The association between Parkinson's disease and anti-epilepsy drug carbamazepine: A case-control study using the UK General Practice Research Database

British Journal of Clinical Pharmacology

Volumn 76, Issue 5, 2013, Pages 816-822

  Skow, Áine ^a   Douglas, Ian ^a   Smeeth, Liam ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Autophagy; Carbamazepine; Epilepsy; Parkinson's disease

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CARBAMAZEPINE;

ADULT; AGE DISTRIBUTION; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; COMPARATIVE STUDY; CONSULTATION; CONTROLLED STUDY; DATA BASE; DIAGNOSTIC TEST ACCURACY STUDY; DRUG EXPOSURE; DRUG SAFETY; EPILEPSY; FEMALE; GENERAL PRACTICE; GENERAL PRACTICE RESEARCH DATABASE; HUMAN; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; POPULATION BASED CASE CONTROL STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX RATIO; SMOKING; TREATMENT DURATION; UNITED KINGDOM;

AUTOPHAGY; CARBAMAZEPINE; EPILEPSY; PARKINSON'S DISEASE;

AGED; AGED, 80 AND OVER; ANTICONVULSANTS; CARBAMAZEPINE; CASE-CONTROL STUDIES; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENERAL PRACTICE; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PREDICTIVE VALUE OF TESTS; RISK FACTORS; TIME FACTORS;

EID: 84886938571     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12100     Document Type: Article

References (20)

1. Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008; 79: 368-376.
2. Fratiglioni L, Qiu C. Prevention of common neurodegenerative disorders in the elderly. Exp Gerontol 2009; 44: 46-50.
3. Winslow AR, Rubinsztein DC. The Parkinson disease protein alpha-synuclein inhibits autophagy. Autophagy 2011; 7: 429-431.
4. Schapira AH. Neurobiology and treatment of Parkinson's disease. Trends Pharmacol Sci 2009; 30: 41-47.
5. Becker C, Jick SS, Meier CR. Use of antihypertensives and the risk of Parkinson disease. Neurology 2008; 70: 1438-1444.
6. Metcalf DJ, Garcia-Arencibia M, Hochfeld WE, Rubinsztein DC. Autophagy and misfolded proteins in neurodegeneration. Exp Neurol 2010; 238: 22-28.
7. Fleming A, Noda T, Yoshimori T, Rubinsztein DC. Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol 2011; 7: 9-17.
8. Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, Maurice N, Mukherjee A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science 2010; 329: 229-232.
9. Wood L, Martinez C. The general practice research database: role in pharmacovigilance. Drug Saf 2004; 27: 871-881.
10. Herrett E, Thomas SL, Schoonen WM, Smeeth L, Hall AJ. Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol 2010; 69: 4-14.
11. Lawson DH, Sherman V, Hollowell J. The General Practice Research Database. Scientific and Ethical Advisory Group. QJM 1998; 91: 445-452.
12. Thanvi B, Treadwell S. Drug induced parkinsonism: a common cause of parkinsonism in older people. Postgrad Med J 2009; 85: 322-326.
13. Hu G, Jousilahti P, Nissinen A, Antikainen R, Kivipelto M, Tuomilehto J. Body mass index and the risk of Parkinson disease. Neurology 2006; 67: 1955-1959.
14. Godwin-Austen RB, Lee PN, Marmot MG, Stern GM. Smoking and Parkinson's disease. J Neurol Neurosurg Psychiatry 1982; 45: 577-581.
15. Hernan MA, Takkouche B, Caamano-Isorna F, Gestal-Otero JJ. A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann Neurol 2002; 52: 276-284.
16. Schlesselman JJ. Case-control Studies: Design, Conduct, Analysis. New York: Oxford University Press, 1982.
17. White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice. Stat Med 2011; 30: 377-399.
18. von Campenhausen S, Bornschein B, Wick R, Botzel K, Sampaio C, Poewe W, Oertel W, Siebert U, Berger K, Dodel R. Prevalence and incidence of Parkinson's disease in Europe. Eur Neuropsychopharmacol 2005; 15: 473-490.
19. Jick H, Jick SS, Derby LE. Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ 1991; 302: 766-768.
20. Lesage S, Brice A. Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum Mol Genet 2009; 18: R48-59.