Novel cancer-targeting SPECT/NIRF dual-modality imaging probe 99mTc-PC-1007: Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6350-6354

  Zhang, Yi ^a   Xiao, Li ^a   Popovic, Kosta ^a   Xie, Xiuzhen ^a   Chordia, Mahendra D ^a   Chung, Leland W K ^b   Williams, Mark B ^a   Yue, Wei ^a   Pan, Dongfeng ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

99m Technetium; Breast cancer; Dual modality; Heptamethine cyanine dye; Near infrared fluorescence; SPECT

Indexed keywords

CYANINE DYE; PC 1007 TC 99M; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER MODEL; CELL STRAIN MCF 7; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CT SPECT SCANNER; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG RETENTION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TUMOR LEVEL; DRUG UPTAKE; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; NUCLEIC ACID PROBE; ORGAN DISTRIBUTION; PLASMA CLEARANCE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR XENOGRAFT;

99M-TECHNETIUM; BREAST CANCER; DUAL-MODALITY; HEPTAMETHINE CYANINE DYE; NEAR INFRARED FLUORESCENCE; SPECT;

ANIMALS; BREAST NEOPLASMS; FEMALE; HETEROGRAFTS; HUMANS; MCF-7 CELLS; MICE; MULTIMODAL IMAGING; RADIOPHARMACEUTICALS; SPECTROSCOPY, NEAR-INFRARED; TECHNETIUM COMPOUNDS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886950897     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.074     Document Type: Article

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