Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 2, 2008, Pages

  Dosdall, Derek J ^a   Tabereaux, Paul B ^b   Kim, Jong J ^a   Walcott, Gregory P ^b   Rogers, Jack M ^a   Killingsworth, Cheryl R ^b   Huang, Jian ^b   Robertson, Peter G ^b   Smith, William M ^a,b   Ideker, Raymond E ^a,b,c,d  

^a and Radiation Oncology   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d NONE   (United States)

Author keywords

Activation rate gradient; Electrophysiology; Lugol ablation; Mapping

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATHETER ABLATION; CONTROLLED STUDY; DOG; ENDOCARDIUM MAPPING; EPICARDIUM MAPPING; HEART PERFUSION; HEART VENTRICLE FIBRILLATION; ISOLATED HEART; LUGOL ABLATION PROCEDURE; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER; QUANTITATIVE ANALYSIS; ACTION POTENTIAL; ANIMAL; DISEASE MODEL; DRUG EFFECT; ELECTROCARDIOGRAPHY; ENDOCARDIUM; HEART PACING; IN VITRO STUDY; PATHOPHYSIOLOGY; TIME;

IODIDE; LUGOL'S SOLUTION;

ACTION POTENTIALS; ANIMALS; BODY SURFACE POTENTIAL MAPPING; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; DOGS; ENDOCARDIUM; IODIDES; PURKINJE FIBERS; TIME FACTORS; VENTRICULAR FIBRILLATION;

EID: 52449117447     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00466.2008     Document Type: Article

References (48)

