of recombinant factor VIIa Thromb Res 122 2008 S14 S19
-
(2008)
Thromb Res
, vol.122
-
-
Schulte, S.1
-
20
-
-
17144437423
-
Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors
-
NS Key, LM Aledort, D Beardsley et al. Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors Thromb Haemost 80 1998 912 918 (Pubitemid 28556692)
-
(1998)
Thrombosis and Haemostasis
, vol.80
, Issue.6
, pp. 912-918
-
-
Key, N.S.1
Aledort, L.M.2
Beardsley, D.3
Cooper, H.A.4
Davignon, G.5
Ewenstein, B.M.6
Gilchrist, G.S.7
Gill, J.C.8
Glader, B.9
Hoots, W.K.10
Kisker, C.T.11
Lusher, J.M.12
Rosenfield, C.G.13
Shapiro, A.D.14
Smith, H.15
Taft, E.16
-
21
-
-
0031743504
-
Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery
-
AD Shapiro, GS Gilchrist, WK Hoots et al. Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery Thromb Haemost 80 1998 773 778 (Pubitemid 28521721)
-
(1998)
Thrombosis and Haemostasis
, vol.80
, Issue.5
, pp. 773-778
-
-
Shapiro, A.D.1
Gilchrist, G.S.2
Hoots, W.K.3
Cooper, H.A.4
Gastineau, D.A.5
-
22
-
-
77449145452
-
Prolonged half-life of recombinant factor VIIa fusion protein-single dose study in rabbits
-
U Kronthaler, S Schmidbauer, U Liebing et al. Prolonged half-life of recombinant factor VIIa fusion protein-single dose study in rabbits J Thromb Haemost 5 Suppl 2 2009 PP-TH-561
-
(2009)
J Thromb Haemost
, vol.5
, Issue.SUPPL. 2
, pp. 561
-
-
Kronthaler, U.1
Schmidbauer, S.2
Liebing, U.3
-
23
-
-
44249093163
-
Prolonged in vivo half-life of FVIIa by fusion to albumin
-
S Schulte, T Weimer, W Wormsbächer et al. Prolonged in vivo half-life of FVIIa by fusion to albumin Blood 110 2007 3142
-
(2007)
Blood
, vol.110
, pp. 3142
-
-
Schulte, S.1
Weimer, T.2
Wormsbächer, W.3
-
24
-
-
43749102313
-
Prolonged in-vivo half-life of factor VIIa by fusion to albumin
-
DOI 10.1160/TH07-08-0525
-
T Weimer, W Wormsbächer, U Kronthaler et al. Prolonged in-vivo half-life of factor VIIa by fusion to albumin Thromb Haemost 99 2008 659 667 (Pubitemid 351694221)
-
(2008)
Thrombosis and Haemostasis
, vol.99
, Issue.4
, pp. 659-667
-
-
Weimer, T.1
Wormsbacher, W.2
Kronthaler, U.3
Lang, W.4
Liebing, U.5
Schulte, S.6
-
26
-
-
0036484156
-
Pharmacokinetic analysis of plasma-derived and recombinant F IX concentrates in previously treated patients with moderate or severe hemophilia B
-
BM Ewenstein, JH Joist, AD Shapiro et al. Pharmacokinetic analysis of plasma-derived and recombinant F IX concentrates in previously treated patients with moderate or severe hemophilia B Transfusion 42 2002 190 197
-
(2002)
Transfusion
, vol.42
, pp. 190-197
-
-
Ewenstein, B.M.1
Joist, J.H.2
Shapiro, A.D.3
-
27
-
-
0035081112
-
Pharmacokinetics of recombinant factor IX in relation to age of the patient: Implications for dosing in prophylaxis
-
DOI 10.1046/j.1365-2516.2001.00465.x
-
S Björkman, AD Shapiro, E Berntorp Pharmacokinetics of recombinant factor IX in relation to age of the patient: implications for dosing in prophylaxis Haemophilia 7 2001 133 139 (Pubitemid 32243794)
-
(2001)
Haemophilia
, vol.7
, Issue.2
, pp. 133-139
-
-
Bjorkman, S.1
Shapiro, A.D.2
Berntorp, E.3
-
28
-
-
4143091398
-
Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits
-
DOI 10.1111/j.1365-2141.2004.05106.x
-
WP Sheffield, A Mamdani, G Hortelano et al. Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits Br J Haematol 126 2004 565 573 (Pubitemid 39093100)
-
(2004)
British Journal of Haematology
, vol.126
, Issue.4
, pp. 565-573
-
-
Sheffield, W.P.1
Mamdani, A.2
Hortelano, G.3
Gataiance, S.4
Eltringham-Smith, L.5
Begbie, M.E.6
Leyva, R.A.7
Liaw, P.S.8
Ofosu, F.A.9
-
29
-
-
70449461639
-
Genetic fusion to albumin improves the pharmacokinetic properties of factor IX
-
HJ Metzner, T Weimer, U Kronthaler et al. Genetic fusion to albumin improves the pharmacokinetic properties of factor IX Thromb Haemost 102 2009 634 644
-
(2009)
Thromb Haemost
, vol.102
, pp. 634-644
-
-
Metzner, H.J.1
Weimer, T.2
Kronthaler, U.3
-
30
-
-
77951215562
-
Half-life extension through albumin fusion technologies
-
S Schulte Half-life extension through albumin fusion technologies Thromb Res 124 2009 S6 S8
-
(2009)
Thromb Res
, vol.124
-
-
Schulte, S.1
-
31
-
-
84875548634
-
Prolonged serum half-life of a recombinant, albumin-fused, human coagulation factor IX (rIX-FP) in different animal species
-
[Abstract 08P41].
