Signal amplification via biological self-assembly of surface-engineered quantum dots for multiplexed subattomolar immunoassays and apoptosis imaging

ACS Nano

Volumn 7, Issue 10, 2013, Pages 9416-9427

  Park, Joonhyuck ^a   Park, Youngrong ^a   Kim, Sungjee ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

apoptosis imaging; immunoassay; quantum dots; self assembly; signal amplification

Indexed keywords

APOPTOSIS IMAGING; BIOLOGICAL FUNCTIONS; HIGHLY SENSITIVE DETECTIONS; IMMUNOASSAY; LINEAR DYNAMIC RANGES; NON-SPECIFIC BINDING; NONSPECIFIC ADSORPTION; SIGNAL AMPLIFICATIONS;

BIOCHEMISTRY; CELL DEATH; COENZYMES; DIAGNOSIS; EQUILIBRIUM CONSTANTS; IMMUNOLOGY; MOLECULAR BIOLOGY; MONTE CARLO METHODS; MULTIPLEXING; PROTEINS; SEMICONDUCTOR QUANTUM DOTS;

SELF ASSEMBLY;

MYOGLOBIN; QUANTUM DOT;

APOPTOSIS; ARTICLE; HEPG2 CELL LINE; HUMAN; IMMUNOASSAY; IMMUNOLOGY; METHODOLOGY;

APOPTOSIS; HEP G2 CELLS; HUMANS; IMMUNOASSAY; MYOGLOBIN; QUANTUM DOTS;

EID: 84887002396     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn4042078     Document Type: Article

References (50)

