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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6269-6273

Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl) phenyl] amide as histamine H3 receptor antagonist for the treatment of depression

(10) Gao, Zhongli a Hurst, William J b Czechtizky, Werngard b Hall, Daniel b Moindrot, Nicolas b Nagorny, Raisa b Pichat, Philippe b Stefany, David b Hendrix, James A b George, Pascal G b

a Sanofi US (United States)

b SANOFI (France)

Author keywords

Anxiety; Depression; Experimental models of anxiety and depression; Forced swimming test

Indexed keywords

3,5 DIMETHYL ISOXAZOLE 4 CARBOXYLIC ACID [2 METHYL 4 ((2S,3'S) 2 METHYL [1,3']BIPYRROLIDINYL 1' YL)PHENYL]AMIDE; ANTIDEPRESSANT AGENT; HISTAMINE H3 RECEPTOR ANTAGONIST; IMIPRAMINE; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; FEMALE; FORCED SWIMMING TEST; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPIDOSIS; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLIC ACTIVATION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STEREOCHEMISTRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TREMOR;

ANXIETY; DEPRESSION; EXPERIMENTAL MODELS OF ANXIETY AND DEPRESSION; FORCED SWIMMING TEST; HISTAMINE H(3) RECEPTOR ANTAGONIST/INVERSE AGONIST;

AMIDES; ANIMALS; ANTIDEPRESSIVE AGENTS; CHO CELLS; CRICETULUS; HISTAMINE ANTAGONISTS; HUMANS; KINETICS; MALE; MICE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3;

EID: 84886946034 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.09.081 Document Type: Article

Times cited : (22)

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