-
HJ Metzner, T Weimer, E Raquet et al. Prolonged serum half-life of a recombinant, albumin-fused, human coagulation factor IX (rIX-FP) in different animal species Haemophilia 16 Suppl 4 2010 40 [Abstract 08P41].
-
(2010)
Haemophilia
, vol.16
, Issue.SUPPL. 4
, pp. 40
-
-
Metzner, H.J.1
Weimer, T.2
Raquet, E.3
-
32
-
-
84865209564
-
Improved kinetics of rIX-FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs
-
MW Nolte, TC Nichols, J Mueller-Cohrs et al. Improved kinetics of rIX-FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs J Thromb Haemost 10 2012 1591 1599
-
(2012)
J Thromb Haemost
, vol.10
, pp. 1591-1599
-
-
Nolte, M.W.1
Nichols, T.C.2
Mueller-Cohrs, J.3
-
33
-
-
84875516983
-
PROLONG-9FP clinical development program-phase i results of recombinant fusion protein linking coagulation factor IX with recombinant albumin (rIX-FP)
-
E Santagostino PROLONG-9FP clinical development program-phase I results of recombinant fusion protein linking coagulation factor IX with recombinant albumin (rIX-FP) Thromb Res 120 2012 2405 2411
-
(2012)
Thromb Res
, vol.120
, pp. 2405-2411
-
-
Santagostino, E.1
-
34
-
-
84866594053
-
Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients
-
E Santagostino, C Negrier, R Klamroth et al. Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients Blood 120 2012 2405 2411
-
(2012)
Blood
, vol.120
, pp. 2405-2411
-
-
Santagostino, E.1
Negrier, C.2
Klamroth, R.3
-
35
-
-
84875539641
-
Phase I/II, open-label, multicenter, safety, efficacy and PK study of a recombinant coagulation factor IX albumin fusion protein (rIX-FP) in subjects with hemophilia B
-
U Martinowitz, A Lubetsky Phase I/II, open-label, multicenter, safety, efficacy and PK study of a recombinant coagulation factor IX albumin fusion protein (rIX-FP) in subjects with hemophilia B Thromb Res 131 Suppl 2 2013 S11 S14
-
(2013)
Thromb Res
, vol.131
, Issue.SUPPL. 2
-
-
Martinowitz, U.1
Lubetsky, A.2
-
36
-
-
84875543180
-
Physico-chemical characterization of recombinant single chain FVIII
-
[Abstract P2-29].
-
S Schmidbauer, R Witzel, J Kreuter et al. Physico-chemical characterization of recombinant single chain FVIII Hämostaeseologie 32 2012 A41 [Abstract P2-29].
-
(2012)
Hämostaeseologie
, vol.32
, pp. 41
-
-
Schmidbauer, S.1
Witzel, R.2
Kreuter, J.3
-
37
-
-
84875485363
-
Preclinical efficacy and safety of CSL627 novel recombinant, single-chain FVIII
-
[Abstract P2-19].
-
SB Zollner, E Raquet, J Müller-Cohrs et al. Preclinical efficacy and safety of CSL627 novel recombinant, single-chain FVIII Hämostaeseologie 32 2012 A38 [Abstract P2-19].
-
(2012)
Hämostaeseologie
, vol.32
, pp. 38
-
-
Zollner, S.B.1
Raquet, E.2
Müller-Cohrs, J.3
|