1. Green, E. D.; Guyer, M. S. Charting a Course for Genomic Medicine from Base Pairs to Bedside Nature 2011, 470, 204-213
2. Wulfkuhle, J. D.; Liotta, L. A.; Petricoin, E. F. Proteomic Applications for the Early Detection of Cancer Nat. Rev. Cancer 2003, 3, 267-275
3. Considine, R. V.; Sinha, M. K.; Heiman, M. L.; Kriauciunas, A.; Stephens, T. W.; Nyce, M. R.; Ohannesian, J. P.; Marco, C. C.; McKee, L. J.; Bauer, T. L. et al. Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans N. Engl. J. Med. 1996, 334, 292-295
4. Hemmila, I. Fluoroimmunoassays and Immunofluorometric Assays Clin. Chem. 1985, 31, 359-370
5. Wild, D. The Immunoassay Handbook, 3 rd ed.; Elsevier: Kidlington, UK, 2005.
6. Giljohann, D. A.; Mirkin, C. A. Drivers of Biodiagnostic Development Nature 2009, 462, 461-464
7. Park, S.-J.; Taton, T. A.; Mirkin, C. A. Array-Based Electrical Detection of DNA with Nanoparticle Probes Science 2002, 295, 1503-1506
8. Qu, W.; Liu, Y.; Liu, D.; Wang, Z.; Jiang, X. Copper-Mediated Amplification Allows Readout of Immunoassays by the Naked Eye Angew. Chem., Int. Ed. 2011, 50, 3442-3445
9. Sano, T.; Smith, C.; Cantor, C. Immuno-PCR: Very Sensitive Antigen Detection by Means of Specific Antibody-DNA Conjugates Science 1992, 258, 120-122
10. Wang, J.; Liu, G.; Munge, B.; Lin, L.; Zhu, Q. DNA-Based Amplified Bioelectronic Detection and Coding of Proteins Angew. Chem., Int. Ed. 2004, 43, 2158-2161
11. Mason, J. T.; Xu, L.; Sheng, Z.-m.; O'Leary, T. J. A Liposome-PCR Assay for the Ultrasensitive Detection of Biological Toxins Nat. Biotechnol. 2006, 24, 555-557
12. Das, J.; Aziz, M. A.; Yang, H. A Nanocatalyst-Based Assay for Proteins: DNA-Free Ultrasensitive Electrochemical Detection Using Catalytic Reduction of p -Nitrophenol by Gold-Nanoparticle Labels J. Am. Chem. Soc. 2006, 128, 16022-16023
13. Nam, J.-M.; Thaxton, C. S.; Mirkin, C. A. Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins Science 2003, 301, 1884-1886
14. Exley, D.; Ekeke, G. I. Fluoroimmunoassay of 5[α]- dihydrotestosterone J. Steroid Biochem. 1981, 14, 1297-1302
15. Alivisatos, P. The Use of Nanocrystals in Biological Detection Nat. Biotechnol. 2004, 22, 47-52
16. Wu, X.; Liu, H.; Liu, J.; Haley, K. N.; Treadway, J. A.; Larson, J. P.; Ge, N.; Peale, F.; Bruchez, M. P. Immunofluorescent Labeling of Cancer Marker Her2 and Other Cellular Targets with Semiconductor Quantum Dots Nat. Biotechnol. 2003, 21, 41-46
17. Chan, W. C. W.; Maxwell, D. J.; Gao, X.; Bailey, R. E.; Han, M.; Nie, S. Luminescent Quantum Dots for Multiplexed Biological Detection and Imaging Curr. Opin. Biotechnol. 2002, 13, 40-46
18. Medintz, I. L.; Uyeda, H. T.; Goldman, E. R.; Mattoussi, H. Quantum Dot Bioconjugates for Imaging, Labelling and Sensing Nat. Mater. 2005, 4, 435-446
19. Goldman, E.; Medintz, I.; Mattoussi, H. Luminescent Quantum Dots in Immunoassays Anal. Bioanal. Chem. 2006, 384, 560-563
20. Bhang, S. H.; Won, N.; Lee, T.-J.; Jin, H.; Nam, J.; Park, J.; Chung, H.; Park, H.-S.; Sung, Y.-E.; Hahn, S. K. et al. Hyaluronic Acid-Quantum Dot Conjugates for In Vivo Lymphatic Vessel Imaging ACS Nano 2009, 3, 1389-1398
21. McLaurin, E. J.; Greytak, A. B.; Bawendi, M. G.; Nocera, D. G. Two-Photon Absorbing Nanocrystal Sensors for Ratiometric Detection of Oxygen J. Am. Chem. Soc. 2009, 131, 12994-13001
22. Snee, P. T.; Somers, R. C.; Nair, G.; Zimmer, J. P.; Bawendi, M. G.; Nocera, D. G. A Ratiometric CdSe/ZnS Nanocrystal pH Sensor J. Am. Chem. Soc. 2006, 128, 13320-13321
23. Kim, S.; Lim, Y. T.; Soltesz, E. G.; De Grand, A. M.; Lee, J.; Nakayama, A.; Parker, J. A.; Mihaljevic, T.; Laurence, R. G.; Dor, D. M. et al. Near-Infrared Fluorescent Type II Quantum Dots for Sentinel Lymph Node Mapping Nat. Biotechnol. 2004, 22, 93-97
24. Wu, Y.; Chakrabortty, S.; Gropeanu, R. A.; Wilhelmi, J.; Xu, Y.; Er, K. S.; Kuan, S. L.; Koynov, K.; Chan, Y.; Weil, T. pH-Responsive Quantum Dots via an Albumin Polymer Surface Coating J. Am. Chem. Soc. 2010, 132, 5012-5014
25. Weiyong, M.; Jia, G.; Wuli, Y.; Changchun, W.; Jia, H.; Jiyao, C. Synthesis of High-Quality Near-Infrared-Emitting CdTeS Alloyed Quantum Dots via the Hydrothermal Method Nanotechnology 2007, 18, 485611
26. Soman, C. P.; Giorgio, T. D. Quantum Dot Self-Assembly for Protein Detection with Sub-picomolar Sensitivity Langmuir 2008, 24, 4399-4404
27. Soman, C. P.; Giorgio, T. D. Sensitive and Multiplexed Detection of Proteomic Antigens via Quantum Dot Aggregation Nanomed. Nanotechnol. Biol. Med. 2009, 5, 402-409
