The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells

Pharmaceutical Research

Volumn 32, Issue 3, 2015, Pages 779-792

  Zhu, Shiguo ^a   Denman, Cecele J ^b   Cobanoglu, Zehra S ^b   Kiany, Simin ^b   Lau, Ching C ^c   Gottschalk, Stephen M ^c   Hughes, Dennis P M ^b   Kleinerman, Eugenie S ^b   Lee, Dean A ^b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

cancer; HDAC inhibitor; natural killer cells; NKG2D; NKG2D ligands

Indexed keywords

ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; ENTINOSTAT; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HISTONE; HISTONE DEACETYLASE INHIBITOR; HLA ANTIGEN CLASS 1; KLRK1 PROTEIN, HUMAN; LIGAND; MHC CLASS I-RELATED CHAIN A; MICB ANTIGEN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; PYRIDINE DERIVATIVE; SIGNAL PEPTIDE; ULBP2 PROTEIN, HUMAN;

ACETYLATION; ANIMAL; BINDING SITE; COCULTURE; COLONIC NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; NATURAL KILLER CELL; NONOBESE DIABETIC MOUSE; PATHOLOGY; PROMOTER REGION; SARCOMA; TIME FACTOR; TRANSGENIC MOUSE; TUMOR CELL LINE; UPREGULATION;

ACETYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; BINDING SITES; CELL LINE, TUMOR; COCULTURE TECHNIQUES; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; GPI-LINKED PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; LIGANDS; MICE, INBRED NOD; MICE, TRANSGENIC; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PROMOTER REGIONS, GENETIC; PYRIDINES; SARCOMA; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886987126     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1231-0     Document Type: Article

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