3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6442-6446

  Boland, Sandro ^a   Defert, Olivier ^a   Alen, Jo ^a   Bourin, Arnaud ^a   Castermans, Karolien ^a   Kindt, Nele ^a   Boumans, Nicki ^a   Panitti, Laura ^a   Van De Velde, Sarah ^b   Stalmans, Ingeborg ^b   Leysen, Dirk ^a  

^a Amakem NV Agoralaan A Bis   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Esterase; Kinase inhibitor; ROCK; SAR; Soft drug

Indexed keywords

3 [2 (AMINOMETHYL) 5 ((PYRIDIN 4 YL)CARBAMOYL)PHENYL]; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMINE; BENZOIC ACID DERIVATIVE; CARBOXYLIC ACID; ESTER; ESTERASE; HYDROLASE; MYOSIN LIGHT CHAIN; NITROGEN; PYRIDINE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CONJUNCTIVA; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; CORNEA; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; ENZYME ACTIVITY; HUMAN; IC 50; IN VIVO STUDY; INTRAOCULAR PRESSURE; MEMBRANE PERMEABILITY; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; RABBIT; SCLERA; VITREOUS BODY;

ORYCTOLAGUS CUNICULUS;

ESTERASE; KINASE INHIBITOR; ROCK; SAR; SOFT DRUG;

AMIDES; ANIMALS; BENZOATES; MODELS, MOLECULAR; PHOSPHORYLATION; PYRIDINES; RABBITS; RHO-ASSOCIATED KINASES;

EID: 84886949600     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.040     Document Type: Article

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