28. Kim, D.; Daniel, W. L.; Mirkin, C. A. Microarray-Based Multiplexed Scanometric Immunoassay for Protein Cancer Markers Using Gold Nanoparticle Probes Anal. Chem. 2009, 81, 9183-9187
29. Park, J.; Nam, J.; Won, N.; Jin, H.; Jung, S.; Jung, S.; Cho, S.-H.; Kim, S. Compact and Stable Quantum Dots with Positive, Negative, or Zwitterionic Surface: Specific Cell Interactions and Non-specific Adsorptions by the Surface Charges Adv. Funct. Mater. 2011, 21, 1558-1566
30. Muro, E.; Pons, T.; Lequeux, N.; Fragola, A.; Sanson, N.; Lenkei, Z.; Dubertret, B. Small and Stable Sulfobetaine Zwitterionic Quantum Dots for Functional Live-Cell Imaging J. Am. Chem. Soc. 2010, 132, 4556-4557
31. Susumu, K.; Oh, E.; Delehanty, J. B.; Blanco-Canosa, J. B.; Johnson, B. J.; Jain, V.; Hervey, W. J.; Algar, W. R.; Boeneman, K.; Dawson, P. E. et al. Multifunctional Compact Zwitterionic Ligands for Preparing Robust Biocompatible Semiconductor Quantum Dots and Gold Nanoparticles J. Am. Chem. Soc. 2011, 133, 9480-9496
32. Choi, H. S.; Liu, W.; Misra, P.; Tanaka, E.; Zimmer, J. P.; Itty Ipe, B.; Bawendi, M. G.; Frangioni, J. V. Renal Clearance of Quantum Dots Nat. Biotechnol. 2007, 25, 1165-1170
33. Jin, H.; Nam, J.; Park, J.; Jung, S.; Im, K.; Hur, J.; Park, J.-J.; Kim, J.-M.; Kim, S. Strong Polyelectrolyte Quantum Dot Surface for Stable Bioconjugation and Layer-by-Layer Assembly Applications Chem. Commun. 2011, 47, 1758-1760
34. Rauf, S.; Glidle, A.; Cooper, J. M. Production of Quantum Dot Barcodes Using Biological Self-Assembly Adv. Mater. 2009, 21, 4020-4024
35. Witherspoon, L. R.; Shuler, S. E.; Garcia, M. M.; Zollinger, L. A. Assessment of Serum Myoglobin as a Marker for Acute Myocardial Infarction J. Nucl. Med. 1979, 20, 115-119
36. MacDougall, D.; Crummett, W. B. Guidelines for Data Acquisition and Data Quality Evaluation in Environmental Chemistry Anal. Chem. 1980, 52, 2242-2249
37. Gul, O.; Calay, E.; Sezerman, U.; Basaga, H.; Gurbuz, Y. Sandwich-Type, Antibody Microarrays for the Detection and Quantification of Cardiovascular Risk Markers Sens. Actuators, B 2007, 125, 581-588
38. Dyke, K. V.; Dyke, C. V.; Woodfork, K. Luminescence Biotechnology; CRC Press: New York, 2002.
39. Seker, U. O. S.; Zengin, G.; Tamerler, C.; Sarikaya, M.; Demir, H. V. Assembly Kinetics of Nanocrystals via Peptide Hybridization Langmuir 2011, 27, 4867-4872
40. Zhao, S.; Walker, D. S.; Reichert, W. M. Cooperativity in the Binding of Avidin to Biotin-Lipid-Doped Langmuir-Blodgett Films Langmuir 1993, 9, 3166-3173
41. Yu, H.; Diamandis, E.; Prestigiacomo, A.; Stamey, T. Ultrasensitive Assay of Prostate-Specific Antigen Used for Early Detection of Prostate Cancer Relapse and Estimation of Tumor-Doubling Time after Radical Prostatectomy Clin. Chem. 1995, 41, 430-434
42. Wiese, R.; Belosludtsev, Y.; Powdrill, T.; Thompson, P.; Hogan, M. Simultaneous Multianalyte ELISA Performed on a Microarray Platform Clin. Chem. 2001, 47, 1451-1457
43. Geißler, D.; Charbonniére, L. J.; Ziessel, R. F.; Butlin, N. G.; Löhmannsröben, H.-G.; Hildebrandt, N. Quantum Dot Biosensors for Ultrasensitive Multiplexed Diagnostics Angew. Chem., Int. Ed. 2010, 49, 1396-1401
44. Geißler, D.; Stufler, S.; Löhmannsröben, H.-G.; Hildebrandt, N. Six-Color Time-Resolved Föster Resonance Energy Transfer for Ultrasensitive Multiplexed Biosensing J. Am. Chem. Soc. 2013, 135, 1102-1109
45. Wegner, K. D.; Jin, Z.; Lindén, S.; Jennings, T. L.; Hildebrandt, N. Quantum-Dot-Based Föster Resonance Energy Transfer Immunoassay for Sensitive Clinical Diagnostics of Low-Volume Serum Samples ACS Nano 2013, 7, 7411-7419
46. Chen, M.-J.; Wu, Y.-S.; Lin, G.-F.; Hou, J.-Y.; Li, M.; Liu, T.-C. Quantum-Dot-Based Homogeneous Time-Resolved Fluoroimmunoassay of α-Fetoprotein Anal. Chim. Acta 2012, 741, 100-105
47. Kerr, J. F. R.; Winterford, C. M.; Harmon, B. V. Apoptosis. Its Significance in Cancer and Cancer Therapy Cancer 1995, 73, 2013-2026
48. Van Engeland, M.; Nieland, L. J. W.; Ramaekers, F. C. S.; Schutte, B.; Reutelingsperger, C. P. M. Annexin V-Affinity Assay: A Review on an Apoptosis Detection System Based on Phosphatidylserine Exposure Cytometry 1998, 31, 1-9
49. Le Gac, S.; Vermes, I.; Van den Berg, A. Quantum Dots Based Probes Conjugated to Annexin V for Photostable Apoptosis Detection and Imaging Nano Lett. 2006, 6, 1863-1869
50. Riss, T. L.; Moravec, R. A. Use of Multiple Assay Endpoints To Investigate the Effects of Incubation Time, Dose of Toxin, and Plating Density in Cell-Based Cytotoxicity Assays Assay Drug Dev. Tech. 2004, 2, 52-61