1. AHA Special Report. Position of the American Heart Association on research animal use. Circulation 71: 849A-850A, 1985.
2. Allison JS, Qin H, Dosdall DJ, Huang J, Newton JC, Allred JD, Smith WM, Ideker RE. The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillation. J Cardiovasc Electrophysiol 18: 1306-1312, 2007.
3. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, Gintant GA, Liu DW. Heterogeneity within the ventricular wall: electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res 69: 1427-1449, 1991.
4. Arnar DO, Bullinga JR, Martins JB. Role of the Purkinje system in spontaneous ventricular tachycardia during acute ischemia in a canine model. Circulation 96: 2421-2429, 1997.
5. Arnar DO, Martins JB. Purkinje involvement in arrhythmias after coronary artery reperfusion. Am J Physiol Heart Circ Physiol 282: H1189-H1196, 2002.
6. Bagdonas AA, Stuckey JH, Piera J, Amer NS, Hoffman BF. Effects of ischemia and hypoxia on the specialized conducting system of the canine heart. Am Heart J 61: 206-218, 1961.
7. Ben-Haim SA, Cable DG, Rath TE, Carmen L, Martins JB. Impulse propagation in the Purkinje system and myocardium of intact dogs. Am J Physiol Heart Circ Physiol 265: H1588-H1595, 1993.
8. Berenfeld O, Jalife J. Purkinje-muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3-dimensional model of the ventricles. Circ Res 82: 1063-1077, 1998.
9. Cates AW, Smith WM, Ideker RE, Pollard AE. Purkinje and ventricular contributions to endocardial activation sequence in perfused rabbit right ventricle. Am J Physiol Heart Circ Physiol 281: H490-H505, 2001.
10. Cha YM, Birgersdotter-Green U, Wolf PL, Peters BB, Chen PS. The mechanism of termination of reentrant activity in ventricular fibrillation. Circ Res 74: 495-506, 1994.
11. Cha YM, Uchida T, Wolf PL, Peters BB, Fishbein MC, Karagueuzian HS, Chen PS. Effects of chemical subendocardial ablation on activation rate gradient during ventricular fibrillation. Am J Physiol Heart Circ Physiol 269: H1998-H2009, 1995.
12. Chen J, Mandapati R, Berenfeld O, Skanes AC, Jalife J. High-frequency periodic sources underlie ventricular fibrillation in the isolated rabbit heart. Circ Res 86: 86-93, 2000.
13. Chen PS, Wolf PL, Cha YM, Peters BB, Topham SL. Effects of subendocardial ablation on anodal supernormal excitation and ventricular vulnerability in open-chest dogs. Circulation 87: 216-229, 1993.
14. Damiano RJ Jr, Smith PK, Tripp HF Jr, Asano T, Small KW, Lowe JE, Ideker RE, Cox JL. The effect of chemical ablation of the endocardium on ventricular fibrillation threshold. Circulation 74: 645-652, 1986.
15. Evans FG, Rogers JM, Smith WM, Ideker RE. Automatic detection of conduction block based on time-frequency analysis of unipolar electrograms. IEEE Trans Biomed Eng 46: 1090-1097, 1999.
16. Fixler DE, Wheeler M, Huffines D. Extent of myocardial flow from luminal collateral circulation. J Appl Physiol 37: 282-285, 1974.
17. Forsgren S, Eriksson A, Kjorell U, Thornell LE. The conduction system in the human heart at midgestation - immunohistochemical demonstration of the intermediate filament protein skeleton. Histochemistry 75: 43-52, 1982.
18. Friedman PL, Stewart JR, Fenoglio JJ, Wit AL. Survival of subendocardial Purkinje fibers after extensive myocardial infarction in dogs. Circ Res 33: 597-611, 1973.
19. Gilmour RF Jr, Zipes DP. Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis. Circ Res 46: 814-825, 1980.
20. Haissaguerre M, Shah DC, Jais P, Shoda M, Kautzner J, Arentz T, Kalushe D, Kadish A, Griffith M, Gaita F, Yamane T, Garrigue S, Hocini M, Clementy J. Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation. Lancet 359: 677-678, 2002.
21. Henry CG, Lowry OH. Enzymes and metabolites of glycogen metabolism in canine cardiac Purkinje fibers. Am J Physiol Heart Circ Physiol 248: H599-H605, 1985.
22. Huang J, Rogers JM, Killingsworth CR, Singh KP, Smith WM, Ideker RE. Evolution of activation patterns during long-duration ventricular fibrillation in dogs. Am J Physiol Heart Circ Physiol 286: H1193-H1200, 2004.
23. Huizar JF, Warren MD, Shvedko AG, Kalifa J, Moreno J, Mironov S, Jalife J, Zaitsev AV. Three distinct phases of VF during global ischemia in the isolated blood-perfused pig heart. Am J Physiol Heart Circ Physiol 293: H1617-H1628, 2007.
24. Janse MJ. Vulnerability to ventricular fibrillation. Chaos 8: 149-156, 1998.
25. Joyner RW, Picone J, Veenstra R, Rawling D. Propagation through electrically coupled cells. Effects of regional changes in membrane properties. Circ Res 53: 526-534, 1983.
26. Lazzara R, el-Sherif N, Scherlag BJ. Electrophysiological properties of canine Purkinje cells in one-day-old myocardial infarction. Circ Res 33: 722-734, 1973.
27. Lee JJ, Kamjoo K, Hough D, Hwang C, Fan W, Fishbein MC, Bonometti C, Ikeda T, Karagueuzian HS, Chen PS. Reentrant wavefronts in Wiggers' stage II ventricular fibrillation. Circ Res 78: 660-675, 1996.
28. Li L, Jin Q, Huang J, Cheng KA, Ideker RE. Intramural foci during long duration fibrillation in the pig ventricle. Circ Res 102: 1256-1264, 2008.
29. Newton JC, Smith WM, Ideker RE. Estimated global transmural distribution of activation rate and conduction block during porcine and canine ventricular fibrillation. Circ Res 94: 836-842, 2004.
30. Nogami A, Sugiyasu A, Kubota S, Kato K. Mapping and ablation of idiopathic ventricular fibrillation from the Purkinje system. Heart Rhythm 2: 646-649, 2005.
31. Overholt ED, Joyner RW, Veenstra RD, Rawling D, Wiedmann R. Unidirectional block between Purkinje and ventricular layers of papillary muscles. Am J Physiol Heart Circ Physiol 247: H584-H595, 1984.
32. Pollard AE, Spitzer KW, Burgess MJ. Contributions of the specialized conduction system to the activation sequence in the canine pulmonary conus. Am J Physiol Heart Circ Physiol 273: H446-H463, 1997.
33. Qin H, Kay MW, Chattipakorn N, Redden DT, Ideker RE, Rogers JM. Effects of heart isolation, voltage-sensitive dye, and electromechanical uncoupling agents on ventricular fibrillation. Am J Physiol Heart Circ Physiol 284: H1818-H1826, 2003.
34. Robinson RB, Boyden PA, Hoffman BF, Hewett KW. Electrical restitution process in dispersed canine cardiac Purkinje and ventricular cells. Am J Physiol Heart Circ Physiol 253: H1018-H1025, 1987.
35. Rogers JM, Walcott GP, Gladden JD, Melnick SB, Kay MW. Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Biophys J 92: 1090-1095, 2007.
36. Schnabel PA, Richter J, Schmiedl A, Bach F, Bartels U, Ramsauer B, Gebhard MM, Bretschneider HJ. Patterns of structural deterioration due to ischemia in Purkinje fibres and different layers of the working myocardium. Thorac Cardiovasc Surg 39: 174-182, 1991.
37. Spach MS, Huang S, Armstrong SI, Canent RV Jr. Demonstration of peripheral conduction system in human hearts. Circulation 28: 333-338, 1963.
38. Tabereaux PB, Walcott GP, Rogers JM, Kim J, Dosdall DJ, Robertson PG, Killingsworth CR, Smith WM, Ideker RE. Activation patterns of Purkinje fibers during long-duration ventricular fibrillation in an isolated canine heart model. Circulation 116: 1113-1119, 2007.
39. Taccardi B, Punske BB, Macchi E, Macleod RS, Ershler PR. Epicardial and intramural excitation during ventricular pacing: effect of myocardial structure. Am J Physiol Heart Circ Physiol 294: H1753-H1766, 2008.
40. Tribulova N, Novakova S, Macsaliova A, Sass S, Thomas S, Goetzfried S, Podzuweit T, Manoach M. Histochemical and ultrastructural characterisation of an arrhythmogenic substrate in ischemic pig heart. Acta Histochem 104: 393-397, 2002.
41. Valderrábano M, Lee MH, Ohara T, Lai AC, Fishbein MC, Lin SF, Karagueuzian HS, Chen PS. Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. Circ Res 88: 839-848, 2001.
42. Veenstra RD, Joyner RW, Rawling DA. Purkinje and ventricular activation sequences of canine papillary muscle. Effects of quinidine and calcium on the Purkinje-ventricular conduction delay. Circ Res 54: 500-515, 1984.
43. Winslow RD, Mehta D, Fuster V. Sudden cardiac death: mechanisms, therapies and challenges. Nat Clin Pract Cardiovasc Med 2: 352-360, 2005.
44. Worley SJ, Swain JL, Colavita PG, Smith WM, Ideker RE. Development of an endocardial-epicardial gradient of activation rate during electrically induced, sustained ventricular fibrillation in dogs. Am J Cardiol 55: 813-820, 1985.
45. Wu TJ, Lin SF, Hsieh YC, Ting CT, Chen PS. Ventricular fibrillation during no-flow global ischemia in isolated rabbit hearts. J Cardiovasc Electrophysiol 17: 1112-1120, 2006.
46. Xing D, Martins JB. Triggered activity due to delayed afterdepolarizations in sites of focal origin of ischemic ventricular tachycardia. Am J Physiol Heart Circ Physiol 287: H2078-H2084, 2004.
47. Zaitsev AV, Berenfeld O, Mironov SF, Jalife J, Pertsov AM. Distribution of excitation frequencies on the epicardial and endocardial surfaces of fibrillating ventricular wall of the sheep heart. Circ Res 86: 408-417, 2000.
48. Zipes DP, Wellens HJJ. Sudden cardiac death. Circulation 98: 2334-2351, 1998.